Cited by 206Skin Protection and AgingProtease and Inhibitor MechanismsDermatologic Treatments and Research

Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging I: Reduced skin elasticity, highly associated with enhanced dermal elastase activity, triggers wrinkling and sagging

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Imokawa, Genji, Ishida, Koichi·2015·International Journal of Molecular Sciences

Abstract

The repetitive exposure of skin to ultraviolet B (UVB) preferentially elicits wrinkling while ultraviolet A (UVA) predominantly elicits sagging. In chronically UVB or UVA-exposed rat skin there is a similar tortuous deformation of elastic fibers together with decreased skin elasticity, whose magnitudes are greater in UVB-exposed skin than in UVA-exposed skin. Comparison of skin elasticity with the activity of matrix metalloproteinases (MMPs) in the dermis of ovariectomized rats after UVB or UVA irradiation demonstrates that skin elasticity is more significantly decreased in ovariectomized rats than in sham-operated rats, which is accompanied by a reciprocal increase in elastase activity but not in the activities of collagenases I or IV. Clinical studies using animal skin and human facial skin demonstrated that topical treatment with a specific inhibitor or an inhibitory extract of skin fibroblast-derived elastase distinctly attenuates UVB and sunlight-induced formation of wrinkling. Our results strongly indicated that the upregulated activity of skin fibroblast-derived elastase plays a pivotal role in wrinkling and/or sagging of the skin via the impairment of elastic fiber configuration and the subsequent loss of skin elasticity.

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Crossref · 10.3390/ijms16047753

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  • UV-A accelerates hydrolysis of skin collagen by promoting production of matrix metalloproteinases, leading to tissue destruction and progressive degeneration of dermal extracellular matrix.

    “It accelerates the hydrolysis of skin collagen by promoting the production of matrix metalloproteinases (MMPs), leading to tissue destruction and progressive degeneration of dermal extracellular matrix [22,23,24].”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [22]

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Authors
Imokawa, G., & Ishida, K.
Affiliations
  • Chubu University (JP)
  • Kao Corporation (Japan) (JP)
Corresponding author
Imokawa, Genji
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2015-04-08
Volume
16
Issue
4
Pages
7753-7775
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2089161677
Cited by
206
References
59
Citations by year
2026: 19 · 2025: 19 · 2024: 35 · 2023: 17 · 2022: 40 · 2021: 17 · 2020: 21 · 2019: 14 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 1
FWCI
1.28
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
ultraviolet radiation, skin aging, skin wrinkling, skin sagging, skin elasticity, elastase, matrix metalloproteinases, elastic fibers, UV-B radiation, UVA, ovariectomy, collagenase, dermal fibroblasts, elastase inhibitors, facial skin
MeSH terms
Animals, Elasticity, Fibroblasts, Humans, Pancreatic Elastase, Ultraviolet Rays, Skin Aging, Dermis

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