The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review
Open accessAbstract
Astaxanthin, a xanthophyll carotenoid, is a secondary metabolite naturally synthesized by a number of bacteria, microalgae, and yeasts. The commercial production of this pigment has traditionally been performed by chemical synthesis, but the microalga Haematococcus pluvialis appears to be the most promising source for its industrial biological production. Due to its collective diverse functions in skin biology, there is mounting evidence that astaxanthin possesses various health benefits and important nutraceutical applications in the field of dermatology. Although still debated, a range of potential mechanisms through which astaxanthin might exert its benefits on skin homeostasis have been proposed, including photoprotective, antioxidant, and anti-inflammatory effects. This review summarizes the available data on the functional role of astaxanthin in skin physiology, outlines potential mechanisms involved in the response to astaxanthin, and highlights the potential clinical implications associated with its consumption.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
Experimental — accuracy not yet measuredIn the citing paper
“Oral administration of astaxanthin is protective against UV-induced skin deterioration and is helpful to maintain healthy skin.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [96]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
In the citing paper
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [222]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
The extracellular matrix: A dynamic niche in cancer progression
Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201102147 · Cited by 3,024
Potential Role of Carotenoids as Antioxidants in Human Health and Disease
Fiedor, J., & Burda, K. (2014) · Nutrients · doi:10.3390/nu6020466 · Cited by 1,420
Astaxanthin: a review of its chemistry and applications
Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957188 · Cited by 1,287
Oxidation events and skin aging
Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980
Shah, M. M. R., Liang, Y., Cheng, J. J., & Daroch, M. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00531 · Cited by 940
Absorption, metabolism, and transport of carotenoids
Parker, R. S. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.5.8621054 · Cited by 747
Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae
Yuan, J., Peng, J., Yin, K., & Wang, J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000414 · Cited by 649
Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response
Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591
Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans
Park, J. S., Chyun, J. H., Kim, Y. K., Line, L. L., & Chew, B. P. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-18 · Cited by 569
Research works printed but not linked: 4
- Seki, 2001, Effects of astaxanthin from Haematococcus pluvialis on human skin, Fragr. J., 12, 98
- Yamahita, 1995, Suppression of post-UVB hyperpigmentation by topical astaxanthin from krill, Fragr. J., 14, 180
- Yamahita, 2006, The Effect of a dietary supplement containing astaxanthin on skin condition, Carotenoid Sci., 10, 91
- Tominaga, 2009, Cosmetic effects of astaxanthin for all layers of skin, Food Style, 13, 25
Cited by
Sorted by citations
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Self-citationPlant-Derived Antioxidants: Significance in Skin Health and the Ageing Process
Michalak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020585 · Cited by 460
Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345
Programmed microalgae-gel promotes chronic wound healing in diabetes
Kang, Y., Xu, L., Dong, J., Xue, Y., Ye, J., Fan, Y., Liu, B., Xie, J., & Ji, X. (2024) · Nature Communications · doi:10.1038/s41467-024-45101-9 · Cited by 331
Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals
Williamson, E. M., Liu, X., & Izzo, A. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14943 · Cited by 323
Chang, M. X., & Xiong, F. (2020) · Molecules · doi:10.3390/molecules25225342 · Cited by 281
Astaxanthin: A super antioxidant from microalgae and its therapeutic potential
Kumar, S., Kumar, R., Diksha, Kumari, A., & Panwar, A. (2021) · Journal of Basic Microbiology · doi:10.1002/jobm.202100391 · Cited by 250
“Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials”
Donoso, A., González-Durán, J., Agurto-Muñoz, A., González, P. A., & Agurto-Muñoz, C. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105479 · Cited by 252
Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases
Kohandel, Z., Farkhondeh, T., Aschner, M., Pourbagher‐Shahri, A. M., & Samarghandian, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112179 · Cited by 238
Meléndez‐Martínez, A. J., Stinco, C. M., & Mapelli‐Brahm, P. (2019) · Nutrients · doi:10.3390/nu11051093 · Cited by 246
Recent advancements in the genetic engineering of microalgae
Sproles, A. E., Fields, F. J., Smalley, T. N., Le, C. H., Badary, A., & Mayfield, S. P. (2021) · Algal Research · doi:10.1016/j.algal.2020.102158 · Cited by 228
Green Extraction Techniques of Bioactive Compounds: A State-of-the-Art Review
Martins, R., Barbosa, A., Advinha, B., Sales, H., Pontes, R., & Nunes, J. (2023) · Processes · doi:10.3390/pr11082255 · Cited by 239
Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
Sztretye, M. T., Dienes, B., Gönczi, M., Czirják, T., Csernoch, L. J., László, A., Szentesi, P., & Keller-Pintér, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3849692 · Cited by 224
Xanthophylls from the Sea: Algae as Source of Bioactive Carotenoids
Pereira, A. G., Otero, P., Echave, J., Carreira-Casais, A., Chamorro, F., Collazo, N., Jaboui, A., Lourenço‐Lopes, C., Simal‐Gándara, J., & Prieto, M. A. (2021) · Marine Drugs · doi:10.3390/md19040188 · Cited by 217
Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications
Rani, A., Saini, K. C., Bast, F., Mehariya, S., Bhatia, S. K., Lavecchia, R., & Zuorro, A. (2021) · Molecules · doi:10.3390/molecules26041142 · Cited by 195
Black, H. S., Boehm, F., Edge, R., & Truscott, T. G. (2020) · Antioxidants · doi:10.3390/antiox9030264 · Cited by 200
Microalgae with Immunomodulatory Activities
Riccio, G., & Lauritano, C. (2019) · Marine Drugs · doi:10.3390/md18010002 · Cited by 191
Astaxanthin: How much is too much? A safety review
Brendler, T., & Williamson, E. M. (2019) · Phytotherapy Research · doi:10.1002/ptr.6514 · Cited by 179
Structures of Astaxanthin and Their Consequences for Therapeutic Application
Brotosudarmo, T. H. P., Limantara, L., Setiyono, E., & Heriyanto (2020) · International Journal of Food Science · doi:10.1155/2020/2156582 · Cited by 167
Mechanisms of and Potential Medications for Oxidative Stress in Ovarian Granulosa Cells: A Review
Liu, S., Jia, Y., Meng, S., Luo, Y., Yang, Q., & Pan, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119205 · Cited by 169
Isolation of Industrial Important Bioactive Compounds from Microalgae
Balasubramaniam, V. R. M. T., Rathi, D.-N. G., Mustar, S., Lee, J. C., & Noh, M. F. M. (2021) · Molecules · doi:10.3390/molecules26040943 · Cited by 167
Sustainable food and feed sources from microalgae: Food security and the circular bioeconomy
Ahmad, A., & Ashraf, S. M. (2023) · Algal Research · doi:10.1016/j.algal.2023.103185 · Cited by 168
Microalgae Derived Astaxanthin: Research and Consumer Trends and Industrial Use as Food
Villaró, S., Ciardi, M., Morillas‐España, A., Sánchez‐Zurano, A., Acién, F. G., & Lafarga, T. (2021) · Foods · doi:10.3390/foods10102303 · Cited by 149
Ito, N., Seki, S., & Ueda, F. (2018) · Nutrients · doi:10.3390/nu10070817 · Cited by 141
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132
Jannel, S., Caro, Y., Bermudes, M., & Petit, T. (2020) · Journal of Marine Science and Engineering · doi:10.3390/jmse8100789 · Cited by 136
Metabolites with Antioxidant Activity from Marine Macroalgae
Tziveleka, L., Tammam, M. A., Tzakou, O. A., Roussis, V., & Ioannou, E. (2021) · Antioxidants · doi:10.3390/antiox10091431 · Cited by 132
Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights
Giannaccare, G., Pellegrini, M., Senni, C., Bernabei, F., Scorcia, V., & Cicero, A. F. G. (2020) · Marine Drugs · doi:10.3390/md18050239 · Cited by 125
Resource recovery from industrial effluents through the cultivation of microalgae: A review
., S. M. A., Peter, A. P., Chew, K. W., Munawaroh, H. S. H., & Show, P. L. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125461 · Cited by 127
Davinelli, S., Saso, L., D’Angeli, F., Calabrese, V., Intrieri, M., & Scapagnini, G. (2022) · Molecules · doi:10.3390/molecules27020502 · Cited by 125
Self-citationCarotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
Koklesová, L., Líšková, A., Samec, M., Buhrmann, C., Samuel, S. M., Varghese, E., Ashrafizadeh, M., Najafi, M., Shakibaei, M., Büsselberg, D., et al. (2020) · Cancers · doi:10.3390/cancers12092425 · Cited by 128
Šimat, V., Rathod, N. B., Čagalj, M., Hamed, I., & Mekinić, I. G. (2022) · Marine Drugs · doi:10.3390/md20030206 · Cited by 132
Luo, L., Huang, F., Zhong, S., Ding, R., Su, J., & Li, X. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121091 · Cited by 125
Lu, Q., Li, H., Zou, Y., Liu, H., & Yang, L. (2021) · Algal Research · doi:10.1016/j.algal.2020.102178 · Cited by 123
Oslan, S. N. H., Tan, J. S., Oslan, S. N., Matanjun, P., Mokhtar, R. A. M., Shapawi, R., & Huda, N. (2021) · Molecules · doi:10.3390/molecules26216470 · Cited by 121
Can Plant Phenolic Compounds Protect the Skin from Airborne Particulate Matter?
Boo, Y. C. (2019) · Antioxidants · doi:10.3390/antiox8090379 · Cited by 123
The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions
Bjørklund, G., Gasmi, A., Lenchyk, L. V., Shanaida, M., Zafar, S., Mujawdiya, P. K., Lysiuk, R., Antonyak, H., Noor, S., Akram, M., et al. (2022) · Molecules · doi:10.3390/molecules27217167 · Cited by 123
De novo synthesis of astaxanthin: From organisms to genes
Fang, N., Wang, C., Liu, X., Zhao, X., Liu, Y., Liu, X., Du, Y., Zhang, Z., & Zhang, H. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.08.016 · Cited by 118
Boosting the Photoaged Skin: The Potential Role of Dietary Components
Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116
Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
McCall, B. J., McPartland, C. K., Moore, R. A., Frank‐Kamenetskii, A., & Booth, B. W. (2018) · Antioxidants · doi:10.3390/antiox7100135 · Cited by 116
Li, Q., Zhao, Y., Ding, W., Han, B., Geng, S., Ning, D., Ma, T., & Yu, X. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.124418 · Cited by 107
Bacterial Carotenoids: Extraction, Characterization, and Applications
López, G.-D., Álvarez‐Rivera, G., Carazzone, C., Ibáñez, E., Leidy, C., & Cifuentes, A. (2021) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2021.2016366 · Cited by 112
Crustacean waste biorefinery as a sustainable cost-effective business model
Vicente, F. A., Ventura, S. P. M., Passos, H., Dias, A. C., Torres‐Acosta, M. A., Novak, U., & Likozar, B. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135937 · Cited by 111
Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin
Patil, A. D., Kasabe, P. J., & Dandge, P. B. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00347-y · Cited by 110
(Bio)Technological Aspects of Microalgae Pigments for Cosmetics
Morocho-Jácome, A. L., Ruscinc, N., Martinez, R. M., de Carvalho, J. C. M., Santos de Almeida, T., Rosado, C., Costa, J. G., Velasco, M. V. R., & Baby, A. R. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10936-x · Cited by 104
Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?
Balić, A., & Mokos, M. (2019) · Antioxidants · doi:10.3390/antiox8080259 · Cited by 104
Pamela, V. M., Sánchez, M. L., & Benavides, J. (2021) · International Wound Journal · doi:10.1111/iwj.13602 · Cited by 101
Gulzar, S., Raju, N., Nagarajarao, R. C., & Benjakul, S. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.04.005 · Cited by 102
Liyanaarachchi, V. C., Nishshanka, G. K. S. H., Premaratne, R. G. M. M., Ariyadasa, T. U., Nimarshana, P. H. V., & Malik, A. (2020) · Biotechnology Reports · doi:10.1016/j.btre.2020.e00538 · Cited by 99
A Critical Review on the Microencapsulation of Bioactive Compounds and Their Application
Huang, K., Yuan, Y., & Xu, B. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1963978 · Cited by 99
Kaur, M., Bhatia, S., Gupta, U., Decker, E., Tak, Y., Bali, M., Gupta, V. K., Dar, R. A., & Bala, S. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-022-09848-7 · Cited by 95
Nrf2 a molecular therapeutic target for Astaxanthin
Kohandel, Z., Farkhondeh, T., Aschner, M., & Samarghandian, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111374 · Cited by 97
Synthetic biology for future food: Research progress and future directions
Lv, X., Wu, Y., Gong, M., Deng, J., Gu, Y. M., Liu, Y., Li, J., Du, G., Ledesma‐Amaro, R., Liu, L., et al. (2021) · Future Foods · doi:10.1016/j.fufo.2021.100025 · Cited by 95
Antioxidants to Defend Healthy and Youthful Skin—Current Trends and Future Directions in Cosmetology
Budzianowska, A., Banaś, K., Budzianowski, J., & Kikowska, M. A. (2025) · Applied Sciences · doi:10.3390/app15052571 · Cited by 104
Natural antioxidants in diabetes treatment and management: prospects of astaxanthin
Kanwugu, O. N., Glukhareva, T. V., Danilova, I. G., & Kovaleva, E. G. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1881434 · Cited by 93
Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent
Bahbah, E. I., Ghozy, S. A., Attia, M. S., Negida, A., Emran, T. B., Mitra, S., Albadrani, G. M., Abdel‐Daim, M. M., Uddin, M. S., & Simal‐Gándara, J. (2021) · Marine Drugs · doi:10.3390/md19040201 · Cited by 89
Algal Carotenoids: Chemistry, Sources, and Application
Mekinić, I. G., Šimat, V., Rathod, N. B., Hamed, I., & Čagalj, M. (2023) · Foods · doi:10.3390/foods12142768 · Cited by 90
Mussagy, C. U., Khan, S., & Kot, A. M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1908222 · Cited by 88
Haematococcus pluvialis: A Potential Feedstock for Multiple-Product Biorefining
Nishshanka, G. K. S. H., Liyanaarachchi, V. C., Nimarshana, P. H. V., Ariyadasa, T. U., & Chang, J.-S. (2022) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2022.131103 · Cited by 85
Reprogramming microorganisms for the biosynthesis of astaxanthin via metabolic engineering
Wan, X., Zhou, X., Moncalián, G., Su, L. C., Chen, W., Zhu, H.-Z., Chen, D., Gong, Y., Huang, F., & Deng, Q. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101083 · Cited by 88
Jafari, Z., Bigham, A., Sadeghi, S., Dehdashti, S. M., Rabiee, N., Abedivash, A., Bagherzadeh, M., Nasseri, B., Karimi‐Maleh, H., Sharifi, E., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01144 · Cited by 88
Hwang, S., Choi, H. I., & Sim, S. J. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.01.080 · Cited by 84
Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing
Zhou, X., Cao, Q., Orfila, C., Zhao, J. J., & Zhang, L. (2021) · Nutrients · doi:10.3390/nu13092917 · Cited by 89
Singh, K. N., Patil, S., & Barkate, H. V. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13019 · Cited by 82
Zhang, Z., Ma, Z., Song, L., & Farag, M. A. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.11.002 · Cited by 83
Carotenoids and Cognitive Outcomes: A Meta-Analysis of Randomized Intervention Trials
Davinelli, S., Alì, S., Solfrizzi, V., Scapagnini, G., & Corbi, G. (2021) · Antioxidants · doi:10.3390/antiox10020223 · Cited by 84
Self-citationApplication of microalgae and microalgal bioactive compounds in skin regeneration
Miguel, S. P., Ribeiro, M. P., Otero, A., & Coutinho, P. (2021) · Algal Research · doi:10.1016/j.algal.2021.102395 · Cited by 85
Astaxanthin from Haematococcus pluvialis : processes, applications, and market
Mota, G. C. P., de Moraes, L. B. S., Oliveira, C. Y. B., Oliveira, D. W. S., de Abreu, J. L., Dantas, D. M. M., & Gálvez, A. O. (2021) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2021.1966802 · Cited by 82
Khmaladze, I., Leonardi, M., Fabre, S., Messaraa, C., & Mavon, A. (2020) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s239367 · Cited by 78
Skin Protection by Carotenoid Pigments
Flieger, J., Raszewska-Famielec, M., Radzikowska-Büchner, E., & Flieger, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031431 · Cited by 81
Tang, Q., Li, Z., Chen, N., Luo, X., & Zhao, Q. L. (2024) · Plant Biotechnology Journal · doi:10.1111/pbi.14522 · Cited by 76
Dutta, S., Kumar, S., & Banerjee, R. (2023) · Algal Research · doi:10.1016/j.algal.2023.103168 · Cited by 77
Pagels, F., Salvaterra, D., Amaro, H. M., & Guedes, A. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818536-0.00018-x · Cited by 80
Oxidative stress in vascular calcification
Hu, C.-T., Shao, Y.-D., Liu, Y., Xiao, X., Cheng, Z.-B., Qu, S.-L., Huang, L., & Zhang, C. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.04.012 · Cited by 75
Honda, M., Murakami, K., Osawa, Y., Kawashima, Y., Hirasawa, K., & Kuroda, I. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c00087 · Cited by 74
Anti-Inflammatory Activity of Mulberry Leaf Flavonoids In Vitro and In Vivo
Lin, Z., Gan, T., Huang, Y., Bao, L., Liu, S., Cui, X., Wang, H., Jiao, F., Zhang, M., Su, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147694 · Cited by 72
Toxicological effects of marine seaweeds: a cautious insight for human consumption
Kumar, M. S., & Sharma, S. A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1738334 · Cited by 70
Astaxanthin Delivery Systems for Skin Application: A Review
Lima, S. G. M., Freire, M. C. L. C., Oliveira, V. D. S., Solisio, C., Converti, A., & de Lima, Á. A. N. (2021) · Marine Drugs · doi:10.3390/md19090511 · Cited by 73
Maghsoudi, S., Shahraki, B. T., Rabiee, N., Fatahi, Y., Bagherzadeh, M., Dinarvand, R., Ahmadi, S., Rabiee, M., Tahriri, M., Hamblin, M. R., et al. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867958 · Cited by 68
Dai, S., Wang, B., Song, Y., Xie, Z., Li, C., Li, S., Huang, Y., & Jiang, M. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147496 · Cited by 71
Genetically engineered microalgae for enhanced bioactive compounds
Ahmad Kamal, A. H., Mohd Hamidi, N. F., Zakaria, M. F., Ahmad, A., Harun, M. R., Chandra Segaran, T., & Jusoh, M. (2024) · Discover Applied Sciences · doi:10.1007/s42452-024-06116-5 · Cited by 66
Ovalbumin fibril-stabilized oleogel-based Pickering emulsions improve astaxanthin bioaccessibility
Wang, Z., Gao, Y., Wei, Z., & Xue, C. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111790 · Cited by 65
Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging
Sorrenti, V., Davinelli, S., Scapagnini, G., Willcox, B. J., Allsopp, R., & Willcox, D. C. (2020) · Marine Drugs · doi:10.3390/md18070351 · Cited by 65
Self-citationCasella, P., Iovine, A., Mehariya, S., Marino, T., Musmarra, D., & Molino, A. (2020) · Antioxidants · doi:10.3390/antiox9050422 · Cited by 66
Li, X., Matsumoto, T., Takuwa, M., Ali, M. S. E. S., Hirabashi, T., Kondo, H., & Fujino, H. (2020) · Biomedicines · doi:10.3390/biomedicines8020018 · Cited by 62
RetractedHu, F., Liu, W., Yan, L., Kong, F., & Wei, K. (2019) · Royal Society Open Science · doi:10.1098/rsos.191184 · Cited by 61
Nan, B., Zhao, Z., Jiang, K., Gu, X., Li, H., & Huang, X. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.07.002 · Cited by 60
Microalgal lipids: biochemistry and biotechnology
Manning, S. R. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.10.018 · Cited by 60
Mixotrophic cultivation of microalgae for carotenoid production
Liaqat, F., Khazi, M. I., Bahadar, A., He, L., Aslam, A., Liaquat, R., Agathos, S. N., & Li, J. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12700 · Cited by 64
Occhipinti, P. S., Russo, N., Foti, P., Zingale, I. M., Pino, A., Romeo, F. V., Randazzo, C. L., & Caggia, C. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13136 · Cited by 58
Yin, Z., Wang, M., & Zeng, M. (2022) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2022.108048 · Cited by 58
Nanocarrier System: State-of-the-Art in Oral Delivery of Astaxanthin
Wahab, N. R. A., Affandi, M. M. R. M. M., Fakurazi, S., Alias, E., & Hassan, H. (2022) · Antioxidants · doi:10.3390/antiox11091676 · Cited by 58
Effects of astaxanthin supplementation on skin health: A systematic review of clinical studies
Ng, Q. X., De Deyn, M. L. Z. Q., Loke, W., Foo, N. X., Chan, H. W., & Yeo, W. S. (2021) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1739187 · Cited by 57
Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why
Januszewski, J., Forma, A., Zembala, J., Flieger, M., Tyczyńska, M., Dring, J. C., Dudek, I., Świątek, K., & Baj, J. (2023) · Medicina · doi:10.3390/medicina60010068 · Cited by 59
Novel Self-Nano-Emulsifying Drug Delivery Systems Containing Astaxanthin for Topical Skin Delivery
Ponto, T., Latter, G., Luna, G., Leite‐Silva, V. R., Wright, A., & Benson, H. A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050649 · Cited by 60
Beneficial effects of seaweed-derived components on metabolic syndrome via gut microbiota modulation
Zang, L., Baharlooeian, M., Terasawa, M., Shimada, Y., & Nishimura, N. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1173225 · Cited by 55
Zeolitic imidazolate framework-8: a versatile nanoplatform for tissue regeneration
Li, Z., Shao, Y., Yang, Y., & Zan, J. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1386534 · Cited by 55
Wang, L., Hu, J., Lv, W., Lu, W., Pei, D., Lv, Y., Wang, W., Zhang, M., Ding, R., & Lv, M. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.130369 · Cited by 54
Nishshanka, G. K. S. H., Liyanaarachchi, V. C., Premaratne, M., Nimarshana, P. H. V., Ariyadasa, T. U., & Kornaros, M. E. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126018 · Cited by 55
Chae, S. Y., Park, R., & Hong, S. W. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00276-4 · Cited by 53
Metadata
- Authors
- Davinelli, S., Nielsen, M. E., & Scapagnini, G.
- Affiliations
- University of Molise (IT)
- FB Dermatology, Borupvang 5C, 2750 Ballerup, Denmark
- Corresponding author
- Davinelli, Sergio
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-04-22
- Volume
- 10
- Issue
- 4
- Pages
- 522
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5946307
- OpenAlex
- W2802266362
- Cited by
- 473
- References
- 84
- Citations by year
- 2026: 38 · 2025: 63 · 2024: 57 · 2023: 66 · 2022: 66 · 2021: 96 · 2020: 56 · 2019: 26 · 2018: 5
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- astaxanthin, xanthophyll carotenoids, skin health, skin repair, Haematococcus pluvialis, microalgae cultivation, nutraceuticals, photoprotection, antioxidant activity, anti-inflammatory activity, skin homeostasis, dietary supplementation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Biological Availability, DNA Damage, DNA Repair, Humans, Skin, Skin Aging, Dietary Supplements, Xanthophylls
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
