Prevention and treatment of sarcopenic obesity in women
Open accessAbstract
Sarcopenic obesity (SO) is referred to as the combination of obesity with low skeletal muscle mass and function. However, its definition and diagnosis is debated. SO represents a sizable risk factor for the development of disability, possibly with a worse prognosis in women. The present narrative review summarizes the current evidence on pharmacological, nutrition and exercise strategies on the prevention and/or treatment of SO in middle-aged and older-aged women. A literature search was carried out in Medline and Google Scholar between 29th January and 14th March 2019. Only controlled intervention studies on mid-age and older women whose focus was on the prevention and/or treatment of sarcopenia associated with obesity were included. Resistance training (RT) appears effective in the prevention of all components of SO in women, resulting in significant improvements in muscular mass, strength, and functional capacity plus loss of fat mass, especially when coupled with hypocaloric diets containing at least 0.8 g/kg body weight protein. Correction of vitamin D deficit has a favorable effect on muscle mass. Treatment of SO already established is yet unsatisfactory, although intense and prolonged RT, diets with higher (1.2 g/kg body weight) protein content, and soy isoflavones all look promising. However, further confirmatory research and trials combining different approaches are required.
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Major RCTs in non-sarcopenic women with obesity suggest that caloric restriction with a 500 kcal deficit and at least 0.8 g/kg protein intake can effectively lose fat and improve physical function.
“Major RCTs in non-sarcopenic women with obesity have suggested that caloric restriction (500 kcal deficit) with at least 0.8 g/kg of protein intake can effectively lose fat and improve physical function (146, 147).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [147]
Sarcopenic obesity is managed with lifestyle interventions, exercise, nutrition, and medical therapies.
“Sarcopenic obesity is treated with a range of management approaches, such as lifestyle interventions, exercise, nutrition and medical therapies.”
From Sarcopenic obesity in older adults: a clinical overview (2024) · cites this paper as [125]
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Role of nutrition in the therapy of obesity
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- Authors
- Petroni, M. L., Caletti, M. T., Dalle Grave, R., Bazzocchi, A., Aparisi Gómez, M. P., & Marchesini, G.
- Affiliations
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Department of Eating and Weight Disorders, Villa Garda Hospital, via Monte Baldo 89, 37016 Garda (VR), Italy
- Istituto Ortopedico Rizzoli (IT)
- Department of Radiology, Auckland City Hospital, Park Road, Grafton, 1023 Auckland, New Zealand
- Corresponding author
- Petroni, Maria L.
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-06-08
- Volume
- 11
- Issue
- 6
- Pages
- 1302
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6627872
- OpenAlex
- W2948270850
- Cited by
- 82
- References
- 75
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 10 · 2023: 18 · 2022: 18 · 2021: 13 · 2020: 9 · 2019: 1 · 2018: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sarcopenic obesity, sarcopenia, obesity, women, middle-aged and older women, resistance training, hypocaloric diet, protein intake, vitamin D deficiency, soy isoflavones, muscle mass, muscle strength, functional capacity, fat loss, disability risk
- MeSH terms
- Physical Functional Performance, Adipose Tissue, Aging, Diet, Dietary Proteins, Female, Humans, Isoflavones, Obesity, Glycine max, Vitamin D Deficiency, Muscle, Skeletal, Muscle Strength, Resistance Training, Sarcopenia
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