Potential Health Benefits of Ropy Exopolysaccharides Produced by Lactobacillus plantarum
Open accessAbstract
The ability of Lactobacillus plantarum to produce exopolysaccharides (EPS) of various structures and properties is effective in showing both starter and probiotic culture qualification. In this study, the potential health promoting functions of the ropy EPS produced by Lactobacillus plantarum strains isolated from tarhana were tested. A stimulation of the pro-inflammatory IL-12 and TNF-α cytokines was observed in the presence of the ropy EPS suggesting an in vitro immune modulation. Similarly, the tested EPS demonstrated promoted the growth of the probiotic strains in fermentation medium. A medium level of radical scavenging activities of ropy EPS was observed whereas the superoxide and hydroxyl scavenging activities were more effective. The ropy EPS also showed α-glucosidase inhibition and cholesterol removal characteristics depending on their concentration. These findings revealed the potential health-promoting functions of ropy EPS from L. plantarum strains and EPS from L. plantarum PFC311 and PFC310 strains demonstrated multiple health-improving effects that can be further evaluated in food and other industries.
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Some EPS produced from different LAB species with antioxidant activity have also shown immunomodulatory and anti-inflammatory properties, suggesting a potential correlation.
“some EPS produced from different LAB species with antioxidant activity have also shown the ability to exert other beneficial effects such as immunomodulatory and anti-inflammatory properties, suggesting a potential correlation [109,119,124,125,126].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [126]
Results §2.3 reports antioxidant activity, and Results §2.1 reports immune modulation in EPS from six L. plantarum strains. But §2.1 says their anti-inflammatory effects in HT-29 cells were limited and their pro-inflammatory effects were stronger. The study examines one LAB species, not different species, and does not establish a correlation between the activities. (LLM, conf=0.86)
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Pro-, Post- and Pre-biotics for Health and Longevity
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Chen, C., Zhang, Y., Zhu, Q., Wang, X., Zhu, Y., & Chen, Z. (2026) · International Journal of Gastronomy and Food Science · doi:10.1016/j.ijgfs.2026.101560
Naderi, F., Salami, M., Razavi, S. H., Miran, M., Serpe, M. J., Saldaña, M. D. A., Löbenberg, R., Mallillin, M. C., Zhao, S., & Davies, N. M. (2026) · Journal of Phytomedicine · doi:10.3390/jphytomed1020007
“L. casei produces higher levels of exopolysac-charides than L. acidophilus [53,54]; given that exopolysaccharides have been linked to α -glucosidase inhibition, the increased inhibitory activity of L. casei -derived preparations is mechanistically plausible.”
Wang, N., Wang, K., Han, H., Fan, J., Song, F., Chen, H., & Li, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1987320
- Authors
- Yılmaz, T., & Şimşek, Ö.
- Affiliations
- Pamukkale University (TR)
- Corresponding author
- Şimşek, Ömer
- ORCID
- Şimşek, Ömer
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2020-07-20
- Volume
- 25
- Issue
- 14
- Pages
- 3293
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC7396996
- OpenAlex
- W3043350268
- Cited by
- 54
- References
- 27
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 17 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 1
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Scientific and Technological Research Council of Turkey (116O525)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- Lactobacillus plantarum, exopolysaccharides, probiotics, tarhana, immunomodulation, IL-12, TNF-α, antioxidant activity, superoxide radical scavenging, hydroxyl radical scavenging, α-glucosidase inhibition, cholesterol removal
- MeSH terms
- Animals, Antioxidants, Cholesterol, Health, Humans, Immunologic Factors, Polysaccharides, Bacterial, Cytokines, Lactiplantibacillus plantarum, Prebiotics, Glycoside Hydrolase Inhibitors
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