The DOI matches its Crossref record; 232 of the 232 references it cites were found in a registry or an index.
Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems
Open accessAbstract
Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability and difficulties in ensuring patient adherence. These challenges have driven the development of advanced drug delivery systems (DDS), with hydrogels and especially nanogels emerging as promising materials to overcome these limitations. Hydrogels, with their biocompatibility, high water content, and stimuli-responsive properties, provide controlled and targeted drug release. This review explores the evolution, properties, and classifications of hydrogels versus nanogels and their applications in drug delivery, detailing synthesis methods, including chemical crosslinking, physical self-assembly, and advanced techniques such as microfluidics and 3D printing. It also examines drug-loading mechanisms (e.g., physical encapsulation and electrostatic interactions) and release strategies (e.g., diffusion, stimuli-responsive, and enzyme-triggered). These gels demonstrate significant advantages in addressing the limitations of traditional DDS, offering improved drug stability, sustained release, and high specificity. Their adaptability extends to various routes of administration, including topical, oral, and injectable forms, while emerging nanogels further enhance therapeutic targeting through nanoscale precision and stimuli responsiveness. Although hydrogels and nanogels have transformative potential in personalized medicine, challenges remain in scalable manufacturing, regulatory approval, and targeted delivery. Future strategies include integrating biosensors for real-time monitoring, developing dual-stimuli-responsive systems, and optimizing surface functionalization for specificity. These advancements aim to establish hydrogels and nanogels as cornerstones of next-generation therapeutic solutions, revolutionizing drug delivery, and paving the way for innovative, patient-centered treatments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hydrogel: Preparation, characterization, and applications: A review
Ahmed, E. M. (2015) · Journal of Advanced Research · doi:10.1016/j.jare.2013.07.006 · Cited by 5,800
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Hydrogels in drug delivery: Progress and challenges
Hoare, T. R., & Kohane, D. S. (2008) · Polymer · doi:10.1016/j.polymer.2008.01.027 · Cited by 3,799
Hydrogels for biomedical applications
Hoffman, A. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.010 · Cited by 3,396
Hydrophilic gels for biological use
WICHTERLE, O., & LÍM, D. (1960) · Nature · doi:10.1038/185117a0 · Cited by 2,996
Biomedical applications of hydrogels: A review of patents and commercial products
Caló, E., & Khutoryanskiy, V. V. (2015) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.11.024 · Cited by 2,634
Chitosan-based hydrogels for controlled, localized drug delivery
Bhattarai, N., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.07.019 · Cited by 2,495
Hydrogels: From controlled release to pH-responsive drug delivery
Gupta, P., Vermani, K., & Garg, S. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02255-9 · Cited by 1,825
The development of microgels/nanogels for drug delivery applications
Oh, J. K., Drumright, R., Siegwart, D. J., & Matyjaszewski, K. A. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.01.002 · Cited by 1,623
Bioinks for 3D bioprinting: an overview
Gungor‐Ozkerim, P. S., İnci, İ., Zhang, Y. S., Khademhosseini, A., & Dokmeci, M. R. (2018) · Biomaterials Science · doi:10.1039/c7bm00765e · Cited by 1,524
Three-dimensional bioprinting of thick vascularized tissues
Kolesky, D. B., Homan, K. A., Skylar-Scott, M. A., & Lewis, J. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521342113 · Cited by 1,492
Thermosensitive sol-gel reversible hydrogels
Jeong, B., Kim, S. W., & Bae, Y. H. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00242-3 · Cited by 1,478
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Annabi, N., Tamayol, A., Uquillas, J. A., Akbari, M., Bertassoni, L. E., Cha, C., Camci‐Unal, G., Dokmeci, M. R., Peppas, N. A., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201303233 · Cited by 1,409
In situ-forming hydrogels--review of temperature-sensitive systems
Ruel-Gariépy, E., & Leroux, J.-C. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.019 · Cited by 1,297
Hydrogels: Properties and Applications in Biomedicine
Ho, T., Chang, C.-C., Chan, H.-P., Chung, T., Shu, C., Chuang, K., Duh, T., Yang, M., & Tyan, Y. (2022) · Molecules · doi:10.3390/molecules27092902 · Cited by 1,224
New Challenges in Biomaterials
Peppas, N. A., & Langer, R. (1994) · Science · doi:10.1126/science.8134835 · Cited by 1,163
Hydrogel scaffolds for tissue engineering: Progress and challenges
El-sherbiny, I. M., & Yacoub, M. H. (2013) · Global Cardiology Science and Practice · doi:10.5339/gcsp.2013.38 · Cited by 1,108
Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects
Begines, B., Ortiz, T., Pérez-Aranda, M., Martínez, G., Merinero, M., Argüelles-Arias, F., & Alcudia, A. (2020) · Nanomaterials · doi:10.3390/nano10071403 · Cited by 1,061
Self-citationAlkaline phosphatase: Structure, expression and its function in bone mineralization
Vimalraj, S. (2020) · Gene · doi:10.1016/j.gene.2020.144855 · Cited by 916
Smart Hydrogels in Tissue Engineering and Regenerative Medicine
Mantha, S., Pillai, S., Khayambashi, P., Upadhyay, A., Zhang, Y., Tao, O., Pham, H. M., & Tran, S. D. (2019) · Materials · doi:10.3390/ma12203323 · Cited by 886
A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Hong, Y., Zhou, F., Hua, Y., Zhang, X., Ni, C., Pan, D., Zhang, Y., Jiang, D., Yang, L., Lin, Q., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10004-7 · Cited by 842
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Homayun, B., Lin, X., & Choi, H.-J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030129 · Cited by 837
Polymer-Based Hydrogels Applied in Drug Delivery: An Overview
Nguyen, H. T., Chien, T. B., & Cường, Đ. X. (2023) · Gels · doi:10.3390/gels9070523 · Cited by 827
Recent progress in drug delivery
Li, C., Wang, J., Wang, Y., Gao, H., Wei, G., Huang, Y., Yu, H., Gan, Y., Wang, Y., Mei, L., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.003 · Cited by 818
Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery
Merino, S., Martín, C., Kostarelos, K., Prato, M., & Vázquez, E. (2015) · ACS Nano · doi:10.1021/acsnano.5b01433 · Cited by 816
Fan, Z., Liu, B., Wang, J., Zhang, S., Lin, Q., Gong, P., Ma, L., & Yang, S. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201304202 · Cited by 812
Ninan, N., Forget, A., Shastri, V. P., Voelcker, N. H., & Blencowe, A. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b10491 · Cited by 677
How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
Icard, P., Shulman, S. D., Farhat, D., Steyaert, J., Alifano, M., & Lincet, H. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.03.001 · Cited by 664
Hydrogels and Their Applications in Targeted Drug Delivery
Narayanaswamy, R., & Torchilin, V. P. (2019) · Molecules · doi:10.3390/molecules24030603 · Cited by 664
McKay, W. F., Peckham, S. M., & Badura, J. M. (2007) · International Orthopaedics · doi:10.1007/s00264-007-0418-6 · Cited by 617
Qu, J., Zhao, X., Ma, P. X., & Guo, B. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.06.001 · Cited by 598
Wang, S., Zheng, H., Zhou, L., Cheng, F., Liu, Z., Zhang, H., Wang, L., & Zhang, Q. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c01371 · Cited by 575
A mini review on hydrogels classification and recent developments in miscellaneous applications
Varaprasad, K., Raghavendra, G. M., Jayaramudu, T., Yallapu, M. M., & Sadiku, R. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.05.096 · Cited by 534
Ultratough, Self-Healing, and Tissue-Adhesive Hydrogel for Wound Dressing
Chen, T., Chen, Y., Rehman, H. U., Chen, Z., Yang, Z., Wang, M., Li, H., & Liu, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b10064 · Cited by 532
Du, J., Sun, T., Song, W., Wu, J., & Wang, J. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200907210 · Cited by 522
Commercial hydrogels for biomedical applications
Aswathy, S. H., NarendraKumar, U., & Manjubala, I. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03719 · Cited by 511
Advanced nanogel engineering for drug delivery
Raemdonck, K., Demeester, J., & Smedt, S. C. D. (2008) · Soft Matter · doi:10.1039/b811923f · Cited by 475
Smart Hydrogels for Advanced Drug Delivery Systems
Khiabani, A. B., & Gasik, M. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073665 · Cited by 414
Genipin-crosslinked catechol-chitosan mucoadhesive hydrogels for buccal drug delivery
Xu, J., Strandman, S., Zhu, X. X., Barralet, J. E., & Cerruti, M. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.024 · Cited by 410
Rational design and latest advances of polysaccharide-based hydrogels for wound healing
Hu, H., & Xu, F. (2020) · Biomaterials Science · doi:10.1039/d0bm00055h · Cited by 406
Gao, Y., Kuang, Y., Guo, Z., et al. (2009) · Journal of the American Chemical Society · doi:10.1021/ja904411z · Cited by 403
Cheng, S., Wang, H., Pan, X., Zhang, C., Zhang, K., Chen, Z., Dong, W., Xie, A., & Qi, X. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c25014 · Cited by 399
Zhu, J., Li, F., Wang, X., Yu, J., & Wu, D. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18927 · Cited by 376
Chen, H., Xing, X., Tan, H., Yang, J., Zhou, T., Chen, Y., Ling, Z., & Hu, X. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.08.086 · Cited by 372
Chen, H., Cheng, R., Zhao, X., Zhang, Y., Tam, A., Yan, Y., Shen, H., Zhang, Y. S., Qi, J., Feng, Y., et al. (2019) · NPG Asia Materials · doi:10.1038/s41427-018-0103-9 · Cited by 369
Gao, F., Xu, Z., Liang, Q., Li, H., Peng, L., Wu, M., Zhao, X., Cui, X., Ruan, C., & Liu, W. (2019) · Advanced Science · doi:10.1002/advs.201900867 · Cited by 365
Therapeutic applications of hydrogels in oral drug delivery
Sharpe, L. A., Daily, A. M., Horava, S. D., & Peppas, N. A. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.902047 · Cited by 354
Varma, M. V. S., Obach, R. S., Rotter, C. J., Miller, H., Chang, G., Steyn, S. J., El‐Kattan, A. F., & Troutman, M. D. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm901371v · Cited by 349
Hydrazone linkages in pH responsive drug delivery systems
Sonawane, S. J., Kalhapure, R. S., & Govender, T. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.12.011 · Cited by 337
Yang, X. N., Zhang, C., Deng, D., et al. (2021) · Small · doi:10.1002/smll.202104368 · Cited by 303
Tao, B., Lin, C., Deng, Y., Yuan, Z., Shen, X., Chen, M., He, Y., Peng, Z., Hu, Y., & Cai, K. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb03272f · Cited by 290
A Comprehensive Map of FDA-Approved Pharmaceutical Products
Zhong, H., Chan, G., Yuanjia, H., Hu, H., & Ouyang, D. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040263 · Cited by 288
Alginate-chitosan oligosaccharide-ZnO composite hydrogel for accelerating wound healing
Zhang, M., Qiao, X., Han, W., Jiang, T., Liu, F., & Zhao, X. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118100 · Cited by 285
Hydrogels for delivery of bioactive agents: A historical perspective
Lee, S. C., Kwon, I. K., & Park, K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.015 · Cited by 273
Song, Q., Yin, Y., Shang, L., Wu, T., Zhang, D., Kong, M., Zhao, Y., He, Y., Tan, S., Guo, Y., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03186 · Cited by 258
Wang, Z., Ye, Q., Yu, S., & Akhavan, B. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300105 · Cited by 249
Injectable polymeric hydrogels for the delivery of therapeutic agents: A review
Nguyen, Q. V., Huỳnh, Đ. P., Park, J. H., & Lee, D. S. (2015) · European Polymer Journal · doi:10.1016/j.eurpolymj.2015.03.016 · Cited by 245
Ma, M., Zhong, Y., & Jiang, X. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116096 · Cited by 244
Liu, W., Ouyang, W., Zhang, C., Wang, Q., Pan, X., Huang, P., Zhang, C., Li, Y., Kong, D., & Wang, W. (2020) · ACS Nano · doi:10.1021/acsnano.0c03855 · Cited by 244
Wang, S., Zheng, H. S., Zhou, L., Cheng, F., Liu, Z., Zhang, H., & Zhang, Q. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120314 · Cited by 233
Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration
Ju, C., Mo, R., Xue, J., Zhang, L., Zhao, Z., Xue, L., Ping, Q., & Zhang, C. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201311227 · Cited by 229
Sobczak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084421 · Cited by 225
Lin, N., Gèze, A., Wouessidjewe, D., Huang, J. T., & Dufresne, A. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00555 · Cited by 224
Nanotheranostics for personalized medicine
Kim, T., Lee, S., & Chen, X. S. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.13.15 · Cited by 221
Sapuła, P., Bialik-Wąs, K., & Malarz, K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010253 · Cited by 218
Li, J., Yu, F., Chen, G., Liu, J. S., Li, X., Cheng, B., Mo, X., Chen, C., & Pan, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b17180 · Cited by 217
Injectable thermosensitive hydrogel-based drug delivery system for local cancer therapy
Xiao, Y., Gu, Y., Qin, L., Chen, L., Chen, X., Cui, W., Li, F., Xiang, N., & He, X. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111581 · Cited by 216
Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy
Yu, H., Gao, R.-Y., Liu, Y. L., Fu, L., Zhou, J., & Li, L. (2023) · Advanced Science · doi:10.1002/advs.202306152 · Cited by 212
(Macro)molecular self-assembly for hydrogel drug delivery
Webber, M. J., & Pashuck, E. T. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.006 · Cited by 204
Current Advances in Stimuli-Responsive Hydrogels as Smart Drug Delivery Carriers
Zhang, Y., & Wu, B. M. (2023) · Gels · doi:10.3390/gels9100838 · Cited by 202
Wu, M. Y., Chen, J., Huang, W., Yan, B., Peng, Q., Liu, J., Chen, L., & Zeng, H. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00347 · Cited by 201
Paclitaxel-loaded pH responsive hydrogel based on self-assembled peptides for tumor targeting
Raza, F., Zhu, Y., Chen, L., You, X., Zhang, J., Asifullah, K., Khan, M. W., Hasnat, M., Zafar, H., Wu, J., et al. (2019) · Biomaterials Science · doi:10.1039/c9bm00139e · Cited by 194
In situ formation of injectable hydrogels for chronic wound healing
Gao, Y., Li, Z., Huang, J., Zhao, M., & Wu, J. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01074j · Cited by 189
pH-Sensitive nanogels for drug delivery in cancer therapy
Li, Z., Huang, J. C., & Wu, J. (2020) · Biomaterials Science · doi:10.1039/d0bm01729a · Cited by 186
Injectable hydrogel composed of hydrophobically modified chitosan/oxidized-dextran for wound healing
Du, X., Liu, Y., Wang, X., Yan, H., Wang, L., Qu, L., Kong, D., Qiao, M., & Wang, L. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109930 · Cited by 182
Gradient nano-engineered in situ forming composite hydrogel for osteochondral regeneration
Radhakrishnan, J., Manigandan, A., Chinnaswamy, P., Subramanian, A., & Sethuraman, S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.01.056 · Cited by 181
Jahanban‐Esfahlan, R., Derakhshankhah, H., Haghshenas, B., Massoumi, B., Abbasian, M., & Jaymand, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.074 · Cited by 178
Liang, H., Hong, M.-H., Ho, R., Chung, C.-K., Lin, Y.-H., Chen, C., & Sung, H. (2004) · Biomacromolecules · doi:10.1021/bm049813w · Cited by 173
Song, S., Liu, Z., Abubaker, M. A., Ding, L., Zhang, J., Yang, S., & Fan, Z. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112171 · Cited by 173
Basu, A., Lindh, J., Ålander, E. M., Strømme, M., & Ferraz, N. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.06.073 · Cited by 166
Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery
Qu, Y., Chu, B., Wei, X., Lei, M., Hu, D., Zha, R., Zhong, L. X., Wang, M., Wang, F., & Qian, Z. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.016 · Cited by 166
Triamcinolone Acetonide Extended-Release: A Review in Osteoarthritis Pain of the Knee
Paik, J., Duggan, S. T., & Keam, S. J. (2019) · Drugs · doi:10.1007/s40265-019-01083-3 · Cited by 164
Fabricating hydrogels to mimic biological tissues of complex shapes and high fatigue resistance
Yang, H., Ji, M., Yang, M., Shi, M., Pan, Y., Zhou, Y., Qi, H. J., Suo, Z., & Tang, J. (2021) · Matter · doi:10.1016/j.matt.2021.03.011 · Cited by 161
Environment sensitive hydrogels for drug delivery applications
Qureshi, D., Nayak, S. K., Maji, S., Anis, A., Kim, D., & Pal, K. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.109220 · Cited by 159
Cunha, S., Forbes, B., Lobo, J. M. S., & Silva, A. C. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s305851 · Cited by 157
Lin, X., Fang, Y., Hao, Z., Wu, H., Zhao, M., Wang, S., & Liu, Y. (2021) · Small · doi:10.1002/smll.202103303 · Cited by 149
Deng, H., Yu, Z., Chen, S., Fei, L., Sha, Q., Zhou, N., Chen, Z., & Xu, C. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115565 · Cited by 143
Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review
Olteanu, G., Neacșu, S. M., JOIȚA, F. A., Musuc, A. M., Lupu, C. E., Ioniță-Mîndrican, C.-B., Lupuliasa, D., & Mititelu, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073849 · Cited by 140
Advancement in nanogel formulations provides controlled drug release
Ahmed, S., Alhareth, K., & Mignet, N. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119435 · Cited by 139
Salehi, S., Naghib, S. M., Garshasbi, H. R., Ghorbanzadeh, S., & Zhang, W. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1104126 · Cited by 133
Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications
Liu, J., Du, C., Huang, W., & Lei, Y. (2023) · Biomaterials Science · doi:10.1039/d3bm01352a · Cited by 133
Elkhoury, K., Koçak, P., Kang, A., Arab‐Tehrany, E., Ward, J. E., & Shin, S. R. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090849 · Cited by 132
Nanogels as target drug delivery systems in cancer therapy: A review of the last decade
Attama, A. A., Nnamani, P. O., Onokala, O. B., Ugwu, A. A., & Onugwu, A. L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.874510 · Cited by 132
Galactose-Decorated pH-Responsive Nanogels for Hepatoma-Targeted Delivery of Oridonin
Duan, C., Gao, J. B., Zhang, D., Jia, L., Liu, Y., Zheng, D., Liu, G., Tian, X., Wang, F., & Zhang, Q. (2011) · Biomacromolecules · doi:10.1021/bm201270m · Cited by 130
Nanogels as novel drug nanocarriers for CNS drug delivery
Vasanthan, M., Nivetha, R. P., Tamilanban, T., Narayanan, J., Subramaniyan, V., Fuloria, N. K., Chinni, S. V., Sekar, M., Fuloria, S., Wong, L. S., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1232109 · Cited by 130
Gou, M., Li, X., Dai, M., Gong, C., Wang, X., Xie, Y., Deng, H., Chen, L., Zhao, X., Qian, Z., et al. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.03.023 · Cited by 129
Synthesis of Nanogels: Current Trends and Future Outlook
Mauri, E., Giannitelli, S., Trombetta, M., & Rainer, A. (2021) · Gels · doi:10.3390/gels7020036 · Cited by 126
Wang, H., Zhou, S., Guo, L., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12355 · Cited by 119
Polymeric Hydrogels as Technology Platform for Drug Delivery Applications
Sosnik, A., & Seremeta, K. P. (2017) · Gels · doi:10.3390/gels3030025 · Cited by 117
Effective Drug Delivery System of Biopolymers Based On Nanomaterials and Hydrogels - A Review
Gopi, S., & Amalraj, A. (2016) · Drug Designing Open Access · doi:10.4172/2169-0138.1000129 · Cited by 115
Lima‐Sousa, R., de Melo‐Diogo, D., Alves, C. G., Cabral, . S. D., Miguel, S. P., Mendonça, A., & Correia, I. J. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111294 · Cited by 113
Kang, T., Cha, G. D., Park, O. K., Cho, H. R., Kim, M.-J., Lee, J., Kim, D., Lee, B., Chu, J., Koo, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c10094 · Cited by 113
An injectable anisotropic alginate hydrogel containing oriented fibers for nerve tissue engineering
Ghaderinejad, P., Najmoddin, N., Bagher, Z., et al. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130465 · Cited by 111
He, P., Du, X., Cheng, Y., Gao, Q., Liu, C., Wang, X., Wei, Y., Yu, Q., & Guo, W. (2022) · Small · doi:10.1002/smll.202200263 · Cited by 107
Li, Q., Zhang, Y., Huang, X., Yang, D., Weng, L., Ou, C., Song, X., & Dong, X. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127200 · Cited by 104
Redox-Responsive Hydrogels for Tunable and “On-Demand” Release of Biomacromolecules
Boz, R. K., Aydin, D., Kocak, S., Golba, B., Sanyal, R., & Sanyal, A. (2022) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.2c00094 · Cited by 104
Kong, X., Fu, J., Shao, K., Wang, L., Lan, X., & Shi, J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.10.011 · Cited by 102
Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules
Witting, M., Molina, M. A., Obst, K., Plank, R., Eckl, K., Hennies, H. C., Calderón, M., Frieß, W., & Hedtrich, S. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.02.017 · Cited by 96
Chen, W., Wang, C., Liu, W., Zhao, B., Zeng, Z., Long, F., Wang, C., Li, S., Lin, N., & Zhou, J. (2023) · Advanced Materials · doi:10.1002/adma.202209041 · Cited by 96
Zhang, H., Zhu, Y., Qu, L., Wu, H., Kong, H., Yang, Z., Chen, D., Mäkilä, E. M., Salonen, J., Santos, H. A., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.7b05210 · Cited by 93
A starch-based stimuli-responsive magnetite nanohydrogel as de novo drug delivery system
Massoumi, B., Mozaffari, Z., & Jaymand, M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.05.211 · Cited by 91
Nadernezhad, A., Caliskan, O. S., Topuz, F., Afghah, F., Erman, B., & Koc, B. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00665 · Cited by 91
The effects of surface topography modification on hydrogel properties
Cui, L., Yao, Y., & Yim, E. K. F. (2021) · APL Bioengineering · doi:10.1063/5.0046076 · Cited by 91
Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery
Ruiz, A. L., Ramirez, A., & McEnnis, K. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020421 · Cited by 91
Nakamura, T., Nakamura-Takahashi, A., Kasahara, M., Yamaguchi, A., & Azuma, T. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.01.136 · Cited by 89
Nezami, S., Sadeghi, M., & Mohajerani, H. (2020) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2020.109255 · Cited by 88
Soleimani, K., Arkan, E., Derakhshankhah, H., Haghshenas, B., Jahanban‐Esfahlan, R., & Jaymand, M. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117229 · Cited by 87
Protein-Based Nanohydrogels for Bioactive Delivery
Chander, S., Kulkarni, G. T., Dhiman, N., & Kharkwal, H. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.573748 · Cited by 87
Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects
Tanga, S., Aucamp, M. E., & Ramburrun, P. (2023) · Gels · doi:10.3390/gels9050418 · Cited by 87
Hajebi, S., Abdollahi, A., Roghani‐Mamaqani, H., & Salami‐Kalajahi, M. (2020) · Langmuir · doi:10.1021/acs.langmuir.9b03892 · Cited by 84
Giulbudagian, M., Yealland, G., Hönzke, S., Edlich, A., Geisendörfer, B., Kleuser, B., Hedtrich, S., & Calderón, M. (2017) · Theranostics · doi:10.7150/thno.21668 · Cited by 81
Cai, C., Wang, W., Liang, J., Li, Y., Lu, M., Cui, W., Fan, C., Deng, L., Li, Y., Wang, F., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202008364 · Cited by 80
Ponrasu, T., Ramachandran, B., Kannan, R., & Muthuvijayan, V. (2016) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33675 · Cited by 79
Nanogel loaded with surfactant based nanovesicles for enhanced ocular delivery of acetazolamide
Abdel-Rashid, R. S., Helal, D. A., Omar, M. M., et al. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s201891 · Cited by 77
Glatiramer acetate (Copaxone®) therapy for multiple sclerosis
Dhib-Jalbut, S. S. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00036-6 · Cited by 76
Single-, Dual-, and Multi-Stimuli-Responsive Nanogels for Biomedical Applications
Naveen Kumar, C. P., Singh, S., Sharma, P., Kumar, B., & Kumar, A. (2024) · Gels · doi:10.3390/gels10010061 · Cited by 74
Cao, Y., Cheng, Y., & Zhao, G. (2021) · Langmuir · doi:10.1021/acs.langmuir.1c00207 · Cited by 73
Luo, Y., Li, J., Hu, Y., Gao, F., Pak-Heng Leung, G., Geng, F., Fu, C., & Zhang, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.05.011 · Cited by 72
Hou, M., Liu, W., Zhang, L., Zhang, L., Xu, Z., Cao, Y., Kang, Y., & Xue, P. (2019) · Biomaterials Science · doi:10.1039/c9bm01472a · Cited by 70
Dual pH-responsive-charge-reversal micelle platform for enhanced anticancer therapy
Liao, J., Peng, H., Liu, C., Li, D., Yin, Y., Lü, B., Zheng, H. S., & Wang, Q. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111527 · Cited by 70
pH-Sensitive Peptide Hydrogels as a Combination Drug Delivery System for Cancer Treatment
Liu, Y., Ran, Y., Ge, Y., Raza, F., Li, S., Zafar, H., Wu, Y., Paiva‐Santos, A. C., Yu, C., Sun, M., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030652 · Cited by 70
Cartier, S., Horbett, T. A., & Ratner, B. D. (1995) · Journal of Membrane Science · doi:10.1016/0376-7388(95)00073-l · Cited by 68
Sabbagh, C. A., Séguin, J., Agapova, E., Kramerich, D., Boudy, V., & Mignet, N. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.10.011 · Cited by 68
Heparin-based temperature-sensitive injectable hydrogels for protein delivery
Sim, H. J., Thambi, T., & Lee, D. S. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01399b · Cited by 67
Naderi, Z., Azizian, J., Moniri, E., & Farhadyar, N. (2019) · Journal of Inorganic and Organometallic Polymers and Materials · doi:10.1007/s10904-019-01301-1 · Cited by 67
Nanogels: Recent Advances in Synthesis and Biomedical Applications
Mastella, P., Todaro, B., & Luin, S. (2024) · Nanomaterials · doi:10.3390/nano14151300 · Cited by 67
Tian, Y., Lei, M., Yan, L., et al. (2020) · Polymer Chemistry · doi:10.1039/d0py00004c · Cited by 65
Bewersdorff, T., Gruber, A., Eravci, M., Dumbani, M., Klinger, D., & Haase, A. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s215935 · Cited by 63
Dai, G., Sun, L., Xu, J., Zhao, G., Tan, Z. H., Wang, C., Sun, X., Xu, K., & Zhong, W. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.006 · Cited by 63
Fiorica, C., Palumbo, F. S., Pitarresi, G. L., et al. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119879 · Cited by 62
Liedtke, D., Hofmann, C., Jakob, F. J., Klopocki, E., & Graser, S. (2020) · Biomolecules · doi:10.3390/biom10121648 · Cited by 62
Chitosan‐Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery
Bai, X., Bao, Z., Bi, S., Yang, L., Yu, X., Hu, S., Tian, M., Zhang, X., Cheng, X., & Chen, X. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201700305 · Cited by 61
Zhou, T., Xiong, H., Yao, S., Wang, S., Li, S., Chang, J., Zhai, Z., Guo, D., Fan, C., & Gao, C. (2023) · Small · doi:10.1002/smll.202308599 · Cited by 61
Hydrogels for biomedical purposes
Rosiak, J. M., Ulański, P., & Rzeźnicki, A. (1995) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/0168-583x(95)00550-1 · Cited by 59
Lin, K., Yi, J., Mao, X., Wu, H., Zhang, L., & Yang, L. (2019) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2019.01.016 · Cited by 59
Bercea, M., & Lupu, A. (2024) · Gels · doi:10.3390/gels10040260 · Cited by 58
Zhang, W., Qi, X., Zhao, Y., Liu, Y., Xu, L., Song, X., Xiao, C., Yuan, X., Zhang, J., & Hou, M. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119543 · Cited by 55
Wei, Q., Ma, L., Zhang, W., Ma, G., & Hu, Z. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00074a · Cited by 54
Yang, Z., & Ding, J. (2008) · Macromolecular Rapid Communications · doi:10.1002/marc.200700872 · Cited by 53
Cai, D., Yang, Y., Lu, J., Yuan, Z., Zhang, Y., Yang, X., Huang, X., Li, T., Tian, X., Xu, B., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c15463 · Cited by 53
Gou, S., Xie, D., Ma, Y., et al. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01676 · Cited by 52
Dual thermoresponsive and pH-responsive self-assembled micellar nanogel for anticancer drug delivery
Chen, D., Yu, H., Sun, K., et al. (2013) · Drug Delivery · doi:10.3109/10717544.2013.838717 · Cited by 51
Mohamed, A. L., Soliman, A. A. F., Ali, E. A., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.068 · Cited by 51
Jahanban‐Esfahlan, R., Soleimani, K., Derakhshankhah, H., Haghshenas, B., Rezaei, A., Massoumi, B., Farnudiyan‐Habibi, A., Samadian, H., & Jaymand, M. (2021) · Journal of materials research/Pratt's guide to venture capital sources · doi:10.1557/s43578-021-00137-1 · Cited by 50
Controlled Release of Therapeutics From Enzyme-Responsive Biomaterials
Minehan, R. L., & Borgo, M. P. D. (2022) · Frontiers in Biomaterials Science · doi:10.3389/fbiom.2022.916985 · Cited by 50
Wang, J., Wang, Y., Sun, X., et al. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1607866 · Cited by 49
An enzyme-responsive membrane for antibiotic drug release and local periodontal treatment
Li, N., Jiang, L., Jin, H., Wu, Y. P., Liu, Y., Huang, W., Li, W., Zhou, Q., Chen, F., Gao, Y., et al. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110454 · Cited by 49
Smart nanogels for cancer treatment from the perspective of functional groups
Yu, J., Liu, Y., Zhang, Y., Ran, R., Kong, Z., Zhao, D., Liu, M., Zhao, W., Cui, Y., Hua, Y., et al. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1329311 · Cited by 49
Advancements in nanocomposite hydrogels: a comprehensive review of biomedical applications
Baishya, G., Parasar, B., Limboo, M., et al. (2024) · Discover Materials · doi:10.1007/s43939-024-00111-8 · Cited by 49
Smart Nanocomposite Hydrogels as Next-Generation Therapeutic and Diagnostic Solutions
Valentino, A., Yazdanpanah, S., Conte, R., Calarco, A., & Peluso, G. (2024) · Gels · doi:10.3390/gels10110689 · Cited by 49
Solomevich, S. O., Bychkovsky, P. M., Yurkshtovich, T. L., Golub, N. V., Мирчук, П. Ю., Ревтович, М. Ю., & Шмак, А. И. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115308 · Cited by 46
Haghighattalab, M., Kajbafzadeh, A. M., Baghani, M., Gharehnazifam, Z., Jobani, B. M., & Baniassadi, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.891166 · Cited by 46
Tang, W., Han, L., Duan, S., Lu, X., Wang, Y., Wu, X., Liu, J., & Ding, B. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00933 · Cited by 45
Magnetic Composite Biomaterials for Neural Regeneration
Funnell, J. L., Balouch, B., & Gilbert, R. J. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00179 · Cited by 44
Stewart, J. D., RAYBURN, W. F., Farmer, K. C., et al. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70127-9 · Cited by 42
Gordon, M. R., Zhao, B., Anson, F., Fernandez, A. C., Singh, K., Homyak, C., Canakci, M., Vachet, R. W., & Thayumanavan, S. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.7b01659 · Cited by 42
Polymer Nanogels as Reservoirs To Inhibit Hydrophobic Drug Crystallization
Li, Z., Zee, N. J. V., Bates, F. S., & Lodge, T. P. (2019) · ACS Nano · doi:10.1021/acsnano.8b06393 · Cited by 41
Off‐Stoichiometric Thiol‐Ene Chemistry to Dendritic Nanogel Therapeutics
Zhang, Y., Andrén, O. C. J., Nordström, R., Fan, Y., Malmsten, M., Mongkhontreerat, S., & Malkoch, M. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201806693 · Cited by 41
Atallah, M. A., Sallam, M. A., Abdelmoneem, M. A., et al. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112657 · Cited by 41
Wang, P., Lv, C., Zhou, X., et al. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01378a · Cited by 41
Lin, X., Miao, L., Wang, X., & Tian, H. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111200 · Cited by 40
Yan, M., Chen, T., Zhang, S., Lu, T., & Sun, X. (2021) · Journal of Biomaterials Science. Polymer Edition · doi:10.1080/09205063.2020.1866350 · Cited by 40
Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents
Kubeil, M., Suzuki, Y., Casulli, M. A., Kamal, R., Hashimoto, T., Bachmann, M. P., Hayashita, T., & Stephan, H. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301404 · Cited by 39
Basheer, A., Shahid, S., Kang, M., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c00676 · Cited by 38
Zhang, Z., Li, A., Min, X., Zhang, Q., Yang, J., Chen, G., Zou, M., Sun, W., & Cheng, G. (2020) · Biomaterials Science · doi:10.1039/d0bm01519a · Cited by 37
Zhu, X., Guan, B., Sun, Z., Tian, X., & Li, X. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01057c · Cited by 37
Robby, A. I., Yang, J., Jin, E., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202402367 · Cited by 37
Mahdavinia, G. R., Afzali, A., Etemadi, H., & Hosseinzadeh, H. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.22034/nmrj.2017.58964.1058 · Cited by 36
Boffito, M., Torchio, A., Tonda‐Turo, C., Laurano, R., Gisbert-Garzarán, M., Berkmann, J. C., Cassino, C., Manzano, M., Duda, G. N., Vallet‐Regí, M., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00384 · Cited by 36
Preparation of magnetic microgels based on dextran for stimuli-responsive release of doxorubicin
He, L., Zheng, R., Min, J., et al. (2020) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2020.167394 · Cited by 36
Wang, Z., Zhai, X., Fan, M., Tan, H., & Chen, Y. (2021) · European Polymer Journal · doi:10.1016/j.eurpolymj.2021.110644 · Cited by 36
Radiation Engineering of Multifunctional Nanogels
Dispenza, C., Spadaro, G., & Jönsson, M. (2016) · Topics in Current Chemistry · doi:10.1007/s41061-016-0071-x · Cited by 35
Tuneable peptide cross-linked nanogels for enzyme-triggered protein delivery
Massi, L., Najer, A., Chapman, R., Spicer, C. D., Nele, V., Che, J., Booth, M. A., Doutch, J., & Stevens, M. M. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01546f · Cited by 35
Debertrand, L., Zhao, J., Creton, C., et al. (2021) · Gels · doi:10.3390/gels7020072 · Cited by 35
Nagano, N., Miyata, S., Obana, S., et al. (2001) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/16.9.1870 · Cited by 34
Glucose-Responsive Injectable Thermogels via Dynamic-Covalent Cross-Linking of Pluronic Micelles
Xian, S., VandenBerg, M. A., Xiang, Y., et al. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00979 · Cited by 34
Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery
Wang, X., Cheng, D., Liu, L., et al. (2017) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2017.1295064 · Cited by 32
Wang, Z., Wu, J., Shi, X., Song, F., Gao, W., & Liu, S. (2020) · Polymers · doi:10.3390/polym12102204 · Cited by 31
Thermal-responsive magnetic hydrogels based on Tragacanth gum for delivery of anticancer drugs
Sayadnia, S., Arkan, E., Jahanban‐Esfahlan, R., Sayadnia, S., & Jaymand, M. (2021) · Journal of Polymer Research · doi:10.1007/s10965-020-02355-3 · Cited by 30
Wang, R. T., Wang, X., Mu, X., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.06.007 · Cited by 30
Wang, Y., Hu, W. S., Ding, B., Chen, D., & Cheng, L. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111195 · Cited by 29
Temperature and pH-responsive nanogels as intelligent drug delivery systems: A comprehensive review
Jha, A., Rama, A., Ladani, B., et al. (2021) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2021.1101201 · Cited by 29
Synthesis of Chemically Cross-Linked pH-Sensitive Hydrogels for the Sustained Delivery of Ezetimibe
Khan, R., Zaman, M., Salawi, A., et al. (2022) · Gels · doi:10.3390/gels8050281 · Cited by 29
Bao, S., Lu, Y., Zhang, J., Xue, L., Zhang, Y., Wang, P., Zhang, F., Gu, N., & Sun, J. (2023) · Nanoscale · doi:10.1039/d2nr05073k · Cited by 29
Manna, S., Ghosh, A. K., & Mandal, S. M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00951 · Cited by 28
Huang, Y., Wang, Z., Zhang, G., Ren, J., Li, Y., Liu, X., Yang, Y., Ravindran, A., Wong, C., & Chen, R. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02442b · Cited by 27
Zhou, D., Li, S., Fei, Z., Zhou, P., Zhao, Y., Zhi, L., Li, C., Peng, X., Liu, X., & Zhao, C. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c00772 · Cited by 27
Novel Nanogels Loaded with Mn(II) Chelates as Effective and Biologically Stable MRI Probes
Carniato, F., Ricci, M., Tei, L., et al. (2023) · Small · doi:10.1002/smll.202302868 · Cited by 27
Hydrogels and their potential uses in burn wound management
Edwards, J. (2010) · British Journal of Nursing · doi:10.12968/bjon.2010.19.sup4.48419 · Cited by 26
Balitaan, J. N. I., Luo, W.-J., Su, Y., et al. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00859 · Cited by 26
Flagged first, then by citations
Research works printed but not linked: 3
- Dwivedi, 2011, Hydrogel-A Conceptual Overview, Int. J. Pharm. Biol. Arch., 2, 1588
- Garg, 2016, Hydrogel: Classification, Properties, Preparation and Technical Features, Asian J. Biomater. Res., 2, 163
- Carruthers, J., Carruthers, A., Dover, J.S., Alam, M., and Ibrahim, O. (2023). Procedures in Cosmetic Dermatology: Soft Tissue Augmentation, Elsevier Health Sciences.
Cited by
Sorted by citations
e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7
“Complementary formulation strategies, such as mucoadhesive hydrogels, biofilm-disrupting adjuvants, and stimulus-responsive release systems, may further potentiate antifungal effects and improve clinical translation [130].”
Metadata
- Authors
- Delgado-Pujol, E. J., Martínez, G., Casado-Jurado, D., Vázquez, J., León-Barberena, J., Rodríguez-Lucena, D., Torres, Y., Alcudia, A., & Begines, B.
- Affiliations
- Universidad de Sevilla (ES)
- Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain
- Corresponding author
- Vázquez, Juan
- Begines, Belén
- ORCID
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2025-02-07
- Volume
- 17
- Issue
- 2
- Pages
- 215
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC11859140
- OpenAlex
- W4407240799
- Cited by
- 216
- References
- 232
- Citations by year
- 2026: 136 · 2025: 80
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by)
- Funders
- MICIU/AEI
- ERDF/EU
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- hydrogels, nanogels, drug delivery systems, controlled drug release, stimuli-responsive materials, chemical crosslinking, microfluidic synthesis, 3D printing, drug loading mechanism, enzyme-triggered release, sustained drug release, topical drug delivery, biosensors, surface functionalization, personalized medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
