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Cited by 79

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Meta-Analysis Examining the Importance of Creatine Ingestion Strategies on Lean Tissue Mass and Strength in Older Adults

Forbes, Scott C., Candow, Darren G., Ostojic, Sergej M., Roberts, Michael D., Chilibeck, Philip D.·2021·Nutrients
DOI 10.3390/nu13061912
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Abstract

Creatine supplementation in conjunction with resistance training (RT) augments gains in lean tissue mass and strength in aging adults; however, there is a large amount of heterogeneity between individual studies that may be related to creatine ingestion strategies. Therefore, the purpose of this review was to (1) perform updated meta-analyses comparing creatine vs. placebo (independent of dosage and frequency of ingestion) during a resistance training program on measures of lean tissue mass and strength, (2) perform meta-analyses examining the effects of different creatine dosing strategies (lower: ≤5 g/day and higher: >5 g/day), with and without a creatine-loading phase (≥20 g/day for 5–7 days), and (3) perform meta-analyses determining whether creatine supplementation only on resistance training days influences measures of lean tissue mass and strength. Overall, creatine (independent of dosing strategy) augments lean tissue mass and strength increase from RT vs. placebo. Subanalyses showed that creatine-loading followed by lower-dose creatine (≤5 g/day) increased chest press strength vs. placebo. Higher-dose creatine (>5 g/day), with and without a creatine-loading phase, produced significant gains in leg press strength vs. placebo. However, when studies involving a creatine-loading phase were excluded from the analyses, creatine had no greater effect on chest press or leg press strength vs. placebo. Finally, creatine supplementation only on resistance training days significantly increased measures of lean tissue mass and strength vs. placebo.

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Citations

Cites

Research works printed but not linked: 29

  1. Shafiee, 2017, Prevalence of sarcopenia in the world: A systematic review and meta- analysis of general population studies, J. Diabetes Metab. Disord., 16, 21, 10.1186/s40200-017-0302-x · DOI · Paper page
  2. Candow, D.G., Forbes, S.C., Kirk, B., and Duque, G. (2021). Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults. Nutrients, 13. · DOI · Paper page
  3. Mitchell, 2012, Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review, Front. Physiol., 3, 260, 10.3389/fphys.2012.00260 · DOI · Paper page
  4. Tournadre, 2019, Sarcopenia, Jt. Bone Spine, 86, 309, 10.1016/j.jbspin.2018.08.001 · DOI · Paper page
  5. Kirk, 2021, Nutrients to mitigate osteosarcopenia: The role of protein, vitamin D and calcium, Curr. Opin. Clin. Nutr. Metab. Care, 24, 25, 10.1097/MCO.0000000000000711 · DOI
  6. Candow, 2014, Creatine supplementation and aging musculoskeletal health, Endocrine, 45, 354, 10.1007/s12020-013-0070-4 · DOI · Paper page
  7. Aguiar, 2013, Long-term creatine supplementation improves muscular performance during resistance training in older women, Eur. J. Appl. Physiol., 113, 987, 10.1007/s00421-012-2514-6 · DOI · Paper page
  8. Bemben, 2010, The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men, J. Nutr. Health Aging, 14, 155, 10.1007/s12603-009-0124-8 · DOI · Paper page
  9. Bermon, 1998, Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults, Acta Physiol. Scand., 164, 147, 10.1046/j.1365-201X.1998.00427.x · DOI · Paper page
  10. Deacon, 2008, Randomized controlled trial of dietary creatine as an adjunct therapy to physical training in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 178, 233, 10.1164/rccm.200710-1508OC · DOI
  11. Eijnde, 2003, Effects of creatine supplementation and exercise training on fitness in men 55–75 yr old, J. Appl. Physiol., 95, 818, 10.1152/japplphysiol.00891.2002 · DOI · Paper page
  12. Gualano, 2014, Creatine supplementation and resistance training in vulnerable older women: A randomized double-blind placebo-controlled clinical trial, Exp. Gerontol., 53, 7, 10.1016/j.exger.2014.02.003 · DOI · Paper page
  13. Hass, 2007, Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: A randomized trial, Neurorehabil. Neural Repair, 21, 107, 10.1177/1545968306293449 · DOI
  14. Pinto, 2016, Impact of creatine supplementation in combination with resistance training on lean mass in the elderly, J. Cachexia Sarcopenia Muscle, 7, 413, 10.1002/jcsm.12094 · DOI · Paper page
  15. Bernat, 2019, Effects of high-velocity resistance training and creatine supplementation in untrained healthy aging males, Appl. Physiol. Nutr. Metab., 44, 1246, 10.1139/apnm-2019-0066 · DOI
  16. Candow, 2015, Strategic creatine supplementation and resistance training in healthy older adults, Appl. Physiol. Nutr. Metab., 40, 689, 10.1139/apnm-2014-0498 · DOI · Paper page
  17. Candow, D.G., Chilibeck, P.D., Gordon, J., Vogt, E., Landeryou, T., Kaviani, M., and Paus-Jensen, L. (2020). Effect of 12 months of creatine supplementation and whole-body resistance training on measures of bone, muscle and strength in older males. Nutr. Health. · DOI · Paper page
  18. Chilibeck, 2015, Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women, Med. Sci. Sports Exerc., 47, 1587, 10.1249/MSS.0000000000000571 · DOI · Paper page
  19. Dalbo, 2008, Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration, Br. J. Sports Med., 42, 567
  20. Ju, 2005, Creatine feeding increases GLUT4 expression in rat skeletal muscle, Am. J. Physiol. Endocrinol. Metab., 288, 347, 10.1152/ajpendo.00238.2004 · DOI
  21. Burke, 2008, Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults, Int. J. Sport Nutr. Exerc. Metab., 18, 389, 10.1123/ijsnem.18.4.389 · DOI
  22. Rahimi, 2011, Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise, J. Strength Cond. Res., 25, 3448, 10.1519/JSC.0b013e3182162f2b · DOI · Paper page
  23. Deminice, 2013, Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans, Nutrition, 29, 1127, 10.1016/j.nut.2013.03.003 · DOI · Paper page
  24. Syrotuik, 2004, Acute creatine monohydrate supplementation: A descriptive physiological profile of responders vs. nonresponders, J. Strength Cond. Res., 18, 610
  25. Candow, 2005, Differences in size, strength, and power of upper and lower body muscle groups in young and older men, J. Gerontol. A Biol. Sci. Med. Sci., 60, 148, 10.1093/gerona/60.2.148 · DOI · Paper page
  26. Robinson, 1999, Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle, J. Appl. Physiol., 87, 598, 10.1152/jappl.1999.87.2.598 · DOI · Paper page
  27. Forbes, 2018, Timing of creatine supplementation and resistance training: A brief review, J. Exerc. Nutr., 1, 1
  28. Ostojic, S.M., Korovljev, D., and Stajer, V. (2021). Dietary creatine and cognitive function in U.S. adults aged 60 years and over. Aging Clin. Exp. Res. · DOI · Paper page
  29. Forbes, S.C., Candow, D.G., Ferreira, L.H.B., and Souza-Junior, T.P. (2021). Effects of Creatine Supplementation on Properties of Muscle, Bone, and Brain Function in Older Adults: A Narrative Review. J. Diet. Suppl., 1–18.

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Metadata

Authors
Forbes, S. C., Candow, D. G., Ostojic, S. M., Roberts, M. D., & Chilibeck, P. D.
Affiliations
  • Department of Physical Education Studies, Faculty of Education, Brandon University, Brandon, MB R7A6A9, Canada
  • Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4SOA2, Canada
  • Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Lovcenska 16, 21000 Novi Sad, Serbia
  • School of Kinesiology, Auburn University, Auburn, AL 36849, USA
  • College of Kinesiology, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2021-06-02
Volume
13
Issue
6
Pages
1912
ISSN
2072-6643
DOI
10.3390/nu13061912
Cited by
79
References
27
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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