Cited by 56Child Nutrition and Feeding IssuesNutritional Studies and DietNutrition, Health and Food Behavior

Dietary Patterns, Eating Behavior, and Nutrient Intakes of Spanish Preschool Children with Autism Spectrum Disorders

Open access
Plaza-Diaz, Julio, Flores-Rojas, Katherine, Torre-Aguilar, María José de la, Gomez-Fernández, Antonio Rafael, Martín-Borreguero, Pilar, Perez-Navero, Juan Luis, Gil, Angel, Gil-Campos, Mercedes·2021·Nutrients

Abstract

Eating behavior problems are characteristic of children with autism spectrum disorders (ASD) with a highly restricted range of food choices, which may pose an associated risk of nutritional problems. Hence, detailed knowledge of the dietary patterns (DPs) and nutrient intakes of ASD patients is necessary to carry out intervention strategies if required. The present study aimed to determine the DPs and macro-and micronutrient intakes in a sample of Spanish preschool children with ASD compared to typically developing control children. Fifty-four children with ASD (two to six years of age) diagnosed with ASD according to the Diagnostic Manual-5 criteria), and a control group of 57 typically developing children of similar ages were recruited. A validated food frequency questionnaire was used, and the intake of energy and nutrients was estimated through three non-consecutive 24-h dietary registrations. DPs were assessed using principal component analysis and hierarchical clustering analysis. Children with ASD exhibited a DP characterized by high energy and fat intakes and a low intake of vegetables and fruits. Likewise, meat intake of any type, both lean and fatty, was associated with higher consumption of fish and dietary fat. Furthermore, the increased consumption of dairy products was associated with increased consumption of cereals and pasta. In addition, they had frequent consumption of manufactured products with poor nutritional quality, e.g., beverages, sweets, snacks and bakery products. The percentages of children with ASD complying with the adequacy of nutrient intakes were higher for energy, saturated fat, calcium, and vitamin C, and lower for iron, iodine, and vitamins of group B when compared with control children. In conclusion, this study emphasizes the need to assess the DPs and nutrient intakes of children with ASD to correct their alterations and discard some potential nutritional diseases.

AI snapshot

Written from the paper’s full text.

TL;DR

This case-control study found that Spanish preschool children with ASD had distinct dietary patterns marked by higher cereals/pasta and dairy intake, lower lean meat/eggs, and poor fruit/vegetable and fish intake compared with typically developing controls. Nutrient adequacy differed by group, with ASD children more often meeting recommendations for energy, saturated fat, calcium, and vitamin C but less often for iron, iodine, and B-group vitamins.

Key findings

  • Among 54 children with ASD (2–6 years) and 57 controls, ASD children consumed more cereals and pasta and milk/dairy products, and fewer lean meats, eggs, and beverages; both groups consumed excess fatty meats and >85% consumed more beverages, snacks, sweets, bakery, and pastry than recommended.
  • ASD dietary patterns featured high energy and fat intake, low vegetables and fruits, and associations between increased dairy and cereals/pasta, and between meat intake and higher fish and dietary fat.
  • Eating behavior differed: 42% of ASD children tolerated solid foods, while 58% tolerated only pureed foods; all controls tolerated solid foods.
  • Nutrient adequacy: 79% of ASD children had adequate calcium intake vs about 50% of controls; 100% of ASD children did not meet the AI for iodine; fiber was not reached by about 51% of ASD children vs 23.4% of controls (p = 0.085); significantly higher percentages of ASD children did not meet EFSA guidelines for vitamins B1, B2, B6, and B12.

Methods

  • Observational case-control study in Córdoba, Spain: 54 children with ASD diagnosed by DSM-5 and ADOS, and 57 typically developing controls of similar age, from similar economic/sociocultural backgrounds.
  • Dietary assessment used a validated food frequency questionnaire and three non-consecutive 24-h dietary registrations (two weekdays, one weekend day); nutrient adequacy was compared with EFSA recommendations and SENC food-based guidelines.
  • Dietary patterns were derived using principal component analysis and hierarchical clustering analysis, with additional two-step cluster analysis; between-group comparisons used t-tests, Mann-Whitney U tests, and Chi-square tests.

Limitations

  • Stated: the study focused on a specific population of ASD children in southern Spain, so results should be cross-validated in other Spanish regions and countries; the ASD sample was very homogeneous in cultural and socioeconomic aspects; gastrointestinal symptoms that could affect dietary patterns and nutrient intakes were not evaluated.
  • Evident: the sample size was small (54 ASD, 57 controls), limiting generalizability; dietary intake relied on memory-based FFQ and 24-h dietary registrations, which the authors note incorporate systematic errors and biases; day-to-day variation in individual intake can distort usual intake estimates despite repeated 24-h recalls.

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Integrity signals

Registry

Crossref · 10.3390/nu13103551

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 38 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    The percentage of ASD children who had an intake of saturated fat above the guidelines was higher compared with control children.

    “the percentage of ASD children who had an intake of saturated fat above the guidelines was higher compared with that of the control children.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • Findingown data

    Children with ASD consumed fewer lean meat, eggs, and beverages than the control group.

    “in contrast, ASD children consumed fewer lean meat, eggs, and beverages.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The control group is comparable to the ASD group in economic and sociocultural conditions and environmental exposure.
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • Findingown data

    Most subjects in both groups did not reach the adequate intake for magnesium.

    “most of the subjects in both groups did not reach the AI for magnesium.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • Findingown data

    The intake of sugars in both groups was higher than recommended in the majority of children.

    “the intake of sugars in both groups was higher than recommended in the majority of children.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • Findingown data

    Within the ASD patient groups (solid vs pureed), significant differences were obtained in vegetables, fruit, fish, and fatty meats (p < 0.05).

    “significant differences were obtained in vegetables, fruit, fish, and fatty meats (p < 0.05)”
    Quote in the paperNot a substantial claim
  • May combine two claims. 28
  • Classified as probably not a substantial claim. 11
  • May combine two claims.

    Findingown data

    The majority of ASD children consumed 2-3 servings of fat daily, whereas 22.8% of control children consumed more than 3 servings per day.

    “The majority of ASD children consumed 2–3 servings of fat daily, whereas 22.8% of the control children consumed more than 3 servings/d.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: The control group is comparable to the ASD group in economic and sociocultural conditions and environmental exposure.
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    The intakes of essential fatty acids linoleic acid and alpha-linolenic acid were similar; the average energy intake was lower than recommended by EFSA (LA: 1.25% and 1.13%; LNA 0.13% and 0.13%, respectively).

    “Even the intakes of essential fatty acids [linoleic acid (LA) and α-linolenic acid (LNA)] were similar; the average energy intake was lower than that recommended by the EFSA (LA: 1.25% and 1.13%; LNA 0.13% and 0.13%, respectively).”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    About 79% of ASD children had an adequate calcium intake compared with only about 50% in the control group.

    “About 79% of ASD children had an adequate calcium intake compared with only about 50% in the control group.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    The intake of carbohydrates was similar in the two groups of children, with more than 70% following the recommendations.

    “The intake of carbohydrates was similar in the two groups of children, with more than 70% following the recommendations.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    All ASD children except one and all healthy children were classified into two distinct clusters.

    “All ASD children, excepting one subject, and all healthy children, were classified into two distinct clusters”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    The intakes of vitamin A and K were similar in both groups, with about one half following the recommendations.

    “The intakes of vitamin A and K were similar in both groups, with about one half following the recommendations.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    The average intake of EPA + DHA was about 0.3 g/d for the control group and 0.15 g/d for ASD children, which is close to the EFSA guidelines.

    “The average intake of EPA + DHA was about 0.3 g/d for the control and 0.15 g/d for ASD children, which is close to the EFSA guidelines.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    The recommended intake of fiber was not reached by about 51% of ASD children compared with only 23.4% in the healthy control group, although only a statistical trend was found (p = 0.085).

    “the recommended intake of fiber was not reached by about 51% of ASD children compared with only 23.4% in the healthy control group, although only a statistical trend was found (p = 0.085).”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    The majority of ASD children had an adequate energy intake, while about 23% of the control group did not reach the EFSA recommendations.

    “The majority of ASD children had an adequate energy intake, while about 23% of the control group did not reach the EFSA recommendations.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    ASD children showed higher milk and dairy consumption and cereals and pasta for the second food cluster.

    “In contrast, ASD children showed higher milk and dairy consumption and cereals and pasta for the second food cluster.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: The control group is comparable to the ASD group in economic and sociocultural conditions and environmental exposure.
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    The adequacy of intake was lower in ASD children than in the control group; 100.0% of ASD children did not meet the adequate intake for iodine.

    “The adequacy of intake was lower in ASD children than in the control group; in fact, 100.0% of ASD children did not meet the AI for iodine (Table 4).”
    Quote in the paperSubstantial claim
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    Most ASD subjects separated well from control subjects because of increased consumption of cereals and pasta and milk and dairy products and relatively lower consumption of lean meat and egg, fatty meats and derivatives, fish and shellfish, beverages, snacks, sweets, and bakery and pastry.

    “Most ASD subjects separated well from the control subjects because of the increased consumption of cereals and pasta and milk and dairy products and the relatively lower consumption of lean meat and egg, fatty meats and derivatives, fish and shellfish, beverages, snacks, sweets, and bakery and pastry, compared with the control children.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The control group is comparable to the ASD group in economic and sociocultural conditions and environmental exposure.
    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    Of the 54 ASD patients, 42% tolerated solid foods, whereas 58% tolerated only pureed foods.

    “Of the ASD 54 patients, 42% tolerated solid foods, whereas 58% tolerated only pureed foods.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingcitation

    The intake of fruits and vegetables was lower than recommended, mimicking what is usual in the whole Spanish population.

    “The intake of fruits and vegetables was lower than that recommended, mimicking what is usual in the whole Spanish population [42,43,44,45].”
    Quote in the paperNot a substantial claim0 of 4 sources checked
    • cites [42] Madrigal, C., Soto-Mendez, M.J., Hernandez-Ruiz, A., Valero, T., Avila, J.M., Ruiz, E., Villoslada, F.L., Leis, R., Martinez de Victoria, E., and Moreno, J.M. (2020). Energy Intake, Macronutrient Profile and Food Sources of Spanish Children Aged One to <10 Years-Results from the EsNuPI Study. Nutrients, 12. source

      Not checked in the free run.

    • cites [43] Partearroyo, T., Samaniego-Vaesken, M.L., Ruiz, E., Aranceta-Bartrina, J., Gil, A., Gonzalez-Gross, M., Ortega, R.M., Serra-Majem, L., and Varela-Moreiras, G. (2019). Current Food Consumption amongst the Spanish ANIBES Study Population. Nutrients, 11. source

      Not checked in the free run.

    • cites [44] Plaza-Diaz, J., Molina-Montes, E., Soto-Mendez, M.J., Madrigal, C., Hernandez-Ruiz, A., Valero, T., Lara Villoslada, F., Leis, R., Martinez de Victoria, E., and Moreno, J.M. (2020). Clustering of Dietary Patterns and Lifestyles Among Spanish Children in the EsNuPI Study (dagger). Nutrients, 12. source

      Not checked in the free run.

    • cites [45] Samaniego-Vaesken, M.L., Partearroyo, T., Valero, T., Rodriguez, P., Soto-Mendez, M.J., Hernandez-Ruiz, A., Villoslada, F.L., Leis, R., Martinez de Victoria, E., and Moreno, J.M. (2020). Carbohydrates, Starch, Total Sugar, Fiber Intakes and Food Sources in Spanish Children Aged One to <10 Years-Results from the EsNuPI Study. Nutrients, 12. source

      Not checked in the free run.

    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Findingown data

    The study found high energy and fat consumption and frequent manufactured products with poor nutritional quality and a low intake of vegetables and fruits in ASD children.

    “This highlights high energy and fat consumption and frequently manufactured products with poor nutritional quality and a low intake of vegetables and fruits in ASD children.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    In our sample, the average daily intake of EPA + DHA in ASD children was about 0.125 g/d, close to the recommendations of the EFSA and other international entities (e.g., FAO-OMS).

    “in our sample the average daily intake of EPA + DHA in ASD children was about 0.125 g/d, close to the recommendations of the EFSA and other international entities e.g., FAO-OMS [63]”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [63] FAO (2008). Grasas y Ácidos Grasos en Nutrición Humana Consulta de Expertos, Organización de las Naciones Unidas para la Alimentación y la Agricultura [FAO] y la Fundación Iberoamericana de Nutrición [FINUT].

      Not checked in the free run.

  • May combine two claims.

    Findingcitation

    In our sample, the intake of protein was higher than the recommendations and similar to the general population.

    “while here the intake of protein was higher than the recommendations and similar to the general population [15,51].”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [15] Sharp, 2013, Feeding problems and nutrient intake in children with autism spectrum disorders: A meta-analysis and comprehensive review of the literature, J. Autism Dev. Disord. source

      Not checked in the free run.

    • cites [51] Canals, 2019, Differences in food consumption and nutritional intake between children with autism spectrum disorders and typically developing children: A meta-analysis, Autism source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    The sample size was calculated assuming a 30% difference in mean plasma docosahexaenoic acid between children with ASD and healthy children, an alpha error of 0.05, a power of 0.90, and 5% dropout.

    “The sample size for the study was calculated assuming a 30% difference in the mean for one of the main study variables (plasma level of docosahexaenoic acid) between children with ASD and healthy children, an α error = 0.05, a power of 0.90 (β error of 0.1) and 5% of dropout during the follow-up of the study.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    Children with ASD frequently have significant eating difficulties with a highly restricted range of food choices.

    “Children with ASD frequently have significant eating difficulties with a highly restricted range of food choices [3]”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [3] Williams, 2000, Eating habits of children with autism, Pediatr. Nurs.

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Children with ASD have stronger preferences for energy-dense foods like snacks, sweets, sugary beverages and juice than children with typical development.

    “they found stronger preferences for energy-dense foods like snacks, sweets, sugary beverages and juice in children with ASD.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [21] Canals-Sans, J., Esteban-Figuerola, P., Morales-Hidalgo, P., and Arija, V. (2021). Do Children with Autism Spectrum Disorders Eat Differently and Less Adequately than Those with Subclinical ASD and Typical Development? EPINED Epidemiological Study. J. Autism Dev. Disord. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The use of nutritional supplements such as omega-3 fatty acids and multivitamins, as well as a gluten-free casein-free diet, is not supported by current scientific evidence.

    “the use of nutritional supplements e.g., those containing omega-3 fatty acids [25], multivitamins, as well as a gluten-free casein-free diet [26], is not supported by the current scientific evidence”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [25] Posar, 2016, Complementary and alternative medicine in autism: The question of omega-3, Pediatr. Ann. source

      Not checked in the free run.

    • cites [26] Hopf, 2016, Use and perceived effectiveness of complementary and alternative medicine to treat and manage the symptoms of autism in children: A survey of parents in a community population, J. Altern. Complement. Med. source

      Not checked in the free run.

  • May combine two claims.

    Study design and conductown data

    There were no significant differences in weight, height, and body mass index between the ASD and control groups.

    “There were no significant differences in weight, height, and body mass index (BMI) between the two groups.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: The control group is comparable to the ASD group in economic and sociocultural conditions and environmental exposure.
  • Classified as probably not a substantial claim. May combine two claims.

    Premisecitation

    There is consensus that children with ASD have selective dietary patterns, food neophobia and sensory issues.

    “there is consensus that children with ASD have selective dietary patterns (DPs), food neophobia and sensory issues [4]”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [4] Ranjan, 2015, Nutritional status of individuals with autism spectrum disorders: Do we know enough?, Adv. Nutr. source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Study design and conductcitation

    Intake of energy and nutrients was estimated from three non-consecutive 24-h dietary registrations following the EFSA Guidance on the EU Menu Methodology.

    “The intake of energy and nutrients was estimated from the data obtained through three non-consecutive 24-h dietary registrations (24-h-DR), registered by parents, including two weekdays and one weekend day, following the Guidance on the EU Menu Methodology of the European Food Safety Agency (EFSA) [32].”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [32] EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2013). Scientific Opinion on nutrient requirements and dietary intakes of infants and young children in the European Union. EFSA J., 11, 3408. source

      Not checked in the free run.

    • Rests on an assumption: Parents accurately recorded the three non-consecutive 24-h dietary registrations.
  • May combine two claims.

    Premisecitation

    A study involving 70 children with ASD with severe food selectivity found that 67% of the sample omitted vegetables and 27% omitted fruits.

    “a study involving a sample of 70 children with ASD with severe food selectivity, i.e., complete omission of one or more food groups (e.g., fruit, vegetable, protein, grain, dairy) or consuming a narrow range of items weekly (e.g., five or fewer total food items) found that67% of the sample omitted vegetables and 27% omitted fruits [46].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [46] Sharp, 2018, Dietary intake, nutrient status, and growth parameters in children with autism spectrum disorder and severe food selectivity: An electronic medical record review, J. Acad. Nutr. Diet. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    High consumption of snacks, sweets, and baked goods in all Spanish children has been repeatedly reported.

    “the high consumption of snacks, sweets, and baked goods in all Spanish children has been repeatedly reported [42,43,44,45]”
    Quote in the paperNot a substantial claim0 of 4 sources checked
    • cites [42] Madrigal, C., Soto-Mendez, M.J., Hernandez-Ruiz, A., Valero, T., Avila, J.M., Ruiz, E., Villoslada, F.L., Leis, R., Martinez de Victoria, E., and Moreno, J.M. (2020). Energy Intake, Macronutrient Profile and Food Sources of Spanish Children Aged One to <10 Years-Results from the EsNuPI Study. Nutrients, 12. source

      Not checked in the free run.

    • cites [43] Partearroyo, T., Samaniego-Vaesken, M.L., Ruiz, E., Aranceta-Bartrina, J., Gil, A., Gonzalez-Gross, M., Ortega, R.M., Serra-Majem, L., and Varela-Moreiras, G. (2019). Current Food Consumption amongst the Spanish ANIBES Study Population. Nutrients, 11. source

      Not checked in the free run.

    • cites [44] Plaza-Diaz, J., Molina-Montes, E., Soto-Mendez, M.J., Madrigal, C., Hernandez-Ruiz, A., Valero, T., Lara Villoslada, F., Leis, R., Martinez de Victoria, E., and Moreno, J.M. (2020). Clustering of Dietary Patterns and Lifestyles Among Spanish Children in the EsNuPI Study (dagger). Nutrients, 12. source

      Not checked in the free run.

    • cites [45] Samaniego-Vaesken, M.L., Partearroyo, T., Valero, T., Rodriguez, P., Soto-Mendez, M.J., Hernandez-Ruiz, A., Villoslada, F.L., Leis, R., Martinez de Victoria, E., and Moreno, J.M. (2020). Carbohydrates, Starch, Total Sugar, Fiber Intakes and Food Sources in Spanish Children Aged One to <10 Years-Results from the EsNuPI Study. Nutrients, 12. source

      Not checked in the free run.

  • Classified as probably not a substantial claim. May combine two claims.

    Study design and conductnone given

    The diagnosis of ASD was assessed following DSM-5 clinical criteria and confirmed with the ADOS.

    “The diagnosis of ASD was assessed following the clinical criteria of the DSM-5 and confirmed with the completion of the ADOS.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisecitation

    Children with ASD have demonstrated low levels of folate, vitamins B6, and B12, which have been associated with simultaneous B6, B9, and B12 deficiencies leading to the accumulation of homocysteine.

    “Children with ASD have also demonstrated low levels of folate, vitamins B6, and B12, which have been associated with simultaneous B6, B9, and B12 deficiencies leading to the accumulation of homocysteine [59,67].”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [59] Karhu, 2020, Nutritional interventions for autism spectrum disorder, Nutr. Rev. source

      Not checked in the free run.

    • cites [67] Adams, 2011, Effect of a vitamin/mineral supplement on children and adults with autism, BMC Pediatr. source

      Not checked in the free run.

  • May combine two claims.

    Study design and conductcitation

    Based on available evidence, most identified dietary patterns showed good reproducibility, fair relative validity, and good construct validity across different statistical solutions.

    “Based on the available evidence, most identified DPs showed good reproducibility, fair relative validity, and good construct validity across different statistical solutions [75].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [75] Edefonti, 2020, Reproducibility and validity of a posteriori dietary patterns: A systematic review, Adv. Nutr. source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Children with ASD have inadequate micronutrient intakes and are at particular risk for specific inadequacies of vitamins and minerals such as calcium, magnesium, vitamin D, and vitamin E.

    “Several studies have shown that children with ASD have inadequate micronutrient intakes [65,66], and they are at particular risk for specific inadequacies of vitamins and minerals such as calcium, magnesium, vitamin D, and vitamin E [39,46,51].”
    Quote in the paperNot a substantial claim0 of 5 sources checked
    • cites [65] Hyman, 2012, Nutrient intake from food in children with autism, Pediatrics source

      Not checked in the free run.

    • cites [66] Malhi, 2017, Feeding problems and nutrient intake in children with and without autism: A comparative study, Indian J. Pediatr. source

      Not checked in the free run.

    • cites [39] Schmitt, 2008, A comparison of nutrient intake and eating behaviors of boys with and without autism, Top. Clin. Nutr. source

      Not checked in the free run.

    • cites [46] Sharp, 2018, Dietary intake, nutrient status, and growth parameters in children with autism spectrum disorder and severe food selectivity: An electronic medical record review, J. Acad. Nutr. Diet. source

      Not checked in the free run.

    • cites [51] Canals, 2019, Differences in food consumption and nutritional intake between children with autism spectrum disorders and typically developing children: A meta-analysis, Autism source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationnone given

    One of the major limitations of our study is that we focused on a specific population of ASD children living in southern Spain.

    “One of the major limitations of our study is that we focused on a specific population of ASD children living in the southern of Spain.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Food selectivity and mealtime problems are common issues in preschoolers, school-age children, and adolescents with ASD, and they are associated with a higher frequency of gastrointestinal symptoms.

    “A recent study demonstrates that food selectivity and mealtime problems are common issues in preschoolers, school-age children, and adolescents with ASD, and they are associated with a higher frequency of gastrointestinal (GI) symptoms [49,50].”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [49] Babinska, K., Celusakova, H., Belica, I., Szapuova, Z., Waczulikova, I., Nemcsicsova, D., Tomova, A., and Ostatnikova, D. (2020). Gastrointestinal Symptoms and Feeding Problems and Their Associations with Dietary Interventions, Food Supplement Use, and Behavioral Characteristics in a Sample of Children and Adolescents with Autism Spectrum Disorders. Int. J. Environ. Res. Public Health, 17. source

      Not checked in the free run.

    • cites [50] Kohane, I.S., McMurry, A., Weber, G., MacFadden, D., Rappaport, L., Kunkel, L., Bickel, J., Wattanasin, N., Spence, S., and Murphy, S. (2012). The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS ONE, 7. source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    We did not attempt to evaluate gastrointestinal symptoms that could affect dietary patterns and nutrient intakes.

    “Finally, we did not attempt to evaluate gastrointestinal symptoms that could affect DPS and nutrient intakes.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationown data

    These data do not seem to justify the use of omega 3 as a treatment in ASD, at least in Spain, where familiar consumption of fish is traditionally higher compared to other countries.

    “So these data do not seem to justify the use of omega 3 as a treatment in ASD, at least in Spain, where the familiar consumption of fish is traditionally higher compared to other countries [64].”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [64] Ministry of Environment and Rural and Marine Affairs (MARM) (2008–2021) (2021, September 01). La Alimentación en España. Ministerio de Agricultura, Pesca y Alimentación, Madrid, España: Madrid, Available online: https://www.mapa.gob.es/es/estadistica/temas/estadisticas-pesqueras/default.aspx.

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Compared to children with typical development, preschoolers with ASD consumed fewer vegetables, fish, and eggs, while primary school children consumed fewer legumes, cheese/yogurt, olive oil, citrus fruits, and more meat.

    “Compared to children with typical development, preschoolers with ASD consumed fewer vegetables, fish, and eggs, while primary school children consumed fewer legumes, cheese/yogurt, olive oil, citrus fruits, and more meat [21].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [21] Canals-Sans, J., Esteban-Figuerola, P., Morales-Hidalgo, P., and Arija, V. (2021). Do Children with Autism Spectrum Disorders Eat Differently and Less Adequately than Those with Subclinical ASD and Typical Development? EPINED Epidemiological Study. J. Autism Dev. Disord. source

      Not checked in the free run.

35 of 35
  • The paper relies on this without support.

    The control group is comparable to the ASD group in economic and sociocultural conditions and environmental exposure.

    “Both groups lived in the same urban area of Córdoba (Spain), with families in similar economic and sociocultural situations and close environmental exposure.”
  • The paper relies on this without support.

    Parents accurately recorded the three non-consecutive 24-h dietary registrations.

    “three non-consecutive 24-h dietary registrations (24-h-DR), registered by parents”
2 of 2

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Plaza-Diaz et al. found higher energy density and elevated saturated fats, calcium, and vitamin C, while showing deficiencies in iron, iodine, and B vitamins such as riboflavin and folic acid.

    “In the study mentioned above by Plaza-Diaz et al., the research group was characterized by higher energy density and elevated levels of saturated fats, calcium, and vitamin C, while showing deficiencies in iron, iodine, and B vitamins (such as riboflavin and folic acid) [51].”
  • Plaza-Diaz et al. found lower intake of fruits and vegetables in ASD children; high fat and high energy foods including juices, snack foods, confectionery, and baked goods characterized dietary choices; increased dairy consumption was associated with greater intake of cereals and pasta; children had lower consumption of lean meat and eggs with excessive intake of fatty meats.

    “A lower intake of fruits and vegetables was reported in the ASD children. Foods of high fat and high energy content, including juices, snack foods, confectionery, and baked goods, characterized the subjects’ dietary choices. Additionally, an increase in dairy consumption was associated with a greater intake of cereals and pasta. Children exhibited lower consumption of lean meat and eggs, with”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Saturated-fat adequacy is described in opposite ways

    Major

    The abstract says a higher percentage of children with ASD complied with the saturated-fat recommendation, but the results say a higher percentage exceeded the guideline. These statements give opposite interpretations of the comparison.

  • Dairy is called the sole exception to guideline compliance

    Minor

    The discussion presents dairy products as the exception to relatively high compliance with food-consumption guidelines. Earlier results also report excess fatty-meat consumption and that more than 85% of both groups exceeded the recommended servings of beverages, snacks, sweets, bakery, and pastry.

  • Two different average EPA + DHA intakes are reported for ASD children

    Minor

    The results give the ASD group's average EPA + DHA intake as about 0.15 g/d, while the discussion gives it as about 0.125 g/d.

3 of 3

Cites

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1 of the 78 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Plaza-Diaz, J., Flores-Rojas, K., Torre-Aguilar, M. J. D. L., Gomez-Fernández, A. R., Martín-Borreguero, P., Perez-Navero, J. L., Gil, A., & Gil-Campos, M.
Affiliations
  • Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain
  • Pediatric Research and Metabolism Unit, Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Av. Menéndez Pidal, s/n, 14010 Córdoba, Spain
  • Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
Venue
Nutrients
Publisher
MDPI AG
Published
2021-10-10
Volume
13
Issue
10
Pages
3551
ISSN
2072-6643 (ISSN-L)
OpenAlex
W3207106718
Cited by
56
References
78
Citations by year
2026: 8 · 2025: 14 · 2024: 14 · 2023: 11 · 2022: 9
FWCI
6.10
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Repository of the University of Granada (University of Granada) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
Funders
  • FUNDACIÓ AGRUPACIÓ (Àmbit de la Infància)
  • Spanish Society of Pediatrics and Red de Salud Materno Infantil (RED SAMID) (404 Research Grant INVEST)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords
autism spectrum disorder, preschool children, dietary habits, nutrient intake, picky eating, energy intake, dietary fat, fruit and vegetable intake, dairy products, processed foods, micronutrient deficiency, nutritional status
MeSH terms
Autism Spectrum Disorder, Child Nutritional Physiological Phenomena, Child, Preschool, Diet, Diet Surveys, Eating, Feeding Behavior, Female, Humans, Male, Nutritive Value, Spain, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-06.

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