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Cited by 12Schizophrenia research and treatmentMental Health and PsychiatryAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia Spectrum Disorders

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Uchino, Takashi, Okubo, Ryo, Takubo, Youji, Aoki, Akiko, Wada, Izumi, Hashimoto, Naoki, Ikezawa, Satoru, Nemoto, Takahiro·2023·Journal of Personalized Medicine
DOI 10.3390/jpm13040683PMC PMC10142841
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Abstract

Background: In schizophrenia spectrum disorders (SSD), social cognition mediates the relationship between neurocognition and social functioning. Although people with major depressive disorder (MDD) also exhibit cognitive impairments, which are often prolonged, little is known about the role of social cognition in MDD. Methods: Using data obtained through an internet survey, 210 patients with SSD or MDD were selected using propensity score matching based on their demographics and illness duration. Social cognition, neurocognition, and social functioning were evaluated using the Self-Assessment of Social Cognition Impairments, Perceived Deficits Questionnaire, and Social Functioning Scale, respectively. The mediation effects of social cognition on the relationship between neurocognition and social functioning were examined in each group. Invariances of the mediation model across the two groups were then analyzed. Results: The SSD and MDD groups had mean ages of 44.49 and 45.35 years, contained 42.0% and 42.8% women, and had mean illness durations of 10.76 and 10.45 years, respectively. In both groups, social cognition had significant mediation effects. Configural, measurement, and structural invariances across the groups were established. Conclusion: The role of social cognition in patients with MDD was similar to that in SSD. Social cognition could be a common endophenotype for various psychiatric disorders.

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  • Social cognition plays a significant mediating role in the relationship between cognitive impairments and social functioning in psychosis.

    “Moreover, social cognition has been found to play a significant mediating role in the relationship between cognitive impairments and social functioning in psychosis (Uchino et al. 2023).”

    From Social Functioning Interventions in Psychosis: A Systematic Review. (2025) · cites this paper as Uchino et al. 2023

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Authors
Uchino, T., Okubo, R., Takubo, Y., Aoki, A., Wada, I., Hashimoto, N., Ikezawa, S., & Nemoto, T.
Affiliations
  • Toho University (JP)
  • National Center of Neurology and Psychiatry (JP)
  • Hokkaido University (JP)
  • The University of Tokyo (JP)
Corresponding author
Nemoto, Takahiro
ORCID
Venue
Journal of Personalized Medicine
Publisher
MDPI AG
Published
2023-04-19
Volume
13
Issue
4
Pages
683
ISSN
2075-4426 (ISSN-L)
DOI
10.3390/jpm13040683
PMC
PMC10142841
OpenAlex
W4366598035
Cited by
12
References
6
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2023: 2
FWCI
2.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Personalized Medicine (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Japan Agency for Medical Research and Development (AMED) (JP20dk0307092)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
social cognition, neurocognitive function, social functioning, major depressive disorder, schizophrenia spectrum disorders, mediation analysis, cognitive impairment, endophenotypes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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