Treatment Response, Symptom Remission, and Wellness in Obsessive-Compulsive Disorder
Open accessAbstract
BACKGROUND: Obsessive-compulsive disorder (OCD) is defined both by intrusive, unwanted thoughts, images, or impulses and by repetitive behavioral or mental acts that are often performed to try to alleviate anxiety. The ultimate goal of treatment for OCD is to reduce the symptoms as well as help patients achieve "wellness." Currently, however, there are no widely accepted, empirically supported criteria for determining wellness in OCD. METHOD: Building on previous research, the current study examined the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score that most reliably identified patients who responded to treatment, those who achieved symptom remission, and those who achieved wellness. The current study pooled data from 4 randomized controlled OCD treatment trials (N = 288), which took place between 1990 and 2011 at 2 academic sites. Participants (mean age = 36.8 years) had a primary diagnosis of DSM-IV-TR OCD (mean Y-BOCS score = 25.9). RESULTS: Signal detection analyses showed that a pretreatment-to-posttreatment reduction of ≥ 35% on the Y-BOCS was most predictive of treatment response as defined by the Clinical Global Impressions (CGI)-Improvement scale. A posttreatment Y-BOCS score of ≤ 14 was the best predictor of symptom remission, whereas a score of ≤ 12 was the best predictor of wellness, as defined by symptom remission (defined by the CGI-Severity scale), good quality of life (as measured by the Quality of Life Enjoyment and Satisfaction Questionnaire), and a high level of adaptive functioning (as assessed by the Social Adjustment Scale-Self-Report). Because efficiency (0.86) and specificity (0.88) were highest at the cutoff of ≤ 12, this cutoff score was determined to be the best indicator of wellness. CONCLUSIONS: The present findings support the convergent validity of the Y-BOCS with other measures of well-being (quality of life, adaptive functioning) and highlight the utility of a Y-BOCS score ≤ 12 as a solo indicator of wellness in outcome studies. The use of empirically supported criteria for defining wellness in OCD is recommended to facilitate comparisons across treatment outcome studies and to inform clinical treatment planning. TRIAL REGISTRATION: Pooled data analyzed in this study were from 4 clinical trials, 3 of which are registered at ClinicalTrials.gov (identifiers: NCT00045903, NCT00389493, NCT00316316).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
75-80% of patients with OCD respond to ERP (reduction of ≥35% of the Y-BOCS score), but only 40-73% achieve remission.
“On the one hand, 75–80% of patients with OCD respond to ERP (reduction of ≥35% of the Y-BOCS score), but, on the other hand, only 40–73% achieve remission (depending on the definition of a Y-BOCS score ≤ 14 or ≤ 12) [21–23].”
From Metacognitive Training for Obsessive-Compulsive Disorder: A study protocol for a randomized controlled trial (2020) · cites this paper as [22]
The Results (Treatment Response; page unavailable) support a ≥35% Y-BOCS reduction as a response cutoff, but report 45.9% responders in the pooled sample—not a 75–80% response rate for ERP patients. The Results (Symptom Remission; page unavailable) report 41.7% remission and support a Y-BOCS cutoff of ≤14; they do not establish the claimed 40–73% range by the ≤14 and ≤12 definitions. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe Y-BOCS ≤12 cutoff indicates minimal symptoms and predicts good quality of life and adaptive functioning.
“this cutoff not only reflects minimal symptoms after treatment but also predicts good quality of life and adaptive functioning (12,26,30).”
From Task-based fMRI predicts response and remission to exposure therapy in obsessive-compulsive disorder (2019) · cites this paper as [30]
A posttreatment Y-BOCS score of 12 or less indicates meaningful symptom reduction and is linked to better quality of life and daily functioning.
“operationalized as a posttreatment Y-BOCS score ≤ 12, given that this cutoff reflects symptom reduction and predicts good quality of life and adaptive functioning (12,26,30).”
From Task-based fMRI predicts response and remission to exposure therapy in obsessive-compulsive disorder (2019) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
(2005) · PubMed · Cited by 7,011 · see citing works
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110054008 · Cited by 2,799 · see citing works
The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication
Ruscio, A. M., Stein, D. J., Chiu, W. T., & Kessler, R. C. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.94 · Cited by 2,771 · see citing works
(1993) · PubMed · Cited by 1,900 · see citing works
Assessment of social adjustment by patient self report.
Weissman, M. M. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770090101010 · Cited by 1,782 · see citing works
Foa, E. B., Liebowitz, M. R., Kozak, M. J., Davies, S., Campeas, R., Franklin, M. E., Huppert, J. D., Kjernisted, K., Rowan, V., Schmidt, A. B., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.151 · Cited by 1,048 · see citing works
Self-citationQuality-of-Life Impairment in Depressive and Anxiety Disorders
Rapaport, M. H., Clary, C., Fayyad, R., & Endicott, J. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1171 · Cited by 914 · see citing works
Jacobson, N. S., Roberts, L. J., Berns, S. B., & McGlinchey, J. B. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.67.3.300 · Cited by 853 · see citing works
Jacobson, N. S., Roberts, L. J., Berns, S. B., & McGlinchey, J. B. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.3.300 · Cited by 853 · see citing works
Social adjustment by self-report in a community sample and in psychiatric outpatients
WEISSMAN, M. M., PRUSOFF, B. A., THOMPSON, W. D., HARDING, P. S., & MYERS, J. K. (1978) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197805000-00002 · Cited by 537 · see citing works
Kappa coefficients in medical research
KRAEMER, H. C., Periyakoil, V. S., & Noda, A. M. (2002) · Statistics in Medicine · doi:10.1002/sim.1180 · Cited by 533 · see citing works
Eddy, K. T., Dutra, L., Bradley, R., & Westen, D. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.08.004 · Cited by 475 · see citing works
Quality of life: expanding the scope of clinical significance.
Gladis, M., Gosch, E. A., Dishuk, N. M., & Crits-Christoph, P. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.3.320 · Cited by 342 · see citing works
Simpson, H. B., Foa, E. B., Liebowitz, M. R., Ledley, D. R., Huppert, J. D., Cahill, S., Vermes, D., Schmidt, A. B., Hembree, E., Franklin, M., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07091440 · Cited by 316 · see citing works
Self-citationHuppert, J. D., Simpson, H. B., Nissenson, K. J., Liebowitz, M. R., & Foa, E. B. (2009) · Depression and Anxiety · doi:10.1002/da.20506 · Cited by 314 · see citing works
Self-citationSimpson, H. B., Foa, E. B., Liebowitz, M. R., Huppert, J. D., Cahill, S., Maher, M. J., McLean, C. P., Bender, J., Marcus, S. M., Williams, M. T., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1932 · Cited by 248 · see citing works
Self-citationReliability and validity of the Yale-Brown Obsessive-Compulsive Scale
Woody, S. R., Steketee, G. S., & Chambless, D. L. (1995) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)00076-v · Cited by 242 · see citing works
Response versus remission in obsessive-compulsive disorder
Simpson, H. B., Huppert, J. D., Petkova, E., Foa, E. B., & Liebowitz, M. R. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0214 · Cited by 241 · see citing works
Self-citationSimpson, H. B., Maher, M. J., Wang, Y., Bao, Y., Foa, E. B., & Franklin, M. (2011) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0022659 · Cited by 217 · see citing works
Self-citationBandelow, B., Baldwin, D. S., Dolberg, O. T., Andersen, H. F., & Stein, D. J. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0914 · Cited by 203 · see citing works
QUALITY OF LIFE IN OBSESSIVE-COMPULSIVE DISORDER
Koran, L. M. (2000) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70177-5 · Cited by 186 · see citing works
Storch, E. A., Lewin, A. B., Nadai, A. S. D., & Murphy, T. K. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.04.005 · Cited by 158 · see citing works
Quality of life in obsessive-compulsive disorder before and after treatment
Moritz, S., Rufer, M., Fricke, S., Karow, A., Morfeld, M., Jelinek, L., & Jacobsen, D. (2005) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2005.04.002 · Cited by 150 · see citing works
Defining Response in Clinical Trials for Obsessive-Compulsive Disorder
Tolin, D. F., Abramowitz, J. S., & Diefenbach, G. J. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1209 · Cited by 148 · see citing works
Assessment of Severity and Change in Obsessive Compulsive Disorder
Goodman, W. K., & Price, L. H. (1992) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30214-4 · Cited by 128 · see citing works
Hollander, E., Koran, L. M., Goodman, W. K., Greist, J. H., Ninan, P. T., Yang, H., Li, D., & Barbato, L. M. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0604 · Cited by 103 · see citing works
Bystritsky, A., Saxena, S., Maidment, K. M., Vapnik, T., Tarlow, G., & Rosen, R. M. (1999) · Psychiatric Services · doi:10.1176/ps.50.3.412 · Cited by 93 · see citing works
Refining clinical judgment of treatment outcome in obsessive–compulsive disorder
Lewin, A. B., Nadai, A. S. D., Park, J. M., Goodman, W. K., Murphy, T. K., & Storch, E. A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.08.021 · Cited by 73 · see citing works
Quality of life in panic disorder: looking beyond symptom remission
Davidoff, J., Christensen, S., Khalili, D. N., Nguyen, J., & IsHak, W. W. (2011) · Quality of Life Research · doi:10.1007/s11136-011-0020-7 · Cited by 68 · see citing works
Ondansetron Augmentation in Treatment-Resistant Obsessive-Compulsive Disorder
Pallanti, S., Bernardi, S., Antonini, S., Singh, N., & Hollander, E. (2009) · CNS Drugs · doi:10.2165/11530240-000000000-00000 · Cited by 66 · see citing works
Bergeron, R., Ravindran, A. V., Chaput, Y., Goldner, E. M., Swinson, R. P., Ameringen, M. A. V., Austin, C., & Hadrava, V. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200204000-00007 · Cited by 62 · see citing works
Zimmerman, M. A., Martinez, J. H., Attiullah, N., Friedman, M. A., Toba, C., Boerescu, D. A., & Rahgeb, M. (2011) · Depression and Anxiety · doi:10.1002/da.20870 · Cited by 52 · see citing works
Standard criteria for relapse are needed in obsessive-compulsive disorder
Simpson, H. B., Franklin, M. E., Cheng, J., Foa, E. B., & Liebowitz, M. R. (2005) · Depression and Anxiety · doi:10.1002/da.20052 · Cited by 50 · see citing works
Self-citationFoa, E. B., Liebowitz, M. R., Kozak, M. J., Davies, S. O., Campeas, R., Franklin, M. E., Huppert, J. D., Kjernisted, K. D., Rowan, V. C., Schmidt, A. B., et al. (2007) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.5.3.foc368 · Cited by 31 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [33]Fischer J Corcoran K Measures for Clinical Practice 2 NY Free Press 1994
Cited by
Sorted by citations
Stein, D. J., Costa, D. L. C., Lochner, C., Miguel, E. C., Reddy, Y. C. J., Shavitt, R. G., van den Heuvel, O. A., & Simpson, H. B. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0102-3 · Cited by 895 · see citing works
Self-citationMataix‐Cols, D., de la Cruz, L. F., Nordsletten, A. E., Lenhard, F., Isomura, K., & Simpson, H. B. (2016) · World Psychiatry · doi:10.1002/wps.20299 · Cited by 386 · see citing works
Self-citationSimpson, H. B., Foa, E. B., Liebowitz, M. R., Huppert, J. D., Cahill, S., Maher, M. J., McLean, C. P., Bender, J., Marcus, S. M., Williams, M. T., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1932 · Cited by 248 · see citing works
Self-citationFineberg, N. A., Reghunandanan, S., Simpson, H. B., Phillips, K. A., Richter, M. A., Matthews, K., Stein, D. J., Sareen, J., Brown, A., & Sookman, D. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2014.12.003 · Cited by 150 · see citing works
Self-citationEvidence-Based Assessment of Obsessive–Compulsive Disorder
Rapp, A. M., Bergman, R. L., Piacentini, J. C., & Mcguire, J. F. (2016) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s38359 · Cited by 148 · see citing works
Skapinakis, P., Caldwell, D., Hollingworth, W., Bryden, P. A., Fineberg, N., Salkovskis, P., Welton, N., Baxter, H., Kessler, D., Churchill, R., et al. (2016) · Health Technology Assessment · doi:10.3310/hta20430 · Cited by 132 · see citing works
The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder
Coenen, V. A., Schlaepfer, T. E., Goll, P., Reinacher, P. C., Voderholzer, U., Tebartz van Elst, L., Urbach, H., & Freyer, T. (2017) · CNS Spectrums · doi:10.1017/s1092852916000286 · Cited by 128 · see citing works
Philipp, R., Kriston, L., Lanio, J., Kühne, F., Härter, M., Moritz, S., & Meister, R. (2019) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2345 · Cited by 114 · see citing works
Turner, C. M., Mataix-Cols, D., Lovell, K., Krebs, G., Lang, K., Byford, S., & Heyman, I. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.09.012 · Cited by 111 · see citing works
Andersson, E., Hedman‐Lagerlöf, E., Enander, J., Djurfeldt, D. R., Ljótsson, B., Červenka, S., Isung, J., Svanborg, C., Mataix‐Cols, D., Kaldo, V., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0546 · Cited by 109 · see citing works
Storch, E. A., Wilhelm, S., Sprich, S. E., Henin, A., Micco, J. A., Small, B. J., Mcguire, J. F., Mutch, P. J., Lewin, A. B., Murphy, T. K., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.1128 · Cited by 107 · see citing works
Lenhard, F., Vigerland, S., Andersson, E., Rück, C., Mataix-Cols, D., Thulin, U., Ljótsson, B., & Serlachius, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100773 · Cited by 104 · see citing works
Hamani (2014) · doi:10.1227/neu.0000000000000499 · Cited by 98 · see citing works
Matsumoto, K., Sutoh, C., Asano, K., Seki, Y., Urao, Y., Yokoo, M., Takanashi, R., Yoshida, T., Tanaka, M., Noguchi, R., et al. (2018) · Journal of Medical Internet Research · doi:10.2196/12091 · Cited by 83 · see citing works
Murray, K., Jassi, A. D., Mataix‐Cols, D., Barrow, F., & Krebs, G. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.03.012 · Cited by 91 · see citing works
Intranasal carbetocin reduces hyperphagia in individuals with Prader-Willi syndrome
Dykens, E. M., Miller, J. E., Angulo, M., Roof, E., Reidy, M., Hatoum, H. T., Willey, R., Bolton, G., & Korner, P. (2018) · JCI Insight · doi:10.1172/jci.insight.98333 · Cited by 86 · see citing works
Kyrios, M., Ahern, C., Fassnacht, D. B., Nedeljkovic, M., Moulding, R., & Meyer, D. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.9566 · Cited by 86 · see citing works
Wheaton, M. G., Galfalvy, H., Steinman, S. A., Wall, M. M., Foa, E. B., & Simpson, H. B. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.07.010 · Cited by 79 · see citing works
Self-citationPatel, S. R., Wheaton, M. G., Andersson, E., Rück, C., Schmidt, A. B., Lalima, C., Galfavy, H., Pascucci, O., Myers, R. W., Dixon, L., et al. (2017) · The Behavior Therapist · doi:10.1016/j.beth.2017.09.003 · Cited by 37 · see citing works
Self-citationBrennan, B. P., Lee, C., Elias, J. A., Crosby, J. M., Mathes, B. M., André, M., Gironda, C. M., Pope, H. G., Jenike, M. A., Fitzmaurice, G. M., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.05.008 · Cited by 64 · see citing works
Rickelt, J., Viechtbauer, W., Lieverse, R., Overbeek, T., van Balkom, A. J., van Oppen, P., van den Heuvel, O. A., Marcelis, M., Eikelenboom, M., Tibi, L., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.06.009 · Cited by 63 · see citing works
Donse, L., Sack, A. T., Fitzgerald, P. B., & Arns, M. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2017.03.006 · Cited by 64 · see citing works
Course and outcome of obsessive–compulsive disorder
Sharma, E., & Math, S. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_521_18 · Cited by 61 · see citing works
Wheaton, M. G., Gershkovich, M., Gallagher, T., Foa, E. B., & Simpson, H. B. (2018) · Depression and Anxiety · doi:10.1002/da.22720 · Cited by 56 · see citing works
Self-citationAthey, A. J., Elias, J. A., Crosby, J. M., Jenike, M. A., Pope, H. G., Hudson, J. I., & Brennan, B. P. (2014) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2014.11.001 · Cited by 55 · see citing works
Bragdon, L. B., & Coles, M. E. (2016) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2016.12.002 · Cited by 55 · see citing works
Defining and Addressing Gaps in Care for Obsessive-Compulsive Disorder in the United States
Senter, M. S., Patel, S. R., Dixon, L. B., Myers, R. W., & Simpson, H. B. (2021) · Psychiatric Services · doi:10.1176/appi.ps.202000296 · Cited by 54 · see citing works
Self-citationYun, J., Jang, J. H., Kim, S. N., Jung, W. H., & Kwon, J. S. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.009 · Cited by 54 · see citing works
Zandberg, L. J., Zang, Y., McLean, C. P., Yeh, R., Simpson, H. B., & Foa, E. B. (2015) · Behaviour Research and Therapy · doi:10.1016/j.brat.2015.03.005 · Cited by 52 · see citing works
Self-citationApp-guided exposure and response prevention for obsessive compulsive disorder: an open pilot trial
Boisseau, C. L., Schwartzman, C. M., Lawton, J., & Mancebo, M. C. (2017) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2017.1321683 · Cited by 51 · see citing works
O'Neill, J., & Feusner, J. (2015) · Psychology Research and Behavior Management · doi:10.2147/prbm.s75106 · Cited by 48 · see citing works
Wootton, B. M., Karin, E., Titov, N., & Dear, B. F. (2019) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2019.102111 · Cited by 51 · see citing works
Castro-Rodrigues, P., Camacho, M., Almeida, S., Marinho, M., Soares, C., Barahona-Corrêa, B., & Oliveira-Maia, A. J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00431 · Cited by 49 · see citing works
Geffen, T., Smallwood, J., Finke, C., Olbrich, S., Sjoerds, Z., & Schlagenhauf, F. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102915 · Cited by 48 · see citing works
A pilot randomized controlled trial of aerobic exercise as an adjunct to OCD treatment
Abrantes, A. M., Brown, R. A., Strong, D. R., McLaughlin, N. C. R., Garnaat, S. L., Mancebo, M. C., Riebe, D. A., Desaulniers, J. A., Yip, A. G., Rasmussen, S. A., et al. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.06.010 · Cited by 48 · see citing works
Feusner, J. D., Moody, T., Lai, T. M., Sheen, C., Khalsa, S., Brown, J., Levitt, J., Alger, J., & O’Neill, J. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00074 · Cited by 46 · see citing works
Skarphéðinsson, G., Nadai, A. S. D., Storch, E. A., Lewin, A. B., & Ivarsson, T. (2016) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-016-0863-0 · Cited by 47 · see citing works
Empirically defining treatment response and remission in body dysmorphic disorder
de la Cruz, L. F., Enander, J., Rück, C., Wilhelm, S., Phillips, K. A., Steketee, G. S., Mothi, S. S., Krebs, G., Bowyer, L., Monzani, B. A., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291719003003 · Cited by 47 · see citing works
The effect of treatment on quality of life and functioning in OCD
Asnaani, A., Kaczkurkin, A. N., Alpert, E., McLean, C. P., Simpson, H. B., & Foa, E. B. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2016.10.004 · Cited by 46 · see citing works
Self-citationVicheva, P., Butler, M., & Shotbolt, P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.007 · Cited by 44 · see citing works
Imagery rescripting as an adjunct clinical intervention for obsessive compulsive disorder
Maloney, G. K., Koh, G., Roberts, S., & Pittenger, C. (2019) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2019.102110 · Cited by 41 · see citing works
The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap
Szechtman, H., Harvey, B., Woody, E., & Hoffman, K. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.017772 · Cited by 33 · see citing works
Holland, M. T., Trapp, N. T., McCormick, L. M., Jareczek, F. J., Zanaty, M., Close, L. N., Beeghly, J. H. L., & Greenlee, J. D. W. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00055 · Cited by 38 · see citing works
Imagery Rescripting on Guilt-Inducing Memories in OCD: A Single Case Series Study
Tenore, K., Basile, B., Cosentino, T., Sanctis, B. D., Fadda, S., Femia, G., Gragnani, A., Luppino, O. I., Pellegrini, V., Perdighe, C., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.543806 · Cited by 38 · see citing works
David, J., Crone, C. L., & Norberg, M. M. (2021) · Clinical Psychology and Psychotherapy · doi:10.1002/cpp.2660 · Cited by 34 · see citing works
Perris, F., Sampogna, G., Giallonardo, V., Agnese, S., Palummo, C., Luciano, M., Fabrazzo, M., Fiorillo, A., & Catapano, F. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113872 · Cited by 38 · see citing works
Simpson, H. B., Foa, E. B., Wheaton, M. G., Gallagher, T., Gershkovich, M., Schmidt, A. B., Huppert, J. D., Campeas, R. B., Imms, P., Cahill, S. P., et al. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103890 · Cited by 37 · see citing works
Self-citationObsessive-Compulsive Disorders
Mathews, C. (2021) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001011 · Cited by 37 · see citing works
A randomized controlled study of brief family-based intervention in obsessive compulsive disorder.
Baruah, U., Pandian, R., Narayanaswamy, J., Math, S. B., Kandavel, T., & Reddy, Y. J. J. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.014 · Cited by 33 · see citing works
Kumar, K. K., Bhati, M. T., Ravikumar, V. K., Ghanouni, P., Stein, S., & Halpern, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00066 · Cited by 31 · see citing works
Thompson, B. L., Twohig, M. P., & Luoma, J. B. (2020) · Behavior Therapy · doi:10.1016/j.beth.2020.04.011 · Cited by 37 · see citing works
Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder in Korea
Seol, S.-H., Kwon, J. S., Kim, Y. Y., Kim, S. N., & Shin, M.-S. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.4.373 · Cited by 35 · see citing works
Schiele, M. A., Thiel, C., Kollert, L., Fürst, L., Putschin, L., Kehle, R., Hauke, W., Mahr, M., Reinhold, E., Gottschalk, M. G., et al. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000509910 · Cited by 36 · see citing works
Su, Y., Carpenter, J. K., Zandberg, L. J., Simpson, H. B., & Foa, E. B. (2016) · Behavior Therapy · doi:10.1016/j.beth.2016.03.003 · Cited by 32 · see citing works
Self-citationTask-based fMRI predicts response and remission to exposure therapy in obsessive-compulsive disorder
Pagliaccio, D., Middleton, R., Hezel, D., Steinman, S., Snorrason, I., Gershkovich, M., Campeas, R., Pinto, A., Van Meter, P., Simpson, H. B., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909199116 · Cited by 30 · see citing works
Self-citationFrom Treatment Response to Recovery: A Realistic Goal in OCD
Burchi, E., Hollander, E., & Pallanti, S. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy079 · Cited by 28 · see citing works
Tsuchiyagaito, A., Hirano, Y., Asano, K., Oshima, F., Nagaoka, S., Takebayashi, Y., Matsumoto, K., Masuda, Y., Iyo, M., Shimizu, E., et al. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00143 · Cited by 31 · see citing works
Wheaton, M. G., Huppert, J. D., Foa, E. B., & Simpson, H. B. (2016) · PubMed · Cited by 31 · see citing works
Self-citationRussman Block, S., Norman, L. J., Zhang, X., Mannella, K. A., Yang, H., Angstadt, M., Abelson, J. L., Himle, J. A., Taylor, S. F., & Fitzgerald, K. D. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21111173 · Cited by 30 · see citing works
Dowling, N. L., Thomas, N., Blair‐West, S., Bousman, C., Yap, K., Smith, D. J., & Ng, C. H. (2016) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2016.04.006 · Cited by 30 · see citing works
How resistant is ‘treatment‐resistant’ obsessive‐compulsive disorder in youth?
Krebs, G., Isomura, K., Lang, K., Jassi, A. D., Heyman, I., Diamond, H., Advani, J., Turner, C. M., & Mataix‐Cols, D. (2014) · British Journal of Clinical Psychology · doi:10.1111/bjc.12061 · Cited by 30 · see citing works
Kalanthroff, E., Steinman, S. A., Schmidt, A. B., Campeas, R., & Simpson, H. B. (2018) · Psychotherapy and Psychosomatics · doi:10.1159/000481199 · Cited by 29 · see citing works
Self-citationFaure, K., & Forbes, M. K. (2021) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-021-09868-1 · Cited by 28 · see citing works
Chen, T., Su, H., Jiang, H., Li, X., Zhong, N., Du, J., Meng, Y., Duan, C., Zhang, C., Ke, X., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.05.007 · Cited by 27 · see citing works
Cao, R., Yang, X., Luo, J., Wang, P., Meng, F., Xia, M., Yong He, A., Zhao, T., & Li, Z. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110037 · Cited by 27 · see citing works
Foa, E. B., Simpson, H. B., Gallagher, T., Wheaton, M. G., Gershkovich, M., Schmidt, A. B., Huppert, J. D., Imms, P., Campeas, R. B., Cahill, S. P., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.3997 · Cited by 27 · see citing works
Self-citationMcDonald, S., Melkonian, M., Karin, E., Dear, B. F., Titov, N., & Wootton, B. M. (2023) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465823000103 · Cited by 26 · see citing works
Landmann, S., Cludius, B., Tuschen-Caffier, B., Moritz, S., & Külz, A. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103449 · Cited by 19 · see citing works
A study of oxidative stress biomarkers in obsessive compulsive disorder
Shrivastava, A., Kar, S. K., Sharma, E., Mahdi, A. A., & Dalal, P. (2017) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2017.09.004 · Cited by 26 · see citing works
Jassi, A. D., Vidal‐Ribas, P., Krebs, G., Mataix‐Cols, D., & Monzani, B. A. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01921-4 · Cited by 26 · see citing works
Matsumoto, K., Hamatani, S., Nagai, K., Sutoh, C., Nakagawa, A., & Shimizu, E. (2020) · JMIR Mental Health · doi:10.2196/17157 · Cited by 25 · see citing works
Wootton, B. M., Karin, E., Dear, B. F., Staples, L., Nielssen, O. B., Kayrouz, R., & Titov, N. (2021) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2021.102444 · Cited by 25 · see citing works
Matsumoto, K., Hamatani, S., Makino, T., Takahashi, J., Suzuki, F., Ida, T., Hamamura, S., Takiguchi, S., Tomoda, A., Omori, I. M., et al. (2022) · Internet Interventions · doi:10.1016/j.invent.2022.100515 · Cited by 26 · see citing works
Ashkan, K., Mirza, A. B., Tambirajoo, K., & Furlanetti, L. L. (2020) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2020.09.004 · Cited by 24 · see citing works
de Leeuw, A. S., van Megen, H. J. G. M., Kahn, R. S., & Westenberg, H. G. M. (2016) · European Psychiatry · doi:10.1016/j.eurpsy.2016.06.011 · Cited by 24 · see citing works
Kwak, S., Kim, M., Kim, T., Kwak, Y., Oh, S., Lho, S. K., Moon, S.-Y., Lee, T. Y., & Kwon, J. S. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01045-4 · Cited by 22 · see citing works
Treating OCD: what to do when first-line therapies fail
Castle, D. J., Bosanac, P., & Rossell, S. L. (2015) · Australasian Psychiatry · doi:10.1177/1039856215590027 · Cited by 23 · see citing works
Behura, S. S., & Swain, S. (2016) · Industrial Psychiatry Journal · doi:10.4103/ipj.ipj_94_15 · Cited by 23 · see citing works
Brandt, V. C., Hermanns, J., Beck, C., Bäumer, T., Zurowski, B., & Münchau, A. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.01.041 · Cited by 23 · see citing works
Wheaton, M. G., & Gallina, E. R. (2019) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.33.3.228 · Cited by 22 · see citing works
Elsner, B., Wolfsberger, F., Srp, J., Windsheimer, A., Becker, L., Jacobi, T., Kathmann, N., & Reuter, B. (2020) · Clinical Psychology in Europe · doi:10.32872/cpe.v2i1.2785 · Cited by 22 · see citing works
Sookman, D., Phillips, K. A., Anholt, G. E., Bhar, S. S., Bream, V., Challacombe, F. L., Coughtrey, A. E., Craske, M. G., Foa, E. B., Gagné, J.-P., et al. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113752 · Cited by 22 · see citing works
Self-citationPittenger, C., Brennan, B. P., Koran, L. M., Mathews, C. A., Nestadt, G., Pato, M. T., Phillips, K. A., Rodríguez, C. I., Simpson, H. B., Skapinakis, P., et al. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113853 · Cited by 22 · see citing works
Self-citationJohnco, C. J., Nadai, A. S. D., Lewin, A. B., Ehrenreich, J. T., Wood, J. J., & Storch, E. A. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2483-9 · Cited by 22 · see citing works
Does cognitive-behavioral therapy affect goal-directed planning in obsessive-compulsive disorder?
Wheaton, M. G., Gillan, C. M., & Simpson, H. B. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.079 · Cited by 22 · see citing works
Self-citationPatient-reported outcomes in obsessive-compulsive disorder
Subramaniam, M., Soh, P., Ong, C. W., Seow, E., Picco, L., Vaingankar, J. A., & Chong, S. A. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.2/msubramaniam · Cited by 22 · see citing works
Polak, M., & Tanzer, N. K. (2024) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2989 · Cited by 21 · see citing works
McLean, C. P., Zandberg, L. J., Meter, P. E. V., Carpenter, J. K., Simpson, H. B., & Foa, E. B. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09513 · Cited by 21 · see citing works
Self-citationShaffer, A. L., Naik, A., Bederson, M. M., Arnold, P. M., & Hassaneen, W. (2023) · Neurosurgical FOCUS · doi:10.3171/2022.11.focus22616 · Cited by 20 · see citing works
Maiti, R., Mishra, A., Srinivasan, A., & Mishra, B. R. (2023) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13568 · Cited by 20 · see citing works
Johnco, C. J., Salloum, A., Lewin, A. B., & Storch, E. A. (2015) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0102 · Cited by 20 · see citing works
Fletcher, T. L., Boykin, D. M., Helm, A., Dawson, D. B., Ecker, A. H., Freshour, J., Teng, E., Lindsay, J., & Hundt, N. E. (2022) · Military Psychology · doi:10.1080/08995605.2021.1970983 · Cited by 19 · see citing works
Session-specific effects of the Metacognitive Training for Obsessive-Compulsive Disorder (MCT-OCD)
Miegel, F., Cludius, B., Hottenrott, B., Demiralay, C., Sure, A., & Jelinek, L. (2020) · Psychotherapy Research · doi:10.1080/10503307.2019.1613582 · Cited by 19 · see citing works
Moshfeghinia, R., Najibi, A., Golabi, F., Moradi, M., Malekpour, M., Abdollahifard, S., Slavin, K. V., & Razmkon, A. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106171 · Cited by 19 · see citing works
Meyer, D. M., Spanier, S., Kilian, H. M., Reisert, M., Urbach, H., Sajonz, B., Reinacher, P. C., Normann, C., Domschke, K., Coenen, V. A., et al. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.03.004 · Cited by 19 · see citing works
Bennett, S. D., Stark, D. L., Shafran, R., Heyman, I., & Krebs, G. (2015) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2015.03.004 · Cited by 18 · see citing works
Miegel, F., Demiralay, C., Moritz, S., Wirtz, J., Hottenrott, B., & Jelinek, L. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02648-3 · Cited by 18 · see citing works
Feng, B., Zhang, Z., Zhu, R.-M., Yuan, G., Luo, L., McAlonan, G. M., Xu, F.-Z., Chen, J., Liu, L., Lv, Y.-Y., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.05.015 · Cited by 17 · see citing works
de la Cruz, L. F., Jassi, A. D., Krebs, G., Clark, B., & Mataix‐Cols, D. (2014) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2014.11.003 · Cited by 17 · see citing works
Jensen, S. S., Hybel, K. A., Højgaard, D. R. M. A., Nissen, J. B., Weidle, B., Ivarsson, T., Skarphéðinsson, G., Melin, K., Torp, N. C., Carlsen, A. H., et al. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01775-w · Cited by 16 · see citing works
- Authors
- Farris, S. G., McLean, C. P., Van Meter, P. E., Simpson, H. B., & Foa, E. B.
- Affiliations
- University of Pennsylvania (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Farris, Samantha G.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2013-07-15
- Volume
- 74
- Issue
- 07
- Pages
- 685-690
- ISSN
- 0160-6689 (ISSN-L)
- PMC
- PMC3959901
- OpenAlex
- W1979431943
- Cited by
- 216
- References
- 33
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 19 · 2023: 10 · 2022: 20 · 2021: 23 · 2020: 21 · 2019: 21 · 2018: 11 · 2017: 10 · 2016: 22 · 2015: 16 · 2014: 9 · 2013: 1
- FWCI
- 17.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH-04504-19, K24MH091555, R01MH045404, R34MH071570, K23MH001907, K23 MH-01907, MH-04504-05A2, R01MH045436, MH-04504-10A1, R01MH-45436)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, treatment response, symptom remission, wellness, Yale-Brown Obsessive Compulsive Scale, cut-off values, quality of life, adaptive behavior, convergent validity, treatment outcome measures, signal detection analysis, Clinical Global Impression Scale, treatment planning
- MeSH terms
- Adaptation, Psychological, Adult, Female, Health Status Indicators, Humans, Male, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Psychotropic Drugs, Quality of Life, Remission Induction, Research Design, Sensitivity and Specificity, Reproducibility of Results, Cognitive Behavioral Therapy, Treatment Outcome, Diagnostic and Statistical Manual of Mental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
