Beneficial effects of lactobacillus casei strain shirota on academic stress-induced sleep disturbance in healthy adults: A double-blind, randomised, placebo-controlled trial

Takada, M.; Nishida, K.; Gondo, Y.; Kikuchi-Hayakawa, H.; Ishikawa, H.; Suda, K.; Kawai, M.; Hoshi, R.; Kuwano, Y.; Miyazaki, K.; Rokutan, K.

doi:10.3920/bm2016.0150

Cited by 160Probiotics and Fermented FoodsSleep and related disordersSleep and Wakefulness Research

Beneficial effects of lactobacillus casei strain shirota on academic stress-induced sleep disturbance in healthy adults: A double-blind, randomised, placebo-controlled trial

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Takada, M., Nishida, K., Gondo, Y., Kikuchi-Hayakawa, H., Ishikawa, H., Suda, K., Kawai, M., Hoshi, R. +3 more·2017·Beneficial Microbes

DOI 10.3920/bm2016.0150

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Abstract

year medical students exposed to academic examination stress. The trial was repeated over two consecutive years in different groups of students, and the data were pooled. For 8 weeks prior to and 3 weeks after a national standardised examination, a total of 48 and 46 subjects received a daily dose of 100 ml of LcS-fermented milk or non-fermented placebo milk, respectively. Study measures included subjective anxiety, overnight single-channel electroencephalography (EEG) recordings, and the Oguri-Shirakawa-Azumi (OSA) sleep inventory scores of subjective sleep quality. Total OSA scores were significantly lower than baseline on the day before the exam and recovered after the exam, indicating a stress-induced decline in sleep quality. There was a significant positive effect of LcS treatment on OSA factors for sleepiness on rising and sleep length. Sleep latency measured by EEG lengthened as the exam approached in the placebo group but was significantly suppressed in the LcS group. The percentage of stage 3 non-REM (N3) sleep decreased in the placebo group as the exam approached, whereas it was maintained in the LcS group throughout the trial. Delta power during the first sleep cycle, measured as an index of sleep intensity, increased as the exam approached in the LcS group and was significantly higher than in the placebo group. These findings suggest that daily consumption of LcS may help to maintain sleep quality during a period of increasing stress. The observed retention of N3 sleep and increased delta power in the LcS group may have contributed to higher perceived sleep satisfaction.

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Treatment with Lactobacillus casei strain Shirota (LcS) causes a positive impact on patients' sleep duration and quality of sleep.
“the treatment with Lactobacillus casei strain Shirota (LcS) causes a positive impact on patients’ sleep duration and quality of sleep [92].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [92]

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Culture Techniques Yielding a High Count and High Density of Lactobacillus casei Strain Shirota and Investigation of Novel Health Applications of Gut-brain Interaction
Kawai, M., Kato-Kataoka, A., Takada, M., Hoshi, R., & Nishida, K. (2021) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.74.75
Self-citation

Authors: Takada, M., Nishida, K., Gondo, Y., Kikuchi-Hayakawa, H., Ishikawa, H., Suda, K., Kawai, M., Hoshi, R., Kuwano, Y., Miyazaki, K., & Rokutan, K.
Affiliations: Yakult Central Institute (JP)
Tokushima University (JP)
Yakult Honsha (Japan) (JP)
ORCID: Nishida, K.
Ishikawa, H.
Suda, K.
Kawai, M.
Kuwano, Y.
Miyazaki, K.
Venue: Beneficial Microbes
Publisher: Walter de Gruyter GmbH
Published: 2017-04-26
Volume: 8
Issue: 2
Pages: 153-162
ISSN: 1876-2883 (ISSN-L)
1876-2891
DOI: 10.3920/bm2016.0150
OpenAlex: W2609196293
Cited by: 160
References: 30
Citations by year: 2026: 16 · 2025: 29 · 2024: 24 · 2023: 17 · 2022: 14 · 2021: 24 · 2020: 15 · 2019: 12 · 2018: 7 · 2017: 2
FWCI: 11.07
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (unspecified)
Locations: Beneficial Microbes (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: University of Tokushima
Yakult Honsha
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: Lactobacillus casei Shirota, fermented milk, academic stress, exam stress, sleep quality, sleep disorders, NREM sleep, stage 3 sleep, delta power, sleep latency, anxiety, medical students, probiotics
MeSH terms: Sleep Aids, Pharmaceutical, Adult, Anxiety, Double-Blind Method, Electroencephalography, Female, Humans, Lacticaseibacillus casei, Male, Surveys and Questionnaires, Sleep Wake Disorders, Stress, Psychological, Students, Medical, Dietary Supplements, Probiotics, Young Adult, Brain Waves

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Beneficial effects of lactobacillus casei strain shirota on academic stress-induced sleep disturbance in healthy adults: A double-blind, randomised, placebo-controlled trial

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