Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides
Abstract
BACKGROUND: Immunomodulation by probiotic microorganisms has become a topic of increasing interest in food microbiology. Polysaccharides are broadly used in the food industry as gelling, thickening, stabilizing, or emulsifying agents. Some probiotics such as lactic acid bacteria also produce exopolysaccharides that stimulate macrophage production of cytokines. The aim of this study was to characterize the effects of exopolysaccharides of Lactobacillus paracasei subsp. paracasei NTU 101 (101EP) and Lactobacillus plantarum NTU 102 (102EP) exopolysaccharides on antioxidant activity and immunomodulation in vitro. RESULTS: The sugar composition (including arabinose, galactose, glucose, fructose, mannose, and maltose) of 101EP and 102EP was quantified by high-performance anion-exchange chromatography. Cytokine production (including IL-6, TNF-α, and IL-1β) was induced by 101EP and 102EP in Raw 264.7 in a dose-dependent manner (5-500 µg mL(-1) ). 101EP and 102EP also demonstrated potential antioxidant properties (1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, chelation of ferrous ions, inhibition of linoleic acid peroxidation, and reducing power) in vitro. CONCLUSION: 101EP and 102EP stimulate cell proliferation and may be useful as a mild immune modulator of macrophages.
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Some EPS produced from different LAB species with antioxidant activity have also shown immunomodulatory and anti-inflammatory properties, suggesting a potential correlation.
“some EPS produced from different LAB species with antioxidant activity have also shown the ability to exert other beneficial effects such as immunomodulatory and anti-inflammatory properties, suggesting a potential correlation [109,119,124,125,126].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [119]
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- Authors
- Liu, C., Tseng, K., Chiang, S., Lee, B., Hsu, W., & Pan, T.
- Affiliations
- National Taiwan University (TW)
- National Chung Hsing University (TW)
- Corresponding author
- Pan, Tzu‐Ming
- Venue
- Journal of the Science of Food and Agriculture
- Publisher
- Wiley
- Published
- 2011-05-10
- Volume
- 91
- Issue
- 12
- Pages
- 2284-2291
- ISSN
- 0022-5142 (ISSN-L)
- 1097-0010
- OpenAlex
- W2058568791
- Cited by
- 230
- References
- 52
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 9 · 2023: 16 · 2022: 26 · 2021: 23 · 2020: 21 · 2019: 19 · 2018: 19 · 2017: 12 · 2016: 16 · 2015: 16 · 2014: 14 · 2013: 9 · 2012: 9
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Science of Food and Agriculture (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- Lacticaseibacillus paracasei subsp. paracasei, Lactobacillus plantarum, exopolysaccharides, probiotics, immunomodulation, antioxidant activity, macrophages, cytokine production, sugar composition, DPPH radical scavenging, ferrous ion chelation, linoleic acid peroxidation, reducing power, cell proliferation
- MeSH terms
- Adjuvants, Immunologic, Animals, Antioxidants, Cell Line, Transformed, Chromatography, High Pressure Liquid, Iron Chelating Agents, Lactobacillus, Macrophages, Maltose, Monosaccharides, Oxidation-Reduction, Phagocytosis, Polysaccharides, Bacterial, Species Specificity, Surface Properties, Lipid Peroxidation, Free Radical Scavengers, Cytokines, Probiotics, Lactiplantibacillus plantarum, Lactobacillus plantarum, Cell Proliferation, Mice
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