Cited by 178Muscle metabolism and nutritionMuscle Physiology and DisordersSports Performance and Training

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Protein Blend Ingestion Following Resistance Exercise Promotes Human Muscle Protein Synthesis

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Reidy, Paul T., Walker, Dillon K., Dickinson, Jared M., Gundermann, David M., Drummond, Micah J., Timmerman, Kyle L., Fry, Christopher S., Borack, Michael S., Cope, Mark B., Mukherjea, Ratna, Jennings, Kristofer, Volpi, Elena, Rasmussen, Blake B.·2013·The Journal of Nutrition

DOI 10.3945/jn.112.168021PMC PMC3738242

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Abstract

High-quality proteins such as soy, whey, and casein are all capable of promoting muscle protein synthesis postexercise by activating the mammalian target of rapamycin (mTORC1) signaling pathway. We hypothesized that a protein blend of soy and dairy proteins would capitalize on the unique properties of each individual protein and allow for optimal delivery of amino acids to prolong the fractional synthetic rate (FSR) following resistance exercise (RE). In this double-blind, randomized, clinical trial, 19 young adults were studied before and after ingestion of ∼19 g of protein blend (PB) or ∼18 g whey protein (WP) consumed 1 h after high-intensity leg RE. We examined mixed-muscle protein FSR by stable isotopic methods and mTORC1 signaling with western blotting. Muscle biopsies from the vastus lateralis were collected at rest (before RE) and at 3 postexercise time points during an early (0-2 h) and late (2-4 h) postingestion period. WP ingestion resulted in higher and earlier amplitude of blood branched-chain amino acid (BCAA) concentrations. PB ingestion created a lower initial rise in blood BCAA but sustained elevated levels of blood amino acids later into recovery (P < 0.05). Postexercise FSR increased equivalently in both groups during the early period (WP, 0.078 ± 0.009%; PB, 0.088 ± 0.007%); however, FSR remained elevated only in the PB group during the late period (WP, 0.074 ± 0.010%; PB, 0.087 ± 0.003%) (P < 0.05). mTORC1 signaling similarly increased between groups, except for no increase in S6K1 phosphorylation in the WP group at 5 h postexercise (P < 0.05). We conclude that a soy-dairy PB ingested following exercise is capable of prolonging blood aminoacidemia, mTORC1 signaling, and protein synthesis in human skeletal muscle and is an effective postexercise nutritional supplement.

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Slow and fast dietary proteins differently modulate postprandial protein accretion
Boirie, Y., Dangin, M., Gachon, P., Vasson, M.-P., Maubois, J.-L., & Beaufrère, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14930 · Cited by 1,453
Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men
Tang, J. E., Moore, D. R., Kujbida, G. W., Tarnopolsky, M. A., & Phillips, S. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00076.2009 · Cited by 998
Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men
Moore, D. R., Robinson, M. J., Fry, J. L., Tang, J. E., Glover, E. I., Wilkinson, S. B., Prior, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26401 · Cited by 973
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein
Biolo, G., Tipton, K. D., Klein, S., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e122 · Cited by 825
Postexercise net protein synthesis in human muscle from orally administered amino acids
Tipton, K. D., Ferrando, A. A., Phillips, S. M., Doyle, D., & Wolfe, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e628 · Cited by 616
The digestion rate of protein is an independent regulating factor of postprandial protein retention
Dangin, M., Boirie, Y., Garcia-Rodenas, C., Gachon, P., Fauquant, J., Callier, P., Ballèvre, O., & Beaufrère, B. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e340 · Cited by 572
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
Dreyer, H. C., Fujita, S., Cadenas, J. G., Chinkes, D. L., Volpi, E., & Rasmussen, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113175 · Cited by 570 · cited 3×
“Mixed-muscle, protein-bound phenylalanine enrichment was analyzed by GC-MS after protein hydrolysis and amino acid extraction (22,35) using the external standard curve approach (41).”
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Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage
Wilkinson, S. B., Tarnopolsky, M. A., MacDonald, M. J., MacDonald, J. R., Armstrong, D., & Phillips, S. M. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1031 · Cited by 530

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“[195] indicated that a mixture of whey and soy protein over a four-hour measurement window similarly increased MPS rates during the early (0–2 h) time-period versus whey protein, but only the protein blend was able to stimulate significantly increased MPS rates during the later (2– 4 h) measurement window.”
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Thrane, M., Paulsen, P., Orcutt, M. W., & Krieger, T. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802778-3.00002-0 · Cited by 146
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Feeding intact proteins, peptides, or free amino acids to monogastric farm animals
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Kerksick, C. M., Jagim, A. R., Hagele, A. M., & Jäger, R. (2021) · Nutrients · doi:10.3390/nu13061962 · Cited by 46
Interaction between casein and rice glutelin: Binding mechanisms and molecular assembly behaviours
He, C., Hu, Y., Liu, Z., Woo, M. W., Xiong, H., & Zhao, Q. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.105967 · Cited by 39
Dietary Fuels in Athletic Performance
Fritzen, A. M., Lundsgaard, A., & Kiens, B. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124337 · Cited by 42
Dietary protein considerations for muscle protein synthesis and muscle mass preservation in older adults
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Synergistic effects of resistance training and protein intake: Practical aspects
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He, W., Connolly, E. D., Cross, H. R., & Wu, G. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2348549 · Cited by 39
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Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle
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Relationship between dietary amino acid release kinetics and nitrogen deposition in growing pigs
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Pinckaers, P. J., Weijzen, M. E. G., Houben, L. H. P., Zorenc, A. H. G., Kouw, I. W. K., de Groot, C. P. G. M., Verdijk, L. B., Snijders, T., & van Loon, L. J. C. (2024) · Amino Acids · doi:10.1007/s00726-023-03377-z · Cited by 22
Reconsidering the pre-eminence of dietary leucine and plasma leucinemia for predicting the stimulation of postprandial muscle protein synthesis rates
Monteyne, A. J., West, S., Stephens, F. B., & Wall, B. T. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.04.032 · Cited by 20
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Pasiakos, S. M., McClung, H. L., Margolis, L. M., Murphy, N. E., Lin, G. G., Hydren, J. R., & Young, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140863 · Cited by 18
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Effects of fish protein hydrolysate ingestion on postexercise aminoacidemia compared with whey protein hydrolysate in young individuals
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Authors: Reidy, P. T., Walker, D. K., Dickinson, J. M., Gundermann, D. M., Drummond, M. J., Timmerman, K. L., Fry, C. S., Borack, M. S., Cope, M. B., Mukherjea, R., Jennings, K., Volpi, E., & Rasmussen, B. B.
Affiliations: The University of Texas Medical Branch at Galveston (US)
Corresponding author: Rasmussen, Blake B.
ORCID: Reidy, Paul T.
Dickinson, Jared M.
Gundermann, David M.
Drummond, Micah J.
Timmerman, Kyle L.
Fry, Christopher S.
Mukherjea, Ratna
Jennings, Kristofer
Volpi, Elena
Rasmussen, Blake B.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2013-04
Volume: 143
Issue: 4
Pages: 410-416
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.112.168021
PMC: PMC3738242
OpenAlex: W2168338325
Cited by: 178
References: 60
Citations by year: 2026: 5 · 2025: 8 · 2024: 14 · 2023: 14 · 2022: 17 · 2021: 15 · 2020: 21 · 2019: 12 · 2018: 11 · 2017: 15 · 2016: 16 · 2015: 14 · 2014: 10 · 2013: 6
FWCI: 8.90
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3600 d)
Locations: Journal of Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Solae LLC with assistance from NIH (R01 AR49877, T32-HD07539)
National Institute on Disability and Rehabilitation Research (H133P110012)
NIH Clinical and Translational Science Award (UL1TR000071)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: protein blends, soy protein, whey protein, resistance training, muscle protein synthesis, mTORC1 signaling, S6K1 phosphorylation, branched-chain amino acids, aminoacidemia, skeletal muscle, vastus lateralis, fractional synthesis rate
MeSH terms: Whey Proteins, Mechanistic Target of Rapamycin Complex 1, Adolescent, Adult, Amino Acids, Branched-Chain, Caseins, Dietary Proteins, Double-Blind Method, Female, Humans, Isotope Labeling, Kinetics, Male, Milk Proteins, Muscle Proteins, Signal Transduction, Exercise, Dietary Supplements, Soybean Proteins, Multiprotein Complexes, Resistance Training, Young Adult, TOR Serine-Threonine Kinases

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Protein Blend Ingestion Following Resistance Exercise Promotes Human Muscle Protein Synthesis

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