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The Global Prevalence of Anxiety Among Medical Students: A Meta-Analysis
Open accessAbstract
Anxiety, although as common and arguably as debilitating as depression, has garnered less attention, and is often undetected and undertreated in the general population. Similarly, anxiety among medical students warrants greater attention due to its significant implications. We aimed to study the global prevalence of anxiety among medical students and the associated factors predisposing medical students to anxiety. In February 2019, we carried out a systematic search for cross-sectional studies that examined the prevalence of anxiety among medical students. We computed the aggregate prevalence and pooled odds ratio (OR) using the random-effects model and used meta-regression analyses to explore the sources of heterogeneity. We pooled and analyzed data from sixty-nine studies comprising 40,348 medical students. The global prevalence rate of anxiety among medical students was 33.8% (95% Confidence Interval: 29.2–38.7%). Anxiety was most prevalent among medical students from the Middle East and Asia. Subgroup analyses by gender and year of study found no statistically significant differences in the prevalence of anxiety. About one in three medical students globally have anxiety—a prevalence rate which is substantially higher than the general population. Administrators and leaders of medical schools should take the lead in destigmatizing mental illnesses and promoting help-seeking behaviors when students are stressed and anxious. Further research is needed to identify risk factors of anxiety unique to medical students.
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“a meta-analysis revealed that approximately 1 in 3 medical students worldwide experiences anxiety, a rate significantly exceeding that of the general population [5].”
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de Moraes, M. C., Russo, G. C., Prado, J. D. S., Lima‐Costa, A. R., Araujo, B. B., & Schermer, J. A. (2023) · Behavioral Sciences · doi:10.3390/bs13090778 · Cited by 7
Starosolski, M., Kapłan, C., Kalemba, A., & Majewska, K. (2023) · Medical Science Monitor · doi:10.12659/msm.940372 · Cited by 3
“Anxiety, compulsion, and cognitive overload are integral to the work of medical professionals and are especially noticeable when providing respiratory protection in cases in which not all things work out as planned and the situation requires an immediate reaction and the ability to make the right decisions [1].”
BackgroundInfluencing Factors and Prevalence of Anxiety in Medical Students: A Cross-Sectional Study
Nguyen, H. T., Phan, Y., Nguyen-Hoang, A.-V., Nguyen, T.-B., & Tran-Thien, G. (2024) · Journal of Public Health and Pharmacy · doi:10.56338/jphp.v4i1.5046 · Cited by 3
Alghamdi, A., Syed, W., Samarkhandi, O. A., Albalawi, . M. M., Alsulaihim, I. N., Almutairi, S. M., & Al‐Rawi, M. B. A. (2024) · Medical Science Monitor · doi:10.12659/msm.943399 · Cited by 3
Su, Y., Lu, N., Wang, P., Li, Q., Wen, H., Zhang, J., Fan, L., Li, J., Yu, Z., Cui, M., et al. (2024) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s455418 · Cited by 3
“18 Medical students, constrained by their academic and professional commitments, may possess limited expertise in disease pathology.”
Self-citationHELP SEEKING ATTITUDES FOR MENTAL ILLNESSES AMONG UNDER-GRADUATE MEDICAL STUDENTS IN LAHORE
Amin, H., Wazeer, M., Imran, N., Rashid, A., Kiran, R., & Haider, I. I. (2023) · Journal of Pakistan Psychiatric Society · doi:10.63050/jpps.20.03.203 · Cited by 3
Prevalence of Depression, Anxiety and Stress among Secondary School Students in Jeddah City
Al-Shehri, M. M., Harazi, N. M., Elmagd, M. H. A., Maram Alghabbashi, T., & Alshmemri, M. (2022) · ASEAN Journal of Psychiatry · doi:10.54615/2231-7805.47264 · Cited by 3
Akbayram, H. T., Demir, M., & Keten, H. S. (2024) · Psychiatric Quarterly · doi:10.1007/s11126-024-10086-7 · Cited by 3
“Meta-analysis and systematic review studies before the pandemic revealed that the prevalence of global anxiety among medical students was 33.8% and the prevalence of depression was 27% [22, 23].”
InfluentialFraij, A., Shukry, A., Omira, A., Habbal, J., Ali, M. A., Jamal, N., Alawsi, S., & Talaat, I. M. (2024) · Cureus · doi:10.7759/cureus.71758 · Cited by 6
Anxiety in Higher Education: A Comprehensive Review
Choubey, V., Verma, H. P., Hajong, C., & Purohit, A. (2024) · Archives of Current Research International · doi:10.9734/acri/2024/v24i121018 · Cited by 4
Vishwakarma, D. K. (2021) · Indian Journal of Public Health Research & Development · doi:10.37506/ijphrd.v12i1.13831 · Cited by 4
“The anxiety and stress symptoms were found to be present in 49.06% and 43.19% of premedical students, respectively which is much more than the global prevalence of anxiety which was 33.8% and anxiety was most prevalent among medical students from the Middle East and Asia.”
BackgroundInfluentialKulibina, O. V., Pleshchev, I. E., & Skobeleva, T. N. (2021) · Sanitarnyj vrač (Sanitary Doctor) · doi:10.33920/med-08-2110-05 · Cited by 3
Braquehais, M. D., Vargas-Cáceres, S., Nieva, G., Mantilla, M. F., Ortega‐Hernández, G., Valero, S., Ramos‐Quiroga, J. A., & Bruguera, E. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-055184 · Cited by 4
Kim, S. Y., Yoo, D. M., Kwon, M. J., Kim, J. H., Kim, J., Bang, W. J., & Choi, H. G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144011 · Cited by 3
The mental health and wellbeing of medical students-A case study reflection
Sahota, A. (2020) · Archives of Depression and Anxiety · doi:10.17352/2455-5460.000049 · Cited by 3
Iran’s higher education and COVID-19: the “new normal” for Tehran University of Medical Sciences
Memari, A. H., Kordi, R., Ziaee, V., Shahi, M. H. P., Sohrabpour, A. A., Dastjerdi, N., & Nakhostin-Ansari, A. (2021) · Journal of Clinical and Translational Science · doi:10.1017/cts.2021.879 · Cited by 3
“…of these issues compared to the prepandemic situation where the global prevalences of depression and anxiety among medical students were estimated to be 20.5% and 33.8%, respectively [7,8]. been a reduction in elective admissions during the COVID-19 pandemic [12], reducing learning opportunities.”
InfluentialCahyaratri, M. T., Saktini, F., Asikin, H. G., & Sumekar, T. A. (2022) · Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) · doi:10.14710/dmj.v11i3.33244 · Cited by 3
A saúde mental dos estudantes de medicina: uma revisão integrativa
Ferreira, R. R., Gomes, T. M., Dias, C. P., Costa, N. S. C. P., Rebouças, R. C. C. P., Reis, L. C. S., & de Carvalho, S. D. (2023) · Research Society and Development · doi:10.33448/rsd-v12i3.39975 · Cited by 3
Kalikotay, B., Uprety, K., Rai, M. L., & Pathak, S. (2023) · International Journal of Nursing Education · doi:10.37506/ijone.v15i2.19251 · Cited by 3
Yaskevich, R. A., & Moskalenko, O. L. (2023) · Russian Journal of Education and Psychology · doi:10.12731/2658-4034-2023-14-3-221-240 · Cited by 3
A tricentric medical student perspective on open book examinations
Limaye, N., Rao, C. B., & Wallace, W. J. (2020) · Medical Teacher · doi:10.1080/0142159x.2020.1800614 · Cited by 3
Ji, Z., Zhang, Y., Xu, X., Yan, X., Gao, B., Sun, Q., Wu, L., Mu, H., & Zhao, M. (2026) · Psychology, Health & Medicine · doi:10.1080/13548506.2025.2539932 · Cited by 2
(2023) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.47750/jptcp.2023.30.05.022 · Cited by 2
The impact of emotional labor towards professional identity among psychological counsellors in China
Zhao, H., Li, M., & Li, L. (2023) · Environment and Social Psychology · doi:10.54517/esp.v9i2.1909 · Cited by 2
“It also encompasses how individuals in the professional field exhibit commitment to oneself and the society at large [17] .”
BackgroundPrevalence of Obsessive-Compulsive Personality Disorder in Medical Students
Al-Na’she, M., Massad, A., Khraisat, L. A., Rafai, M. A., Albashtawi, Y., Almohtasib, S., Alhayek, A. M., Elheet, A. M., Alaqtash, R., & Jaber, R. M. (2024) · Jordan Medical Journal · doi:10.35516/jmj.v58i1.2397 · Cited by 5
Kansakar, S., Poudel, U., Guragain, A., Paudel, P., Sharma, P., Dhungana, B., Adhikari, A., & Pokhrel, P. (2023) · Journal of Chitwan Medical College · doi:10.54530/jcmc.1418 · Cited by 2
Frequency of Anxiety During Exam / Assessments among Medical Students
Butt, A., & Ishaque, A. (2023) · Annals of Punjab Medical College · doi:10.29054/apmc/2023.1380 · Cited by 2
Contribuições de egressos de Medicina para a avaliação do curso
Senger, M. H., & de Castro, J. C. M. (2024) · Revista Brasileira de Educação Médica · doi:10.1590/1981-5271v48.3-2022-0065 · Cited by 2
Sadeghi, H., Khoei, S. G., Shahsavari, S., Aslanimehr, M., Nikkhahi, F., Babaei, A., Gheibi, N., & Bizhani, B. (2024) · GERMS · doi:10.18683/germs.2024.1417 · Cited by 2
Yang, J., Song, X., Zhang, J., Zheng, Y., Chen, G., Bu, T., Zhou, J., Tong, Y., Yang, Y., & Qiao, Z. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1427616 · Cited by 2
“Medical students are a high-stress group due to the specific nature of their profession (14, 17, 21), and they also have high levels of anxiety (22, 23).”
The impact of affective and cognitive empathy on stress in medical students
Maximiano‐Barreto, M. A., Bueno, J. L., Bueno, M. L., Wercelens, V. O., Ydy, J. G. M., Abrahim, R. P., Montayre, J., & de Melo, K. M. M. (2025) · Psicologia Reflexão e Crítica · doi:10.1186/s41155-024-00336-9 · Cited by 2
Amini, A., Rami, A., Teng, R. W., Baselga‐Garriga, C., Esmail, K., Raza, M. M., Oles, W. C., Cerda, I. H., Czeisler, M. É., Sander, M. T., et al. (2025) · MedEdPORTAL · doi:10.15766/mep_2374-8265.11537 · Cited by 2
Fatores protetores e de risco à saúde mental de estudantes de Medicina na perspectiva deles
Custódio, C. G., do Cabo, J. S., Fasanella, N. A., de Almeida, F. A., & Pavan, M. V. (2025) · Revista Brasileira de Educação Médica · doi:10.1590/1981-5271v49.3-2024.0295 · Cited by 2
Metadata
- Authors
- Tian-Ci Quek, T., Wai-San Tam, W., X. Tran, B., Zhang, M., Zhang, Z., Su-Hui Ho, C., & Chun-Man Ho, R.
- Affiliations
- Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119007, Singapore
- Alice Lee Centre for Nursing Studies, National University of Singapore, Singapore 119007, Singapore
- Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam
- Huaibei Normal University (CN)
- Department of Psychological Medicine, National University Health System, Singapore 119007, Singapore
- Corresponding author
- Zhang, Zhisong
- ORCID
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2019-07-31
- Volume
- 16
- Issue
- 15
- Pages
- 2735
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC6696211
- OpenAlex
- W2965255255
- Cited by
- 990
- References
- 136
- Citations by year
- 2026: 141 · 2025: 130 · 2024: 186 · 2023: 165 · 2022: 174 · 2021: 124 · 2020: 66 · 2019: 3
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- National University of Singapore (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- This study received funding from the National Social Science Fund (General Project of Education) (BBA170063)
- Topics
- Health Sciences › Health Professions › General Health Professions › Healthcare professionals’ stress and burnout
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- anxiety, medical students, prevalence, risk factors, mental health, medical education, help-seeking, stigma, gender differences, year of study
- MeSH terms
- Anxiety, Humans, Risk Factors, Students, Medical, Global Health, Models, Statistical, Prevalence, Odds Ratio
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