The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
Open accessAbstract
Background Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.Objective The aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.Design Habitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.Results Coffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.Conclusions Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake.
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“Analyses with fibrinogen and white blood cell count showed similar results (249) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [249]
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Cites
Lindström, J., & Tuomilehto, J. O. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.725 · Cited by 1,937
Adiponectin and protection against type 2 diabetes mellitus
Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120
Adiponectin and development of type 2 diabetes in the Pima Indian population
Lindsay, R. S., Funahashi, T., Hanson, R. L., Matsuzawa, Y., Tanaka, S., Tataranni, P. A., Knowler, W. C., & Krakoff, J. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09335-2 · Cited by 1,094
Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975
Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review
van Dam, R. M., & Hu, F. B. (2005) · JAMA · doi:10.1001/jama.294.1.97 · Cited by 662
Dietary pattern, inflammation, and incidence of type 2 diabetes in women
Schulze, M. B., Hoffmann, K., Manson, J. E., Willett, W. C., Meigs, J. B., Weikert, C., Heidemann, C., Colditz, G. A., & Hu, F. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.675 · Cited by 457
Dietary Intake and Major Food Sources of Polyphenols in Finnish Adults3
Ovaskainen, M., Törrönen, R., Koponen, J. M., Sinkko, H., Hellström, J., Reinivuo, H., & Mattila, P. H. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.562 · Cited by 434
Stalmach, A., Mullen, W., Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G., & Crozier, A. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.028019 · Cited by 401
An immune origin of type 2 diabetes?
Kolb, H., & Mandrup-Poulsen, T. (2005) · Diabetologia · doi:10.1007/s00125-005-1764-9 · Cited by 394
Self-citationCoffee Drinking Influences Plasma Antioxidant Capacity in Humans
Natella, F., Nardini, M., Giannetti, I., Dattilo, C., & Scaccini, C. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf025768c · Cited by 324
Cited by
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
“Plasma caffeine concentrations were positively associated with plasma adiponectin concentrations((404)).”
Polyphenols and Human Health: The Role of Bioavailability
Lorenzo, C. D., Colombo, F., Biella, S., Stockley, C. S., & Restani, P. (2021) · Nutrients · doi:10.3390/nu13010273 · Cited by 969
Antioxidant Property of Coffee Components: Assessment of Methods that Define Mechanisms of Action
Liang, N., & Kitts, D. D. (2014) · Molecules · doi:10.3390/molecules191119180 · Cited by 560
“, 600 mL/day for one month and 1,200 mL/day for another month) exhibited decreased levels of interleukin 18, an inflammatory biomarker, and 8-isoprotane, a free lipid peroxidation product [115].”
BackgroundThe role of polyphenols in modern nutrition
Williamson, G. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12278 · Cited by 551
“In studies of the latter design, coffee over 4 weeks, after a 4-week washout, attenuated DNA damage, reduced bodyweight and body fat (Bakuradze et al. 2011), and exerted beneficial effects on subclinical inflammation and HDL-cholesterol (Kempf et al. 2010).”
BackgroundCoffee: Biochemistry and Potential Impact on Health
Ludwig, I. A., Clifford, M. N., Lean, M. E. J., Ashihara, H., & Crozier, A. (2014) · Food Funct. · doi:10.1039/c4fo00042k · Cited by 537
Metadata
- Authors
- Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., & Jaakko, T.
- Affiliations
- Deutsches Diabetes-Zentrum e.V. (DE)
- Heinrich Heine University Düsseldorf (DE)
- Finnish Institute for Health and Welfare (FI)
- University of Helsinki (FI)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 91
- Issue
- 4
- Pages
- 950-957
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2139329734
- Cited by
- 364
- References
- 40
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 21 · 2021: 28 · 2020: 29 · 2019: 13 · 2018: 28 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 37 · 2013: 38 · 2012: 28
- FWCI
- 22.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- coffee consumption, type 2 diabetes, subclinical inflammation, oxidative stress, caffeine, chlorogenic acid, methylxanthines, IL-18, 8-isoprostane, adiponectin, HDL cholesterol, apolipoprotein A-I, lipid metabolism, glucose metabolism, dietary intervention
- MeSH terms
- Adult, Anti-Inflammatory Agents, Apolipoproteins, Blood Glucose, Caffeic Acids, Caffeine, Chlorogenic Acid, Cholesterol, Coffee, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Lipids, Male, Middle Aged, Risk Factors, Dinoprost, Biomarkers, Single-Blind Method, Interleukin-18, Plant Preparations, Adiponectin
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