Characterization of an Exopolysaccharide with Potential Health-Benefit Properties from a Probiotic Lactobacillus plantarum RJF4
Abstract
Exopolysaccharides (EPS) are macromolecules composed of sugar and sugar derivatives and the function and applications mainly depend on their monosaccharide composition, molecular weight and branching. EPS from the food-grade Lactic acid bacteria (LAB) serves as natural alternatives to commercial additives. One heteropoysaccharide produced by a recently isolated (from rotten jack fruit) Lactobacillus plantarum RJF4 was extracted and purified. HPLC analysis and FTIR spectroscopy revealed that it is composed of glucose and mannose. The EPS was tolerant to temperature up to 225 °C. In vitro assays showed that the EPS possesses total antioxidant capacity (32%), DPPH radical scavenging ability (23.63%) and reduction potential (50% compared to the control ascorbic acid). It also displayed cholesterol lowering property (42.24%) and α-amylase inhibition (40%), which is an in vitro assay for evaluating anti diabetic property. The cytotoxicity studies (MTT assay and Alamar Blue assay) revealed cancer cell specific anti proliferative effects of EPS. It showed to be toxic to MiaPaCa2-pancreatic cancer cell line in dose dependent manner and remained nontoxic to normal cell line (L6 and L929 fibroblast cells).
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Some EPS produced from different LAB species with antioxidant activity have also shown immunomodulatory and anti-inflammatory properties, suggesting a potential correlation.
“some EPS produced from different LAB species with antioxidant activity have also shown the ability to exert other beneficial effects such as immunomodulatory and anti-inflammatory properties, suggesting a potential correlation [109,119,124,125,126].”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [125]
EPS from Lpb. plantarum RJF4 was able to reduce cholesterol level by 42.24% in an in vitro assay.
“in an in vitro assay, EPS from Lpb. plantarum RJF4 (from rotten jack fruit) was able to reduce cholesterol level by 42.24% [125]”
From Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods (2021) · cites this paper as [125]
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- Authors
- Dilna, S. V., Surya, H., Aswathy, R. G., Varsha, K. K., Sakthikumar, D. N., Pandey, A., & Nampoothiri, K. M.
- Affiliations
- National Institute for Interdisciplinary Science and Technology (IN)
- Toyo University (JP)
- Corresponding author
- Nampoothiri, Kesavan Madhavan
- Venue
- LWT - Food Science and Technology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 64
- Issue
- 2
- Pages
- 1179-1186
- ISSN
- 0023-6438 (ISSN-L)
- OpenAlex
- W878845476
- Cited by
- 262
- References
- 39
- Citations by year
- 2026: 11 · 2025: 30 · 2024: 34 · 2023: 35 · 2022: 42 · 2021: 22 · 2020: 23 · 2019: 22 · 2018: 19 · 2017: 14 · 2016: 8 · 2015: 2
- FWCI
- 19.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- LWT (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- CSIR XIIth Five Year Plan Network Project-FUNHEALTH (CSC 0133)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- exopolysaccharides, Lactobacillus plantarum, probiotic bacteria, heteropolysaccharide, antioxidant activity, cholesterol lowering, α-amylase inhibition, antidiabetic activity, cytotoxicity, pancreatic cancer cells, MIA PaCa-2 cells, health-promoting properties
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