The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review
Open accessAbstract
Astaxanthin, a xanthophyll carotenoid, is a secondary metabolite naturally synthesized by a number of bacteria, microalgae, and yeasts. The commercial production of this pigment has traditionally been performed by chemical synthesis, but the microalga Haematococcus pluvialis appears to be the most promising source for its industrial biological production. Due to its collective diverse functions in skin biology, there is mounting evidence that astaxanthin possesses various health benefits and important nutraceutical applications in the field of dermatology. Although still debated, a range of potential mechanisms through which astaxanthin might exert its benefits on skin homeostasis have been proposed, including photoprotective, antioxidant, and anti-inflammatory effects. This review summarizes the available data on the functional role of astaxanthin in skin physiology, outlines potential mechanisms involved in the response to astaxanthin, and highlights the potential clinical implications associated with its consumption.
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In the citing paper
“Oral administration of astaxanthin is protective against UV-induced skin deterioration and is helpful to maintain healthy skin.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [96]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
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Citations
Cites
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
The extracellular matrix: A dynamic niche in cancer progression
Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201102147 · Cited by 3,024
Potential Role of Carotenoids as Antioxidants in Human Health and Disease
Fiedor, J., & Burda, K. (2014) · Nutrients · doi:10.3390/nu6020466 · Cited by 1,420
Astaxanthin: a review of its chemistry and applications
Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957188 · Cited by 1,287
Oxidation events and skin aging
Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980
Shah, M. M. R., Liang, Y., Cheng, J. J., & Daroch, M. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00531 · Cited by 940
Absorption, metabolism, and transport of carotenoids
Parker, R. S. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.5.8621054 · Cited by 747
Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae
Yuan, J., Peng, J., Yin, K., & Wang, J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000414 · Cited by 649
Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response
Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591
Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans
Park, J. S., Chyun, J. H., Kim, Y. K., Line, L. L., & Chew, B. P. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-18 · Cited by 569
Flagged first, then by citations
Research works printed but not linked: 4
- Seki, 2001, Effects of astaxanthin from Haematococcus pluvialis on human skin, Fragr. J., 12, 98
- Yamahita, 1995, Suppression of post-UVB hyperpigmentation by topical astaxanthin from krill, Fragr. J., 14, 180
- Yamahita, 2006, The Effect of a dietary supplement containing astaxanthin on skin condition, Carotenoid Sci., 10, 91
- Tominaga, 2009, Cosmetic effects of astaxanthin for all layers of skin, Food Style, 13, 25
Cited by
Sorted by citations
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Self-citationPlant-Derived Antioxidants: Significance in Skin Health and the Ageing Process
Michalak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020585 · Cited by 460
Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345
Programmed microalgae-gel promotes chronic wound healing in diabetes
Kang, Y., Xu, L., Dong, J., Xue, Y., Ye, J., Fan, Y., Liu, B., Xie, J., & Ji, X. (2024) · Nature Communications · doi:10.1038/s41467-024-45101-9 · Cited by 331
Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals
Williamson, E. M., Liu, X., & Izzo, A. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14943 · Cited by 323
Metadata
- Authors
- Davinelli, S., Nielsen, M. E., & Scapagnini, G.
- Affiliations
- University of Molise (IT)
- FB Dermatology, Borupvang 5C, 2750 Ballerup, Denmark
- Corresponding author
- Davinelli, Sergio
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-04-22
- Volume
- 10
- Issue
- 4
- Pages
- 522
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5946307
- OpenAlex
- W2802266362
- Cited by
- 473
- References
- 84
- Citations by year
- 2026: 38 · 2025: 63 · 2024: 57 · 2023: 66 · 2022: 66 · 2021: 96 · 2020: 56 · 2019: 26 · 2018: 5
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- astaxanthin, xanthophyll carotenoids, skin health, skin repair, Haematococcus pluvialis, microalgae cultivation, nutraceuticals, photoprotection, antioxidant activity, anti-inflammatory activity, skin homeostasis, dietary supplementation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Biological Availability, DNA Damage, DNA Repair, Humans, Skin, Skin Aging, Dietary Supplements, Xanthophylls
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