Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation
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Somatic stem cells have been identified in multiple adult tissues. Whether self-renewal occurs symmetrically or asymmetrically is key to understanding long-term stem cell maintenance and generation of progeny for cell replacement. In the adult mouse brain, neural stem cells (NSCs) (B1 cells) are retained in the walls of the lateral ventricles (ventricular-subventricular zone [V-SVZ]). The mechanism of B1 cell retention into adulthood for lifelong neurogenesis is unknown. Using multiple clonal labeling techniques, we show that the vast majority of B1 cells divide symmetrically. Whereas 20%-30% symmetrically self-renew and can remain in the niche for several months before generating neurons, 70%-80% undergo consuming divisions generating progeny, resulting in the depletion of B1 cells over time. This cellular mechanism decouples self-renewal from the generation of progeny. Limited rounds of symmetric self-renewal and consuming symmetric differentiation divisions can explain the levels of neurogenesis observed throughout life.
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Stem cell heterogeneity during ageing may be due to a decrease in symmetrical divisions and an increase in asymmetrical divisions in old NSCs.
“Such stem cell heterogeneity during ageing may be due to a decrease in symmetrical divisions and an increase in asymmetrical divisions in old NSCs27,28.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [27]
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- Authors
- Obernier, K., Cebrian-Silla, A., Thomson, M., Parraguez, J. I., Anderson, R., Guinto, C., Rodas Rodriguez, J., Garcia-Verdugo, J.-M., & Alvarez-Buylla, A.
- Affiliations
- University of California, San Francisco (US)
- California Institute of Technology (US)
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 22
- Issue
- 2
- Pages
- 221-234.e8
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC5802882
- OpenAlex
- W2786235809
- Cited by
- 250
- References
- 71
- Citations by year
- 2026: 10 · 2025: 27 · 2024: 26 · 2023: 26 · 2022: 28 · 2021: 26 · 2020: 49 · 2019: 38 · 2018: 20
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institute of Dental and Craniofacial Research (DP5 OD012194)
- National Institute of General Medical Sciences (P50 GM081879, NS028478, HD032116)
- Generalitat Valenciana (PROMETEOII/2014/075)
- National Cancer Institute
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- adult neurogenesis, neural stem cells, asymmetric cell division, ventricular-subventricular zone, stem cell niche, stem cell depletion, neuronal differentiation, stem cell maintenance
- MeSH terms
- Cell Self Renewal, Animals, Cell Count, Cell Differentiation, Humans, Interneurons, Mice, Transgenic, Time Factors, Neurogenesis, Neural Stem Cells
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