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Cited by 52Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentNeural and Behavioral Psychology Studies

Functions of the dopaminergic innervation of the nucleus accumbens.

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Gray, Jeffrey A., Kumari, Veena, Lawrence, Natalia, Young, Andrew M. J.·1999·Psychobiology
DOI 10.3758/bf03332116
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Abstract

Two different current views hold that the mesolimbic dopaminergic projection to the nucleus accumbens mediates (1) the behavioral effects of reward or positive incentive motivation and (2) the cognitive functions that go awry in acute schizophrenia. These two views are difficult to integrate with each other. The former view fits better with the established role that the nucleus accumbens plays in the motor programming circuitry of the basal ganglia; but it fits poorly with evidence that dopamine release is provoked in the nucleus accumbens not only by rewarding, but also by aversive, stimuli. We review evidence, especially from experiments using the prepulse and latent inhibition paradigms, consistent with a role for the mesolimbic dopaminergic pathway in the cognitive dysfunctions of schizophrenia. We also propose a new model for the functions of this pathway which draws on recent evidence that the nucleus accumbens has outputs to perceptual as well as motor systems. The model is able in principle to account for the data sets that support both major current views of the functions of the mesolimbic dopaminergic system. It has not yet received support, however, from direct experimental tests.

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  • In people, strength of mesolimbic incentive salience has been linked to personality traits of impulsiveness and sensation-seeking.

    “In people, also, strength of mesolimbic incentive salience has also been linked to personality traits of impulsiveness and sensation-seeking (e.g., Gray’s BAS [behavioral activation system]) (Gray et al., 1999; Beaver et al., 2008; Hickey and Peelen, 2015).”

    From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Gray et al., 1999

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Research works printed but not linked: 4

  1. BUTLER, R. W.,JENKINS, M. A., GEYER, M. A., & BRAFF, D. L. (1991). Wisconsin Card Sorting deficits and diminished sensorimotor gating in a discrete subgroup of schizophrenic patients. In C. A. Tamminga & S. C. Schultz (Eds.), Schizophrenia research: Advances in neu- ropsychiatry and psychopharmacology (Vol. I, pp. 163-168). New York: Raven Press.
  2. GRAY, 1. A. (1975). Elements of a two-process theory of learning. Lon- don: Academic Press.
  3. LUBOW, R. E. (1989). Latent inhibition and conditional attention the- ory. Cambridge: Cambridge University Press.
  4. WEINER, I. (1990). Neural substrates oflatent inhibition: The switching model. Psychological Bulletin, 108, 442-461.

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Authors
Gray, J. A., Kumari, V., Lawrence, N., & Young, A. M. J.
Affiliations
University of Leicester (GB)
Corresponding author
Gray, Jeffrey A.
ORCID
Venue
Psychobiology
Publisher
Springer Science and Business Media LLC
Published
1999-06
Volume
27
Issue
2
Pages
225-235
ISSN
0889-6313 (ISSN-L)
DOI
10.3758/bf03332116
OpenAlex
W1622949992
Cited by
52
References
108
Citations by year
2025: 1 · 2018: 3 · 2015: 1 · 2014: 1 · 2012: 2
FWCI
1.81
Type
journal article
Language
en
Open access
Licence
Locations
Psychobiology (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
nucleus accumbens, mesolimbic dopamine system, dopamine release, reward, incentive motivation, schizophrenia, cognitive impairment, prepulse inhibition, latent inhibition, aversive stimuli, basal ganglia, perceptual processing, functional model

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