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Cited by 293Coffee research and impactsNatural Antidiabetic Agents StudiesDiet, Metabolism, and Disease

Acute Effects of Decaffeinated Coffee and the Major Coffee Components Chlorogenic Acid and Trigonelline on Glucose Tolerance

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van Dijk, Aimée E., Olthof, Margreet R., Meeuse, Joke C., Seebus, Elin, Heine, Rob J., van Dam, Rob M.·2009·Diabetes Care
DOI 10.2337/dc09-0207PMC PMC2681030
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Abstract

OBJECTIVE: Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. RESEARCH DESIGN AND METHODS: We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee, 1 g chlorogenic acid, 500 mg trigonelline, and placebo (1 g mannitol) on glucose and insulin concentrations during a 2-h oral glucose tolerance test (OGTT) in 15 overweight men. RESULTS: Chlorogenic acid and trigonelline ingestion significantly reduced glucose (−0.7 mmol/l, P = 0.007, and −0.5 mmol/l, P = 0.024, respectively) and insulin (−73 pmol/l, P = 0.038, and −117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. None of the treatments affected insulin or glucose area under the curve values during the OGTT compared with placebo. CONCLUSIONS: Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT.

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  1. [3]Clifford MN: Chlorogenic acids and other cinnamates: nature, occurrence and dietary burden. J Sci Food Agric 1999; 79: 362– 372

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Authors
van Dijk, A. E., Olthof, M. R., Meeuse, J. C., Seebus, E., Heine, R. J., & van Dam, R. M.
Affiliations
  • Department of Health Sciences and the EMGO Institute for Health and Care Research, VU University Amsterdam, the Netherlands;
  • Amsterdam Public Health (NL)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
  • Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts;
Corresponding author
Olthof, Margreet R.
ORCID
Olthof, Margreet R.
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2009-02-24
Volume
32
Issue
6
Pages
1023-1025
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc09-0207
PMC
PMC2681030
OpenAlex
W2151356634
Cited by
293
References
15
Citations by year
2026: 4 · 2025: 11 · 2024: 7 · 2023: 16 · 2022: 22 · 2021: 21 · 2020: 24 · 2019: 15 · 2018: 24 · 2017: 21 · 2016: 19 · 2015: 17 · 2014: 21 · 2013: 22 · 2012: 17
FWCI
11.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes Care (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • VU Research Portal (publishedVersion, other-oa)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Eli Lilly and Company
  • Vrije Universiteit Amsterdam
  • Diabetes Fonds
  • National Center for Advancing Translational Sciences (L30 TR001051)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
decaffeinated coffee, chlorogenic acid, trigonelline, glucose tolerance, insulin response, type 2 diabetes risk, oral glucose tolerance test, overweight men
MeSH terms
Alkaloids, Blood Glucose, Caffeine, Chlorogenic Acid, Coffee, Glucose Tolerance Test, Humans, Insulin, Male, Mannitol, Placebos, Cross-Over Studies, Overweight

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