Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review
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Type 2 diabetes is a complicated metabolic disorder with both short- and long-term undesirable complications. In recent years, there has been growing evidence that functional foods and their bioactive compounds, due to their biological properties, may be used as complementary treatment for type 2 diabetes mellitus. In this review, we have highlighted various functional foods as missing part of medical nutrition therapy in diabetic patients. Several in vitro, animal models and some human studies, have demonstrated that functional foods and nutraceuticals may improve postprandial hyperglycemia and adipose tissue metabolism modulate carbohydrate and lipid metabolism. Functional foods may also improve dyslipidemia and insulin resistance, and attenuate oxidative stress and inflammatory processes and subsequently could prevent the development of long-term diabetes complications including cardiovascular disease, neuropathy, nephropathy and retinopathy. In conclusion available data indicate that a functional foods-based diet may be a novel and comprehensive dietary approach for management of type 2 diabetes.
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Functional foods attempt to improve health by incorporating bioactive compounds that may alter lipid, vascular, and other metabolic pathways, microbiome composition and function, and digestive and inflammatory systems.
“Similar to dietary supplements, functional foods attempt to improve health by incorporating bioactive compounds that may alter lipid, vascular, and other metabolic pathways, microbiome composition and function, and digestive and inflammatory systems.114-121”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [117]
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- Authors
- Mirmiran, P.
- Affiliations
- National Nutrition and Food Technology Research Institute (IR)
- Corresponding author
- Mirmiran, Parvin
- ORCID
- Mirmiran, Parvin
- Venue
- World Journal of Diabetes
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 5
- Issue
- 3
- Pages
- 267
- ISSN
- 1948-9358 (ISSN-L)
- PMC
- PMC4058731
- OpenAlex
- W2021722567
- Cited by
- 215
- References
- 208
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 18 · 2023: 21 · 2022: 26 · 2021: 35 · 2020: 20 · 2019: 19 · 2018: 13 · 2017: 15 · 2016: 15 · 2015: 14 · 2014: 2
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Diabetes (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- type 2 diabetes, functional foods, nutraceuticals, medical nutrition therapy, postprandial hyperglycemia, insulin resistance, dyslipidemia, oxidative stress, inflammation, diabetes complications, cardiovascular disease, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, carbohydrate metabolism, lipid metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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