Cited by 178Muscle metabolism and nutritionMuscle Physiology and DisordersSports Performance and Training

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Protein Blend Ingestion Following Resistance Exercise Promotes Human Muscle Protein Synthesis

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Reidy, Paul T., Walker, Dillon K., Dickinson, Jared M., Gundermann, David M., Drummond, Micah J., Timmerman, Kyle L., Fry, Christopher S., Borack, Michael S., Cope, Mark B., Mukherjea, Ratna, Jennings, Kristofer, Volpi, Elena, Rasmussen, Blake B.·2013·The Journal of Nutrition

DOI 10.3945/jn.112.168021PMC PMC3738242

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Abstract

High-quality proteins such as soy, whey, and casein are all capable of promoting muscle protein synthesis postexercise by activating the mammalian target of rapamycin (mTORC1) signaling pathway. We hypothesized that a protein blend of soy and dairy proteins would capitalize on the unique properties of each individual protein and allow for optimal delivery of amino acids to prolong the fractional synthetic rate (FSR) following resistance exercise (RE). In this double-blind, randomized, clinical trial, 19 young adults were studied before and after ingestion of ∼19 g of protein blend (PB) or ∼18 g whey protein (WP) consumed 1 h after high-intensity leg RE. We examined mixed-muscle protein FSR by stable isotopic methods and mTORC1 signaling with western blotting. Muscle biopsies from the vastus lateralis were collected at rest (before RE) and at 3 postexercise time points during an early (0-2 h) and late (2-4 h) postingestion period. WP ingestion resulted in higher and earlier amplitude of blood branched-chain amino acid (BCAA) concentrations. PB ingestion created a lower initial rise in blood BCAA but sustained elevated levels of blood amino acids later into recovery (P < 0.05). Postexercise FSR increased equivalently in both groups during the early period (WP, 0.078 ± 0.009%; PB, 0.088 ± 0.007%); however, FSR remained elevated only in the PB group during the late period (WP, 0.074 ± 0.010%; PB, 0.087 ± 0.003%) (P < 0.05). mTORC1 signaling similarly increased between groups, except for no increase in S6K1 phosphorylation in the WP group at 5 h postexercise (P < 0.05). We conclude that a soy-dairy PB ingested following exercise is capable of prolonging blood aminoacidemia, mTORC1 signaling, and protein synthesis in human skeletal muscle and is an effective postexercise nutritional supplement.

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Authors: Reidy, P. T., Walker, D. K., Dickinson, J. M., Gundermann, D. M., Drummond, M. J., Timmerman, K. L., Fry, C. S., Borack, M. S., Cope, M. B., Mukherjea, R., Jennings, K., Volpi, E., & Rasmussen, B. B.
Affiliations: The University of Texas Medical Branch at Galveston (US)
Corresponding author: Rasmussen, Blake B.
ORCID: Reidy, Paul T.
Dickinson, Jared M.
Gundermann, David M.
Drummond, Micah J.
Timmerman, Kyle L.
Fry, Christopher S.
Mukherjea, Ratna
Jennings, Kristofer
Volpi, Elena
Rasmussen, Blake B.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2013-04
Volume: 143
Issue: 4
Pages: 410-416
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.112.168021
PMC: PMC3738242
OpenAlex: W2168338325
Cited by: 178
References: 60
Citations by year: 2026: 5 · 2025: 8 · 2024: 14 · 2023: 14 · 2022: 17 · 2021: 15 · 2020: 21 · 2019: 12 · 2018: 11 · 2017: 15 · 2016: 16 · 2015: 14 · 2014: 10 · 2013: 6
FWCI: 8.90
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3600 d)
Locations: Journal of Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Solae LLC with assistance from NIH (R01 AR49877, T32-HD07539)
National Institute on Disability and Rehabilitation Research (H133P110012)
NIH Clinical and Translational Science Award (UL1TR000071)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: protein blends, soy protein, whey protein, resistance training, muscle protein synthesis, mTORC1 signaling, S6K1 phosphorylation, branched-chain amino acids, aminoacidemia, skeletal muscle, vastus lateralis, fractional synthesis rate
MeSH terms: Whey Proteins, Mechanistic Target of Rapamycin Complex 1, Adolescent, Adult, Amino Acids, Branched-Chain, Caseins, Dietary Proteins, Double-Blind Method, Female, Humans, Isotope Labeling, Kinetics, Male, Milk Proteins, Muscle Proteins, Signal Transduction, Exercise, Dietary Supplements, Soybean Proteins, Multiprotein Complexes, Resistance Training, Young Adult, TOR Serine-Threonine Kinases

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Protein Blend Ingestion Following Resistance Exercise Promotes Human Muscle Protein Synthesis

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