The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Zhang, Xing; Flaws, Jodi A.; Spinella, Michael J.; Irudayaraj, Joseph

doi:10.3390/toxics11010032

Cited by 63Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactPer- and polyfluoroalkyl substances research

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

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Zhang, Xing, Flaws, Jodi A., Spinella, Michael J., Irudayaraj, Joseph·2022·Toxics

DOI 10.3390/toxics11010032PMC PMC9863798

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Abstract

Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.

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Zhang et al. found that short-chain PFASs such as PFBA have a shorter half-life in blood and do not accumulate as extensively in kidney tissue, while PFOS was more prevalent in human kidneys.
“Zhang et al. [204] compared long-chain and short-chain PFASs, highlighting that short-chain PFASs, such as perfluorobutyric acid (PFBA), have a shorter half-life in blood and do not accumulate as extensively in kidney tissue. In contrast, PFOS was found to be more prevalent in human kidneys.”
From Industrial Applications, Environmental Fate, Human Exposure, and Health Effects of PFAS (2025) · cites this paper as [204]
Section 3.1 says short-chain PFAS such as PFBA have a relatively short blood half-life and do not accumulate at high levels in human kidney tissue. It reports PFOS as abundant in the kidneys of Baltic guillemots, not as more prevalent in human kidneys. The human-kidney part of the PFOS comparison is therefore unsupported. (LLM, conf=0.88)
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RETRACTED: 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line
Fiorito, F., Ciarcia, R., Granato, G. E., Marfè, G., Iovane, V., Florio, S., Martino, L. D., & Pagnini, U. (2011) · Toxicology · doi:10.1016/j.tox.2011.10.004 · Cited by 40 · see citing works
Retracted
Production, use, and fate of all plastics ever made
Geyer, R., Jambeck, J. R., & Law, K. L. (2017) · Science Advances · doi:10.1126/sciadv.1700782 · Cited by 18,606 · see citing works
Lost at sea: where is all the plastic?
Thompson, R. C., Olsen, Y., Mitchell, R. P., Davis, A., Rowland, S. J., John, A. W. G., McGonigle, D., & Russell, A. E. (2004) · Science · doi:10.1126/science.1094559 · Cited by 7,765 · see citing works
A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects
Sunderland, E. M., Hu, X. C., Dassuncao, C., Tokranov, A. K., Wagner, C. C., & Allen, J. G. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0094-1 · Cited by 2,786 · see citing works
Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research
Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., & Roberts, S. M. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4890 · Cited by 2,445 · see citing works
Per- and polyfluoroalkyl substances in the environment
Evich, M. G., Davis, M. J. B., McCord, J. P., Acrey, B., Awkerman, J. A., Knappe, D. R. U., Lindstrom, A. B., Speth, T. F., Tebes-Stevens, C., Strynar, M. J., et al. (2022) · Science · doi:10.1126/science.abg9065 · Cited by 2,157 · cited 1× · see citing works
“Per- and polyfluoroalkyl substances are a class of chemicals (Figure 2b) used in many industrial and consumer products with the main function of resisting heat, stains, water, and grease [62,63].”
Background
Classify plastic waste as hazardous
Rochman, C. M., Browne, M. A., Halpern, B. S., Hentschel, B. T., Hoh, E., Karapanagioti, H. K., Rios-Mendoza, L. M., Takada, H., Teh, S., & Thompson, R. C. (2013) · Nature · doi:10.1038/494169a · Cited by 1,752 · see citing works
Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants
Hu, X. C., Andrews, D. Q., Lindstrom, A. B., Bruton, T. A., Schaider, L. A., Grandjean, P., Lohmann, R., Carignan, C. C., Blum, A., Balan, S. A., et al. (2016) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.6b00260 · Cited by 1,333 · see citing works
Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer
Nebert, D. W., Dalton, T. P., Okey, A. B., & Gonzalez, F. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400004200 · Cited by 1,185 · see citing works
Polystyrene Spherules in Coastal Waters
Carpenter, E. J., Anderson, S. J., Harvey, G. R., Miklas, H. P., & Peck, B. B. (1972) · Science · doi:10.1126/science.178.4062.749 · Cited by 1,115 · see citing works
Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs
EFSA Panel on Food Contact Materials, E. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.3978 · Cited by 1,026 · see citing works
Metabolism and Kinetics of Bisphenol A in Humans at Low Doses Following Oral Administration
Völkel, W., Colnot, T., Csanády, G. A., Filser, J. G., & Dekant, W. (2002) · Chemical Research in Toxicology · doi:10.1021/tx025548t · Cited by 1,006 · see citing works
Microplastic contamination of river beds significantly reduced by catchment-wide flooding
Hurley, R., Woodward, J., & Rothwell, J. J. (2018) · Nature Geoscience · doi:10.1038/s41561-018-0080-1 · Cited by 1,003 · see citing works
BIOCONCENTRATION AND TISSUE DISTRIBUTION OF PERFLUORINATED ACIDS IN RAINBOW TROUT (ONCORHYNCHUS MYKISS)
Martin, J. W., Mabury, S. A., Solomon, K. R., & Muir, D. C. G. (2003) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620220126 · Cited by 960 · see citing works
Phthalates and their impacts on human health
Wang, Y., & Qian, H. (2021) · Healthcare · doi:10.3390/healthcare9050603 · Cited by 633 · see citing works
Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life
Zhang, Y., Beesoon, S., Zhu, L., & Martin, J. W. (2013) · Environmental Science & Technology · doi:10.1021/es401905e · Cited by 530 · see citing works
Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure
Kundakovic, M., Gudsnuk, K., Franks, B., Madrid, J., Miller, R. L., Perera, F. P., & Champagne, F. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214056110 · Cited by 490 · see citing works
Dioxins sources and current remediation technologies — A review
Kulkarni, P. S., Crespo, J. G., & Afonso, C. A. M. (2007) · Environment International · doi:10.1016/j.envint.2007.07.009 · Cited by 461 · see citing works
The effects of phthalate ester exposure on human health: A review
Chang, W., Herianto, S., Lee, C.-C., Hung, H. Y., & Chen, H. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147371 · Cited by 397 · see citing works
Cancer Risk Among Firefighters: A Review and Meta-analysis of 32 Studies
Lemasters, G., Genaidy, A., Succop, P., Deddens, J., Sobeih, T. M., Barriera-Viruet, H., Dunning, K., & Lockey, J. (2006) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000246229.68697.90 · Cited by 377 · see citing works
Early Life Stage Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Zebrafish (Danio rerio)
Henry, T. R., Spitsbergen, J. M., Hornung, M. W., Abnet, C. C., & Peterson, R. E. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.8024 · Cited by 341 · see citing works
Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950–2009)
Daniels, R. D., Kubale, T. L., Yiin, J. H., Dahm, M. M., Hales, T. R., Baris, D., Zahm, S. H., Beaumont, J. J., Waters, K. M., & Pinkerton, L. E. (2014) · Occupational and Environmental Medicine · doi:10.1136/oemed-2013-101662 · Cited by 334 · see citing works
Hazardous Chemicals Associated with Plastics in the Marine Environment
Takada, H., Karapanagioti, H. K., & Amaral‐Zettler, L. (2018) · The handbook of environmental chemistry · doi:10.1007/978-3-319-95568-1 · Cited by 333 · see citing works
Hepatocarcinogenic Potential of Di(2-Ethylhexyl)phthalate in Rodents and its Implications on Human Risk
Huber, W. W., Grasl-Kraupp, B., & Schulte‐Hermann, R. (1996) · Critical Reviews in Toxicology · doi:10.3109/10408449609048302 · Cited by 302 · see citing works
Sex hormone-regulated renal transport of perfluorooctanoic acid
Kudo, N., Katakura, M., Sato, Y., & Kawashima, Y. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00006-6 · Cited by 293 · see citing works
Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion
Harada, K. H., Inoue, K., Morikawa, A., Yoshinaga, T., Saito, N., & Koizumi, A. (2005) · Environmental Research · doi:10.1016/j.envres.2004.12.003 · Cited by 286 · see citing works
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
Wang, L.-Q., Liu, T., Yang, S., Sun, L., Zhao, Z., Li, L.-Y., She, Y., Zheng, Y.-Y., Ye, X., Bao, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23201-0 · Cited by 263 · see citing works
Absorption, Distribution, and Toxicity of Per- and Polyfluoroalkyl Substances (PFAS) in the Brain: a Review
Cao, Y., & Ng, C. (2021) · Environmental Science: Processes & Impacts · doi:10.1039/d1em00228g · Cited by 250 · see citing works
The effects of environmental chemicals on renal function
Kataria, A., Trasande, L., & Trachtman, H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.94 · Cited by 248 · see citing works
Inhibition of Gap Junctional Intercellular Communication by Perfluorinated Compounds in Rat Liver and Dolphin Kidney Epithelial Cell Lines in Vitro and Sprague-Dawley Rats in Vivo
Hu, W. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.2.429 · Cited by 245 · see citing works
Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort
Blake, B. E., Pinney, S. M., Hines, E. P., Fenton, S. E., & Ferguson, K. K. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.07.042 · Cited by 236 · see citing works
Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma
Shearer, J. J., Callahan, C. L., Calafat, A. M., Huang, W., Jones, R. R., Sabbisetti, V. S., Freedman, N. D., Sampson, J. N., Silverman, D. T., Purdue, M. P., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa143 · Cited by 236 · see citing works
Perfluorinated Chemicals as Emerging Environmental Threats to Kidney Health: A Scoping Review
Stanifer, J. W., Stapleton, H. M., Souma, T., Wittmer, A., Zhao, X., & Boulware, L. E. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04670418 · Cited by 233 · see citing works
Chemical and Toxicological Evaluations of Isolated and Synthetic Chloro Derivatives of Dibenzo-p-dioxin
Higginbotham, G. R., Huang, A., Firestone, D., et al. (1968) · Nature · doi:10.1038/220702a0 · Cited by 184 · see citing works
Bioaccumulation and trophic magnification of pharmaceuticals and endocrine disruptors in a Mediterranean river food web
Ruhí, A., Acuña, V., Barceló, ‪., et al. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.06.009 · Cited by 180 · see citing works
A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and cancer risk in humans
Chang, E. T., Adami, H.-O., Boffetta, P., Cole, P., Starr, T. B., & Mandel, J. S. (2014) · Critical Reviews in Toxicology · doi:10.3109/10408444.2014.905767 · Cited by 180 · see citing works
Elimination of Endocrine Disrupting Chemicals using White Rot Fungi and their Lignin Modifying Enzymes: A Review
Cabana, H., Jones, J. P., & Agathos, S. N. (2007) · Engineering in Life Sciences · doi:10.1002/elsc.200700017 · Cited by 169 · see citing works
Di(2-ethylhexyl) phthalate inhibits antral follicle growth, induces atresia, and inhibits steroid hormone production in cultured mouse antral follicles
Hannon, P. R., Brannick, K. E., Wang, W., Gupta, R. K., & Flaws, J. A. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.02.010 · Cited by 166 · see citing works
Self-citation
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse
Moriguchi, T., Motohashi, H., Hosoya, T., Nakajima, O., Takahashi, S., Ohsako, S., Aoki, Y., Nishimura, N., Tohyama, C., Fujii-Kuriyama, Y., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1037886100 · Cited by 164 · see citing works
Phospholipid Levels Predict the Tissue Distribution of Poly- and Perfluoroalkyl Substances in a Marine Mammal
Dassuncao, C., Pickard, H. M., Pfohl, M., Tokranov, A. K., Li, M., Mikkelsen, B., Slitt, A. L., & Sunderland, E. M. (2019) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.9b00031 · Cited by 160 · see citing works
Per- and Polyfluoroalkyl Substances (PFAS) in Integrated Crop–Livestock Systems: Environmental Exposure and Human Health Risks
Jha, G., Kankarla, V., Mclennon, E., Pal, S., Sihi, D., Dari, B., Diaz, D., & Nocco, M. A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182312550 · Cited by 160 · see citing works
Exposure to Perfluoroalkyl Acids and Markers of Kidney Function Among Children and Adolescents Living Near a Chemical Plant
Watkins, D. J., Josson, J., Elston, B., Bartell, S. M., Shin, H.-M., Vieira, V. M., Savitz, D. A., Fletcher, T., & Wellenius, G. A. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205838 · Cited by 158 · see citing works
Pharmacokinetics of Perfluorooctanoate in Cynomolgus Monkeys
Butenhoff, J. L. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh302 · Cited by 151 · see citing works
Critical review on PFOA, kidney cancer, and testicular cancer
Bartell, S. M., & Vieira, V. M. (2021) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2021.1909668 · Cited by 151 · see citing works
In utero bisphenol A concentration, metabolism, and global DNA methylation across matched placenta, kidney, and liver in the human fetus
Nahar, M. S., Liao, C., Kannan, K., Harris, C., & Dolinoy, D. C. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2014.10.071 · Cited by 146 · see citing works
Environmental Pollution and Chronic Kidney Disease
Tsai, H.-J., Wu, P.-Y., Huang, J., & Chen, S. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.51594 · Cited by 141 · see citing works
Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study
Nagao, T., Ohta, R., Marumo, H., et al. (2000) · Reproductive Toxicology · doi:10.1016/s0890-6238(00)00105-2 · Cited by 140 · see citing works
A Critical Review about Human Exposure to Polychlorinated Dibenzo-p-Dioxins (PCDDs), Polychlorinated Dibenzofurans (PCDFs) and Polychlorinated Biphenyls (PCBs) through Foods
Fernández-González, R., Yebra-Pimentel, I., Martínez‐Carballo, E., & Simal‐Gándara, J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.710279 · Cited by 139 · see citing works
Endocrine disruption in aquatic systems: up‐scaling research to address ecological consequences
Windsor, F. M., Ormerod, S. J., & Tyler, C. R. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12360 · Cited by 137 · see citing works
Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid β-Oxidation Disorder, and Kidney Injury in a Manufactory in China
Lü, Y., Gao, K., Li, X., Tang, Z., Xiang, L., Zhao, H., Fu, J., Wang, L., Zhu, N., Cai, Z., et al. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b01608 · Cited by 134 · see citing works
Mono(2-Ethylhexyl) Phthalate Accelerates Early Folliculogenesis and Inhibits Steroidogenesis in Cultured Mouse Whole Ovaries and Antral Follicles1
Hannon, P. R., Brannick, K. E., Wang, W., & Flaws, J. A. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.129148 · Cited by 125 · see citing works
Self-citation
Tissue Distribution of Perfluorinated Surfactants in Common Guillemot (Uria aalge) from the Baltic Sea
Berger, U. (2008) · Environmental Science & Technology · doi:10.1021/es800529h · Cited by 124 · see citing works
Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco
Trowbridge, J., Gerona, R. R., Lin, T., Rudel, R. A., Bessonneau, V., Buren, H., & Morello-Frosch, R. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b05490 · Cited by 116 · see citing works
Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats
Doerge, D. R., Twaddle, N. C., Vanlandingham, M. M., Brown, R. P., & Fisher, J. W. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.009 · Cited by 113 · see citing works
Epigenetic toxicity of PFOA and GenX in HepG2 cells and their role in lipid metabolism
Wen, Y., Mirji, N., & Irudayaraj, J. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104797 · Cited by 113 · see citing works
Self-citation
Damaging Effects of Bisphenol A on the Kidney and the Protection by Melatonin: Emerging Evidences from In Vivo and In Vitro Studies
Kobroob, A., Peerapanyasut, W., Chattipakorn, N., & Wongmekiat, O. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3082438 · Cited by 112 · see citing works
Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer
Boyd, R. I., Ahmad, S., Singh, R., Fazal, Z., Prins, G. S., Madak‐Erdogan, Z., Irudayaraj, J., & Spinella, M. J. (2022) · Cancers · doi:10.3390/cancers14122919 · Cited by 112 · see citing works
Self-citation
Effects of Di-isononyl Phthalate, Di-2-ethylhexyl Phthalate, and Clofibrate in Cynomolgus Monkeys
Pugh, G. (2000) · Toxicological Sciences · doi:10.1093/toxsci/56.1.181 · Cited by 111 · see citing works
Metals as Catalysts during the Formation and Decomposition of Chlorinated Dioxins and Furans in Incineration Processes
Olie, K., Addink, R., & Schoonenboom, M. H. (1998) · Journal of the Air & Waste Management Association · doi:10.1080/10473289.1998.10463656 · Cited by 110 · see citing works
Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
Doerge, D. R., Twaddle, N. C., Woodling, K. A., & Fisher, J. W. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.07.009 · Cited by 109 · see citing works
Bisphenol S Interacts with Catalase and Induces Oxidative Stress in Mouse Liver and Renal Cells
Zhang, R., Liu, R., & Zong, W. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b02656 · Cited by 109 · see citing works
How the AHR Became Important in Cancer: The Role of Chronically Active AHR in Cancer Aggression
Wang, Z., Snyder, M., Kenison, J. E., Yang, K., Lara, B., Lydell, E., Bennani, K., Novikov, O., Federico, A. N., Monti, S., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010387 · Cited by 107 · see citing works
Tissue Distribution of Perfluorinated Chemicals in Harbor Seals ( Phoca vitulina ) from the Dutch Wadden Sea
de Vijver, K. I. V., Hoff, P. T., Das, K., Brasseur, S., Dongen, W. V., Esmans, E. L., Reijnders, P. J. H., Blust, R., & Coen, W. D. (2005) · Environmental Science & Technology · doi:10.1021/es050942+ · Cited by 104 · see citing works
Analytical Methodologies for the Determination of Endocrine Disrupting Compounds in Biological and Environmental Samples
Sosa‐Ferrera, Z., Santana, C. M., & Santana‐Rodríguez, J. J. (2013) · BioMed Research International · doi:10.1155/2013/674838 · Cited by 102 · see citing works
Effects of exposure to BDE-99 on oxidative status of liver and kidney in adult rats
Albina, M. L., Alonso, V., Linares, V., Bellés, M., Sirvent, J. J., Domingo, J. L., & Sánchez, D. J. (2010) · Toxicology · doi:10.1016/j.tox.2010.03.006 · Cited by 97 · see citing works
Evaluation of the developmental toxicity of 2,7-dibromocarbazole to zebrafish based on transcriptomics assay
Ji, C., Yan, L., Chen, Y., Yue, S., Dong, Q., Chen, J., & Zhao, M. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.01.079 · Cited by 95 · see citing works
Occurrence of Perfluorooctane Sulfonate and Other Perfluorinated Alkylated Substances in Harbor Porpoises from the Black Sea
de Vijver, K. I. V., Holsbeek, L., Das, K., Blust, R., Joiris, C. R., & Coen, W. D. (2006) · Environmental Science & Technology · doi:10.1021/es060827e · Cited by 91 · see citing works
Adverse Impact of Environmental Chemicals on Developmental Origins of Kidney Disease and Hypertension
Hsu, C., & Tain, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745716 · Cited by 88 · see citing works
Automated analysis of perfluorinated compounds in human hair and urine samples by turbulent flow chromatography coupled to tandem mass spectrometry
Pérez, F., Llorca, M., Farré, M., & Barceló, ‪. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5660-5 · Cited by 87 · see citing works
Comparison of potential drinking water source contamination across one hundred U.S. cities
Turner, S. W. D., Rice, J. S., Nelson, K. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27509-9 · Cited by 87 · see citing works
Renal Function, Bisphenol A, and Alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003–2006)
Li, Y., Zhu, X., Shrubsole, M. J., Fan, H. X., Chen, J., Dong, J., Hao, C., & Dai, Q. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002572 · Cited by 86 · see citing works
Acute PFOA exposure promotes epigenomic alterations in mouse kidney tissues
Rashid, F., Ramakrishnan, A., Fields, C. J., & Irudayaraj, J. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2019.12.010 · Cited by 86 · see citing works
Self-citation
A food web bioaccumulation model for the accumulation of per- and polyfluoroalkyl substances (PFAS) in fish: how important is renal elimination?
Sun, J., Kelly, B. C., Gobas, F. A. P. C., & Sunderland, E. M. (2022) · Environmental Science Processes & Impacts · doi:10.1039/d2em00047d · Cited by 85 · see citing works
Serially assessed bisphenol A and phthalate exposure and association with kidney function in children with chronic kidney disease in the US and Canada: A longitudinal cohort study
Jacobson, M. H., Wu, Y., Liu, M., Attinà, T. M., Naidu, M., Karthikraj, R., Kannan, K., Warady, B. A., Furth, S. L., Vento, S., et al. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003384 · Cited by 84 · see citing works
Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice
Harrill, J. A., Hukkanen, R. R., Lawson, M., Martin, G., Gilger, B., Soldatow, V., LeCluyse, E. L., Budinsky, R. A., Rowlands, J. C., & Thomas, R. S. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.06.024 · Cited by 83 · see citing works
Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes
Gwinn, W. M., Auerbach, S. S., Parham, F., et al. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa081 · Cited by 82 · see citing works
Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes
Conway, B., Badders, A., Costacou, T., Arthur, J., & Innes, K. (2018) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s173809 · Cited by 80 · see citing works
Effects of chronic phthalate exposure on the kidney
Crocker, J. F. S., Safe, S. H., & Acott, P. D. (1988) · Journal of Toxicology and Environmental Health · doi:10.1080/15287398809531126 · Cited by 79 · see citing works
Perfluorinated compounds in the aquatic food chains of two subtropical estuaries
Fauconier, G., Groffen, T., Wepener, V., & Bervoets, L. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135047 · Cited by 78 · see citing works
Plasticizer Di-(2-Ethylhexyl)Phthalate Induces Epithelial-to-Mesenchymal Transition and Renal Fibrosis In Vitro and In Vivo
Wu, C., Wang, C., Huang, L.-C., Liu, S., & Chiang, C. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy094 · Cited by 77 · see citing works
Renal Function and exposure to Bisphenol A and phthalates in children with Chronic Kidney Disease
Malits, J. R., Attinà, T. M., Karthikraj, R., Kannan, K., Naidu, M., Furth, S. L., Warady, B. A., Vento, S., Trachtman, H., & Trasande, L. (2018) · Environmental Research · doi:10.1016/j.envres.2018.08.006 · Cited by 77 · see citing works
Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women
Kang, H., Kim, S., Lee, G., Lee, I., Lee, J. P., Lee, J., Park, H., Moon, H., Park, J., Kim, S., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.01.028 · Cited by 77 · see citing works
Renal Endothelin-1 and Endothelin Receptor Type B Expression in Glomerular Diseases with Proteinuria
Lehrke, I., Waldherr, R., Ritz, E., et al. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12112321 · Cited by 76 · see citing works
Absorption, disposition and metabolism of di‐isononyl phthalate (DINP) in F‐344 rats
McKee, R. H., El-Hawari, M., Stoltz, M., Pallas, F., & Lington, A. W. (2002) · Journal of Applied Toxicology · doi:10.1002/jat.861 · Cited by 75 · see citing works
Effects of PCBs and PBDEs on thyroid hormone, lymphocyte proliferation, hematology and kidney injury markers in residents of an e-waste dismantling area in Zhejiang, China
Xu, P., Lou, X., Ding, G., Shen, H., Wu, L., Chen, Z., Han, J., & Wang, X. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.07.025 · Cited by 71 · see citing works
Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway
Bao, L., Zhao, C., Feng, L., Zhao, Y., Duan, S., Qiu, M., Wu, K., Zhang, N., Hu, X., & Fu, Y. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.112909 · Cited by 71 · see citing works
Transfer of persistent organic pollutants in food of animal origin – Meta-analysis of published data
Amutova, F., Delannoy, M., Baubekova, A., Konuspayeva, G. S., & Jurjanz, S. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128351 · Cited by 70 · see citing works
B isphenol A in Chronic Kidney Disease
Krieter, D. H., Canaud, B., Lemke, H., Rodriguez, A., Morgenroth, A., von Appen, K., Gp, D., & Wanner, C. (2012) · Artificial Organs · doi:10.1111/j.1525-1594.2012.01556.x · Cited by 69 · see citing works
Pretreatment techniques and analytical methods for phenolic endocrine disrupting chemicals in food and environmental samples
Deng, Z., Li, N., Jiang, H., et al. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.07.003 · Cited by 69 · see citing works
Aryl hydrocarbon receptor activation mediates kidney disease and renal cell carcinoma
Zhao, H., Chen, L., Tian, Y., Feng, Y., Vaziri, N. D., Liu, B., Liu, Q., Guo, Y. P., & Zhao, Y. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2054-5 · Cited by 69 · see citing works
Association between serum concentrations of perfluoroalkyl substances (PFAS) and expression of serum microRNAs in a cohort highly exposed to PFAS from drinking water
Xu, Y., Mlakar, S. J., Li, Y., Wahlberg, K. E., Scott, K., Pineda, D., Lindh, C. H., Jakobsson, K., & Engström, K. (2020) · Environment International · doi:10.1016/j.envint.2019.105446 · Cited by 69 · see citing works
Exposure to phthalates DEHP and DINP May lead to oxidative damage and lipidomic disruptions in mouse kidney
Gu, Y., Mei, G., Zhang, W., Yan, L., Shao, F., & Zhou, J. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.129740 · Cited by 69 · see citing works
Lycopene Preventing DEHP-Induced Renal Cell Damage Is Targeted by Aryl Hydrocarbon Receptor
Li, M., Zhao, Y. P., Wang, H.-R., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05250 · Cited by 69 · see citing works
Effect of Body Condition on Tissue Distribution of Perfluoroalkyl Substances (PFASs) in Arctic Fox (Vulpes lagopus)
Bakken, C., Fuglei, E., Herzke, D., Yoccoz, N. G., & Routti, H. (2014) · Environmental Science & Technology · doi:10.1021/es503147n · Cited by 67 · see citing works
Organ-specific effects of long term feeding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-p-dioxin on I-compounds in hepatic and renal DNA of female Sprague-Dawley rats
Randerath, K., Putman, K. L., Randerath, E., et al. (1988) · Carcinogenesis · doi:10.1093/carcin/9.12.2285 · Cited by 66 · see citing works
Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration
Dzierlenga, A. L., Robinson, V. G., Waidyanatha, S., DeVito, M. J., Eifrid, M. A., Gibbs, S. T., Granville, C. A., & Blystone, C. R. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1683776 · Cited by 66 · see citing works
Mechanisms of Developmental Toxicity of Dioxins and Related Compounds
Yoshioka, W., & Tohyama, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030617 · Cited by 64 · see citing works
Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice
Priego, A. R., Parra, E. G., Mas, S., Morgado‐Pascual, J. L., Ruiz‐Ortega, M., & Rayego‐Mateos, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137189 · Cited by 64 · see citing works
Toxicological Evaluation of Bisphenol A and Its Analogues
İYİGÜNDOĞDU, İ., Üstündağ, A., & Duydu, Y. (2020) · Turkish Journal of Pharmaceutical Sciences · doi:10.4274/tjps.galenos.2019.58219 · Cited by 62 · see citing works
Dioxin-Dependent and Dioxin-Independent Gene Batteries: Comparison of Liver and Kidney in AHR-Null Mice
Boutros, P. C., Bielefeld, K. A., Pohjanvirta, R., & Harper, P. A. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp191 · Cited by 58 · see citing works
Effect of di(2-ethylhexyl) phthalate on Nrf2-regulated glutathione homeostasis in mouse kidney
Amara, I., Salah, A., Timoumi, R., et al. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-020-01127-8 · Cited by 57 · see citing works
Approach to distribution and accumulation of dibutyl phthalate in rats by immunoassay
Zeng, Q., Wei, C., Wu, Y., Li, K., Ding, S., Yuan, J., Yang, X., & Chen, M. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.01.045 · Cited by 53 · see citing works
Di(2-ethylhexyl)phthalate-induced renal oxidative stress in rats and protective effect of selenium
Erkekoğlu, P., Giray, B., Kızılgün, M., Rachidi, W., Hininger‐Favier, I., Roussel, A., Favier, A. E., & Hıncal, F. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2012.666652 · Cited by 53 · see citing works
Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
Moreno‐Gómez‐Toledano, R., Arenas, M. I., Vélez, E. V., Coll, E., Quiroga, B., Bover, J., & Bosch, R. J. (2021) · Biomolecules · doi:10.3390/biom11071046 · Cited by 53 · see citing works
Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN)
Park, S. K., Wang, X., Ding, N., Karvonen-Gutierrez, C. A., Calafat, A. M., Herman, W. H., Mukherjee, B., & Harlow, S. D. (2022) · Diabetologia · doi:10.1007/s00125-022-05695-5 · Cited by 53 · see citing works
Epigenetic Modifications, and Alterations in Cell Cycle and Apoptosis Pathway in A549 Lung Carcinoma Cell Line upon Exposure to Perfluoroalkyl Substances
Jabeen, M., Fayyaz, M., & Irudayaraj, J. (2020) · Toxics · doi:10.3390/toxics8040112 · Cited by 50 · see citing works
Self-citation
A SPE-HPLC-MS/MS method for the simultaneous determination of prioritised pharmaceuticals and EDCs with high environmental risk potential in freshwater
Li, Y., Taggart, M. A., McKenzie, C., Zhang, Z., Lü, Y., Pap, S., & Gibb, S. W. (2020) · Journal of Environmental Sciences · doi:10.1016/j.jes.2020.07.013 · Cited by 49 · see citing works
Bisphenol A-induced apoptosis, oxidative stress and DNA damage in cultured rhesus monkey embryo renal epithelial Marc-145 cells
Yuan, J., Kong, Y., Ommati, M. M., Tang, Z., Li, H., Li, L., Zhao, C., Shi, Z., & Wang, J. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.06.125 · Cited by 47 · see citing works
Effects of intravenous and oral di(2-ethylhexyl) phthalate (DEHP) and 20% Intralipid vehicle on neonatal rat testis, lung, liver, and kidney
Camacho, L., Latendresse, J. R., Muskhelishvili, L., Law, C., & Delclos, K. B. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111497 · Cited by 47 · see citing works
The antagonistic effect of bisphenol A and nonylphenol on liver and kidney injury in rats
Shi, R., Liu, Z., & Liu, T. (2021) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2021.1950179 · Cited by 46 · see citing works
TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys
Dong, B., Nishimura, N., Vogel, C. F. A., Tohyama, C., & Matsumura, F. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.08.031 · Cited by 45 · see citing works
Serum bisphenol A as a predictor of chronic kidney disease progression in primary hypertension
Hu, J., Wang, Y., Xiang, X., Peng, C. X., Gao, R., Goswami, R., Zhou, H., Zhang, Y., Zhen, Q., Cheng, Q., et al. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000780 · Cited by 45 · see citing works
Dibutyl phthalate-induced activation of ROS and ERK1/2 causes hepatic and renal damage in Kunming mice
Cheng, L., Li, J., Cheng, J., et al. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119843583 · Cited by 45 · see citing works
High Concentrations of Unidentified Extractable Organofluorine Observed in Blubber from a Greenland Killer Whale ( Orcinus orca )
Schultes, L., van Noordenburg, C., Spaan, K. M., Plassmann, M. M., Simon, M. J., Roos, A. M., & Benskin, J. P. (2020) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.0c00661 · Cited by 45 · see citing works
In vitro studies in microsomes from rat and human liver, kidney, and intestine suggest that perfluorooctanoic acid is not a substrate for microsomal UDP-glucuronosyltransferases
Kemper, R. A., & Nabb, D. L. (2005) · Drug and Chemical Toxicology · doi:10.1081/dct-200064468 · Cited by 44 · see citing works
Body size–dependent bioaccumulation, tissue distribution, and trophic and maternal transfer of phenolic endocrine-disrupting contaminants in a freshwater ecosystem
Peng, X., Zheng, K., Liu, J., Fan, Y., Tang, C., & Xiong, S. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4150 · Cited by 44 · see citing works
Oxidative damage in the liver and kidney induced by dermal exposure to diisononyl phthalate in Balb/c mice
Liang, F., & Yan, B. (2020) · Toxicology and Industrial Health · doi:10.1177/0748233719900861 · Cited by 44 · see citing works
Perfluorobutanoic acid (PFBA): No high-level accumulation in human lung and kidney tissue
Abraham, K., El‐Khatib, A. H., Schwerdtle, T., & Monien, B. H. (2021) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2021.113830 · Cited by 44 · see citing works
Relationship between emergent BPA-substitutes and renal and cardiovascular diseases in adult population
Moreno‐Gómez‐Toledano, R. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120106 · Cited by 44 · see citing works
Urinary phthalate metabolites mixture, serum cytokines and renal function in children: A panel study
Liu, M., Zhao, L., Liu, L., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126963 · Cited by 43 · see citing works
Hepatic and renal functions in growing male rats after bisphenol A and octylphenol exposure
Yıldız, N., & Barlas, N. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327112464796 · Cited by 42 · see citing works
Bisphenol A aggravates renal ischemia–reperfusion injury by disrupting mitochondrial homeostasis and N‐acetylcysteine mitigates the injurious outcomes
Peerapanyasut, W., Kobroob, A., Palee, S., Chattipakorn, N., & Wongmekiat, O. (2019) · IUBMB Life · doi:10.1002/iub.2175 · Cited by 42 · see citing works
Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factors
Wen, Y., Rashid, F., Fazal, Z., Singh, R., Spinella, M. J., & Irudayaraj, J. (2022) · Current Zoology · doi:10.1093/eep/dvac010 · Cited by 42 · see citing works
Self-citation
First evidence of polybrominated diphenyl ether (flame retardants) effects in feral barbel from the Ebro River basin (NE, Spain)
Raldúa, D., Padrós, F., Solé, M., et al. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.05.037 · Cited by 41 · see citing works
Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke
Ishida, M., Mikami, S., Shinojima, T., Kosaka, T., Mizuno, R., Kikuchi, E., Miyajima, A., Okada, Y., & Oya, M. (2014) · International Journal of Cancer · doi:10.1002/ijc.29398 · Cited by 40 · see citing works
Dioxins (PCDD/Fs) and PCBs in offal: Occurrence and dietary exposure
Fernandes, A., Mortimer, D., Rose, M., & Gem, M. (2010) · Chemosphere · doi:10.1016/j.chemosphere.2010.06.034 · Cited by 40 · see citing works
Effects of bisphenol A treatment during pregnancy on kidney development in mice: a stereological and histopathological study
Núñez, P., Fernández, T.-R., García‐Arévalo, M., Alonso‐Magdalena, P., Nadal, Á., Perillán, C., & Argüelles, J. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417000939 · Cited by 39 · see citing works
Pregnancy-induced changes in serum concentrations of perfluoroalkyl substances and the influence of kidney function
Nielsen, C., Hall, U. A., Lindh, C. H., Ekström, U., Xu, Y.-Y., Li, Y., Holmäng, A., & Jakobsson, K. (2020) · Environmental Health · doi:10.1186/s12940-020-00626-6 · Cited by 39 · see citing works
Nephrotoxicity of Bisphenol A (BPA) -An Updated Review
Gowder, S. J. (2014) · Current Molecular Pharmacology · doi:10.2174/1874467207666140410115823 · Cited by 38 · see citing works
Association of Dioxin and Other Persistent Organic Pollutants (POPs) with Diabetes: Epidemiological Evidence and New Mechanisms of Beta Cell Dysfunction
Tata, V. D. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15057787 · Cited by 37 · see citing works
Dynamics of associations between perfluoroalkyl substances and uric acid across the various stages of glomerular function
Jain, R. B., & DUCATMAN, A. M. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-04666-5 · Cited by 37 · see citing works
Using Polychlorinated Naphthalene Concentrations in the Soil from a Southeast China E-Waste Recycling Area in a Novel Screening-Level Multipathway Human Cancer Risk Assessment
Niu, S., Tao, W., Chen, R., et al. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c00128 · Cited by 37 · see citing works
Bisphenol A aggravates renal apoptosis and necroptosis in selenium‐deficient chickens via oxidative stress and PI3K/AKT pathway
Chen, H., Zhang, Y., Zou, M., Qi, X., & Xu, S. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30781 · Cited by 37 · see citing works
Risk assessment for PFOA and kidney cancer based on a pooled analysis of two studies
Steenland, K., Hofmann, J. N., Silverman, D. T., & Bartell, S. M. (2022) · Environment International · doi:10.1016/j.envint.2022.107425 · Cited by 37 · see citing works
Determination of Free and Conjugated Forms of Endocrine-Disrupting Chemicals in Human Biological Fluids by Gc−MS
Azzouz, A., Rascón, A. J., & Ballesteros, E. (2016) · Bioanalysis · doi:10.4155/bio-2015-0008 · Cited by 36 · see citing works
Kidney cancer in utility workers exposed to polychlorinated biphenyls (PCBs)
Shalat, S. L., True, L. D., Fleming, L. E., et al. (1989) · Occupational and Environmental Medicine · doi:10.1136/oem.46.11.823 · Cited by 35 · see citing works
Perfluoroalkylated Substance Effects in Xenopus laevis A6 Kidney Epithelial Cells Determined by ATR-FTIR Spectroscopy and Chemometric Analysis
Gorrochategui, E., Lacorte, S., Tauler, R., & Martin, F. L. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00076 · Cited by 34 · see citing works
Renal function and the exposure to melamine and phthalates in Shanghai adults
Chen, J., Shi, X., Zhou, X., Dong, R., Yuan, Y., Wu, M., Chen, W., Liu, X., Jia, F., Li, S., et al. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.125820 · Cited by 34 · see citing works
Role of neutrophil extracellular traps in chronic kidney injury induced by bisphenol-A
Tong, S., Yang, S., Li, T., Gao, R., Hu, J., Luo, T., 青华, Zhen, Q., Hu, R., Li, X., et al. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0608 · Cited by 33 · see citing works
Association between two common environmental toxicants (phthalates and melamine) and urinary markers of renal injury in the third trimester of pregnant women: The Taiwan Maternal and Infant Cohort Study (TMICS)
Tsai, H.-J., Kuo, F.-C., Wu, C., et al. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.129925 · Cited by 33 · see citing works
Association of CYP1A1 gene polymorphism with chronic kidney disease: A case control study
Siddarth, M., Datta, S. K., Ahmed, R. S., et al. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.03.008 · Cited by 32 · see citing works
Short-term effect of bisphenol-a on oxidative stress responses in Atlantic salmon kidney cell line: a transcriptional study
Yazdani, M., Andresen, A. M. S., & Gjøen, T. (2016) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2016.1177864 · Cited by 32 · see citing works
Maternal exposure to di-n-butyl phthalate promotes Snail1-mediated epithelial-mesenchymal transition of renal tubular epithelial cells via upregulation of TGF-β1 during renal fibrosis in rat offspring
Zhao, S., Jiang, J., Deng, L., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.10.073 · Cited by 32 · see citing works
Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health
Singh, R. D., Koshta, K., Tiwari, R., Khan, H., Sharma, V., & Srivastava, V. K. (2021) · Frontiers in Toxicology · doi:10.3389/ftox.2021.663372 · Cited by 30 · see citing works
PFOA induces alteration in DNA methylation regulators and SARS-CoV-2 targets Ace2 and Tmprss2 in mouse lung tissues
Ahmad, S., Wen, Y., & Irudayaraj, J. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.11.014 · Cited by 30 · see citing works
Self-citation
Bisphenol A analogs in patients with chronic kidney disease and dialysis therapy
Shen, Y., Liu, T., Shi, Y., et al. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109684 · Cited by 29 · see citing works
Endocrine disruptor bisphenol A is implicated in urinary voiding dysfunction in male mice
Nicholson, T. M., Nguyen, J. L., LEVERSON, G. E., Taylor, J. A., Saal, F. S. V., Wood, R. W., & Ricke, W. A. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00582.2017 · Cited by 28 · see citing works
Phthalates in children toys available in Malaysian market: Quantification and potential human health risk
Praveena, S. M., Fong, C., & Amaruddin, A. F. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105955 · Cited by 28 · see citing works
Maternal exposure to ambient particulate matter and green spaces and fetal renal function
Sani, A. R., Abroudi, M., Heydari, H., Adli, A., Miri, M., Mehrabadi, S., Pajohanfar, N. S., Raoufinia, R., Bazghandi, M. S., Ghalenovi, M., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109285 · Cited by 27 · see citing works
Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice
Taylor, J. A., Jones, M. B., Besch-Williford, C. L., Berendzen, A. F., Ricke, W. A., & Saal, F. S. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113902 · Cited by 27 · see citing works
Associations of serum bisphenol A levels with incident chronic kidney disease risk
Nie, H., Wang, F., Zhang, Y., Zhang, S., Han, X., Zhang, X., Guo, H., & He, M. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145401 · Cited by 27 · see citing works
Self-citation
Associations between serum PFOA and PFOS levels and incident chronic kidney disease risk in patients with type 2 diabetes
Li, Z., Zhang, Y., Wang, F., Wang, R., Zhang, S., Zhang, Z., Li, P., Yao, J., Bi, J., He, J., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.113060 · Cited by 27 · see citing works
Self-citation
Mitigation of PFAS in U.S. Public Water Systems: Future steps for ensuring safer drinking water
Voulgaropoulos, A. (2022) · Environmental Progress & Sustainable Energy · doi:10.1002/ep.13800 · Cited by 27 · see citing works
The emerging contaminant 3,3′-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio)
Roy, M. A., Sant, K. E., Venezia, O. L., Shipman, A. B., McCormick, S. D., Saktrakulkla, P., Hornbuckle, K. C., & Timme‐Laragy, A. R. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113027 · Cited by 26 · see citing works
Activation of the RhoA/ROCK pathway contributes to renal fibrosis in offspring rats induced by maternal exposure to di-n-butyl phthalate
Ye, Q., Zhao, S., Zhang, Y., et al. (2020) · Toxicology · doi:10.1016/j.tox.2020.152573 · Cited by 26 · see citing works
Thymoquinone protection against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induced nephrotoxicity in rats
Erdemli, M. E., Yiğitcan, B., Erdemli, Z., et al. (2020) · Biotechnic & Histochemistry · doi:10.1080/10520295.2020.1735520 · Cited by 25 · see citing works
Combined Effects of Repeated Administration of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Polychlorinated Biphenyls on Kidneys of Male Rats
Lu, C., Wang, Y., Peng, S., et al. (2009) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-009-9323-x · Cited by 24 · see citing works
Early life PCB138 exposure induces kidney injury secondary to hyperuricemia in male mice
Ruan, F., Liu, C., Hu, W., Ruan, J., Ding, X., Zhang, L., Yang, C., Zuo, Z., He, C., & Huang, J. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.118977 · Cited by 24 · see citing works
A Pretreatment Method for GC–MS Determination of Endocrine Disrupting Chemicals in Mollusk Tissues
Liu, Y., Guan, Y., Mizuno, T., et al. (2008) · Chromatographia · doi:10.1365/s10337-008-0852-7 · Cited by 23 · see citing works
Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children
Lee, Y. J., Lim, Y., Shin, C. H., Kim, B.-N., Kim, J. I., Hong, Y., Cho, Y. M., & Lee, Y. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268503 · Cited by 23 · see citing works
The independent and interactive effects of phthalates exposure and hypertension on the indicators of early renal injury in US adults: Evidence from NHANES 2001–2004
Liu, S., Yang, R., Yang, Q., He, G., Chen, B., & Dong, R. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113733 · Cited by 23 · see citing works
Environmental toxicants impair liver and kidney function and sperm quality of captive pandas
Chen, Y., Liu, Q., Ma, Q., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.07.008 · Cited by 22 · see citing works
Exacerbating lupus nephritis following BPA exposure is associated with abnormal autophagy in MRL/lpr mice.
Dong, Y., Zhang, Z., Liu, H., Jia, L., Qin, M., & Wang, X. (2020) · PubMed Central · Cited by 22 · see citing works
Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis
Liang, F., Xi, J., Chen, X., et al. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211001124 · Cited by 21 · see citing works
Transgenerational mass balance and tissue distribution of PCBs and PCDD/Fs from grass silage and soil into cow-calf continuum
Driesen, C., Zennegg, M., Rothacher, M., Dubois, S., Wyss, U., Nowack, B., & Lerch, S. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135745 · Cited by 21 · see citing works
Phthalates Exposure as Determinant of Albuminuria in Subjects With Type 2 Diabetes: A Cross-Sectional Study
Mengozzi, A., Carli, F., Biancalana, E., Latta, V. D., Seghieri, M., Gastaldelli, A., & Solini, A. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01797 · Cited by 20 · see citing works
Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice
Esteban, J., Sánchez-Pérez, I., Hamscher, G., Miettinen, H. M., Korkalainen, M., Viluksela, M., Pohjanvirta, R., & Håkansson, H. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.02.004 · Cited by 20 · see citing works
Critical review on PFOA, kidney cancer, and testicular cancer
Stevenson, E. D., Kleinman, M. T., Bai, X., Barlaz, M. A., Abraczinskas, M., Guidry, V. T., Watson, J. G., & Chow, J. (2021) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2021.1975995 · Cited by 20 · see citing works
Effect of bisphenol A on Ca 2+ fluxes and viability in Madin-Darby canine renal tubular cells
Kuo, C., Huang, J., Chou, C., et al. (2011) · Drug and Chemical Toxicology · doi:10.3109/01480545.2011.556645 · Cited by 19 · see citing works
Renal and hepatic effects following neonatal exposure to low doses of Bisphenol-A and 137Cs
Esplugas, R., Llovet, M. I., Bellés, M., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.02.046 · Cited by 19 · see citing works
Comparison of the renal effects of bisphenol A in mice with and without experimental diabetes. Role of sexual dimorphism
Moreno‐Gómez‐Toledano, R., Arenas, M. I., Muñóz‐Moreno, C., Olea‐Herrero, N., Reventún, P., Izquierdo‐Lahuerta, A., Antón-Cornejo, A., Martínez, M. G.-S., Zaragoza, C., Saura, M., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166296 · Cited by 19 · see citing works
Distribution, Transformation, and Long-Term Accumulation of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in Different Tissues of Fish and Piscivorous Birds
Wu, W. Z., Zhang, Q. H., Schramm, K., et al. (2000) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.2000.1920 · Cited by 18 · see citing works
Female AhR Knockout Mice Develop a Minor Renal Insufficiency in an Adenine-Diet Model of Chronic Kidney Disease
Makhloufi, C., Nicolas, F., McKay, N., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072483 · Cited by 18 · see citing works
Bisphenol A impairs renal function by reducing Na+/K+-ATPase and F-actin expression, kidney tubule formation in vitro and in vivo
Yoo, M. H., Lee, S., Kim, W., Kim, Y., Kim, Y., Moon, K., & Lee, B. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114141 · Cited by 18 · see citing works
In utero di-n-butyl phthalate exposure induced abnormal autophagy in renal tubular cells via hedgehog signaling in newborn rats
Zhao, S., Pan, L., Chen, M., et al. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109189 · Cited by 16 · see citing works
Benchmark dose in the presence of coexposure to melamine and diethylhexyl phthalate and urinary renal injury markers in pregnant women
Chen, C., Wang, Y.-H., Wu, C., Hsieh, C., Wang, S., Chen, M.-L., Tsai, H.-J., Li, S.-S., Liu, C., Tsai, Y., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114187 · Cited by 16 · see citing works
Regulation of mRNA Translation Is a Novel Mechanism for Phthalate Toxicity
Ling, J., Lopez-Dee, Z. P., Cottell, C., Wolfe, L. G., & Nye, D. M. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167914 · Cited by 15 · see citing works
Emerging Endocrine Disrupting Chemicals and Pharmaceuticals in Vietnam: A Review of Environmental Occurrence and Fate in Aquatic and Indoor Environments
Tran, T. M., Anh, D. H., Hoai, P. M., Minh, N. H., Nam, V. D., Viet, P. H., & Minh, T. B. (2016) · ACS symposium series · doi:10.1021/bk-2016-1244.ch010 · Cited by 14 · see citing works
Selective endothelin A receptor antagonism in patients with proteinuric chronic kidney disease
Provenzano, M., Andreucci, M., Garofalo, C., Minutolo, R., Serra, R., & Nicola, L. D. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2021.1869720 · Cited by 14 · see citing works
Toxicological assessment of low-dose bisphenol A, lead and endosulfan combination: chronic toxicity study in male rats
Dökmeci, A. H., Karaboğa, İ., Güzel, S., et al. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16407-8 · Cited by 14 · see citing works
Zinc Deficiency Exacerbates Bisphenol A–Induced Hepatic and Renal Damage: Delineation of Molecular Mechanisms
Charaya, A., Sahu, C., Singla, S., & Jena, G. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03392-3 · Cited by 14 · see citing works
Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney
Kitazawa, T., Sato, T., Nishiyama, K., et al. (2011) · Gene Expression Patterns · doi:10.1016/j.gep.2011.04.001 · Cited by 13 · see citing works
Selenium deficiency aggravates bisphenol A‐induced autophagy in chicken kidney through regulation of nitric oxide and adenosine monophosphate activated protein kinase /mammalian target of rapamycin signaling pathway
Chen, H., Zhang, Y., Qi, X., Xu, S., Huang, X., & Xu, S. (2022) · Environmental Toxicology · doi:10.1002/tox.23613 · Cited by 13 · see citing works
Transfer and uptake of polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) and polychlorinated biphenyls (PCBs) into meat and organs of indoor and outdoor reared pigs
Rose, M., Fernandes, A., Foxall, C. D., et al. (2011) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2011.635346 · Cited by 12 · see citing works
Is PFOA a renal carcinogen?
Fenner, A. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-00388-3 · Cited by 12 · see citing works
Kidney cancer in utility workers exposed to polychlorinated biphenyls (PCBs)
Lees, R. E. M. (1990) · Occupational and Environmental Medicine · doi:10.1136/oem.47.5.358 · Cited by 11 · see citing works
Association between Blood Dioxin Level and Chronic Kidney Disease in an Endemic Area of Exposure
Huang, C.-Y., Wu, C.-L., Wu, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150248 · Cited by 10 · see citing works
Concentrations of bisphenol A and its associations with urinary albumin creatinine ratios across the various stages of renal function
Jain, R. B. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11535-z · Cited by 9 · see citing works
War on carcinogens: Industry disputes human relevance of chemicals causing cancer in laboratory animals based on unproven hypotheses, using kidney tumors as an example
Melnick, R. L., Ward, J. M., & Huff, J. (2013) · International Journal of Occupational and Environmental Health · doi:10.1179/1077352513z.00000000090 · Cited by 8 · see citing works
New Evidence of Renal and Cardiovascular Alterations Promoted by Bisphenol A
Moreno‐Gómez‐Toledano, R., Arenas, M. I., Vélez, E. V., Saura, M., & Bosch, R. J. (2021) · Biomolecules · doi:10.3390/biom11111649 · Cited by 8 · see citing works
Derivation of a Human In Vivo Benchmark Dose for Bisphenol A from ToxCast In Vitro Concentration Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation
Loizou, G. D., McNally, K., Paini, A., & Hogg, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.754408 · Cited by 8 · see citing works
Histopathological Changes in the Kidney of Mosquito Fish , Gambusia Affinis and Guppy Fish , Poecilia Reticulata Exposed to Bisphenol A
Elshaer, F. M., Walid, A. A.-S., & Sayed, A. (2013) · Egyptian Journal of Aquatic Biology and Fisheries · doi:10.12816/0011055 · Cited by 7 · see citing works
Effects of bisphenol-A (BPA) on body weight, hematological parameters and histo-texture of kidney in swiss albino mice
Hoque, E., Sujan, K. M., Mia, M. S., et al. (2021) · Asian Journal of Medical and Biological Research · doi:10.3329/ajmbr.v6i4.51229 · Cited by 7 · see citing works
Impact of Firefighting Aqueous Film-Forming Foams on Human Cell Proliferation and Cellular Mortality
Kafkoutsou, A. L., Yang, Y.-P., Zeynaloo, E., Deo, S. K., Solle, N. S., Kobetz, E. N., Daunert, S., & Caban-Martinez, A. J. (2022) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000002527 · Cited by 6 · see citing works
Nephrotoxicity of flame retardants: An understudied but critical toxic endpoint
Kramer, N. E., Barnett, L. M. A., & Cummings, B. S. (2022) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2022.100359 · Cited by 6 · see citing works
Metabolic profiles in serum of mouse after chronic exposure to drinking water
Zhang, Y., Wu, B., Zhang, X., et al. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110386817 · Cited by 5 · see citing works
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Trends in concentrations of selected dioxins and furans across various stages of kidney function for US adults
Jain, R. B. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-13844-3 · Cited by 5 · see citing works
Association between Bisphenol A Urine Level with Low-Grade Albuminuria in Egyptian Children and Adolescents
Mahfouz, N. N., El-Din, E. M. S., Armaneous, A. F., et al. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.6499 · Cited by 5 · see citing works
Global DNA Hypomethylation and Rassf1a and c-myc Promoter Hypermethylation in Rat Kidney Cells after Bisphenol a Exposure
TuzcuoĞlu, P., & Özden, S. (2020) · Turkish Journal of Pharmaceutical Sciences · doi:10.4274/tjps.galenos.2019.57983 · Cited by 4 · see citing works
Impact of kidney hyperfiltration on concentrations of selected perfluoroalkyl acids among US adults for various disease groups
Jain, R. B. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11855-0 · Cited by 4 · see citing works

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Industrial Applications, Environmental Fate, Human Exposure, and Health Effects of PFAS
Hasan, M., Habib, A., Alam, M., Islam, S., & Halim, E. (2025) · Pollutants · doi:10.3390/pollutants5040043 · Cited by 21 · see citing works
“Regarding kidney disease, Zhang et al. [204] compared long-chain and short-chain PFASs, highlighting that short-chain PFASs, such as perfluorobutyric acid (PFBA), have a shorter half-life in blood and do not accumulate as extensively in kidney tissue.”

Authors: Zhang, X., Flaws, J. A., Spinella, M. J., & Irudayaraj, J.
Affiliations: University of Illinois Urbana-Champaign (US)
Corresponding author: Irudayaraj, Joseph
ORCID: Flaws, Jodi A.
Spinella, Michael J.
Irudayaraj, Joseph
Venue: Toxics
Publisher: MDPI AG
Published: 2022-12-29
Volume: 11
Issue: 1
Pages: 32
ISSN: 2305-6304 (ISSN-L)
DOI: 10.3390/toxics11010032
PMC: PMC9863798
OpenAlex: W4313362030
Cited by: 63
References: 204
Citations by year: 2026: 12 · 2025: 22 · 2024: 21 · 2023: 8
FWCI: 1.24
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Toxics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: External Research Board, OVCRI, University of Illinois at Urbana-Champaign (R01ES034112-01A1)
NIEHS (R01ES034112-01A1)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Keywords: endocrine disruptors, kidney disease, dioxins, per- and polyfluoroalkyl substances, bisphenol A, phthalates, proteinuria, glomerular lesions, renal tubules, renal fibrosis, kidney cancer, renal accumulation, target genes, signaling pathways

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The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

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