Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
Open accessAbstract
PURPOSE OF REVIEW: The authors present evidence published during the past 2 years of the roles of commensal and pathogenic bacteria in the pathogenesis of the inflammatory bowel diseases. RECENT FINDINGS: Rodent models conclusively implicate commensal enteric bacteria in chronic, immune-mediated, experimental colitis, and genetically determined defects in bacterial killing by innate immune cells are found in a subset of patients with Crohn's disease. There is no evidence that a single pathogen, including Mycobacterium avium subspecies paratuberculosis, causes Crohn's disease or ulcerative colitis. However, adherent/invasive Escherichia coli are associated with ileal Crohn's disease, with the mechanisms and genetics of adherent/invasive E. coli virulence being elucidated. Molecular characterization of the microbiota in patients with inflammatory bowel diseases reveals decreased biodiversity of commensal bacteria, most notably the phyla Bacteroidetes and Firmicutes, including the clinically relevant Faecalibacterium prausnitzii, and increased E. coli concentrations. VSL#3 is one probiotic preparation shown to be efficacious in certain clinical situations in small clinical trials. SUMMARY: Further characterization of altered microbiota in patients with inflammatory bowel diseases and linking dysbiosis with host genetic alterations in immunoregulation, innate microbial killing and barrier function are critical, so that individualized treatments to increase beneficial commensals and their metabolic products (probiotic and prebiotic administration) and diminish deleterious species such as adherent/invasive E. coli can be tailored for defined patient subsets.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many studies have reported that alterations in the gut microbiota induce both pro- and anti-inflammatory effects in the host.
“Many studies have reported that alterations in the gut microbiota induce both pro- and anti-inflammatory effects in the host.5–7”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593 · see citing works
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927 · see citing works
Self-citationNod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,776 · see citing works
Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works
Darfeuille-Michaud, A., Boudeau, J., Bulois, P., Neut, C., Glasser, A.-L., Barnich, N., Bringer, M.-A., Swidsinski, A., Beaugerie, L., & Colombel, J.-F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.061 · Cited by 1,566 · see citing works
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., et al. (2008) · Nature · doi:10.1038/nature07416 · Cited by 1,542 · see citing works
Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485 · see citing works
Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,411 · see citing works
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310 · see citing works
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147 · see citing works
Sartor, R. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.024 · Cited by 1,053 · see citing works
Self-citationReduced Paneth cell α-defensins in ileal Crohn's disease
Wehkamp, J., Salzman, N. H., Porter, E. M., Nuding, S., Weichenthal, M., Petras, R. E., Shen, B., Schaeffeler, E., Schwab, M. G., Linzmeier, R. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505256102 · Cited by 988 · see citing works
Direct Health Care Costs of Crohn's Disease and Ulcerative Colitis in US Children and Adults
Kappelman, M. D., Rifas‐Shiman, S. L., Porter, C. Q., Ollendorf, D. A., Sandler, R. S., Galanko, J. A., & Finkelstein, J. A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.09.012 · Cited by 634 · see citing works
Baumgart, M., Dogan, B., Rishniw, M., Weitzman, G., Bosworth, B. P., Yantiss, R. K., Orsi, R. H., Wiedmann, M., McDonough, P. L., Kim, S. G., et al. (2007) · The ISME Journal · doi:10.1038/ismej.2007.52 · Cited by 630 · see citing works
Barnich, N., Carvalho, F. A., Glasser, A.-L., Darcha, C., Jantscheff, P., Allez, M., Peeters, H., Bommelaer, G., Desreumaux, P., Colombel, J., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30504 · Cited by 590 · see citing works
Impact of Clostridium difficile on Inflammatory Bowel Disease
Issa, M., Vijayapal, A., Graham, M. B., Beaulieu, D. B., Otterson, M. F., Lundeen, S. J., Skaros, S., Weber, L. R., KOMOROWSKI, R. A., Knox, J. F., et al. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.028 · Cited by 570 · see citing works
Fellermann, K., Stange, D. E., Schaeffeler, E., Schmalzl, H., Wehkamp, J., Bevins, C. L., Reinisch, W., Teml, A., Schwab, M. G., Lichter, P., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/505915 · Cited by 565 · see citing works
Mow, W. S., Vasiliauskas, E. A., Lin, Y.-C., Fleshner, P. R., Papadakis, K. A., Taylor, K. D., Landers, C. J., Abreu-Martin, M. T., Rotter, J. I., Yang, H., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.015 · Cited by 517 · see citing works
Molecular analysis of the gut microbiota of identical twins with Crohn's disease
Dicksved, J., Halfvarson, J., Rosenquist, M., Järnerot, G., Tysk, C., Apajalahti, J., Engstrand, L. G., & Jansson, J. K. (2008) · The ISME Journal · doi:10.1038/ismej.2008.37 · Cited by 459 · see citing works
Kotłowski, R., Bernstein, C. N., Sepehri, S., & Krause, D. O. (2006) · Gut · doi:10.1136/gut.2006.099796 · Cited by 422 · see citing works
The mechanism of action of probiotics
Boirivant, M., & Strober, W. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f0cffc · Cited by 379 · see citing works
Selby, W. S., Pavli, P., Crotty, B. J., Florin, T., Radford‐Smith, G. L., Gibson, P. G., Mitchell, B., Connell, W., Read, R. B., Merrett, M. N., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.031 · Cited by 360 · see citing works
Takaishi, H., Matsuki, T., Nakazawa, A., Takada, T., Kado, S., Asahara, T., Kamada, N., Sakuraba, A., Yajima, T., Higuchi, H., et al. (2007) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.07.016 · Cited by 325 · see citing works
Prescott, N. J., Fisher, S. A., Franke, A., Hampe, J., Onnie, C. M., Soars, D., Bagnall, R. D., Mirza, M. M., Sanderson, J. D., Forbes, A., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.034 · Cited by 301 · see citing works
Gossum, A. V., Dewit, O., Louis, E. J., Hertogh, G., Baert, F., Fontaine, F., Devos, M., Enslen, M., Paintin, M., & Franchimont, D. P. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20063 · Cited by 296 · see citing works
The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-4
Wehkamp, J., Wang, G., Kübler, I., Nuding, S., Gregorieff, A., Schnabel, A., Kays, R. J., Fellermann, K., Burk, O., Schwab, M. G., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3109 · Cited by 286 · see citing works
Swidsinski, A. V., Loening-Baucke, V. A., Vaneechoutte, M., & Dörffel, Y. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20330 · Cited by 276 · see citing works
Invasive Escherichia coli are a feature of Crohn's disease
Sasaki, M., Sitaraman, S. V., Babbin, B. A., Gerner‐Smidt, P., Ribot, E. M., Garrett, N. A., Alpern, J. A., Akyildiz, A., Theiss, A. L., Nusrat, A., et al. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700661 · Cited by 243 · see citing works
Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun
Lin, Y. P., Thibodeaux, C., Peña, J. A., Ferry, G. D., & Versalovic, J. A. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20448 · Cited by 235 · see citing works
Pronio, A., Montesani, C., Butteroni, C., Vecchione, S., Mumolo, G. M., Vestri, A., Vitolo, D., & Boirivant, M. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20369 · Cited by 212 · see citing works
Hedin, C. R. H., Whelan, K., & Lindsay, J. O. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005563 · Cited by 211 · see citing works
Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission
Martinez, C., Antolin, M., Santos, J., Torrejon, A., Casellas, F., Borruel, N., Guarner, F., & Malagelada, J.-R. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01592.x · Cited by 208 · see citing works
Carroll, I. M., Andrus, J. M., Bruno-Bárcena, J. M., Klaenhammer, T. R., Hassan, H. M., & Threadgill, D. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00132.2007 · Cited by 208 · see citing works
Infectious Gastroenteritis and Risk of Developing Inflammatory Bowel Disease
Porter, C. K., Tribble, D. R., Aliaga, P. A., Halvorson, H. A., & Riddle, M. S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.081 · Cited by 198 · see citing works
Eaves-Pyles, T. D., Allen, C. A., Taormina, J., Swidsinski, A. V., Tutt, C. B., Jezek, G. E., Islas-Islas, M., & Torres, A. G. (2007) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.05.011 · Cited by 188 · see citing works
Imaoka, A., Shima, T., Kato, K., Mizuno, S., Uehara, T., Matsumoto, S., Setoyama, H., Hara, T., & Umesaki, Y. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2511 · Cited by 179 · see citing works
High dose probiotic and prebiotic cotherapy for remission induction of active Crohn’s disease
Fujimori, S., Tatsuguchi, A., Gudis, K., Kishida, T., Mitsui, K., Ehara, A., Kobayashi, T., Sekita, Y., Seo, T., & Sakamoto, C. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04535.x · Cited by 176 · see citing works
Does Mycobacterium avium subspecies paratuberculosis cause Crohn’s disease?: Table 1
Sartor, R. B. (2005) · Gut · doi:10.1136/gut.2004.055889 · Cited by 173 · see citing works
Self-citationProbiotic Effects on Inflammatory Bowel Disease1,
Sheil, B., Shanahan, F., & O’Mahony, L. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.3.819s · Cited by 167 · see citing works
Adherent-invasive Escherichia coli and Crohnʼs disease
Barnich, N., & Darfeuille–Michaud, A. (2006) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3280105a38 · Cited by 155 · see citing works
Enterotoxigenic Bacteroides fragilis: A potential instigator of colitis
Rabizadeh, S., Rhee, K., Wu, S., Huso, D. L., Gan, C. M., Golub, J. E., Wu, X., Zhang, M., & Sears, C. L. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20265 · Cited by 147 · see citing works
Huynh, H. Q., deBruyn, J. C. C., Guan, L. L., Díaz, H., Li, M., Girgis, S., Turner, J. M., Fedorak, R. N., & Madsen, K. L. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20816 · Cited by 147 · see citing works
Lactobacillus casei downregulates commensalsʼ inflammatory signals in Crohnʼs disease mucosa
Llopis, M., Antolı́n, M., Carol, M., Borruel, N., Casellas, F., Martínez, C., Espín, E., Guarner, F., & Malagelada, J. R. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20736 · Cited by 145 · see citing works
Scanu, A. M., Bull, T. J., Cannas, S., Sanderson, J. D., Sechi, L. A., Dettori, G., Zanetti, S., & Hermon-Taylor, J. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01371-07 · Cited by 133 · see citing works
Kim, S. C., Tonkonogy, S. L., Karrasch, T., Jobin, C., & Sartor, R. B. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20246 · Cited by 131 · see citing works
Self-citationCarvalho, F. A., Barnich, N., Sauvanet, P., Darcha, C., Gelot, A., & Darfeuille–Michaud, A. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20423 · Cited by 130 · see citing works
Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro
Meconi, S., Vercellone, A., Levillain, F., Payré, B., Saati, T. A., Capilla, F., Desreumaux, P., Darfeuille–Michaud, A., & Altare, F. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00868.x · Cited by 129 · see citing works
Diversity of mucosa-associated microbiota in active and inactive ulcerative colitis
Nishikawa, J., Kudo, T., Sakata, S., Benno, Y., & Sugiyama, T. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802433231 · Cited by 129 · see citing works
Rolhion, N., Carvalho, F. A., & Darfeuille–Michaud, A. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05638.x · Cited by 125 · see citing works
An Antibiotic-Responsive Mouse Model of Fulminant Ulcerative Colitis
Kang, S. S., Bloom, S. M., Norian, L. A., Geske, M. J., Flavell, R. A., Stappenbeck, T. S., & Allen, P. M. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050041 · Cited by 118 · see citing works
Perán, L., Camuesco, D., Comalada, M., Bailón, E., Henriksson, A., Xaus, J., Zarzuelo, A., & Gálvez, J. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03302.x · Cited by 118 · see citing works
Andoh, A., Sakata, S., Koizumi, Y., Mitsuyama, K., Fujiyama, Y., & Benno, Y. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20151 · Cited by 113 · see citing works
Lee, J., Lee, B., Lee, H.-S., et al. (2008) · International Journal of Colorectal Disease · doi:10.1007/s00384-008-0618-6 · Cited by 106 · see citing works
Role of probiotic therapy in IBD
Isaacs, K. L., & Herfarth, H. H. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20465 · Cited by 104 · see citing works
Ott, S. J., Plamondon, S., Hart, A. L., Begun, A., Rehman, A., Kamm, M. A., & Schreiber, S. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01512-08 · Cited by 95 · see citing works
The inheritance of selective adult-type lactose malabsorption.
Sahi, T. (1974) · PubMed · Cited by 88 · see citing works
Keita, Å. V., Salim, S. Y., Jiang, T., Yang, P., Franzén, L. E., Söderkvist, P., Magnusson, K., & Söderholm, J. D. (2008) · The Journal of Pathology · doi:10.1002/path.2337 · Cited by 86 · see citing works
Zhang, M., Liu, B.-Y., Zhang, Y., Wei, H., Lei, Y., & Zhao, L. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01720-06 · Cited by 82 · see citing works
Bringer, M.-A., Rolhion, N., Glasser, A.-L., et al. (2007) · Journal of Bacteriology · doi:10.1128/jb.00233-07 · Cited by 80 · see citing works
Abubakar, I., Myhill, D., Hart, A. R., LAKE, I. R., Harvey, I. M., Rhodes, J. M., Robinson, R., Lobo, A., Probert, C. S., & Hunter, P. R. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwk067 · Cited by 75 · see citing works
Is Crohn’s disease due to defective immunity?
Korzenik, J. R. (2006) · Gut · doi:10.1136/gut.2006.095588 · Cited by 72 · see citing works
Juste, R. A., Elguezábal, N., Garrido, J. M., Pavón, A., Geijó, M., Sevilla, I. A., Cabriada, J. L., Tejada, A., García-Campos, F., Casado, R., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002537 · Cited by 70 · see citing works
Singh, A. V., Singh, S. V., Makharia, G. K., et al. (2007) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2007.06.008 · Cited by 70 · see citing works
Kim, N., Kunisawa, J., Kweon, M., Ji, G. E., & Kiyono, H. (2007) · Clinical Immunology · doi:10.1016/j.clim.2006.11.005 · Cited by 70 · see citing works
Bentley, R. W., Keenan, J. I., Gearry, R. B., Kennedy, M. A., Barclay, M. L., & Roberts, R. L. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01742.x · Cited by 65 · see citing works
Kim, H., Rhee, S. H., Pothoulakis, C., & LaMont, J. T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.063 · Cited by 63 · see citing works
Vasquez, N., Mangin, I., Lepage, P., Seksik, P., Huyen, J. D. V., Blum, S., Schiffrin, E. J., Suau, A., Allez, M., Vernier, G., et al. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20084 · Cited by 61 · see citing works
Winslet, M. C., Allan, A., Poxon, V., et al. (1994) · Gut · doi:10.1136/gut.35.2.236 · Cited by 57 · see citing works
Roediger, W. E. W. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03612.x · Cited by 55 · see citing works
Visualization of Mycobacterium avium in Crohn's tissue by oil-immersion microscopy
Jeyanathan, M., Boutross‐Tadross, O., Radhi, J. M., Semret, M., Bitton, A., & Behr, M. A. (2007) · Microbes and Infection · doi:10.1016/j.micinf.2007.09.001 · Cited by 54 · see citing works
Clancy, R. L., Ren, Z., Turton, J., Pang, G., & Wettstein, A. R. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.12.006 · Cited by 49 · see citing works
Effects of the Probiotic Formulation VSL#3 on Colitis in Weanling Rats
Fitzpatrick, L. R., Hertzog, K. L., Quatse, A. L., et al. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31803bda51 · Cited by 45 · see citing works
Peeters, H., Bogaert, S., Laukens, D., et al. (2007) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2007.00670.x · Cited by 36 · see citing works
Bernstein, C. N., Wang, M., Sargent, M. J., Brant, S. R., & Collins, M. T. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.02062-06 · Cited by 34 · see citing works
Isolation and characterisation of new putative probiotic bacteria from human colonic flora
Raz, I., Gollop, N., Polak‐Charcon, S., & Schwartz, B. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450747249x · Cited by 31 · see citing works
Singh, U. P., Singh, S., Singh, R., Karls, R. K., Quinn, F. D., Potter, M. E., & Lillard, J. W. (2007) · Infection and Immunity · doi:10.1128/iai.01770-06 · Cited by 25 · see citing works
Detection ofHelicobacterspecies in chronic liver disease and chronic inflammatory bowel disease
Veijola, L., Nilsson, I. M. S., Halme, L., et al. (2007) · Annals of Medicine · doi:10.1080/07853890701545714 · Cited by 23 · see citing works
Unresolved ER Stress Inflames the Intestine
Ma, A. I. (2008) · Cell · doi:10.1016/j.cell.2008.08.023 · Cited by 18 · see citing works
Ren, Z., Turton, J., Borody, T. J., et al. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04865.x · Cited by 17 · see citing works
Mycobacterium avium subspecies paratuberculosis and Crohn's disease granulomas
Toracchio, S., El-Zimaity, H. M. T., Urmacher, C., et al. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802116455 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [41]Liu B Schmitz JM Holt LC Increased intracellular survival of E. coli NC101 within macrophages may contribute to its ability to induce colitis Gastroenterology 2009 in press (abstract)
Cited by
Sorted by citations
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., Reyes, J. A., Shah, S. A., LeLeiko, N., Snapper, S. B., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-9-r79 · Cited by 2,713 · see citing works
Machiels, K., Joossens, M., Sabino, J., De Preter, V., Arijs, I., Eeckhaut, V., Ballet, V., Claes, K., Van Immerseel, F., Verbeke, K., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-304833 · Cited by 1,904 · see citing works
How glycan metabolism shapes the human gut microbiota
Koropatkin, N. M., Cameron, E. A., & Martens, E. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2746 · Cited by 1,419 · see citing works
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286 · see citing works
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
Chu, H., Khosravi, A., Kusumawardhani, I. P., Kwon, A. H. K., Vasconcelos, A. C., Cunha, L. D., Mayer, A. E., Shen, Y., Wu, W.-L., Kambal, A., et al. (2016) · Science · doi:10.1126/science.aad9948 · Cited by 647 · see citing works
(2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.08.014 · Cited by 536 · see citing works
Bloom, S. M., Bijanki, V. N., Nava, G. M., Sun, L., Malvin, N. P., Donermeyer, D. L., Dunne, W. M., Allen, P. M., & Stappenbeck, T. S. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.009 · Cited by 488 · see citing works
Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas
Shen, X. J., Rawls, J. F., Randall, T. A., Burcall, L., Mpande, C., Jenkins, N., Jovov, B., Abdo, Z., Sandler, R. S., & Keku, T. O. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12360 · Cited by 418 · see citing works
Le Huërou-Luron, I., Blat, S., & Boudry, G. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000065 · Cited by 407 · see citing works
Angelberger, S., Reinisch, W., Makristathis, A., Lichtenberger, C., Dejaco, C., Papay, P., Novacek, G., Trauner, M., Loy, A., & Berry, D. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.257 · Cited by 330 · see citing works
Ramanan, D., Tang, M. S., Bowcutt, R., Loke, P., & Cadwell, K. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.015 · Cited by 269 · see citing works
Frantz, A. L., Rogier, E. W., Weber, C. R., Shen, L., Cohen, D. A., Fenton, L. A., Bruno, M. E. C., & Kaetzel, C. S. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.23 · Cited by 230 · see citing works
Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases
Huang, E. Y., Inoue, T., Leone, V. A., Dalal, S., Touw, K., Wang, Y., Musch, M. W., Theriault, B., Higuchi, K., Donovan, S., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000332 · Cited by 204 · see citing works
Maharshak, N., Packey, C. D., Ellermann, M., Manick, S., Siddle, J. P., Huh, E. Y., Plevy, S., Sartor, R. B., & Carroll, I. M. (2013) · Gut Microbes · doi:10.4161/gmic.25486 · Cited by 174 · see citing works
Self-citationTakagi, T., Naito, Y., Inoue, R., Kashiwagi, S., Uchiyama, K., Mizushima, K., Tsuchiya, S., Okayama, T., Dohi, O., Yoshida, N., et al. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17-78 · Cited by 121 · see citing works
Healthy hosts rule within: ecological forces shaping the gut microbiota
Byndloss, M. X., Pernitzsch, S. R., & Bäumler, A. J. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0010-y · Cited by 109 · see citing works
Sartor, R. B. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13436 · Cited by 60 · see citing works
Self-citationBile acids: Key players in inflammatory bowel diseases?
Kriaa, A., Mariaule, V., Jablaoui, A., Rhimi, S., Mkaouar, H., Hernandez, J., Korkmaz, B., Lesner, A., Maguin, E., Aghdassi, A., et al. (2022) · Cells · doi:10.3390/cells11050901 · Cited by 53 · see citing works
De Preter, V., Arijs, I., Windey, K., Vanhove, W., Vermeire, S., Schuit, F., Rutgeerts, P., & Verbeke, K. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22949 · Cited by 49 · see citing works
- Authors
- Packey, C. D., & Sartor, R. B.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Sartor, R Balfour
- ORCID
- Sartor, R Balfour
- Venue
- Current Opinion in Infectious Diseases
- Published
- 2009-06
- Volume
- 22
- Issue
- 3
- Pages
- 292-301
- ISSN
- 0951-7375 (ISSN-L)
- PMC
- PMC2763597
- OpenAlex
- W1978636470
- Cited by
- 319
- References
- 83
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 12 · 2023: 11 · 2022: 11 · 2021: 14 · 2020: 15 · 2019: 25 · 2018: 16 · 2017: 13 · 2016: 30 · 2015: 15 · 2014: 30 · 2013: 21 · 2012: 34
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK53347, R01DK040249, R01 DK 40249, P30‐DK34987, R01DK053347, P30DK034987, T32DK007737)
- National Center for Research Resources (P40RR018603)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, commensal bacteria, dysbiosis, gut microbiota, adherent-invasive Escherichia coli, Mycobacterium avium subsp. paratuberculosis, Faecalibacterium prausnitzii, Bacteroidetes, Firmicutes, probiotics, VSL#3, prebiotics, experimental colitis, host genetic susceptibility
- MeSH terms
- Bacteria, Humans, Inflammatory Bowel Diseases, Immunity, Mucosal, Probiotics, Gastrointestinal Tract, Biodiversity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
