CHRONOTYPE ASSOCIATIONS WITH DEPRESSION AND ANXIETY DISORDERS IN A LARGE COHORT STUDY: Research Article: Chronotypes in Depression and Anxiety
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BACKGROUND: The chronotype, being a morning or an evening type, can influence an individual's psychological health. Studies have shown a link between depressed mood and being an evening type; however, most studies have used symptom scales and not diagnostic criteria, and confounding factors such as sleep patterns and somatic health factors have often not been considered. This study aims to examine the association between chronotype and depressive (major depressive disorder (MDD), dysthymia) and anxiety (generalized anxiety disorder, panic disorder, agoraphobia, and social phobia) disorders diagnosed using clinical interviews, while taking into account relevant sociodemographic, clinical, somatic health, and sleep parameters. METHODS: Data from a large cohort, the Netherlands Study of Depression and Anxiety were used (n = 1,944), which included 676 currently depressed and/or anxious patients, 831 remitted patients, and 437 healthy controls. Chronotype was assessed using the Munich Chronotype Questionnaire. RESULTS: Our results showed that current depressive and/or anxiety disorders were associated with a late chronotype (β = .10, P = .004) even when adjusting for sociodemographic, somatic health, and sleep-related factors (β = .09, P = .03). When examining each type of disorder separately, MDD only, but not dysthymia or specific anxiety disorders, was associated with the late chronotype. The late chronotype also reported significant diurnal mood variation (worse mood in the morning). CONCLUSIONS: Our findings show a clear association between MDD and late chronotype (being an evening type), after controlling for a range of pertinent factors. A late chronotype is therefore associated with a current status of MDD and deserves the relevant clinical attention when considering treatments.
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The evening chronotype has been linked to greater risk of depression and anxiety, greater dietary energy density, reduced physical activity, and lower cardiorespiratory fitness.
“Importantly, the evening chronotype has been linked to greater risk of depression and anxiety, 25 greater dietary energy density, 26 as well as reduced physical activity and lower cardiorespiratory fitness, 27”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [25]
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- Authors
- Antypa, N., Vogelzangs, N., Meesters, Y., Schoevers, R., & Penninx, B. W. J. H.
- Affiliations
- Leiden University (NL)
- Amsterdam Neuroscience (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Antypa, Niki
- Penninx, Brenda W. J. H.
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2015-09-14
- Volume
- 33
- Issue
- 1
- Pages
- 75-83
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W1870078818
- Cited by
- 252
- References
- 79
- Citations by year
- 2026: 15 · 2025: 30 · 2024: 22 · 2023: 24 · 2022: 24 · 2021: 19 · 2020: 31 · 2019: 21 · 2018: 28 · 2017: 22 · 2016: 16
- FWCI
- 33.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- chronotype, evening chronotype, major depressive disorder, dysthymia, anxiety disorders, generalized anxiety disorder, panic disorder, agoraphobia, social anxiety disorder, sleep patterns, physical health, Munich Chronotype Questionnaire, NESDA
- MeSH terms
- Adult, Aged, Anxiety Disorders, Circadian Rhythm, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Interview, Psychological, Longitudinal Studies, Male, Middle Aged, Netherlands, Surveys and Questionnaires, Cohort Studies, Young Adult
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