Cited by 364Coffee research and impactsNutritional Studies and DietAlcohol Consumption and Health Effects

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Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial

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Kempf, Kerstin, Herder, Christian, Erlund, Iris, Kolb, Hubert, Martin, Stephan, Carstensen, Maren, Koenig, Wolfgang, Sundvall, Jouko, Bidel, Siamak, Kuha, Suvi, Jaakko, Tuomilehto·2010·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.2009.28548

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Abstract

Background Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress.Objective The aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.Design Habitual coffee drinkers (n = 47) refrained for 1 mo from coffee drinking; in the second month they consumed 4 cups of filtered coffee/d and in the third month 8 cups of filtered coffee/d (150 mL/cup). Blood samples were analyzed by gas chromatography-mass spectrometry, bead-based multiplex technology, enzyme-linked immunosorbent assay, or immunonephelometry.Results Coffee consumption led to an increase in coffee-derived compounds, mainly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d). No changes were seen for markers of glucose metabolism in an oral-glucose-tolerance test.Conclusions Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no changes in glucose metabolism were found in our study. Furthermore, many coffee-derived methylxanthines and caffeic acid metabolites appear to be useful as biomarkers of coffee intake.

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Associations of Coffee Drinking with Systemic Immune and Inflammatory Markers
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“We also found null associations for coffee drinking and four markers [monocyte chemoattractant protein-1 (CCL2/MCP-1), IL1b, IL1ra, and insulin] consistent with the results from prior studies (17, 20, 21).”
Result
The effect of coffee consumption on insulin sensitivity and other biological risk factors for type 2 diabetes: a randomized placebo-controlled trial
Alperet, D. J., Rebello, S. A., Khoo, E. Y.-H., Tay, Z., Seah, S. S. Y., Tai, B., Tai, E. S., Emady‐Azar, S., Chou, C. J., Darimont, C., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz306 · Cited by 81
Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: A systematic review and meta-analysis
Peluso, I., Raguzzini, A., & Serafini, M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200721 · Cited by 83
“Studies are listed in [25–134].”
Background
Impact of coffee components on inflammatory markers: A review
Frost-Meyer, N. J., & Logomarsino, J. V. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.05.010 · Cited by 79
Effects of 16-Week Consumption of Caffeinated and Decaffeinated Instant Coffee on Glucose Metabolism in a Randomized Controlled Trial
Ohnaka, K., Ikeda, M., Maki, T., Okada, T., Shimazoe, T., Adachi, M., Nomura, M., Takayanagi, R., & Kono, S. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/207426 · Cited by 87
“None of these studies showed a clear effect on either fasting [15, 16] or postload [17, 18]”
Background
Coffee silver skin as a source of polyphenols: High resolution mass spectrometric profiling of components and antioxidant activity
Regazzoni, L., Saligari, F., Marinello, C., Rossoni, G., Aldini, G., Carini, M., & Orioli, M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.11.027 · Cited by 80
Coffee Consumption and Cardiovascular Health: Getting to the Heart of the Matter
Rebello, S. A., & van Dam, R. M. (2013) · Current Cardiology Reports · doi:10.1007/s11886-013-0403-1 · Cited by 78
“The limited clinical studies done thus far have been somewhat promising, with increases in total ex vivo antioxidant capacity [36], ex vivo hemocyte antioxidant enzyme activity [36–38], and reductions in urinary 8-isoprostane concentration [9, 39], in vitro/ex vivo oxidative DNA damage”
Influential
Coffee and tea consumption in relation to inflammation and basal glucose metabolism in a multi-ethnic Asian population: a cross-sectional study
Rebello, S. A., Chen, C. H., Naidoo, N., Xu, W., Lee, J., Chia, K. S., Tai, E. S., & van Dam, R. M. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-61 · Cited by 77
“In an intervention study, serum adiponectin concentration increased when participants consumed eight cups of coffee per day as compared to when they did not consume coffee [17].”
Background
The Role of Nutrition on Meta-inflammation: Insights and Potential Targets in Communicable and Chronic Disease Management
Ramos-López, O., Martínez‐Urbistondo, D., Vargas-Núñez, J. A., & Martínez, J. A. (2022) · Current Obesity Reports · doi:10.1007/s13679-022-00490-0 · Cited by 82
Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality
Hu, Y., Ding, M., Yuan, C., Wu, K., Smith-Warner, S. A., Hu, F. B., Chan, A. T., Meyerhardt, J. A., Ogino, S., Fuchs, C. S., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.11.010 · Cited by 75
Caffeinated Coffee Does Not Acutely Affect Energy Intake, Appetite, or Inflammation but Prevents Serum Cortisol Concentrations from Falling in Healthy Men1–4
Gavrieli, A., Yannakoulia, M., Fragopoulou, E., Margaritopoulos, D., Chamberland, J. P., Kaisari, P., Kavouras, S. A., & Mantzoros, C. S. (2011) · Journal of Nutrition · doi:10.3945/jn.110.137323 · Cited by 75
Caffeine Synergizes with Another Coffee Component to Increase Plasma GCSF: Linkage to Cognitive Benefits in Alzheimer's Mice
Cao, C., Wang, L., Lin, X., Mamcarz, M. B., Zhang, C., Bai, G., Nong, J., Sussman, S., & Arendash, G. W. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110110 · Cited by 80
Impact of Acute Caffeine Ingestion on Endothelial Function in Subjects with and without Coronary Artery Disease
Shechter, M., Shalmon, G., Scheinowitz, M., Koren-Morag, N., Feinberg, M. S., Harats, D., Sela, B. A., Sharabi, Y., & Chouraqui, P. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.12.035 · Cited by 74
Dose‐dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists
Erk, T., Williamson, G., Renouf, M., Marmet, C., Steiling, H., Dionisi, F., Barron, D., Melcher, R., & Richling, E. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200222 · Cited by 74
Neuroprotection comparison of chlorogenic acid and its metabolites against mechanistically distinct cell death-inducing agents in cultured cerebellar granule neurons
Taram, F., Winter, A. N., & Linseman, D. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.07.028 · Cited by 73
Pharmacokinetics of caffeine and its metabolites in plasma and urine after consuming a soluble green/roasted coffee blend by healthy subjects
Martínez-López, S., Sarriá, B., Baeza, G., Mateos, R., & Bravo, L. (2014) · Food Research International · doi:10.1016/j.foodres.2014.05.043 · Cited by 72
Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study , ,
Jacobs, S., Kröger, J., Floegel, A., Boeing, H., Drogan, D., Pischon, T., Fritsche, A., Prehn, C. P., Adamski, J., Isermann, B., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.080317 · Cited by 73
In Reply—Association of Coffee Consumption With All-Cause and Cardiovascular Disease Mortality
Liu, J., Sui, X., Blair, S. N., & Lavie, C. J. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.003 · Cited by 70
Coffee induces autophagy in vivo
Pietrocola, F., Malik, S. A., Mariño, G., Vacchelli, E., Senovilla, L., Chaba, K., Niso‐Santano, M., Maiuri, M. C., Madeo, F., & Kroemer, G. (2014) · Cell Cycle · doi:10.4161/cc.28929 · Cited by 68
Association between Coffee Consumption and Its Polyphenols with Cardiovascular Risk Factors: A Population-Based Study
Miranda, A. M., Steluti, J., Fisberg, R. M., & Marchioni, D. M. L. (2017) · Nutrients · doi:10.3390/nu9030276 · Cited by 67
“This cardiovascular protection has been demonstrated in vivo, and can be explained by various mechanisms, including their anti-inflammatory properties [16], the strong antioxidant capacity [17] related to nitric oxide (NO) bioavailability, as well as low-density lipoprotein (LDL) oxidation, and antithrombotic properti…”
Background
Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging
Solfrizzi, V., and for the Italian Longitudinal Study on Aging Working Group 2, Panza, F., Imbimbo, B. P., D’Introno, A., Galluzzo, L., Gandin, C., Misciagna, G., Guerra, V., Osella, A., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150333 · Cited by 65
French and Mediterranean-style diets: Contradictions, misconceptions and scientific facts-A review
Ndlovu, T., van Jaarsveld, F. P., & Caleb, O. J. (2018) · Food Research International · doi:10.1016/j.foodres.2018.09.020 · Cited by 67
Use of asparaginase for acrylamide mitigation in coffee and its influence on the content of caffeine, chlorogenic acid, and caffeic acid
Corrêa, C. L. O., Penha, E. D. M., dos Anjos, M. R., Pacheco, S., Freitas‐Silva, O., Luna, A. S., & Gottschalk, L. M. F. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128045 · Cited by 65
Polyphenols: Potential anti‐inflammatory agents for treatment of metabolic disorders
Zamani‐Garmsiri, F., Emamgholipour, S., Fard, S. R., Ghasempour, G., Jahangard, R., & Meshkani, R. (2021) · Phytotherapy Research · doi:10.1002/ptr.7329 · Cited by 65
Bioavailability of Dietary Polyphenols and the Cardiovascular Diseases
Shivashankara, K. S., & Acharya, S. N. (2010) · The Open Nutraceuticals Journal · doi:10.2174/1876396001003010227 · Cited by 67
“Drinking 8 cups of coffee per day significantly increased serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I and decreased the ratios of LDL to HDL cholesterol [120].”
Background
Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects
Noguchi, K., Matsuzaki, T., Sakanashi, M., Hamadate, N., Uchida, T., Kina-Tanada, M., Kubota, H., Nakasone, J., Sakanashi, M., Ueda, S., et al. (2015) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2015.01.003 · Cited by 63
Sfrp5 correlates with insulin resistance and oxidative stress
Carstensen, M., Herder, C., Kempf, K., Erlund, I., Martin, S., Köenig, W., Sundvall, J., Bidel, S., Kuha, S., Roden, M., et al. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12052 · Cited by 63
Potential nutraceutical and food additive properties and risks of coffee: a comprehensive overview
Saeed, M., Naveed, M., Bibi, J., Kamboh, A. A., Phil, L., & Sun, C. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1489368 · Cited by 68
“(Kempf et al. 2010; Sang, Kong, and Kim 2015; Cho et al. 2010) Prebiotics In addition to antimicrobial effects coffee has been acknowledged for its prebiotic properties.”
Background
Coffee and green tea consumption is associated with insulin resistance in Japanese adults
Pham, N. M., Nanri, A., Kochi, T., Kuwahara, K., Tsuruoka, H., Kurotani, K., Akter, S., Kabe, I., Sato, M., Hayabuchi, H., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.11.008 · Cited by 62
“[40] Kempf K, Herder C, Erlund I, et al.”
Background
Coffee, tea, and alcohol intake in relation to risk of type 2 diabetes in African American women
Boggs, D. A., Rosenberg, L. A., Ruiz-Narváez, E., & Palmer, J. R. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29598 · Cited by 65
“However, a recent intervention trial showed favorable effects of coffee on inflammatory markers and lipids but not on glucose metabolism (36).”
Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research
Cornelis, M. C., & Hu, F. B. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0052-4 · Cited by 64
“Confirmed metabolite markers of coffee exposure, for example, include mainly methylxanthines and reduced, sulfated, and methylated forms of hydroxycinnamates [108–111], which are coffee-derived metabolites.”
Background
Caffeinated Coffee Consumption and Health Outcomes in the US Population: A Dose–Response Meta-Analysis and Estimation of Disease Cases and Deaths Avoided
Maso, M. D., Boffetta, P., Negri, E., Vecchia, C. L., & Bravi, F. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa177 · Cited by 64
“compounds with potentially beneficial effects, such as insulin-sensitizing (5), antioxidative (6), and antiinflammatory (7).”
Background
Medium Light and Medium Roast Paper-Filtered Coffee Increased Antioxidant Capacity in Healthy Volunteers: Results of a Randomized Trial
Corrêa, T. A. F., Monteiro, M. P., Mendes, T. M. N., de Oliveira, D. M., Rogero, M. M., Benites, C. I., Vinagre, C. G. C. D. M., Mioto, B. M., Tarasoutchi, D., Tuda, V. L., et al. (2012) · Plant Foods for Human Nutrition · doi:10.1007/s11130-012-0297-x · Cited by 61
“[26] verified a decrease in these concentrations after a daily intake of 1,200 ml of filtered coffee for one month, twice the amount consumed in our study.”
Background
Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: A clinical trial
Corrêa, T. A. F., Rogero, M. M., Mioto, B. M., Tarasoutchi, D., Tuda, V. L., César, L. A. M., & Torres, E. A. F. S. (2013) · Nutrition · doi:10.1016/j.nut.2013.01.003 · Cited by 61
“A few studies found a positive association between filtered coffee consumption and an increase in HDL-C concentration [4,30], as we did, which can counterbalance the deleterious effects of increased LDL-C.”
BackgroundInfluential
Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions
Machado-Filho, J. A., Correia, A. O., Montenegro, A. B. A., Nobre, M. E. P., Cerqueira, G. S., Neves, K. R. T., Naffah‐Mazzacoratti, M. D. G., Cavalheiro, É. A., Brito, G. A. D. C., & Viana, G. S. D. B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.051 · Cited by 61
Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial
Shahmohammadi, H. A., Hosseini, S. A., Hajiani, E., Malehi, A. S., & Alipour, M. (2017) · Hepatitis Monthly · doi:10.5812/hepatmon.45609 · Cited by 61
“In addition to differences in dosages, coffee types, and duration of studies, an explanation for the trials’ findings (37-39) regarding no beneficial effect of coffee on HOMA-IR may be the differences in weight of the studied samples.”
Background
The effect of green coffee extract supplementation on cardio metabolic risk factors: a systematic review and meta-analysis of randomized controlled trials
Morvaridi, M., Rayyani, E., Jafari, M., Khiabani, A., & Rahimlou, M. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00536-x · Cited by 60
“In this regard, some studies indicated that CGA decreased TG, cholesterol, and LDL [60, 65, 67, 68], but increased HDL concentrations [63, 67].”
Background
Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro
Guo, Y., Niu, K., Okazaki, T., Wu, H., Yoshikawa, T., Ohrui, T., Furukawa, K., Ichinose, M., Yanai, K., Arai, H., et al. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.005 · Cited by 60
“A human clinical trial alsodemonstrated that coffee intake had beneficial effects on subclinical inflammation (Kempf et al., 2010).”
Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption
Farrell, T. L., Gómez‐Juaristi, M., Poquet, L., Redeuil, K. M., Nagy, K., Renouf, M., & Williamson, G. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200021 · Cited by 59
Coffee consumption but not green tea consumption is associated with adiponectin levels in Japanese males
Imatoh, T., Tanihara, S., Miyazaki, M., Momose, Y., Uryu, Y., & Une, H. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0136-5 · Cited by 59
“[12] indicated a significant increase in adiponectin levels in response to increased coffee consumption in an intervention trial.”
Background
Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fat-diet/streptozotocin-induced diabetes in male albino rats
Alamri, O., Albeltagy, R. S., Akabawy, A. M. A., Mahgoub, S., Abdel-Mohsen, D. M., Moneim, A. E. A., & Amin, H. K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103996 · Cited by 62

Authors: Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., & Jaakko, T.
Affiliations: Deutsches Diabetes-Zentrum e.V. (DE)
Heinrich Heine University Düsseldorf (DE)
Finnish Institute for Health and Welfare (FI)
University of Helsinki (FI)
ORCID: Kempf, Kerstin
Herder, Christian
Erlund, Iris
Kolb, Hubert
Kuha, Suvi
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2010-04
Volume: 91
Issue: 4
Pages: 950-957
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.2009.28548
OpenAlex: W2139329734
Cited by: 364
References: 40
Citations by year: 2026: 8 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 21 · 2021: 28 · 2020: 29 · 2019: 13 · 2018: 28 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 37 · 2013: 38 · 2012: 28
FWCI: 22.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4706 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: coffee consumption, type 2 diabetes, subclinical inflammation, oxidative stress, caffeine, chlorogenic acid, methylxanthines, IL-18, 8-isoprostane, adiponectin, HDL cholesterol, apolipoprotein A-I, lipid metabolism, glucose metabolism, dietary intervention
MeSH terms: Adult, Anti-Inflammatory Agents, Apolipoproteins, Blood Glucose, Caffeic Acids, Caffeine, Chlorogenic Acid, Cholesterol, Coffee, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Lipids, Male, Middle Aged, Risk Factors, Dinoprost, Biomarkers, Single-Blind Method, Interleukin-18, Plant Preparations, Adiponectin

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Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial

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