Insomnia and sleep duration in a large cohort of patients with major depressive disorder and anxiety disorders
Abstract
OBJECTIVE: Disturbed sleep has a high impact on daily functioning and has been correlated with psychopathology. We investigated the extent to which insomnia and sleep duration were associated with both current and remitted depressive and anxiety disorders in a large-scale epidemiologic study, taking sociodemographics, health factors, and medication use into account. METHOD: Data of 2,619 individuals from the Netherlands Study of Depression and Anxiety (NESDA) were analyzed. Psychopathology was classified as no, current, or remitted DSM-IV-based diagnosis of major depressive or anxiety disorder. Outcome measures were insomnia (Women's Health Initiative Insomnia Rating Scale score >or= 9) and sleep duration ( or= 10 hours). Baseline measurement was conducted between September 2004 and February 2007. RESULTS: Both current and remitted depressive disorder and current anxiety disorder were associated with insomnia and short sleep duration with odds ratios (ORs) for insomnia ranging from 1.42 to 3.23 and for short sleep duration ranging from 1.41 to 2.53. Associations were stronger for current than for remitted diagnoses and stronger for depressive than for anxiety disorders. Also long sleep duration was associated with current depressive disorder and anxiety disorders (OR range, 1.53-2.66). Sociodemographic factors, health indicators, and psychotropic medication use did contribute to sleep outcomes but could not explain much of the psychopathology and sleep associations. CONCLUSION: Depressive disorder-but also anxiety disorder-is strongly associated with sleep disturbances. Insomnia and short sleep duration persist after remittance of these disorders, suggesting that these are residual symptoms or possibly trait markers. Also, long sleep duration is associated with current depressive or anxiety disorders.
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Sleep disturbances are the most frequent residual symptoms after remission of a depressive episode.
“Sleep disturbances are the most frequent residual symptoms after remission of a depressive episode [8,9].”
From The effects of exercise on sleep in unipolar depression: a systematic review and network meta-analysis (2021) · cites this paper as [9]
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- Authors
- van Mill, J. G., Hoogendijk, W. J. G., Vogelzangs, N., van Dyck, R., & Penninx, B. W. J. H.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2010-03-15
- Volume
- 71
- Issue
- 03
- Pages
- 239-246
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2160222704
- Cited by
- 251
- References
- 52
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 22 · 2023: 18 · 2022: 10 · 2021: 20 · 2020: 15 · 2019: 14 · 2018: 21 · 2017: 16 · 2016: 19 · 2015: 14 · 2014: 21 · 2013: 20 · 2012: 11
- FWCI
- 18.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- VU Research Portal (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- insomnia, sleep duration, major depressive disorder, anxiety disorders, remitted depression, sleep disorders, residual symptoms, trait markers, psychotropic drugs, sociodemographic factors, long sleep
- MeSH terms
- Adult, Age Factors, Anxiety Disorders, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Sleep Initiation and Maintenance Disorders, Life Change Events, Longitudinal Studies, Male, Netherlands, Psychiatric Status Rating Scales, Sex Factors, Sleep Wake Disorders, Smoking, Cohort Studies, Comorbidity, Body Mass Index, Diagnostic and Statistical Manual of Mental Disorders
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