Cited by 136Child Nutrition and Feeding IssuesAutism Spectrum Disorder ResearchBehavioral and Psychological Studies

Evidence of the Gluten-Free and Casein-Free Diet in Autism Spectrum Disorders: A Systematic Review

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Marí-Bauset, Salvador, Zazpe, Itziar, Mari-Sanchis, Amelia, Llopis-González, Agustín, Morales-Suárez-Varela, María·2014·Journal of Child Neurology

Abstract

In autism spectrum disorders, many parents resort to alternative treatments and these are generally perceived as risk free. Among these, the most commonly used is the gluten-free, casein-free diet. The objective of this work was to conduct a systematic review of studies published from 1970 to date related to the gluten-free, casein-free diet in autism spectrum disorder patients. Few studies can be regarded as providing sound scientific evidence since they were blinded randomized controlled trials, and even these were based on small sample sizes, reducing their validity. We observed that the evidence on this topic is currently limited and weak. We recommend that it should be only used after the diagnosis of an intolerance or allergy to foods containing the allergens excluded in gluten-free, casein-free diets. Future research should be based on this type of design, but with larger sample sizes.

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Authors
Marí-Bauset, S., Zazpe, I., Mari-Sanchis, A., Llopis-González, A., & Morales-Suárez-Varela, M.
Affiliations
  • Universitat de València (ES)
  • Department of Nutrition and Food Sciences and Physiology, University of Navarra, Navarra, Spain
  • Clinical Nutrition and Dietetics Unit, Navarra Hospital Complex, Navarra, Spain
  • Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Valencia, Spain
Venue
Journal of Child Neurology
Published
2014-04-30
Volume
29
Issue
12
Pages
1718-1727
ISSN
  • 0883-0738 (ISSN-L)
  • 1708-8283
OpenAlex
W2011447176
Cited by
136
References
67
Citations by year
2026: 3 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 10 · 2021: 17 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 18 · 2016: 9 · 2015: 12 · 2014: 8
FWCI
11.96
Type
journal article
Language
en
Open access
Locations
  • Journal of Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Keywords
gluten-free diet, casein-free diet, autism spectrum disorder, dietary intervention, food intolerance, food allergy, alternative treatment, quality of evidence
MeSH terms
Caseins, Child Development Disorders, Pervasive, Diet Therapy, Humans, Diet, Gluten-Free

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