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FoxO3 Modulates Circadian Rhythms in Neural Stem Cells

Draijer, Swip, Timmerman, Raissa, Pannekeet, Jesse, van Harten, Alexandra, Farshadi, Elham Aida, Kemmer, Julius, van Gilst, Demy, Chaves, Inês, Hoekman, Marco F. M.·2023·International Journal of Molecular Sciences
DOI 10.3390/ijms241713662PMC PMC10563086
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Abstract

Both FoxO transcription factors and the circadian clock act on the interface of metabolism and cell cycle regulation and are important regulators of cellular stress and stem cell homeostasis. Importantly, FoxO3 preserves the adult neural stem cell population by regulating cell cycle and cellular metabolism and has been shown to regulate circadian rhythms in the liver. However, whether FoxO3 is a regulator of circadian rhythms in neural stem cells remains unknown. Here, we show that loss of FoxO3 disrupts circadian rhythmicity in cultures of neural stem cells, an effect that is mediated via regulation of Clock transcriptional levels. Using Rev-Erbα-VNP as a reporter, we then demonstrate that loss of FoxO3 does not disrupt circadian rhythmicity at the single cell level. A meta-analysis of published data revealed dynamic co-occupancy of multiple circadian clock components within FoxO3 regulatory regions, indicating that FoxO3 is a Clock-controlled gene. Finally, we examined proliferation in the hippocampus of FoxO3-deficient mice and found that loss of FoxO3 delayed the circadian phase of hippocampal proliferation, indicating that FoxO3 regulates correct timing of NSC proliferation. Taken together, our data suggest that FoxO3 is an integral part of circadian regulation of neural stem cell homeostasis.

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Metadata

Authors
Draijer, S., Timmerman, R., Pannekeet, J., van Harten, A., Farshadi, E. A., Kemmer, J., van Gilst, D., Chaves, I., & Hoekman, M. F. M.
Affiliations
  • Swammerdam Institute of Life Sciences, University of Amsterdam, 1018 WB Amsterdam, The Netherlands
  • Department of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
ORCID
Chaves, Inês
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-09-04
Volume
24
Issue
17
Pages
13662
ISSN
1422-0067
DOI
10.3390/ijms241713662
PMC
PMC10563086
Cited by
7
References
10
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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