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Cited by 282

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants

Open access
Sgarbossa, Antonella, Giacomazza, Daniela, Di Carlo, Marta·2015·Nutrients
DOI 10.3390/nu7075246
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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the deposition of extracellular amyloid-beta peptide (Aβ) and intracellular neurofibrillar tangles, associated with loss of neurons in the brain and consequent learning and memory deficits. Aβ is the major component of the senile plaques and is believed to play a central role in the development and progress of AD both in oligomer and fibril forms. Inhibition of the formation of Aβ fibrils as well as the destabilization of preformed Aβ in the Central Nervous System (CNS) would be an attractive therapeutic target for the treatment of AD. Moreover, a large number of studies indicate that oxidative stress and mitochondrial dysfunction may play an important role in AD and their suppression or reduction via antioxidant use could be a promising preventive or therapeutic intervention for AD patients. Many antioxidant compounds have been demonstrated to protect the brain from Aβ neurotoxicity. Ferulic acid (FA) is an antioxidant naturally present in plant cell walls with anti-inflammatory activities and it is able to act as a free radical scavenger. Here we present the role of FA as inhibitor or disaggregating agent of amyloid structures as well as its effects on biological models.

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Metadata

Authors
Sgarbossa, A., Giacomazza, D., & Di Carlo, M.
Venue
Nutrients
Publisher
MDPI AG
Published
2015-07-15
Volume
7
Issue
7
Pages
5764-5782
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu7075246
OpenAlex
W1570813833
Cited by
282
References
92
FWCI
12.91
Type
journal article
Language
en
Open access
gold

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