The DOI matches its Crossref record; 140 of the 141 references it cites were found in a registry or an index.
Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management
Open accessAbstract
Functional foods contain biologically active ingredients associated with physiological health benefits for preventing and managing chronic diseases, such as type 2 diabetes mellitus (T2DM). A regular consumption of functional foods may be associated with enhanced anti-oxidant, anti-inflammatory, insulin sensitivity, and anti-cholesterol functions, which are considered integral to prevent and manage T2DM. Components of the Mediterranean diet (MD)—such as fruits, vegetables, oily fish, olive oil, and tree nuts—serve as a model for functional foods based on their natural contents of nutraceuticals, including polyphenols, terpenoids, flavonoids, alkaloids, sterols, pigments, and unsaturated fatty acids. Polyphenols within MD and polyphenol-rich herbs—such as coffee, green tea, black tea, and yerba maté—have shown clinically-meaningful benefits on metabolic and microvascular activities, cholesterol and fasting glucose lowering, and anti-inflammation and anti-oxidation in high-risk and T2DM patients. However, combining exercise with functional food consumption can trigger and augment several metabolic and cardiovascular protective benefits, but it is under-investigated in people with T2DM and bariatric surgery patients. Detecting functional food benefits can now rely on an “omics” biological profiling of individuals’ molecular, genetics, transcriptomics, proteomics, and metabolomics, but is under-investigated in multi-component interventions. A personalized approach for preventing and managing T2DM should consider biological and behavioral models, and embed nutrition education as part of lifestyle diabetes prevention studies. Functional foods may provide additional benefits in such an approach.
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“Thus, according to Alkhatib et al., the tea has beneficial effects on the pathogenesis of diabetes mellitus by improving glucose metabolism and consequently lowering the fasting glucose level.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [10]
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“Finally, the positive properties of the MedDiet for prevention and management of T2D are not confined within selected PUFA- and/or MUFA-enriched functional foods, but incorporate additional and synergistic benefits from the ingestion of numerous promising bioactive polyphenol compounds [56], which are currently under investigation.”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [56]
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2 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257
RetractedEstruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1806491 · Cited by 1,008
RetractedReduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · cited 3×
“Large lifestyle interventions consisting of combining various forms of structured or unstructured exercise with mainly caloric restriction diets have shown up to 58% reduction of the T2DM incidence rate in high risk individuals, especially those with glucose intolerance from different countries including multiethnic A…”
BackgroundTuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Self-citationPolyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Adherence to a Mediterranean diet and survival in a Greek population
Trichopoulou, A., Costacou, T., Bamia, C., & Trichopoulos, D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025039 · Cited by 4,397
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658 · cited 1×
“Phenolics are generally thought to be poorly absorbed with plasma concentrations rarely exceeding 1 μM following ingestion of a single phenolic compound [59].”
BackgroundWeight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis
Buchwald, H., Estok, R., Fahrbach, K., Banel, D., Jensen, M. D., Pories, W. J., Bantle, J. P., & Sledge, I. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.09.041 · Cited by 2,551
Flagged first, then by citations
1 of the 141 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- 2016, Food consumption and risk of malnutrition in community-dwelling very old Spanish adults (≥80 years), Nutr. Hosp., 33, 263
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Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review
Clemente‐Suárez, V. J., Beltrán-Velasco, A. I., Redondo-Flórez, L., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2023) · Nutrients · doi:10.3390/nu15122749 · Cited by 933
Alagawany, M. M., Elnesr, S. S., Farag, M. R., Tiwari, R., Yatoo, M. I., Karthik, K., Michalak, I., & Dhama, K. (2020) · Veterinary Quarterly · doi:10.1080/01652176.2020.1857887 · Cited by 357
Inflammation, not Cholesterol, Is a Cause of Chronic Disease
Τσούπρας, Α., Lordan, R., & Zabetakis, I. (2018) · Nutrients · doi:10.3390/nu10050604 · Cited by 333
Banwo, K., Olojede, A. O., Adesulu-Dahunsi, A. T., Verma, D. K., Thakur, M., Tripathy, S., Singh, S., Patel, A. R., Gupta, A. K., Aguilar, C. N., et al. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101320 · Cited by 313
Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288
Metadata
- Authors
- Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A., & Tuomilehto, J.
- Affiliations
- Dasman Diabetes Institute (KW)
- Edge Hill University (GB)
- Mauritius Sugarcane Industry Research Institute (MU)
- Dasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait
- King Abdulaziz University (SA)
- Corresponding author
- Alkhatib, Ahmad
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-12-01
- Volume
- 9
- Issue
- 12
- Pages
- 1310
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5748760
- OpenAlex
- W2772650360
- Cited by
- 376
- References
- 141
- Citations by year
- 2026: 26 · 2025: 48 · 2024: 42 · 2023: 50 · 2022: 53 · 2021: 69 · 2020: 51 · 2019: 24 · 2018: 12 · 2017: 1
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Edge Hill University Research Information Repository (Edge Hill University) (publishedVersion, cc-by)
- TeesRep (Teesside University) (acceptedVersion, other-oa)
- Northumbria Research Link (Northumbria University) (acceptedVersion, other-oa)
- Edge Hill University (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Queen Margaret University Publications Repository (Queen Margaret University) (submittedVersion, cc-by)
- Funders
- Dasman Diabetes Institute
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- functional foods, type 2 diabetes, diabetes prevention, diabetes management, Mediterranean diet, nutraceuticals, polyphenols, anti-inflammatory activity, antioxidant activity, insulin sensitivity, physical activity, bariatric surgery, personalized nutrition, omics profiling, lifestyle intervention, nutrition education, olive oil, green tea, Ilex paraguariensis
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Life Style, Diet, Mediterranean, Functional Food
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