Alcohol use disorder and depressive disorders

McHugh, RK

doi:10.35946/arcr.v40.1.01

Cited by 517Substance Abuse Treatment and OutcomesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

Alcohol use disorder and depressive disorders

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McHugh, RK·2019·Alcohol Research: Current Reviews

DOI 10.35946/arcr.v40.1.01PMC PMC6799954

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Abstract

Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance. The aim of this review is to characterize the prevalence, course, and treatment of co-occurring AUD and depressive disorders. Studies have indicated that the co-occurrence of AUD and depressive disorders is associated with greater severity and worse prognosis for both disorders. Both pharmacologic and behavioral treatments have demonstrated efficacy for this population. However, treatment response is somewhat modest, particularly for drinking outcomes, highlighting the importance of further research on the etiology and treatment of co-occurring AUD and depressive disorders. Key future directions include studies to understand the heterogeneity of both AUD and depressive disorders, research on novel treatment approaches to enhance outcomes, and better understanding of sex and gender differences.

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Abstinence from or reduction in SUD behaviors often accompanies similar reductions in mood, anxiety and other comorbid symptoms.
“Similarly, abstinence from or a reduction in SUD behaviors often accompanies similar reductions in mood, anxiety and other comorbid symptoms (241, 242).”
From The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines (2023) · cites this paper as [242]
The Course and prognosis section (page unavailable) says depressive symptoms significantly improve after 3–4 weeks of alcohol abstinence. The Medication trials section also reports that alcohol abstinence had a strong effect on remission of depression. The paper does not establish the same pattern for SUDs generally or for anxiety and other comorbid symptoms. (LLM, conf=0.86)
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Mekonen, T., Ford, S., Chan, G., Hides, L. M., Connor, J. P., & Leung, J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.046 · Cited by 60 · see citing works
Addictive and other mental disorders: a call for a standardized definition of dual disorders
Szerman, N., Torrens, M., Maldonado, R. J., Balhara, Y. P. S., Salom, C., Maremmani, I., Sher, L., Didia-Attas, J., Chen, J., & Baler, R. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02212-5 · Cited by 59 · see citing works
“, cannabis/attention deficit [54], tobacco use disorder/ schizophrenia [55], alcoholism/depression [56], gambling/ADHD [57–59], drug use/schizophrenia [60]; smoking/suicide attempts [61], cocaine/ADHD [62], seem to show at least some common genetic bases.”
Background
Metabolic syndrome — a new definition and management guidelines
Dobrowolski, P., Prejbisz, A., Kuryłowicz, A., Baska, A., Burchardt, P., Chlebus, K., Dzida, G. J., Jankowski, P., Jaroszewicz, J., Jaworski, P., et al. (2022) · Arterial Hypertension · doi:10.5603/ah.a2022.0012 · Cited by 53 · see citing works
Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies
Вячеславовна, Г. А., Svirin, E. P., Pavlov, D., Cespuglio, R., Proshin, A. T., Schroeter, C. A., Lesch, K., & Strekalova, T. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020915 · Cited by 54 · see citing works
Advances in the mechanisms of polysaccharides in alleviating depression and its complications
Guo, Y., Chen, X., Gong, P., Li, Z., Wu, Y., Zhang, J., Wang, J., Yao, W., Yang, W., & Chen, F. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154566 · Cited by 53 · see citing works
Mood and Anxiety Symptoms in Persons Taking Prescription Opioids: A Systematic Review with Meta-Analyses of Longitudinal Studies
Leung, J., Santo, T., Colledge‐Frisby, S., Mekonen, T., Thomson, K., Degenhardt, L. J., Connor, J. P., Hall, W., & Stjepanović, D. (2022) · Pain Medicine · doi:10.1093/pm/pnac029 · Cited by 49 · see citing works
“Mood disorders can be triggered by the use of, misuse of, or withdrawal from other substances [9], with a notably high co-occurrence of depression and alcohol use disorder [10].”
The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines
Brewerton, T. D. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1149433 · Cited by 46 · see citing works
“Similarly, abstinence from or a reduction in SUD behaviors often accompanies similar reductions in mood, anxiety and other comorbid symptoms (241, 242).”
Background
Understanding Mental Health Challenges in Cardiovascular Care
Borkowski, P., & Borkowska, N. (2024) · Cureus · doi:10.7759/cureus.54402 · Cited by 45 · see citing works
Winning The Game Against Depression: A Systematic Review of Video Games for the Treatment of Depressive Disorders
Ruiz, M., Moreno, M., Serrano, B. G., Díaz-Oliván, I., Muñoz, L. J., González‐Garrido, C., & Porras‐Segovia, A. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01314-7 · Cited by 45 · see citing works
Psychological Stressors Predicting Increased Drinking During the COVID-19 Crisis: A Longitudinal National Survey Study of Workers in Finland
Oksanen, A., Savolainen, I., Savela, N., & Oksa, R. (2020) · Alcohol and Alcoholism · doi:10.1093/alcalc/agaa124 · Cited by 43 · see citing works
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
Ben‐Azu, B., Moke, E. G., Chris-Ozoko, L. E., Jaiyeoba-Ojigho, E. J., Adebayo, O. G., Ajayi, A. M., Oyovwi, M. O., Odjugo, G., Omozojie, V. I., Ejomafuwe, G., et al. (2024) · Psychopharmacology · doi:10.1007/s00213-023-06509-1 · Cited by 38 · see citing works
“…people who consume alcohol during difficult life situations as a coping strategy may develop a chronic alcohol use disorder (AUDs), a highly disabling and comorbid condition, pro-foundly associated with social withdrawal, anxiety, and cognitive decline (Kuria et al. 2012; McHugh and Weiss 2019).”
The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults
Jahan-Mihan, A., Stevens, P., Medero-Alfonso, S., Brace, G., Overby, L. K., Berg, K., & Labyak, C. A. (2024) · Nutrients · doi:10.3390/nu16121902 · Cited by 40 · see citing works
Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review
Fischler, P. V., Soyka, M., Seifritz, E., & Mutschler, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927703 · Cited by 34 · see citing works
“Furthermore, there is a potentiation of harm due to frequent co-occurrence of alcohol disorder with depression and other comorbid psychiatric disorders (McHugh and Weiss, 2019), in addition to the association with other substance use disorders (Alcover et al.”
Background
Alcohol and melatonin
Kurhaluk, N. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1899198 · Cited by 34 · see citing works
Structural sexism and Women's alcohol use in the United States, 1988–2016
McKetta, S. C., Prins, S. J., Hasin, D. S., Patrick, M. E., & Keyes, K. M. (2022) · Social Science & Medicine · doi:10.1016/j.socscimed.2022.114976 · Cited by 34 · see citing works
Trends in US Alcohol Consumption Frequency During the First Wave of the SARS‐CoV‐2 Pandemic
McKetta, S. C., Morrison, C. N., & Keyes, K. M. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14575 · Cited by 33 · see citing works
“We additionally include two mental health covariates, depression and anxiety, both of which are associated with alcohol consumption (Marmorstein, 2009; McHugh and Weiss, 2019; Smith and Randall, 2012).”
Background
Alcohol Withdrawal and the Associated Mood Disorders—A Review
Ngui, H. H. L., Kow, A. S. F., Lai, S., Tham, C. L., Ho, Y., & Lee, M. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314912 · Cited by 31 · see citing works
“Individuals suffering from alcoholinduced depression would experience emotional distress and depressive symptoms during the course of alcohol intoxication or withdrawal, where their condition usually alleviates following about one month of complete abstinence [99].”
BackgroundInfluential
Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis
Pacho, M., Aymerich, C., Pedruzo, B., de Pablo, G. S., Pardo, E. S., Bordenave, M., Dieguez, R., Lopez-Zorroza, I., Herrero, J., Laborda, M., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1264998 · Cited by 30 · see citing works
“Comorbidity between depression and alcohol use occurs in both directions and common but not fully understood pathophysiological processes have been postulated to explain their co-occurrence (88).”
Background
Substance use and mental health burden in head and neck and other cancer survivors: A National Health Interview Survey analysis
Balachandra, S., Eary, R. L., Lee, R. C., Wynings, E. M., Sher, D. J., Sura, T., Liu, Y., Tillman, B. N., Sumer, B. D., Arnold, E. M., et al. (2021) · Cancer · doi:10.1002/cncr.33881 · Cited by 30 · see citing works
Real-Time Assessment of Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and Depressive Disorders
King, A. C., Fischer, A. M., Cursio, J., Didier, N. A., Lee, Z., & Fridberg, D. J. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240069 · Cited by 29 · see citing works
Comorbid alcohol use disorder in psychiatric MDD patients: A five-year prospective study
Holma, M., Holma, I. A. K., & Isometsä, E. T. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.024 · Cited by 29 · see citing works
Mental health in medical and biomedical doctoral students during the 2020 COVID-19 pandemic and racial protests
Schad, A., Layton, R. L., Ragland, D. A., & Cook, J. G. (2022) · eLife · doi:10.7554/elife.69960 · Cited by 29 · see citing works
Alcohol consumption and associated factors among middle-aged and older adults: results from China Health and Retirement Longitudinal Study
Wang, Q., Zhang, Y., & Wu, C. (2022) · BMC Public Health · doi:10.1186/s12889-022-12718-8 · Cited by 28 · see citing works
“Several variables such as depression, poor health status and sleeping problems, commonly co-occur with alcohol use disorder, and alcohol use disorder might increase the risk of those health-related disorders [28, 29].”
Background
Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy
Gatta, E., Camussi, D., Auta, J., Guidotti, A., & Pandey, S. C. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108299 · Cited by 28 · see citing works
Neuroprotective effect of fucoidan by regulating gut-microbiota-brain axis in alcohol withdrawal mice
Xue, M., Teng, X., Liang, H. W., Zhao, J., Jiang, Y., Qiu, X., Zhang, Z., Pei, Z., Zhang, N., & Qin, Y. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104726 · Cited by 27 · see citing works
Contribution of sleep disturbances to the heterogeneity of cognitive and brain alterations in alcohol use disorder
Lanièpce, A., Lahbairi, N., Cabé, N., Pitel, A., & Rauchs, G. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101435 · Cited by 26 · see citing works
State earned income tax credits and depression and alcohol misuse among women with children
Morgan, E. R., Hill, H. D., Mooney, S. J., Rivara, F. P., & Rowhani‐Rahbar, A. (2022) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2022.101695 · Cited by 25 · see citing works
“Given the cyclical relationship between poverty, poor mental health, and substance misuse, policies that aim to reduce economic hardship may also alleviate depressive symptoms and alcohol misuse (McHugh and Weiss, 2019; Boden and Fergusson, 2011).”
Background
Substance use, microbiome and psychiatric disorders
Chivero, E. T., Sil, S., Kumar, M., & Buch, S. J. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173432 · Cited by 24 · see citing works
Temporal associations between depressive features and self-stigma in people with substance use disorders related to heroin, amphetamine, and alcohol use: a cross-lagged analysis
Saffari, M., Chang, K., Chen, J., Chang, C.-W., Chen, I., Huang, S.-W., Liu, C.-H., Lin, C., & Potenza, M. N. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04468-z · Cited by 25 · see citing works
“Nearly three million deaths annually may be attributable to alcohol consumption worldwide, and alcohol use may contribute substantially to psychological problems [17, 18].”
Background
Effects of GLP‐1 Receptor Agonists in Alcohol Use Disorder
Klausen, M. K., Knudsen, G. M., Vilsbøll, T., & Fink‐Jensen, A. (2025) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70004 · Cited by 23 · see citing works
Learn, Engage, Act, Dedicate (LEAD): development and feasibility testing of a task-shifted intervention to improve alcohol use, depression and family engagement for fathers
Giusto, A. M., Ayuku, D., & Puffer, E. S. (2022) · International Journal of Mental Health Systems · doi:10.1186/s13033-022-00522-1 · Cited by 22 · see citing works
“Most common among these is depression [32].”
Substance use and common contributors to morbidity: A genetics perspective
Sanchez‐Roige, S., Kember, R. L., & Arpana Agrawal, A. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104212 · Cited by 23 · see citing works
The effects of lipopolysaccharide exposure on social interaction, cytokine expression, and alcohol consumption in male and female mice
Ramirez, E. B. D., Arnold, M. E., McConnell, K. T., Solomon, M. G., Amico, K. N., & Schank, J. R. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114159 · Cited by 23 · see citing works
“One longitudinal study found that AUD in adolescent participants predicted MDD in early adulthood, and MDD in early adulthood predicted later AUD [15].”
Influential
Anxiety, Depression, Coping, Alcohol Use and Consequences in Young Adult College Students
McConaha, C. D., McCabe, B. E., & Falcon, A. L. (2023) · Substance Use & Misuse · doi:10.1080/10826084.2023.2270550 · Cited by 23 · see citing works
“Anxiety and depression are commonly comorbid with alcohol use; alcohol use disorder doubles the risk of anxiety or major depression (Smith & Randall, 2012; McHugh & Weiss, 2019).”
Background
Trends and characteristics in ketamine use among US adults with and without depression, 2015–2022
Yang, K. H., Kepner, W. E., Cleland, C. M., & Palamar, J. J. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.12.108 · Cited by 22 · see citing works
Effect of vortioxetine in subjects with major depressive and alcohol use disorders: a 6-month retrospective analysis
Nicola, M. D., Pepe, M., Panaccione, I., Moccia, L., Dattoli, L., Molinaro, M., Sani, G., Janiri, L., & McIntyre, R. S. (2020) · CNS Spectrums · doi:10.1017/s109285292000173x · Cited by 22 · see citing works
“Therefore, some authors suggest that treatment should be considered even in substance-induced depression.(13) The evaluation of further clinical and psychopathological dimensions, such as anhedonia, cognitive features, and overall functioning, might be useful to better understand the full spectrum of severity ofMDD+AU…”
BackgroundInfluential
Alcohol Induced Depression: Clinical, Biological and Genetic Features
Farré, A., Tirado-Muñoz, J., Spataro, N., Alías-Ferri, M., Torrens, M., & Fonseca, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082668 · Cited by 22 · see citing works
“Diagnosis and treatment of the commonly co-occurring AUD and depressive disorders implies many challenges [15].”
Background
Sex Differences in the Association Between Poor Sleep Quality and Alcohol-Related Problems Among Heavy Drinkers With Insomnia
Verlinden, J. J., Moloney, M., Whitehurst, L. N., & Weafer, J. J. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.875168 · Cited by 21 · see citing works
Association between clinical measures of unhealthy alcohol use and subsequent year hospital admissions in a primary care population
Jack, H. E., Oliver, M. M., Berger, D. B., Bobb, J. F., Bradley, K. A., & Hallgren, K. A. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.109821 · Cited by 22 · see citing works
Update on Pharmacological Treatment for Comorbid Major Depressive and Alcohol Use Disorders: The Role of Extended-release Trazodone
Nicola, M. D., Pepe, M., Panaccione, I., Moccia, L., Janiri, L., & Sani, G. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230403080624 · Cited by 21 · see citing works
“This clinical population is often difficult to manage in real-world practice and, given the lack of comparative trials, the most effective approach is still uncertain [6].”
BackgroundResultInfluential
Socio-economic inequalities in the association between alcohol use disorder and depressive disorder among Thai adults: a population-based study
Assanangkornchai, S., Nontarak, J., Aekplakorn, W., Chariyalertsak, S., Kessomboon, P., & Taneepanichskul, S. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02958-6 · Cited by 21 · see citing works
“Research evidence reveals some potential developmental pathways for the co-occurrence of AUD and depressive disorders, including: (1) depressive disorders increase the risk for AUD, (2) AUD increases the risk for depressive disorders, and (3) both conditions share a similar pathophysiology or have common risk factors,…”
Background
Is the association between psychological distress and risky alcohol consumption shifting over time? An age-period-cohort analysis of the Australian population
Halladay, J. E., Slade, T. N., Chapman, C., Mewton, L. R., O’Dean, S., Visontay, R., Baillie, A., Teesson, M., & Sunderland, M. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115356 · Cited by 20 · see citing works
“The positive correlation between distress and alcohol may suggest that increases in population-level distress over time should also generate similar increases in alcohol use (Bell and Britton, 2014; Berg et al., 2019; Fernandes et al., 2020; McHugh and Weiss, 2019).”
Chronic Pain in Relation to Depressive Disorders and Alcohol Abuse
Maleki, N., & Oscar‐Berman, M. (2020) · Brain Sciences · doi:10.3390/brainsci10110826 · Cited by 20 · see citing works
“Similarly, the synergistic effects of comorbid depression and ALC have been associated with greater severity for both disorders [37].”
Background
Changes in Substance Use and Mental Health Burden among Women during the Second Wave of COVID-19 in Germany
Schecke, H., Fink, M., Bäuerle, A., Skoda, E., Schweda, A., Musche, V., Dinse, H., Weismüller, B., Moradian, S., Scherbaum, N., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189728 · Cited by 21 · see citing works
“Co-occurrence of AUD and depressive disorders is associated with greater severity and worse prognosis for both disorders [53].”
Background
Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders
Nunes, E. J., Kebede, N., Bağdaş, D., & Addy, N. (2022) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.747 · Cited by 18 · see citing works
Major Depression in Comorbidity with Substance use Disorders: Patients’ Features and Clinical-Neurobiological Rationale of Antidepressant Treatments
Filippis, S. D., Martinotti, G., Nicoletti, F., Mastrostefano, A., Trovini, G., Pugliese, A., & Nicola, M. D. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240827165327 · Cited by 20 · see citing works
“Patients with comorbid MDD-AUD show a more severe course of illness, serious cognitive impairments, worse adherence and response to treatment, and a higher risk of suicide [80, 81].”
Effects of a digital cognitive behavioral therapy for insomnia on sleep and alcohol consumption in heavy drinkers: A randomized pilot study
Verlinden, J. J., Moloney, M., Vsevolozhskaya, O. A., Ritterband, L. M., Winkel, F., & Weafer, J. J. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15209 · Cited by 19 · see citing works
Masculine depression and its problem behaviors: use alcohol and drugs, work hard, and avoid psychiatry!
von Zimmermann, C., Hübner, M., Mühle, C., Müller, C. P., Weinland, C., Kornhuber, J., & Lenz, B. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01567-0 · Cited by 19 · see citing works
“Substance abuse frequently co-occurs with Major Depressive Disorder (MDD) [21–23].”
Background
Lavender essential oil alleviates depressive-like behavior in alcohol-withdrawn rats: Insights from gut metabolites and hippocampal transcriptome analysis
Li, X., Xiao, D., Li, C., Wu, T., Li, L., Li, T., Pan, X., Liu, Q., Chi, M., Li, R., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116835 · Cited by 18 · see citing works
Effectiveness of digital interventions for people with comorbid heavy drinking and depression: A systematic review and narrative synthesis
O'Donnell, A. J., Schmidt, C. S., Beyer, F. R., Schrietter, M., Anderson, P., Jané‐Llopis, E., Kaner, E., & Schulte, B. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.039 · Cited by 17 · see citing works
Alcohol misuse in patients with alcohol‐related liver disease: How can we do better? A narrative review of the literature
Horrell, J., Callaghan, L., & Dhanda, A. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14895 · Cited by 17 · see citing works
Alcohol use as a predictor of the course of major depressive disorder: a prospective population-based study
Schouten, M. J. E., ten Have, M., Tuithof, M., de Graaf, R., Dekker, J., Goudriaan, A. E., & Blankers, M. (2023) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796023000070 · Cited by 17 · see citing works
“These studies’ findings shed light on both the complexity and high degree of variability of the course of co-occurring AUD and depression (McHugh and Weiss, 2019).”
Distress tolerance and emotional regulation in individuals with alcohol use disorder
Zaorska, J., Rydzewska, M., Kopera, M., Wiśniewski, P., Trucco, E. M., Kobyliński, P., & Jakubczyk, A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1175664 · Cited by 17 · see citing works
Tutorial in Biostatistics: The use of generalized additive models to evaluate alcohol consumption as an exposure variable
White, L. F., Jiang, W., Ma, Y., So‐Armah, K., Samet, J. H., & Cheng, D. M. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.107944 · Cited by 17 · see citing works
“Alcohol has been studied in connection with cancers, cardiovascular diseases and mental health (Bell et al., 2017; Conner, 2019; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; McHugh, 2019).”
Background
Building community-based helping practices by training peer-father counselors: A novel intervention to reduce drinking and depressive symptoms among fathers through an expanded masculinity lens
Giusto, A. M., Johnson, S. L., Lovero, K. L., Wainberg, M. L., Rono, W., Ayuku, D., & Puffer, E. S. (2021) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2021.103291 · Cited by 18 · see citing works
Prediction of Probable Major Depressive Disorder in the Taiwan Biobank: An Integrated Machine Learning and Genome-Wide Analysis Approach
Lin, E., Kuo, P., Lin, W., Liu, Y., Yang, A. C., & Tsai, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11070597 · Cited by 16 · see citing works
“The clinical variable regarding current alcohol drinking was included as alcohol consumption might contribute to any underlying condition of sadness/melancholy in MDD subjects with a comorbid condition of alcoholism [44,45].”
Background
Association between health behaviors and depression: findings from the 2019 Brazilian National Health Survey
Barros, M. B. D. A., Medina, L. D. P. B., Lima, M. G., de Azevedo, R. C. S., Sousa, N. F. D. S., & Malta, D. C. (2021) · Revista Brasileira de Epidemiologia · doi:10.1590/1980-549720210010.supl.2 · Cited by 18 · see citing works
Cytokine level in patients with mood disorder, alcohol use disorder and their comorbidity
Mednova, I. A., Levchuk, L. A., Boiko, A. S., Roschina, O. V., Simutkin, G. G., Bokhan, N. A., LOONEN, A. J. M., & Ivanova, S. А. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2095439 · Cited by 16 · see citing works
Prevalence of depression among patients with chronic pancreatitis: A systematic review and meta-analysis
Beas, R., Riva-Moscoso, A., Ribaudo, I., Chambergo‐Michilot, D., Norwood, D. A., Karkash, A., Izquierdo-Veraza, D., Montrose, J. A., Rojas, M. R., & Montalvan-Sanchez, E. E. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102115 · Cited by 16 · see citing works
Ethanol-Induced Depression: Exploring the Underlying Molecular Mechanisms
Mashayekhi‐Sardoo, H., Razazpour, F., Hakemi, Z., Hedayati‐Moghadam, M., & Baghcheghi, Y. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01569-7 · Cited by 15 · see citing works
“Inpatient populations with severe AUD often present with “secondary depression,” characterized by melancholic features such as diurnal mood variation and non-reactive affect, which resolve partially with sustained abstinence (McHugh and Weiss 2019).”
Fatty Liver and the Coronavirus Disease 2019 Pandemic: Health Behaviors, Social Factors, and Telemedicine Satisfaction in Vulnerable Populations
Kim, R. G., Medina, S. P., Magee, C., & Khalili, M. (2021) · Hepatology Communications · doi:10.1002/hep4.1873 · Cited by 15 · see citing works
Genetic Variability of Incretin Receptors and Alcohol Dependence: A Pilot Study
Tsermpini, E. E., Goričar, K., Plesničar, B. K., Ilješ, A. P., & Dolžan, V. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.908948 · Cited by 15 · see citing works
“…in the Diagnostic and Statistical Manual of mental disorders (DSM-IV), whereas, in DSM-V, they are integrated into one broader category of alcohol use disorder (AUD) which includes sub-classifications, depending on the severity of the symptoms (Kathryn Mchugh and Weiss, 2019; Nutt et al., 2021).”
Background
Problematic substance use in depressed adolescents: Prevalence and clinical correlates
Marino, E. N., Jha, M. K., Minhajuddin, A., Ayvaci, E. R., Levinson, S., Pipes, R., Emslie, G. J., & Trivedi, M. H. (2024) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2024.100539 · Cited by 15 · see citing works
“…disorder), as well as alterations to brain development in regions that control higher order cognitive functioning and inhibitory control (Clayborne et al., 2019; Esmaeelzadeh et al., 2018; Fergusson et al., 2009; Gray & Squeglia, 2018; McHugh & Weiss, 2019; Pedrelli et al., 2016; Spear, 2018).”
Background
The Prevalence of Mild Cognitive Impairment in a Convenience Sample of 202 Gulf War Veterans
Chao, L. L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17197158 · Cited by 16 · see citing works
Voluntary binge‐patterned alcohol drinking and sex‐specific influences on monoamine‐related neurochemical signatures in the mouse gut and brain
Bauer, E. E., Shoeman, A., Buhr, T. J., Daniels, K. M., Lyte, M., & Clark, P. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14592 · Cited by 15 · see citing works
Screening for depression in patients in treatment for alcohol use disorder using the Beck Depression Inventory-II and the Hopkins Symptom Checklist-10
Lien, I. A., Bolstad, I., Lien, L., & Bramness, J. G. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114363 · Cited by 17 · see citing works
“The higher cut-off in AUD patients could be due to overlapping MDD and withdrawal symptoms such as insomnia and psychomotor agitation (Barral et al., 2016; McHugh and Weiss, 2019; Weiss et al., 2006).”
Background
Culturally Appropriate Assessment of Depression and Anxiety in Older Torres Strait Islanders: Limitations and Recommendations
Russell, S., Quigley, R., Thompson, F., Sagigi, B., Miller, G., LoGiudice, D., Smith, K., Strivens, E., & Pachana, N. A. (2022) · Clinical Gerontologist · doi:10.1080/07317115.2022.2086090 · Cited by 15 · see citing works
High levels of poor mental health among young men in urban informal settlements in South Africa: a community-based study of social determinants
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Authors: McHugh, R.
Affiliations: Harvard University (US)
Corresponding author: McHugh, RK
ORCID: McHugh, RK
Venue: Alcohol Research: Current Reviews
Publisher: National Institute on Alcohol Abuse and Alcoholism
Published: 2019
Volume: 40
Issue: 1
ISSN: 2168-3492 (ISSN-L)
2169-4796
DOI: 10.35946/arcr.v40.1.01
PMC: PMC6799954
OpenAlex: W2972722553
Cited by: 517
References: 64
Citations by year: 2026: 38 · 2025: 125 · 2024: 104 · 2023: 93 · 2022: 93 · 2021: 48 · 2020: 16
FWCI: 5.72
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: public-domain
Locations: Alcohol research (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: Charles Engelhard Foundation
National Institute on Drug Abuse (K24DA022288, K23DA035297)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords: alcoholism, depressive disorders, comorbidities, prevalence, clinical course, treatment response, pharmacotherapy, behavior therapy, prognosis, sex and gender differences
MeSH terms: Alcoholism, Depressive Disorder, Humans, Prognosis, Comorbidity, Prevalence

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