The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Acute sleep deprivation reduces energy expenditure in healthy men
Open accessAbstract
Background Epidemiologic evidence indicates that chronic sleep curtailment increases risk of developing obesity, but the mechanisms behind this relation are largely unknown.Objective We examined the influence of a single night of total sleep deprivation on morning energy expenditures and food intakes in healthy humans.Design According to a balanced crossover design, we examined 14 normal-weight male subjects on 2 occasions during a regular 24-h sleep-wake cycle (including 8 h of nocturnal sleep) and a 24-h period of continuous wakefulness. On the morning after regular sleep and total sleep deprivation, resting and postprandial energy expenditures were assessed by indirect calorimetry, and the free-choice food intake from an opulent buffet was tested in the late afternoon at the end of the experiment. Circulating concentrations of ghrelin, leptin, norepinephrine, cortisol, thyreotropin, glucose, and insulin were repeatedly measured over the entire 24-h session.Results In comparison with normal sleep, resting and postprandial energy expenditures assessed on the subsequent morning were significantly reduced after sleep deprivation by ≈5% and 20%, respectively (P < 0.05 and P < 0.0001). Nocturnal wakefulness increased morning plasma ghrelin concentrations (P < 0.02) and nocturnal and daytime circulating concentrations of thyreotropin, cortisol, and norepinephrine (P < 0.05) as well as morning postprandial plasma glucose concentrations (P < 0.05). Changes in food intakes were variable, and no differences between wake and sleep conditions were detected.Conclusion Our findings show that one night of sleep deprivation acutely reduces energy expenditure in healthy men, which suggests that sleep contributes to the acute regulation of daytime energy expenditure in humans.
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In the citing paper
“When appraised collectively, these studies show that sleep restriction increases afternoon cortisol: Table 2.”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [83]
In the citing paper
“In general, studies reported increases in 24-hour energy intake when participants underwent sleep restriction relative to habitual sleep (Table 1), with the degree of overeating ranging from ≈180 to 559 kcal/d.”
From Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association (2016) · cites this paper as [63]
In the citing paper
“In the study by Benedict et al. [5], the decreased glucose tolerance in a state of sleep debt was the consequence of reduced SI combined to beta-cell dysfunction since insulin levels were not affected by the presence or absence of sleep.”
From Sleep and metabolic function (2012) · cites this paper as [5]
In the citing paper
“Glucose tolerance was found to be altered in two studies, i.e., after 72–126 h of TSD [86] and after 24 h of TSD [5].”
From Sleep and metabolic function (2012) · cites this paper as [5]
In the citing paper
“Thus, of the three studies that assessed SI after a glucose load, two found reduced SI after sleep loss [5, 195] and one found reduced SI after recovery sleep [204].”
From Sleep and metabolic function (2012) · cites this paper as [5]
In the citing paper
“Increased fasting glucose was reported after 120 h of TSD [200] but not after 72–126 h [86] or one single night of TSD [5, 143, 195, 204]”
From Sleep and metabolic function (2012) · cites this paper as [5]
In the citing paper
“More recently, two studies [5, 143] reported that a night of TSD resulted in increased subjective hunger the following morning.”
From Sleep and metabolic function (2012) · cites this paper as [5]
In the citing paper
“Two groups found that one night of total sleep deprivation increased EE during the night, whereas the following day, resting and postprandial EE were reduced by 5% and 20%, respectively, overall leading to a positive energy balance43,100”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [100]
In the citing paper
“Partial and total sleep deprivation resulted in elevated salivary and plasma cortisol the following afternoon and evening100,101,109,114,117 (Table 1), while morning cortisol levels may be unchanged or even decreased.90,97,117”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [100]
In the citing paper
“The effects of sleep restriction on leptin levels in subsequent studies have been mixed, with some studies reporting an increase in leptin [25, 41–45] while others reported no significant difference [33, 46–51] after sleep restriction.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [33]
In the citing paper
“A similar finding was also reported in a crossover study of 14 healthy males during 24-h continuous wakefulness [33]. They reported an increase in nocturnal and daytime levels of norepinephrine (p<0.05).”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [33]
In the citing paper
“A similar study with 14 men also showed elevations in morning ghrelin levels (p<0.02) following the night after TSD [33].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [33]
In the citing paper
“In 14 normal-weight men in the morning after 24-h of continuous wakefulness both resting and postprandial EE were assessed along with hunger ratings before the standardized breakfast. The resting (−5%, p<0.05) and postprandial (−20%, p<0.001) EE were significantly reduced after one night of total sleep deprivation with a significant increase in hunger ratings while no changes in ad libitum food”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [33]
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Sleep curtailment is accompanied by increased intake of calories from snacks
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Itani, O., Jike, M., Watanabe, N., & Kaneita, Y. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2016.08.006 · Cited by 1,252
St-Onge, M.-P., Grandner, M. A., Brown, D., Conroy, M. B., Jean-Louis, G., Coons, M., & Bhatt, D. L. (2016) · Circulation · doi:10.1161/cir.0000000000000444 · Cited by 1,044
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Reutrakul, S., & Van Cauter, E. (2018) · Metabolism · doi:10.1016/j.metabol.2018.02.010 · Cited by 584
Interactions between sleep, stress, and metabolism: From physiological to pathological conditions
Hirotsu, C., Tufik, S., & Andersen, M. L. (2015) · Sleep Science · doi:10.1016/j.slsci.2015.09.002 · Cited by 567
Sleep patterns, diet quality and energy balance
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Metadata
- Authors
- Benedict, C., Hallschmid, M., Lassen, A., Mahnke, C., Schultes, B., Schiöth, H. B., Born, J., & Lange, T.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Benedict, Christian
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 93
- Issue
- 6
- Pages
- 1229-1236
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2139560142
- Cited by
- 243
- References
- 34
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 10 · 2023: 6 · 2022: 11 · 2021: 13 · 2020: 18 · 2019: 11 · 2018: 11 · 2017: 15 · 2016: 22 · 2015: 15 · 2014: 28 · 2013: 33 · 2012: 24
- FWCI
- 38.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, energy expenditure, dietary intake, ghrelin, leptin, cortisol, norepinephrine, postprandial energy expenditure, obesity risk, healthy men
- MeSH terms
- Adult, Blood Glucose, Energy Intake, Calorimetry, Indirect, Diet, Energy Metabolism, Humans, Hydrocortisone, Male, Norepinephrine, Obesity, Reference Values, Rest, Sleep, Sleep Deprivation, Thyrotropin, Wakefulness, Cross-Over Studies, Postprandial Period, Ghrelin, Young Adult
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