The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Impact of Oxidative Stress on Exercising Skeletal Muscle
Open accessAbstract
It is well established that muscle contractions during exercise lead to elevated levels of reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have many deleterious effects, such as a reduction of force generation and increased muscle atrophy. Since the discovery of exercise-induced oxidative stress several decades ago, evidence has accumulated that ROS produced during exercise also have positive effects by influencing cellular processes that lead to increased expression of antioxidants. These molecules are particularly elevated in regularly exercising muscle to prevent the negative effects of ROS by neutralizing the free radicals. In addition, ROS also seem to be involved in the exercise-induced adaptation of the muscle phenotype. This review provides an overview of the evidences to date on the effects of ROS in exercising muscle. These aspects include the sources of ROS, their positive and negative cellular effects, the role of antioxidants, and the present evidence on ROS-dependent adaptations of muscle cells in response to physical exercise.
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Citations
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Cited by
Redox Mechanism of Reactive Oxygen Species in Exercise
He, F., Li, J., Liu, Z., Chuang, C.-C., Yang, W., & Zuo, L. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00486 · Cited by 385
The role of exercise-induced myokines in regulating metabolism
Huh, J. Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0994-y · Cited by 242
Jamwal, S., Blackburn, J. K., & Elsworth, J. D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107705 · Cited by 236
Myokines mediate the cross talk between skeletal muscle and other organs
Chen, W., Wang, L., You, W., & Shan, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30033 · Cited by 162
Oh, S., Komine, S., Warabi, E., Akiyama, K., Ishii, A., Ishige, K., Mizokami, Y., Kuga, K., Horie, M., Miwa, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12926-y · Cited by 70
Metadata
- Authors
- Steinbacher, P., & Eckl, P.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2015-04-10
- Volume
- 5
- Issue
- 2
- Pages
- 356-377
- ISSN
- 2218-273X (ISSN-L)
- OpenAlex
- W2037055992
- Cited by
- 412
- References
- 27
- FWCI
- 31.27
- Type
- journal article
- Language
- en
- Open access
- gold
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