Lean mass loss is associated with low protein intake during dietary-induced weight loss in postmenopausal women
Open accessAbstract
The health and quality-of-life implications of overweight and obesity span all ages in the United States. We investigated the association between dietary protein intake and loss of lean mass during weight loss in postmenopausal women through a retrospective analysis of a 20-week randomized, controlled diet and exercise intervention in women aged 50 to 70 years. Weight loss was achieved by differing levels of caloric restriction and exercise. The diet-only group reduced caloric intake by 2,800 kcal/week, and the exercise groups reduced caloric intake by 2,400 kcal/week and expended approximately 400 kcal/week through aerobic exercise. Total and appendicular lean mass was measured using dual energy x-ray absorptiometry. Linear regression analysis was used to examine the association between changes in lean mass and appendicular lean mass and dietary protein intake. Average weight loss was 10.8+/-4.0 kg, with an average of 32% of total weight lost as lean mass. Protein intake averaged 0.62 g/kg body weight/day (range=0.47 to 0.8 g/kg body weight/day). Participants who consumed higher amounts of dietary protein lost less lean mass and appendicular lean mass (r=0.3, P=0.01 and r=0.41, P<0.001, respectively). These associations remained significant after adjusting for intervention group and body size. Therefore, inadequate protein intake during caloric restriction may be associated with adverse body-composition changes in postmenopausal women.
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Weight loss (~10%) induced by energy restriction resulted in slightly higher lean mass loss than the CCI (8.4% appendicular lean mass and 7.6% total lean mass loss at 20 weeks).
“Weight loss (~10%) induced by energy restriction resulted in slightly higher lean mass loss than the CCI (8.4% appendicular lean mass and 7.6% total lean mass loss at 20 weeks) (88).”
From Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial (2019) · cites this paper as [88]
The Results and Discussion section (page unavailable) reports a 20-week intervention with 12.2% average weight loss and loss of lean mass, broadly supporting the weight-loss finding. Our copy does not report 8.4% appendicular or 7.6% total lean-mass loss, and it does not compare the intervention with CCI. (LLM, conf=0.86)
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Cites
(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,452 · see citing works
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720 · see citing works
Trumbo, P., Schlicker, S., Yates, A. A., & Poos, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90346-9 · Cited by 5,993 · see citing works
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004 · see citing works
(1998) · PubMed · Cited by 2,737 · see citing works
Ross, R., Dagnone, D., Jones, P. J. H., Smith, H., Paddags, A., Hudson, R., & Janssen, I. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-2-200007180-00008 · Cited by 1,435 · see citing works
Layman, D. K., Boileau, R. A., Erickson, D. J., Painter, J. E., Shiue, H., Sather, C., & Christou, D. D. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.2.411 · Cited by 541 · see citing works
Krieger, J. W., Sitren, H. S., Daniels, M. J., & Langkamp-Henken, B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.260 · Cited by 466 · see citing works
Campbell, W. W., Trappe, T. A., Wolfe, R. R., & Evans, W. J. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.6.m373 · Cited by 397 · see citing works
Layman, D. K., Evans, E., Baum, J. I., Seyler, J., Erickson, D. J., & Boileau, R. A. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.8.1903 · Cited by 330 · see citing works
Janssen, I., Fortier, A., Hudson, R., & Ross, R. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.431 · Cited by 326 · see citing works
Castaneda, C., Charnley, J., Evans, W., & Crim, M. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.1.30 · Cited by 290 · see citing works
Higher Protein Intake Preserves Lean Mass and Satiety with Weight Loss in Pre‐obese and Obese Women
Leidy, H. J., Carnell, N. S., Mattes, R. D., & Campbell, W. W. (2007) · Obesity · doi:10.1038/oby.2007.531 · Cited by 277 · see citing works
Young, V. R. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-709-3_5 · Cited by 266 · see citing works
Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., Klein, S., Ehsani, A. A., Holloszy, J. O., & Washington University School of Medicine CALERIE Group (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00853.2006 · Cited by 218 · see citing works
Total-body potassium in health: effects of age, sex, height, and fat
Pierson, R., Lin, D., & Phillips, R. H. (1974) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1974.226.1.206 · Cited by 171 · see citing works
Linking age-related changes in skeletal muscle mass and composition with metabolism and disease.
Janssen, I., & Ross, R. (2006) · PubMed · Cited by 169 · see citing works
Harris, T. B., Launer, L. J., Madans, J. H., & Feldman, J. J. (1997) · BMJ · doi:10.1136/bmj.314.7097.1791 · Cited by 144 · see citing works
Overweight and obesity and the burden of disease and disability in elderly men
Wannamethee, S. G., Shaper, A. G., Whincup, P. H., & Walker, M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802775 · Cited by 93 · see citing works
Addition of aerobic exercise to dietary weight loss preferentially reduces abdominal adipocyte size
You, T., Murphy, K. M., Lyles, M. F., Demons, J. L., Lenchik, L., & Nicklas, B. J. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803245 · Cited by 74 · see citing works
Self-citationEffects of dietary protein on the composition of weight loss in post-menopaus al women
Gordons, M. M., Bopp, M. J., Easter, L., Miller, G. D., Lyles, M. F., Houston, D. K., Nicklas, B. J., & Kritchevsky, S. B. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02983202 · Cited by 50 · see citing works
Self-citationUse of the Health and Activities Limitation Index as a Measure of Quality of Life in Obesity
Livingston, E. H., & Ko, C. Y. (2002) · Obesity Research · doi:10.1038/oby.2002.111 · Cited by 46 · see citing works
Sahyoun, N. R., Hochberg, M. C., Helmick, C. G., Harris, T. B., & Pamuk, E. R. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.3.391 · Cited by 40 · see citing works
Gallagher, S. (2003) · CRC Press eBooks · doi:10.1201/9780203491775.ch10 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [4]Gallagher S Bariatrics: Considering Mobility, Patient Safety and Caregiver Injury 2004 CRC Press New York
Cited by
Sorted by citations
Preserving Healthy Muscle during Weight Loss
Cava, E., Yeat, N. C., & Mittendorfer, B. (2017) · Advances in Nutrition · doi:10.3945/an.116.014506 · Cited by 452 · see citing works
Weinheimer, E. M., Sands, L. P., & Campbell, W. W. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00298.x · Cited by 391 · see citing works
Chow, L. S., Manoogian, E. N. C., Alvear, A., Fleischer, J. G., Thor, H., Dietsche, K., Wang, Q., Hodges, J. S., Esch, N., Malaeb, S., et al. (2020) · Obesity · doi:10.1002/oby.22756 · Cited by 359 · see citing works
Athinarayanan, S. J., Adams, R. N., Hallberg, S. J., McKenzie, A. L., Bhanpuri, N. H., Campbell, W. W., Volek, J. S., Phinney, S. D., & McCarter, J. P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00348 · Cited by 324 · see citing works
Weight loss strategies and the risk of skeletal muscle mass loss
McCarthy, D., & Berg, A. (2021) · Nutrients · doi:10.3390/nu13072473 · Cited by 163 · see citing works
Eglseer, D., Traxler, M., Embacher, S., Reiter, L., Schoufour, J. D., Weijs, P. J. M., Voortman, T., Boirie, Y., Cruz-Jentoft, A., & Bauer, S. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.001 · Cited by 102 · see citing works
“[45] 2008 United States 70 Female 3 20 wk DXA 1.”
BackgroundPeng, L., Lee, W., Liu, L., Lin, M., & Chen, L. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12302 · Cited by 93 · see citing works
Jabekk, P. T., Moe, I. A., Meen, H. D., Tomten, S. E., & Høstmark, A. T. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-17 · Cited by 85 · see citing works
Prevention and treatment of sarcopenic obesity in women
Petroni, M. L., Caletti, M. T., Dalle Grave, R., Bazzocchi, A., Aparisi Gómez, M. P., & Marchesini, G. (2019) · Nutrients · doi:10.3390/nu11061302 · Cited by 82 · see citing works
Johnson, B., Milstead, M., Thomas, O., McGlasson, T., Green, L., Kreider, R., & Jones, R. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1566498 · Cited by 64 · see citing works
Dudgeon, W. D., Kelley, E. P., & Scheett, T. P. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0112-9 · Cited by 57 · see citing works
Yoshimura, E., Kumahara, H., Tobina, T., Matsuda, T., Watabe, K., Matono, S., Ayabe, M., Kiyonaga, A., Anzai, K., Higaki, Y., et al. (2014) · Obesity Facts · doi:10.1159/000358576 · Cited by 48 · see citing works
- Authors
- Bopp, M. J., Houston, D. K., Lenchik, L., Easter, L., Kritchevsky, S. B., & Nicklas, B. J.
- Affiliations
- Wake Forest University Health Sciences (US)
- Corresponding author
- Nicklas, Barbara J.
- Venue
- Journal of the American Dietetic Association
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 108
- Issue
- 7
- Pages
- 1216-1220
- ISSN
- 0002-8223 (ISSN-L)
- PMC
- PMC3665330
- OpenAlex
- W2048874676
- Cited by
- 93
- References
- 24
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 1
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of the American Dietetic Association (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01-AG/DK20583, R01AG020583, P30AG-21332, P30AG028740, P30AG021332)
- National Center for Research Resources (M01RR-07122, M01RR007122)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- lean mass loss, protein intake, postmenopausal women, weight loss, caloric restriction, appendicular lean mass, body composition, aerobic exercise, obesity
- MeSH terms
- Adipose Tissue, Aged, Body Composition, Combined Modality Therapy, Diet, Reducing, Dietary Proteins, Dose-Response Relationship, Drug, Female, Humans, Middle Aged, Obesity, Retrospective Studies, Weight Loss, Exercise, Absorptiometry, Photon, Body Mass Index, Randomized Controlled Trials as Topic, Postmenopause, Muscle, Skeletal
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