Cited by 215RNA Interference and Gene DeliveryRNA Research and SplicingRNA regulation and disease

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Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

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McManus, Michael T, Haines, Brian B, Dillon, Christopher P, Whitehurst, Charles E, van Parijs, Luk, Chen, Jianzhu, Sharp, Phillip A·2002·The Journal of Immunology

DOI 10.4049/jimmunol.169.10.5754

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Abstract

Introduction of small interfering RNAs (siRNAs) into a cell can cause a specific interference of gene expression known as RNA interference (RNAi). However, RNAi activity in lymphocytes and in normal primary mammalian cells has not been thoroughly demonstrated. In this report, we show that siRNAs complementary to CD4 and CD8α specifically reduce surface expression of these coreceptors and their respective mRNA in a thymoma cell line model. We show that RNAi activity is only caused by a subset of siRNAs complementary to the mRNA target and that ineffective siRNAs can compete with effective siRNAs. Using primary differentiated T lymphocytes, we provide the first evidence of siRNA-mediated RNAi gene silencing in normal nontransformed somatic mammalian lymphocytes.

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Authors: McManus, M. T., Haines, B. B., Dillon, C. P., Whitehurst, C. E., van Parijs, L., Chen, J., & Sharp, P. A.
Affiliations: Massachusetts Institute of Technology (US)
Center for Cancer Research, Massachusetts Institute of Technology , Cambridge, MA 02139
ORCID: McManus, Michael T
Haines, Brian B
Dillon, Christopher P
Whitehurst, Charles E
Chen, Jianzhu
Sharp, Phillip A
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2002-11
Volume: 169
Issue: 10
Pages: 5754-5760
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.169.10.5754
OpenAlex: W2157078151
Cited by: 215
References: 40
Citations by year: 2025: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 14
FWCI: 9.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research Institute
Arthritis Foundation
National Institutes of Health (CA42063)
National Cancer Institute (P01CA042063, P01 CA 42063)
National Institute of General Medical Sciences (R37-GM34277, R37GM034277)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: siRNA, RNA interference, gene silencing, T cells, CD4, CD8A, primary lymphocytes
MeSH terms: Animals, Luminescent Proteins, Membrane Glycoproteins, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, Transgenic, RNA, Messenger, Spleen, T-Lymphocytes, Thymus Gland, Tumor Cells, Cultured, CD4 Antigens, CD8 Antigens, Gene Silencing, RNA Stability, RNA, Small Interfering, Green Fluorescent Proteins, Mice

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Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

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