Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging I: Reduced skin elasticity, highly associated with enhanced dermal elastase activity, triggers wrinkling and sagging
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The repetitive exposure of skin to ultraviolet B (UVB) preferentially elicits wrinkling while ultraviolet A (UVA) predominantly elicits sagging. In chronically UVB or UVA-exposed rat skin there is a similar tortuous deformation of elastic fibers together with decreased skin elasticity, whose magnitudes are greater in UVB-exposed skin than in UVA-exposed skin. Comparison of skin elasticity with the activity of matrix metalloproteinases (MMPs) in the dermis of ovariectomized rats after UVB or UVA irradiation demonstrates that skin elasticity is more significantly decreased in ovariectomized rats than in sham-operated rats, which is accompanied by a reciprocal increase in elastase activity but not in the activities of collagenases I or IV. Clinical studies using animal skin and human facial skin demonstrated that topical treatment with a specific inhibitor or an inhibitory extract of skin fibroblast-derived elastase distinctly attenuates UVB and sunlight-induced formation of wrinkling. Our results strongly indicated that the upregulated activity of skin fibroblast-derived elastase plays a pivotal role in wrinkling and/or sagging of the skin via the impairment of elastic fiber configuration and the subsequent loss of skin elasticity.
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UV-A accelerates hydrolysis of skin collagen by promoting production of matrix metalloproteinases, leading to tissue destruction and progressive degeneration of dermal extracellular matrix.
“It accelerates the hydrolysis of skin collagen by promoting the production of matrix metalloproteinases (MMPs), leading to tissue destruction and progressive degeneration of dermal extracellular matrix [22,23,24].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [22]
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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Tanaka, M., Yamamoto, Y., Misawa, E., Nabeshima, K., Saito, M., Yamauchi, K., Abe, F., & Furukawa, F. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000454718 · Cited by 1,092 · see citing works
Mechanical properties and Young's modulus of human skin in vivo
Agache, P. G., Monneur, C., Lévêque, J., & de Rigal, J. (1980) · Archives of Dermatological Research · doi:10.1007/bf00406415 · Cited by 742 · see citing works
Slominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., & Steketee, J. D. (2012) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-19683-6 · Cited by 502 · see citing works
Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works
Key role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works
Elastic properties of human skin: relation to age, sex, and anatomical region
Cua, A. B., Wilhelm, K., & Maibach, H. I. (1990) · Archives of Dermatological Research · doi:10.1007/bf00375720 · Cited by 383 · see citing works
Age-related changes in the elastic properties and thickness of human facial skin
Takema, Y., Yorimoto, Y., Kawai, M., & Imokawa, G. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb04975.x · Cited by 340 · see citing works
Self-citationStructural Changes in Aging Human Skin
Montagna, W., & Carlisle, K. S. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532761 · Cited by 322 · see citing works
Alterations in Human Dermal Connective Tissue with Age and Chronic Sun Damage
Smith, J. G., Davidson, E. A., SAMS, W. M., & Clark, R. D. (1962) · Journal of Investigative Dermatology · doi:10.1038/jid.1962.122 · Cited by 293 · see citing works
Cutaneous hypothalamic–pituitary–adrenal axis homolog: regulation by ultraviolet radiation
Skobowiat, C., Dowdy, J. C., Sayre, R. M., Tuckey, R. C., & Slominski, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00217.2011 · Cited by 269 · see citing works
Elastin Degradation by Matrix Metalloproteinases
Mecham, R. P., Broekelmann, T. J., Fliszar, C. J., Shapiro, S. D., Welgus, H. G., & Senior, R. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18071 · Cited by 221 · see citing works
Shah, M., & Maïbach, H. I. (2001) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200102030-00003 · Cited by 213 · see citing works
Tsuji, N., Moriwaki, S., Suzuki, Y., Takema, Y., & Imokawa, G. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740283troesb2.0.co2 · Cited by 195 · see citing works
Self-citationNeutral endopeptidase modulates neurogenic inflammation
Nadel, J. A. (1991) · European Respiratory Journal · doi:10.1183/09031936.93.04060745 · Cited by 178 · see citing works
Chronic Solar Dermatosis: A Light and Electron Microscopic Study of the Dermis*
Mitchell, R. E. (1967) · Journal of Investigative Dermatology · doi:10.1038/jid.1967.33 · Cited by 176 · see citing works
Dunn, L. B. (1997) · Archives of Dermatology · doi:10.1001/archderm.133.3.339 · Cited by 172 · see citing works
Shu, Y., & Maïbach, H. I. (2011) · American Journal of Clinical Dermatology · doi:10.2165/11589180-000000000-00000 · Cited by 146 · see citing works
Local Melatoninergic System as the Protector of Skin Integrity
Slominski, A. T., Kleszczyński, K., Semak, I. V., Janjetović, Z., Zmijewski, M. A., Kim, T., Slominski, R. M., Reiter, R. J., & Fischer, T. W. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151017705 · Cited by 145 · see citing works
Does Estrogen Prevent Skin Aging?
Dunn, L. B. (1997) · Archives of Dermatology · doi:10.1001/archderm.1997.03890390077010 · Cited by 135 · see citing works
Age-related changes in skin wrinkles assessed by a novel three-dimensional morphometric analysis
Akazaki, S., Nakagawa, H., Kazama, H., Osanai, O., Kawai, M., Takema, Y., & Imokawa, G. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04874.x · Cited by 131 · see citing works
Self-citationSkin connective tissue and ageing
Calleja-Agius, J., Brincat, M., & Borg, M. (2013) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.06.004 · Cited by 131 · see citing works
Skin water-holding capacity and transdermal estrogen therapy for menopause: a pilot study
Piérard-Franchimont, C., Letawe, C., Goffin, V., & Pierard, G. (1995) · Maturitas · doi:10.1016/0378-5122(95)00924-a · Cited by 120 · see citing works
Skobowiat, C., Sayre, R. M., Dowdy, J. C., & Slominski, A. T. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12096 · Cited by 115 · see citing works
Creidi, P., Faivre, B., Agache, P. G., Richard, E. G., Haudiquet, V., & Sauvanet, J.-P. (1994) · Maturitas · doi:10.1016/0378-5122(94)90074-4 · Cited by 114 · see citing works
Imayama, S., & Braverman, I. M. (1989) · PubMed · Cited by 108 · see citing works
Effects of Aging, Menopause, and Hormone Replacement Therapy on Forearm Skin Elasticity in Women
Sumino, H., Ichikawa, S., Abe, M., Endo, Y., Ishikawa, O., & Kurabayashi, M. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52262.x · Cited by 98 · see citing works
Imokawa, G. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.11 · Cited by 93 · see citing works
Self-citationTsukahara, K., Takema, Y., Moriwaki, S., Tsuji, N., Suzuki, Y., Fujimura, T., & Imokawa, G. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01450.x · Cited by 93 · see citing works
Self-citationAge dependent increase of elastase type protease activity in mouse skin
Labat-Robert, J., Fourtanier, A., Boyer-Lafargue, B., & Robert, L. (2000) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(00)00085-3 · Cited by 90 · see citing works
Imokawa, G. (2007) · Archives of Dermatological Research · doi:10.1007/s00403-007-0798-x · Cited by 89 · see citing works
Self-citationTsukahara, K., Nakagawa, H., Moriwaki, S., Takema, Y., Fujimura, T., & Imokawa, G. (2006) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2006.02557.x · Cited by 82 · see citing works
Self-citationBolognia, J. L. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80066-7 · Cited by 79 · see citing works
Sauvaigo, S., Douki, T., Odin, F., Caillat, S., Ravanat, J., & Cadet, J. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)073 · Cited by 79 · see citing works
Neutral endopeptidase-24.11 (enkephalinase). Biosynthesis and localization in human fibroblasts
Lorkowski, G., Zijderhand-Bleekemolen, J. E., Erdös, E. G., FIGURA, K. V., & Hasilík, A. (1987) · Biochemical Journal · doi:10.1042/bj2480345 · Cited by 66 · see citing works
Neprilysin Is Identical to Skin Fibroblast Elastase
Morisaki, N., Moriwaki, S., Sugiyama‐Nakagiri, Y., Haketa, K., Takema, Y., & Imokawa, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.161547 · Cited by 64 · see citing works
Self-citationDegree of Ultraviolet-Induced Tortuosity of Elastic Fibers in Rat Skin Is Age Dependent
Imokawa, G., Takema, Y., Yorimoto, Y., Tsukahara, K., Kawai, M., & Imayama, S. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12317607 · Cited by 60 · see citing works
Self-citationTsukahara, K., Nakagawa, H., Moriwaki, S., Kakuo, S., Ohuchi, A., Takema, Y., & Imokawa, G. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06203.x · Cited by 57 · see citing works
Self-citationCharacterization of Human Skin Fibroblasts Elastase Activity
Homsy, R., Pelletier-Lebon, P., Tixier, J. M., Godeau, G., Robert, L., & Hornebeck, W. (1988) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12476608 · Cited by 56 · see citing works
Sumino, H., Ichikawa, S., Masatoshi, A. B. E., Endo, Y., NAKAJIMA, Y., Minegishi, T., Ishikawa, O., & Kurabayashi, M. (2004) · Endocrine Journal · doi:10.1507/endocrj.51.159 · Cited by 53 · see citing works
Szendrői, M., Barlovatz‐Meimon, G., Bakala, H., Francès, C., Robert, L., Godeau, G., & Hornebeck, W. (1984) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12263609 · Cited by 52 · see citing works
A photographic scale for the assessment of human facial wrinkles
Tsukahara, K., Takema, Y., Kazama, H., Yorimoto, Y., Fujimura, T., Moriwaki, S., Kitahara, T., Kawai, M., & Imokawa, G. (2000) · Journal of the Society of Cosmetic Chemists · Cited by 52 · see citing works
Self-citationImayama, S., Nakamura, K. M., Takeuchi, M., Hori, Y., Takema, Y., Sakaino, Y., & Imokawa, G. (1994) · Journal of Dermatological Science · doi:10.1016/0923-1811(94)90019-1 · Cited by 50 · see citing works
Self-citation[Neuro-immuno-cutaneous system (NICS)].
Misery, L. (1996) · PubMed · Cited by 46 · see citing works
The Effects of UVA and UVB Irradiation on the Viscoelastic Properties of Hairless Mouse Skin in vivo
Takema, Y., & Imokawa, G. (1998) · Dermatology · doi:10.1159/000017931 · Cited by 39 · see citing works
Self-citationInterleukin-1β stimulates fibroblast elastase activity
Croute, F., DELAPORTE, E., Bonnefoy, J., Fertin, C., Thivolet, J., & Nicolas, J. (1991) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1991.tb04946.x · Cited by 39 · see citing works
Godeau, G., & Hornebeck, W. (1988) · PubMed · Cited by 37 · see citing works
Schwartz, E., Cruickshank, F. A., & Lebwohl, M. G. (1988) · Clinica Chimica Acta · doi:10.1016/0009-8981(88)90211-2 · Cited by 35 · see citing works
Takema, Y., Fujimura, T., Ohsu, H., & Imokawa, G. (1996) · Experimental Dermatology · doi:10.1111/j.1600-0625.1996.tb00109.x · Cited by 32 · see citing works
Self-citationBiomarkers of Connective Tissue Aging: Biosynthesis of Fibronectin, Collagen Type III, and Elastase
Labat‐Robert, J., Kern, P., & Robert, L. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27431.x · Cited by 32 · see citing works
Takema, Y., Yorimoto, Y., & Kawai, M. (1995) · Journal of the Society of Cosmetic Chemists · Cited by 32 · see citing works
Mid-dermal elastolysis: an ultrastructural and biochemical study
Fimiani, M., Mazzatenta, C., Alessandrini, C., Paola, M. D., Paola, C., & Andreassi, L. (1995) · Archives of Dermatological Research · doi:10.1007/bf01262324 · Cited by 31 · see citing works
Ovariectomy Accelerates Photoaging of Rat Skin¶
Tsukahara, K., Moriwaki, S., Ohuchi, A., Fujimura, T., & Takema, Y. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0730525oapors2.0.co2 · Cited by 27 · see citing works
Schwartz, D. E., Paller, A. S., Lizak, P. P., & Pearson, R. W. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12283833 · Cited by 24 · see citing works
All-transretinoic acid promotes the repair of tortuosity of elastic fibres in rat skin
Tsukahara, Takema, Fujimura, Moriwaki, Kitahara, Imayama, & Imokawa (1999) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1999.02902.x · Cited by 21 · see citing works
Stevanović, D. V. (1976) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1976.tb04337.x · Cited by 20 · see citing works
Tsukahara, K., Takema, Y., Moriwaki, S., Fujimura, T., Imayama, S., & Imokawa, G. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04067.x · Cited by 20 · see citing works
Self-citationMechanical methods for evaluating skin surface architecture in relation to wrinkling
Akazaki, S., & Imokawa, G. (2001) · Journal of Dermatological Science · doi:10.1016/s0923-1811(01)00115-3 · Cited by 19 · see citing works
Self-citationElastase-like Enzyme Activity in Cultured Human Fibroblast
Nakagawa, K., Tsuji, T., Kadoya, A., & Hamada, T. (1987) · Skin research · doi:10.11340/skinresearch1959.29.793 · Cited by 15 · see citing works
Fujimura, T., Takema, Y., Moriwaki, S., Tsukahara, K., Imokawa, G., Yamada, A., & Imayama, S. (2001) · Lasers in Surgery and Medicine · doi:10.1002/lsm.1061 · Cited by 10 · see citing works
Self-citationA mathematical evaluation of dose-dependent PpIX fluorescence kinetics in vivo
Chatelain (2001) · Pure Amsterdam UMC · doi:10.1562/0031-8655(2001)074 · Cited by 6 · see citing works
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Molecular Mechanisms of Dermal Aging and Antiaging Approaches
Shin, J.-W., Kwon, S.-H., Choi, J.-Y., Na, J.-I., Huh, C.-H., Choi, H.-R., & Park, K.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092126 · Cited by 875 · see citing works
The role of matrix metalloproteinases in aging: Tissue remodeling and beyond
Freitas‐Rodríguez, S., Folgueras, A. R., & López-Otı́n, C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.05.007 · Cited by 367 · see citing works
Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
Lee, H. J., Hong, Y., & Kim, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212489 · Cited by 269 · see citing works
Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
Boo, Y. C. (2022) · Antioxidants · doi:10.3390/antiox11091663 · Cited by 218 · see citing works
Boo, Y. C. (2021) · Antioxidants · doi:10.3390/antiox10081315 · Cited by 215 · see citing works
Bernerd, F., Passeron, T., Castiel, I., & Marionnet, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158243 · Cited by 182 · see citing works
Chiocchio, I., Mandrone, M., Sanna, C., Maxia, A., Tacchini, M., & Poli, F. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.06.029 · Cited by 170 · see citing works
Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases
Orioli, D., & Dellambra, E. (2018) · Cells · doi:10.3390/cells7120268 · Cited by 144 · see citing works
Neuroendocrine Aspects of Skin Aging
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112798 · Cited by 137 · see citing works
Protective Role of Melatonin and Its Metabolites in Skin Aging
Bocheva, G., Slominski, R. M., Janjetović, Z., Kim, T., Böhm, M., Steinbrink, K., Reiter, R. J., Kleszczyński, K., & Slominski, A. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031238 · Cited by 133 · see citing works
The Impact of Vitamin D on Skin Aging
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169097 · Cited by 129 · see citing works
Czajka, A., Kania, E. M., Genovese, L., Corbo, A., Merone, G., Luci, C., & Sibilla, S. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.06.001 · Cited by 117 · see citing works
Matrix Metalloproteinases on Skin Photoaging
Feng, C., Chen, X., Yin, X., Jiang, Y., & Zhao, C. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16558 · Cited by 112 · see citing works
Ultraviolet Radiation, Vitamin D and Multiple Sclerosis
Lucas, R. M., Byrne, S. N., Correale, J. D., Ilschner, S., & Hart, P. H. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.15.33 · Cited by 112 · see citing works
Protective Effects of Melatonin on the Skin: Future Perspectives
Rusanova, I., Martínez-Ruiz, L., Florido, J., Rodríguez-Santana, C., Guerra‐Librero, A., Acuña-Castroviejo, D., & Escames, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194948 · Cited by 111 · see citing works
Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin Cancer
Lee, J. W., Ratnakumar, K., Hung, K., Rokunohe, D., & Kawasumi, M. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13245 · Cited by 112 · see citing works
Current advances of Dendrobium officinale polysaccharides in dermatology: a literature review
Guo, L., Qi, J., Du, D., Yin, L., & Jiang, X. L. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1787470 · Cited by 107 · see citing works
Oh, S., Lee, J. H., Kim, H. M., Batsukh, S., Sung, M. J., Lim, T. H., Lee, M. H., Son, K. H., & Byun, K. (2023) · Cells · doi:10.3390/cells12091320 · Cited by 115 · see citing works
Choi, W., Cho, J. H., Park, S. H., Kim, D. S., Lee, H. P., Kim, D.-H., Kim, H. S., Kim, J. H., & Cho, J. Y. (2024) · Journal of Ginseng Research · doi:10.1016/j.jgr.2024.01.001 · Cited by 99 · see citing works
Allegra, A., Pioggia, G., Tonacci, A., Musolino, C., & Gangemi, S. (2020) · Antioxidants · doi:10.3390/antiox9050448 · Cited by 83 · see citing works
Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing
Zhou, X., Cao, Q., Orfila, C., Zhao, J. J., & Zhang, L. (2021) · Nutrients · doi:10.3390/nu13092917 · Cited by 84 · see citing works
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Fania, L., Mazzanti, C., Campione, E., Candi, E., ABENI, D. D., & Dellambra, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235946 · Cited by 88 · see citing works
Lee, K., Kim, H. J., Kim, S. A., Park, S.-D., Shim, J.-J., & Lee, J.-L. (2021) · Molecules · doi:10.3390/molecules26061651 · Cited by 76 · see citing works
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Freitas, R., Martins, A., Silva, J., Alves, C., Pintéus, S., Alves, J., Teodoro, F., Ribeiro, H. M., Gonçalves, L., Petrovski, Ž., et al. (2020) · Antioxidants · doi:10.3390/antiox9070611 · Cited by 71 · see citing works
Letsiou, S., Kalliampakou, K. I., Gardikis, Κ., Mantecón, L., Infante, C., Chatzikonstantinou, M., Labrou, N. E., & Flemetakis, E. (2017) · Frontiers in Marine Science · doi:10.3389/fmars.2017.00221 · Cited by 60 · see citing works
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Hubert, J., Angelis, A., Aligiannis, N., Rosalia, M., Abedini, A., Bakiri, A., Reynaud, R., Nuzillard, J., Gangloff, S. C., Skaltsounis, A., et al. (2016) · Planta Medica · doi:10.1055/s-0042-110180 · Cited by 55 · see citing works
Effect of aging on breast skin thickness and elasticity: implications for breast support
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Molecular Docking, Tyrosinase, Collagenase, and Elastase Inhibition Activities of Argan By-Products
Mechqoq, H., Hourfane, S., Yaagoubi, M. E., Hamdaoui, A. E., Almeida, J. R. G. D. S., Rocha, J. M., & Aouad, N. E. (2022) · Cosmetics · doi:10.3390/cosmetics9010024 · Cited by 52 · see citing works
Park, E., Lee, H., Lee, H., Kim, J., Hwang, J., Koo, J. I., & Kim, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071995 · Cited by 48 · see citing works
Kim, Y.-J., Kim, M.-J., Kweon, D.-K., Lim, S.-T., & Lee, S.-J. (2020) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-03171-2 · Cited by 48 · see citing works
Kim, H. M., Byun, K.-A., Oh, S., Yang, J. Y., Park, H. J., Chung, M. S., Son, K. H., & Byun, K. (2022) · Molecules · doi:10.3390/molecules27041276 · Cited by 48 · see citing works
Non-animal models in dermatological research
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Widowati, W., Ginting, C. N., Lister, I. N. E., Girsang, E., Amalia, A., Wibowo, S. H. B., Kusuma, H. S. W., & Rizal, R. (2020) · Tropical Life Sciences Research · doi:10.21315/tlsr2020.31.3.9 · Cited by 50 · see citing works
Yoshimoto, S., Kohara, N., Sato, N., Ando, H., & Ichihashi, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020554 · Cited by 41 · see citing works
Oh, S., Rho, N., Byun, K.-A., Yang, J. Y., Sun, H. J., Jang, M., Kang, D., Son, K. H., & Byun, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23062993 · Cited by 38 · see citing works
Pintus, F., Floris, S., Fais, A., Era, B., Kumar, A., Gatto, G., Uriarte, E., & Matos, M. J. (2022) · Molecules · doi:10.3390/molecules27206914 · Cited by 38 · see citing works
Wang, Y., Cho, J., Hwang, E., Yang, J.-E., Gao, W., Fang, M., Zheng, S., & Yi, T. (2017) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-017-2611-4 · Cited by 38 · see citing works
Ho, C., Ng, S., Chuang, H., Wen, S., Kuo, C., Mahalakshmi, B., Huang, C., & Kuo, W. (2021) · Environmental Toxicology · doi:10.1002/tox.23065 · Cited by 37 · see citing works
Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro
Costello, L., DiColandrea, T., Tasseff, R. A., Isfort, R. J., Bascom, C., von Zglinicki, T., & Przyborski, S. A. (2022) · Aging Cell · doi:10.1111/acel.13550 · Cited by 35 · see citing works
Novel Siprulina platensis Bilosomes for Combating UVB Induced Skin Damage
Zewail, M., Gaafar, P. M. E., Youssef, N. A. H. A., Ali, M. E., Ragab, M. F., Kamal, M. F., Noureldin, M. H., & Abbas, H. (2022) · Pharmaceuticals · doi:10.3390/ph16010036 · Cited by 35 · see citing works
Nayak, K., Katiyar, S. S., Kushwah, V., & Jain, S. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1379527 · Cited by 33 · see citing works
Landa-Cansigno, C., Servière‐Zaragoza, E., Morales-Martínez, T. K., Ascacio-Valdés, J. A., Morreeuw, Z. P., Gauyat, C., Stiger‐Pouvreau, V., & Reyes, A. G. (2023) · Algal Research · doi:10.1016/j.algal.2023.103271 · Cited by 33 · see citing works
Ginseng and ginseng byproducts for skincare and skin health
Kim, J.-H., Lee, R., Hwang, S., Choi, S.-H., Kim, J., Cho, I., Lee, J. I., & Nah, S.-Y. (2024) · Journal of Ginseng Research · doi:10.1016/j.jgr.2024.09.006 · Cited by 31 · see citing works
Angelis, A., Mavros, P., Nikolaou, P., Mitakou, S., Halabalaki, M., & Skaltsounis, A. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104602 · Cited by 30 · see citing works
Comparative analyses and evaluation of the cosmeceutical potential of selected Chlorella strains
Chatzikonstantinou, M., Kalliampakou, K. I., Gatzogia, M., Flemetakis, E., Katharios, P., & Labrou, N. E. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0909-1 · Cited by 30 · see citing works
Elsheikh, M. A., Gaafar, P. M. E., Khattab, M. A., Helwah, M. K. A., Noureldin, M. H., & Abbas, H. (2023) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2023.100170 · Cited by 29 · see citing works
Hartono, S. P., Bedell, V. M., Alam, S. K., O’Gorman, M., Serres, M. R., Hall, S. R., Pal, K., Kudgus, R. A., Mukherjee, P., Seelig, D. M., et al. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2021.08.018 · Cited by 29 · see citing works
Jackson, E., Heidl, M., Imfeld, D., Meeus, L., Schütz, R., & Campiche, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246143 · Cited by 27 · see citing works
Navabhatra, A., Maniratanachote, R., & Yingngam, B. (2021) · Toxicological Research · doi:10.1007/s43188-021-00107-z · Cited by 26 · see citing works
Lee, J. E., & Boo, Y. C. (2022) · Biomedicines · doi:10.3390/biomedicines10051029 · Cited by 26 · see citing works
Mechqoq, H., Hourfane, S., Yaagoubi, M. E., Hamdaoui, A. E., Msanda, F., Almeida, J. R. G. D. S., Rocha, J. M., & Aouad, N. E. (2022) · Cosmetics · doi:10.3390/cosmetics9050094 · Cited by 26 · see citing works
Khmaladze, I., Österlund, C., Smiljanic, S., Hrapovic, N., Lafon‐Kolb, V., Amini, N., Li, X., & Fabre, S. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13176 · Cited by 26 · see citing works
Tomasello, B., Malfa, G. A., Acquaviva, R., Mantia, A. L., & Giacomo, C. D. (2022) · Cells · doi:10.3390/cells11091447 · Cited by 25 · see citing works
Lee, Y., Lim, H.-W., Ryu, I. W., Huang, Y.-H., Park, M., Chi, Y. M., & Lim, C. (2020) · BioMed Research International · doi:10.1155/2020/1759067 · Cited by 24 · see citing works
Pujimulyani, D., Suryani, C. L., Setyowati, A., Handayani, R. A. S., Arumwardana, S., Widowati, W., & Maruf, A. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04921 · Cited by 23 · see citing works
Research on the Correlation Between Skin Elasticity Evaluation Parameters and Age
Chen, D., Yin, S., Lu, X., Fu, H., Gao, H., & Zhang, S. (2024) · Cosmetics · doi:10.3390/cosmetics11060205 · Cited by 22 · see citing works
Abdallah, H. M., Koshak, A. E., Farag, M. A., Sayed, N. S. E., Badr-Eldin, S. M., Ahmed, O. A. A., Algandaby, M. M., Abdel‐Naim, A. B., Ibrahim, S. R. M., Mohamed, G. A., et al. (2023) · ACS Omega · doi:10.1021/acsomega.3c04756 · Cited by 22 · see citing works
Elloumi, W., Maalej, A., Ortíz, S., Michel, S., Chamkha, M., Boutefnouchet, S., & Sayadi, S. (2022) · Molecules · doi:10.3390/molecules27030855 · Cited by 22 · see citing works
Girsang, E., Ginting, C. N., Lister, I. N. E., Widowati, W., Wibowo, S. H. B., Perdana, F. S., & Rizal, R. (2019) · The Thai Journal of Pharmaceutical Sciences · doi:10.56808/3027-7922.2427 · Cited by 22 · see citing works
Recent information on photoaging mechanisms and the preventive role of topical sunscreen products
Pedić, L., Pondeljak, N., & Šitum, M. (2020) · Acta Dermatovenerologica Alpina Pannonica et Adriatica · doi:10.15570/actaapa.2020.40 · Cited by 22 · see citing works
Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts
Lee, H., Park, H.-Y., & Jeong, T. (2021) · Life · doi:10.3390/life11020147 · Cited by 21 · see citing works
Frazão, D. F., Martins‐Gomes, C., Steck, J., Keller, J., Delgado, F., Gonçalves, J. C., Bunzel, M., Pintado, C. M. B. S., Sosa, T., & Silva, A. M. (2022) · Plants · doi:10.3390/plants11111477 · Cited by 21 · see citing works
Exosomal microRNA-Based therapies for skin diseases
Chen, J., Weiping, L., Yuwei, Y., Bingzheng, F., & Xu, Z. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.12.005 · Cited by 20 · see citing works
O’Brien, M. E., Chandra, D., Wilson, R. C., Karoleski, C. M., Fuhrman, C. R., Leader, J. K., Pu, J., Zhang, Y., Morris, A. M., Nouraie, M. S., et al. (2019) · Respiratory Research · doi:10.1186/s12931-019-1098-7 · Cited by 22 · see citing works
Campiche, R., Sandau, P., Kurth, E., Massironi, M., Imfeld, D., & Schütz, R. (2018) · International Journal of Cosmetic Science · doi:10.1111/ics.12450 · Cited by 19 · see citing works
Yang, S., Liu, X., He, J., & Liu, M. (2021) · Molecules · doi:10.3390/molecules26206102 · Cited by 18 · see citing works
Cheng, F., Feng, J., Cao, Z., Qu, D., & Li, H. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16710 · Cited by 17 · see citing works
Genetic profiling and precision skin care: a review
Geusens, B., & Haykal, D. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1559510 · Cited by 16 · see citing works
Kiattisin, K., Srithongchai, P., Jaiyong, W., Boonpisuttinant, K., Ruksiriwanich, W., Jantrawut, P., & Sainakham, M. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101004 · Cited by 16 · see citing works
Nakajima, H., Terazawa, S., Niwano, T., Yamamoto, Y., & Imokawa, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161580 · Cited by 16 · see citing works
Self-citationTerazawa, S., Takada, M., Sato, Y., Nakajima, H., & Imokawa, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042057 · Cited by 16 · see citing works
Self-citationAxiotis, E., Angelis, A., Antoniadi, L., Petrakis, E. A., & Skaltsounis, A. (2021) · Antioxidants · doi:10.3390/antiox11010101 · Cited by 16 · see citing works
Сабитов, А. С., Gaweł‐Bęben, K., Sakipova, Z., Strzępek-Gomółka, M., Hoian, U., Маратовна, С. Э., Głowniak, K., & Ludwiczuk, A. (2021) · Molecules · doi:10.3390/molecules26092578 · Cited by 15 · see citing works
Lee, S. J., Kim, J. E., Choi, Y. J., Jin, Y. J., Roh, Y. J., Seol, A., Song, H. J., Park, S. H., Uddin, M. S., Lee, S.-W., et al. (2022) · Antioxidants · doi:10.3390/antiox11071317 · Cited by 16 · see citing works
Fikry, E., Mahdi, I., Ortaakarsu, A. B., Tawfeek, N., Ochieng, M. A., Bakrim, W. B., Abdelfattah, M. A. O., Omari, K. W., Mahmoud, M. F., & Sobeh, M. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.101778 · Cited by 15 · see citing works
Terazawa, S., Nakano, M., Yamamoto, A., & Imokawa, G. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011139 · Cited by 15 · see citing works
Self-citationLiu, S., Lu, Y., Kurono, M., Matahira, Y., Manabe, Y., & Sugawara, T. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11537 · Cited by 17 · see citing works
Elbouzidi, A., Taibi, M., Baraich, A., Haddou, M., Mothana, R. A., Alsufyani, S. A., Darwish, H. W., Molinié, R., Fontaine, J., Fliniaux, O., et al. (2025) · Frontiers in Chemistry · doi:10.3389/fchem.2025.1537877 · Cited by 14 · see citing works
Lorenzo, R. D., Maisto, M., Ricci, L., Piccolo, V., Marzocchi, A., Greco, G., Tenore, G. C., & Laneri, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031677 · Cited by 14 · see citing works
GC-MS-MS analysis and biological properties determination of Mentha piperita L., essential oils
Omari, N. E., Chamkhi, I., Balahbib, A., Benali, T., Akhazzane, M., Ullah, R., Alotaibi, A., Elouafy, Y., Elhrech, H., & Bouyahya, A. (2024) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2024.104875 · Cited by 15 · see citing works
Samy, M. N., Goff, G. L., Lopes, P., Georgousaki, K., Gumeni, S., Almeida, C., González, I., Genilloud, O., Trougakos, I. P., Fokialakis, N., et al. (2019) · Molecules · doi:10.3390/molecules24122239 · Cited by 14 · see citing works
Liu, C., Xu, Y., Kirk, R. D., Li, H., Li, D., DaSilva, N. A., Bertin, M. J., Seeram, N. P., & Ma, H. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104208 · Cited by 14 · see citing works
Hernández-Montes, M. D. S., Santoyo, F. M., Moreno, M. F., Torre-Ibarra, M. H. D. L., Acosta, L. S., & Palacios-Ortega, N. (2020) · Journal of the European Optical Society Rapid Publications · doi:10.1186/s41476-020-00133-8 · Cited by 14 · see citing works
Clinical Assessment, Diagnosis, and Management of Infraorbital Wrinkles and Pigmentation
Rathore, G., Das, K., Landau, M., Verner, I., Kassir, M., Galadari, H., Gold, M. H., Babaei, M., & Goldust, M. (2023) · Dermatologic Clinics · doi:10.1016/j.det.2023.07.005 · Cited by 14 · see citing works
Yao, R., Tanaka, M., Misawa, E., Saito, M., Nabeshima, K., Yamauchi, K., Abe, F., Yamamoto, Y., & Furukawa, F. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13527 · Cited by 14 · see citing works
Im, A., Park, I., Ji, K.-Y., Lee, J. Y., Kim, K. M., Na, M., & Chae, S. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2692-4 · Cited by 14 · see citing works
Ávalos‐Viveros, M., Santolalla-Vargas, C. E., Santes-Hernández, V.-F., Martínez‐Flores, H. E., Torres-Garcia, E., López-Meza, J. E., Virgen-Ortiz, J. J., Pérez-Cálix, E., & García‐Pérez, M. (2023) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2023.101335 · Cited by 12 · see citing works
Ham, S. Y., Pyo, M. J., Kang, M., Kim, Y.-S., Lee, D. H., Chung, J. H., & Lee, S. (2024) · Cells · doi:10.3390/cells13060527 · Cited by 13 · see citing works
Algal biorefinery: focus on cosmeceuticals
Parikh, H. S., Singh, P. K., & Tiwari, A. (2024) · Systems Microbiology and Biomanufacturing · doi:10.1007/s43393-024-00287-3 · Cited by 12 · see citing works
Ramadhania, Z. M., Yang, D. U., Moektiwardojo, M., Han, Y., Park, J. K., Rupa, E. J., Yang, D. C., Lee, S. J., & Kang, S. C. (2022) · Applied Sciences · doi:10.3390/app13010550 · Cited by 12 · see citing works
Achmad, A. A., Tangdilintin, F., Stephanie, S., Sulistiawati, S., Enggi, C. K., Rifai, Y., Aliyah, Wahyudin, E., Permana, A. D., & Manggau, M. A. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114362 · Cited by 11 · see citing works
Champeau, M., Jary, D., Dewalle, A. S., Mordon, S. R., de Lassalle, E. M., Vignoud, S., & Mortier, L. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.120115 · Cited by 11 · see citing works
Histological study of white rhinoceros integument
Plochocki, J. H., Ruiz, S., Rodriguez‐Sosa, J. R., & Hall, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176327 · Cited by 11 · see citing works
Georgakis, N., Ioannou, E., Chatzikonstantinou, M., Merino, M., Chronopoulou, E. G., Mullor, J. L., Madesis, P. B., & Labrou, N. E. (2023) · Cosmetics · doi:10.3390/cosmetics10030075 · Cited by 10 · see citing works
Ko, J., Lee, M. J., Jeong, W., Choi, S., Shin, E., An, Y., Kim, H., Lee, U., Kim, B., Kwak, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c06846 · Cited by 10 · see citing works
Makihara, H., Hidaka, M., Sakai, Y., Horie, Y., Mitsui, H., Ohashi, K., Goshima, Y., & Akase, T. (2016) · Connective Tissue Research · doi:10.1080/03008207.2016.1255205 · Cited by 10 · see citing works
Facial Skin Lifting and Brightening Following Sleep on Copper Oxide Containing Pillowcases
Borkow, G., & Elías, A. D. C. (2016) · Cosmetics · doi:10.3390/cosmetics3030024 · Cited by 9 · see citing works
Bioactive Potential of a Grape Stem Blend: A Sustainable Approach to Skin Regeneration
Serra, M., Botelho, C., Ferreira-Sousa, D., Almeida, H., Casas, A., Teixeira, J. A., & Barros, A. (2025) · Antioxidants · doi:10.3390/antiox14030338 · Cited by 8 · see citing works
Crivelin, L. L., Filho, I. J. Z., de Quadros, L. G., Lopes, A. C. P., André, J. D. L., Joudatt, J., & Kaiser, R. L. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06453-1 · Cited by 8 · see citing works
- Authors
- Imokawa, G., & Ishida, K.
- Affiliations
- Chubu University (JP)
- Kao Corporation (Japan) (JP)
- Corresponding author
- Imokawa, Genji
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2015-04-08
- Volume
- 16
- Issue
- 4
- Pages
- 7753-7775
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4425048
- OpenAlex
- W2089161677
- Cited by
- 206
- References
- 59
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 35 · 2023: 17 · 2022: 40 · 2021: 17 · 2020: 21 · 2019: 14 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- ultraviolet radiation, skin aging, skin wrinkling, skin sagging, skin elasticity, elastase, matrix metalloproteinases, elastic fibers, UV-B radiation, UVA, ovariectomy, collagenase, dermal fibroblasts, elastase inhibitors, facial skin
- MeSH terms
- Animals, Elasticity, Fibroblasts, Humans, Pancreatic Elastase, Ultraviolet Rays, Skin Aging, Dermis
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