Cited by 193Antioxidant Activity and Oxidative StressSkin Protection and AgingPhytochemicals and Antioxidant Activities

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The Role of Carotenoids in Human Skin

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Darvin, Maxim E., Sterry, Wolfram, Lademann, Juergen, Vergou, Theognosia·2011·Molecules

DOI 10.3390/molecules161210491PMC PMC6264659

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Abstract

The human skin, as the boundary organ between the human body and the environment, is under the constant influence of free radicals (FR), both from the outside in and from the inside out. Carotenoids are known to be powerful antioxidant substances playing an essential role in the reactions of neutralization of FR (mainly reactive oxygen species ROS). Carotenoid molecules present in the tissue are capable of neutralizing several attacks of FR, especially ROS, and are then destroyed. Human skin contains carotenoids, such as α-, γ-, β-carotene, lutein, zeaxanthin, lycopene and their isomers, which serve the living cells as a protection against oxidation. Recent studies have reported the possibility to investigate carotenoids in human skin quickly and non-invasively by spectroscopic means. Results obtained from in-vivo studies on human skin have shown that carotenoids are vital components of the antioxidative protective system of the human skin and could serve as marker substances for the overall antioxidative status. Reflecting the nutritional and stress situation of volunteers, carotenoids must be administered by means of antioxidant-rich products, e.g., in the form of fruit and vegetables. Carotenoids are degraded by stress factors of any type, inter alia, sun radiation, contact with environmental hazards, illness, etc. The kinetics of the accumulation and degradation of carotenoids in the skin have been investigated.

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Regensburger, J., Knak, A., Maisch, T., Landthaler, M., & Bäumler, W. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01414.x · Cited by 31
Influence on the Carotenoid Levels of Skin Arising from Age, Gender, Body Mass Index in Smoking/Non-Smoking Individuals
Meinke, M. C., Lauer, A.-C., Taskoparan, B., Gersonde, I. H., Lademann, J. M., & Darvin, M. E. (2011) · Free Radicals and Antioxidants · doi:10.5530/ax.2011.2.4 · Cited by 31
Skin carotenoid levels in adult patients with psoriasis
Lima, X. T. V., & Kimball, A. B. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03888.x · Cited by 29
Raman spectroscopic analysis of the increase of the carotenoid antioxidant concentration in human skin after a 1-week diet with ecological eggs
Hesterberg, K., Lademann, J. M., Patzelt, A., Sterry, W., & Darvin, M. E. (2009) · Journal of Biomedical Optics · doi:10.1117/1.3119257 · Cited by 26
Influence of IR radiation on the carotenoid content in human skin
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Determination of the influence of IR radiation on the antioxidative network of the human skin
Darvin, M. E., Haag, S. F., Meinke, M. C., Sterry, W., & Lademann, J. M. (2010) · Journal of Biophotonics · doi:10.1002/jbio.200900111 · Cited by 21
Measurement of oxygen tension in human skin
Spence, V. A., & Walker, W. F. (1976) · Medical & Biological Engineering & Computing · doi:10.1007/bf02478742 · Cited by 20
Low power cw-laser signatures on human skin
Lihachev, A., Lesins, J., Jakovels, D., & Spīgulis, J. (2011) · Quantum Electronics · doi:10.1070/qe2010v040n12abeh014470 · Cited by 18
Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of Rose bengal
Ranadive, N. S., Menon, I. A., Shirwadkar, S., & Persad, S. (1989) · Inflammation · doi:10.1007/bf00916756 · Cited by 18
Noninvasive reflection spectra provide quantitative information about the spatial distribution of skin chromophores
Niedorf, F., Jungmann, H., & Kietzmann, M. (2005) · Medical Physics · doi:10.1118/1.1851917 · Cited by 14
Recurrent palmar–plantar erythrodysaesthesia following high‐dose cytarabine treatment for acute lymphoblastic leukemia
Crawford, J. H., Eikelboom, J. W., & McQuillan, A. (2002) · European Journal Of Haematology · doi:10.1034/j.1600-0609.2002.02834.x · Cited by 13
Investigation of doxorubicin on the skin: A spectroscopic study to understand the pathogenesis of PPE
Lademann, J. M., Martschick, A., Jacobi, U., Richter, H., Darvin, M. E., Sehouli, J., Oskay-Oezcelik, G., Blohmer, J., Lichtenegger, W., & Sterry, W. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.23.16_suppl.5093 · Cited by 12
Palmar-Plantar Erythrodysaesthesia Syndrome Due to 5-Fluorouracil Therapy–An Underestimated Toxic Event?
Iurlo, A., Fornier, M. N., Caldiera, S., Bertoni, F., & Foa, P. (1997) · Acta Oncologica · doi:10.3109/02841869709001331 · Cited by 7
Prognostic factors for survival after pancreaticoduodenectomy for patients with carcinoma of the pancreatic head region
Lipton (1995) · Pure Amsterdam UMC · doi:10.1002/1097-0142(19950415)75:8 · Cited by 1

Flagged first, then by citations

3 of the 107 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Darvin, 2004, Noninvasive detection of beta-carotene and lycopene in human skin using Raman spectroscopy, Laser Phys., 14, 231

Sorted by citations

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Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345
Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene
Meléndez‐Martínez, A. J., Stinco, C. M., & Mapelli‐Brahm, P. (2019) · Nutrients · doi:10.3390/nu11051093 · Cited by 246

See all 193

Authors: Darvin, M. E., Sterry, W., Lademann, J., & Vergou, T.
Affiliations: Stiftung Charité (DE)
National and Kapodistrian University of Athens (GR)
Corresponding author: Darvin, Maxim E.
ORCID: Darvin, Maxim E.
Lademann, Juergen
Venue: Molecules
Publisher: MDPI AG
Published: 2011-12-16
Volume: 16
Issue: 12
Pages: 10491-10506
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules161210491
PMC: PMC6264659
OpenAlex: W2063103327
Cited by: 193
References: 107
Citations by year: 2026: 9 · 2025: 22 · 2024: 23 · 2023: 18 · 2022: 16 · 2021: 19 · 2020: 21 · 2019: 16 · 2018: 8 · 2017: 13 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 5
FWCI: 3.32
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: carotenoids, human skin, antioxidants, free radicals, reactive oxygen species, oxidative stress, lycopene, lutein, zeaxanthin, carotene, carotenoid degradation, solar radiation, dietary carotenoids

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The Role of Carotenoids in Human Skin

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