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Does Timing Matter? A Narrative Review of Intermittent Fasting Variants and Their Effects on Bodyweight and Body Composition
Abstract
The practice of fasting recently has been purported to have clinical benefits, particularly as an intervention against obesity and its related pathologies. Although a number of different temporal dietary restriction strategies have been employed in practice, they are generally classified under the umbrella term “intermittent fasting” (IF). IF can be stratified into two main categories: (1) intra-weekly fasting (alternate-day fasting/ADF, twice-weekly fasting/TWF) and (2) intra-daily fasting (early time-restricted eating/eTRE and delayed time-restricted eating/dTRE). A growing body of evidence indicates that IF is a viable alternative to daily caloric restriction (DCR), showing effectiveness as a weight loss intervention. This paper narratively reviews the literature on the effects of various commonly used IF strategies on body weight and body composition when compared to traditional DCR approaches, and draws conclusions for their practical application. A specific focus is provided as to the use of IF in combination with regimented exercise programs and the associated effects on fat mass and lean mass.
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“Although IF variants largely lack anthropometric or clinical advantages over CER, each of the IF variants has consistently shown effectiveness as an ad libitum approach [58].”
From International Society of Sports Nutrition position stand: diets for body weight reduction (2026) · cites this paper as [58]
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“The majority of ADF trials involve “fasting” days that consist of approximately 25% of the individual’s maintenance caloric requirements (~500 kcal), and are thus labeled modified ADF [58].”
From International Society of Sports Nutrition position stand: diets for body weight reduction (2026) · cites this paper as [58]
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“[36] compared ad libitum TRE (unrestricted eating from 12 p.”
BackgroundCalorie restriction with or without time-restricted eating in weight loss
Liu, D., Huang, Y., Huang, C., Yang, S., Wei, X., Zhang, P., Guo, D., Lin, J., Xu, B., Li, C., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2114833 · Cited by 516
Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults
Mamerow, M. M., Mettler, J. A., English, K. L., Casperson, S. L., Arentson-Lantz, E., Sheffield-Moore, M., Layman, D. K., & Paddon-Jones, D. (2014) · The Journal of Nutrition · doi:10.3945/jn.113.185280 · Cited by 438
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“Systematic reviews and meta-analyses consistently report a lack of serious adverse events across studies [3,62,63].”
BackgroundInternational society of sports nutrition position stand: diets and body composition
Aragon, A. A., Schoenfeld, B. J., Wildman, R., Kleiner, S., VanDusseldorp, T., Taylor, L., Earnest, C. P., Arciero, P. J., Wilborn, C., Kalman, D. S., et al. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0174-y · Cited by 301
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Cited by
Sorted by citations
Examining Associations Between Fasting Behavior, Orthorexia Nervosa, and Eating Disorders
Domaszewski, P., Rogowska, A. M., & Żylak, K. (2024) · Nutrients · doi:10.3390/nu16244275 · Cited by 8
International Society of Sports Nutrition position stand: diets for body weight reduction
Aragon, A. A., Campbell, B. I., Schoenfeld, B. J., Stout, J. R., Kalman, D., Arciero, P. J., Arent, S. M., Kreider, R. B., Taylor, L. W., Bannock, L., et al. (2026) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2026.2740266
Self-citation
Metadata
- Authors
- Aragon, A. A., & Schoenfeld, B. J.
- Affiliations
- Department of Family and Consumer Sciences, California State University, Northridge, CA 91330, USA
- Department of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY 10468, USA
- ORCID
- Schoenfeld, Brad J.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-11-25
- Volume
- 14
- Issue
- 23
- Pages
- 5022
- ISSN
- 2072-6643
- PMC
- PMC9736182
- Cited by
- 18
- References
- 17
- Language
- en
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