The Level of Cardiovascular Risk Factors in Bipolar Disorder Equals That of Schizophrenia: A Comparative Study
Abstract
OBJECTIVE: In schizophrenia, increased rates of somatic mortality have been shown to correspond with a high prevalence of cardiovascular risk factors, including smoking and the metabolic syndrome. In bipolar disorder, the amount of cardiovascular risk is still largely unknown. This study compares the prevalence of smoking and metabolic disturbances in bipolar disorder and schizophrenia in a representative sample of patients under naturalistic conditions. It also compares the prevalence of risk factors in each diagnostic group with the general population. METHOD: Longitudinal data on clinical groups from October 2002 through December 2005 were from the Oslo TOP Study (DSM-IV bipolar disorder [N = 110] and schizophrenia [N = 163]). Reference data were from the 2000 to 2001 Oslo Health Study (18,770 individuals of the same area). Background variables, prevalence of smoking, and age-adjusted levels of metabolic risk factors were compared between diagnostic groups. Risk factors in both groups were then compared with the general population. RESULTS: Patients with bipolar disorder had higher levels of education, better social functioning, fewer psychiatric symptoms, and less use of medication than patients with schizophrenia. There was no significant difference between diagnostic groups in the prevalence of smoking, obesity, metabolic syndrome, or diabetes. The mean level of high density lipoprotein cholesterol was lower in schizophrenia (p < .001), and systolic blood pressure was higher in bipolar disorder (p < .05). Both diagnostic groups had a prevalence of cardiovascular risk factors about twice that of the general population. CONCLUSION: The prevalence of cardiovascular risk factors was alarmingly high for bipolar disorder and schizophrenia patients compared with the general population, and the prevalence was approximately the same in both diagnostic groups.
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Risk factors for cardiovascular disorders are more common in patients with severe mental disorders than in patients without such disorders.
“Several studies have found that risk factors for cardiovascular disorders were more common in patients with severe mental disorders (Birkenaes et al. 2007, Newcomer & Hennekens 2007) than in patients without such disorders.”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Birkenaes et al. 2007
Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works
The Global Assessment Scale: A Procedure for Measuring Overall Severity of Psychiatric Disturbance
Endicott, J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770060086012 · Cited by 4,982 · see citing works
The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description
Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336 · see citing works
The Metabolic Syndrome: Time for a Critical Appraisal
Kahn, R., Buse, J. B., Ferrannini, E., & D, M. P. S. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2289 · Cited by 2,389 · see citing works
The Inventory of Depressive Symptomatology (IDS): Psychometric properties
Rush, A. J., Gullion, C. M., Basco, M. R., Jarrett, R. B., & Trivedi, M. H. (1996) · Psychological Medicine · doi:10.1017/s0033291700035558 · Cited by 2,177 · see citing works
Association between obesity and psychiatric disorders in the US adult population
Simon, G. E., Von Korff, M., Saunders, K., Miglioretti, D. L., Crane, P. K., van Belle, G., & Kessler, R. C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.824 · Cited by 1,338 · see citing works
Mcevoy, J., Meyer, J., Goff, D., Nasrallah, H., Davis, S., Sullivan, L., Meltzer, H., Hsiao, J. K., Stroup, T., & Lieberman, J. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.07.014 · Cited by 1,220 · see citing works
Hu, G. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1066 · Cited by 1,135 · see citing works
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120 · see citing works
Excess Mortality in Bipolar and Unipolar Disorder in Sweden
Ösby, U., Brandt, L., Correia, N., Ekbom, A., & Sparén, P. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.9.844 · Cited by 1,120 · see citing works
Mortality of patients with mood disorders: follow-up over 34–38 years
Angst, F., Stassen, H. H., Clayton, P. J., & Angst, J. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00377-9 · Cited by 881 · see citing works
Excess mortality of schizophrenia: A meta-analysis
Brown, S. (1997) · British Journal of Psychiatry · doi:10.1192/bjp.171.6.502 · Cited by 869 · see citing works
Impaired Fasting Glucose Tolerance in First-Episode, Drug-Naive Patients With Schizophrenia
Ryan, M. C. M., Collins, P. B., & Thakore, J. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.284 · Cited by 828 · see citing works
Mortality and causes of death in schizophrenia in Stockholm County, Sweden
Ösby, U., Correia, N., Brandt, L., Ekbom, A., & Sparén, P. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00191-7 · Cited by 679 · see citing works
Diet, smoking and cardiovascular risk in people with schizophrenia
McCreadie, R. G., & Scottish Schizophrenia Lifestyle Group (2003) · The British Journal of Psychiatry · doi:10.1192/bjp.183.6.534 · Cited by 494 · see citing works
The Increasing Medical Burden in Bipolar Disorder
Kupfer, D. J. (2005) · JAMA · doi:10.1001/jama.293.20.2528 · Cited by 489 · see citing works
The Oslo Health Study: The impact of self-selection in a large, population-based survey
Søgaard, A. J., Selmer, R. M., Bjertness, E., & Thelle, D. S. (2004) · International Journal for Equity in Health · doi:10.1186/1475-9276-3-3 · Cited by 466 · see citing works
Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians
Fagiolini, A. M., Frank, E., Scott, J., Turkin, S. R., & Kupfer, D. J. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00234.x · Cited by 451 · see citing works
Correlates of overweight and obesity in 644 patients with bipolar disorder.
McElroy, S., Frye, M., Suppes, T., Dhavale, D. M., Keck, P., Leverich, G., Altshuler, L., Denicoff, K., Nolen, W., Kupka, R., et al. (2002) · Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0306 · Cited by 344 · see citing works
ETHNIC DIFFERENCES IN CARDIOVASCULAR DISEASE
Chaturvedi, N. (2003) · Heart · doi:10.1136/heart.89.6.681 · Cited by 321 · see citing works
Binder, M. D., van Winkel, R., Eyck, D. V., Hanssens, L., Wampers, M., Scheen, A. J., & Peuskens, J. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.12.855 · Cited by 314 · see citing works
Elevated Frequency of Diabetes Mellitus in Hospitalized Manic-Depressive Patients
Cassidy, F., Ahearn, E. P., & Carroll, B. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1417 · Cited by 300 · see citing works
Cohn, T. A., Prud’homme, D., Streiner, D. L., Kameh, H., & Remington, G. J. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404901106 · Cited by 290 · see citing works
Bipolar Disorder, Obesity, and Pharmacotherapy-Associated Weight Gain
Keck, P. E., & McElroy, S. L. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n1205 · Cited by 235 · see citing works
Prevalence of Obesity and Weight Change During Treatment in Patients With Bipolar I Disorder
Fagiolini, A. M., Frank, E., Houck, P. R., Mallinger, A. G., Swartz, H. A., Buysse, D. J., Ombao, H., & Kupfer, D. J. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0611 · Cited by 202 · see citing works
Prevalence of Overweight and Obesity in Bipolar Patients
Elmslie, J. L., Silverstone, J. T., Mann, J. I., Williams, S. M., & Romans, S. E. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n0306 · Cited by 193 · see citing works
Atypical antipsychotics related metabolic syndrome in bipolar patients
Yumru, M., SAVAS, H. A., Kurt, E., Kaya, M., Selek, S., Savaş, E., Oral, E., & Atagün, M. İ. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.009 · Cited by 142 · see citing works
Strand, B. H., & Tverdal, A. (2004) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2003.014563 · Cited by 123 · see citing works
Johannessen, L., Strudsholm, U., Foldager, L., & Munk‐Jørgensen, P. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.03.027 · Cited by 109 · see citing works
BLOOD SUGAR STUDIES IN DEMENTIA PRAECOX AND MANIC-DEPRESSIVE INSANITY
Raphael, T. (1921) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1921.02180300052005 · Cited by 74 · see citing works
Birkenaes, A. B., Søgaard, A. J., Engh, J. A., Jónsdóttir, H., Ringen, P. A., Vaskinn, A., Friis, S., Sundet, K. S., Opjordsmoen, S., & Andreassen, O. A. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0314 · Cited by 60 · see citing works
Self-citationZimmet, P., & Alberti, K. G. M. M. (2005) · Cited by 28 · see citing works
Flagged first, then by citations
1 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Excess early mortality in schizophrenia.
Laursen, T. M., Nordentoft, M., & Mortensen, P. B. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153657 · Cited by 913 · see citing works
Can bipolar disorder be viewed as a multi-system inflammatory disease?
Leboyer, M., Soreca, I., Scott, J., Frye, M., Henry, C., Tamouza, R., & Kupfer, D. J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.049 · Cited by 417 · see citing works
Ringen, P. A., Engh, J. A., Birkenaes, A. B., Dieset, I., & Andreassen, O. A. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00137 · Cited by 347 · see citing works
Self-citationVancampfort, D., Wampers, M., Mitchell, A. J., Correll, C. U., Herdt, A. D., Probst, M., & Binder, M. D. (2013) · World Psychiatry · doi:10.1002/wps.20069 · Cited by 320 · see citing works
Laursen, T. M., Munk-Olsen, T., Agerbo, E., Gasse, C., & Mortensen, P. B. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.61 · Cited by 271 · see citing works
Cardiovascular disease and hypertension among adults with bipolar I disorder in the United States
Goldstein, B. I., Fagiolini, A., Houck, P., & Kupfer, D. J. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00735.x · Cited by 259 · see citing works
The epidemiology of excess mortality in people with mental illness
Lawrence, D., Kisely, S., & Pais, J. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005501202 · Cited by 258 · see citing works
Severe Mental Illness and Cardiovascular Disease
Goldfarb, M., Binder, M. D., Detraux, J., Palo, K. E. D., Munir, H., Music, S., Piña, I. L., & Ringen, P. A. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.06.017 · Cited by 250 · see citing works
Self-citationCardiovascular Morbidity and Mortality in Bipolar Disorder
Weiner, M., Warren, L. L., & Fiedorowicz, J. G. (2011) · Annals of Clinical Psychiatry · doi:10.1177/104012371102300107 · Cited by 221 · see citing works
Smoking, nicotine and neuropsychiatric disorders
Döme, P., Lazáry, J., Kalapos, M. P., & Rihmer, Z. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.013 · Cited by 215 · see citing works
Athanasiu, L., Mattingsdal, M., Kähler, A. K., Brown, A. A., Gústafsson, Ó., Agartz, I., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.02.002 · Cited by 210 · see citing works
Self-citationFraguas, D., Correll, C. U., Merchán‐Naranjo, J., Rapado‐Castro, M., Parellada, M., Moreno, C., & Arango, C. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.07.002 · Cited by 209 · see citing works
Cardiovascular mortality in bipolar disorder: a population-based cohort study in Sweden
Westman, J., Hällgren, J., Wahlbeck, K., Erlinge, D., Alfredsson, L., & Ösby, U. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002373 · Cited by 204 · see citing works
Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms
Severance, E. G., Dickerson, F., Viscidi, R. P., Bossis, I., Stallings, C. R., Origoni, A. E., Sullens, A., & Yolken, R. H. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp052 · Cited by 190 · see citing works
Ng, F., Mammen, O. K., Wilting, I., Sachs, G. S., Ferrier, I. N., Cassidy, F., Beaulieu, S., Yatham, L. N., & Berk, M. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00737.x · Cited by 192 · see citing works
Kilbourne, A. M., Morden, N. E., Austin, K., Ilgen, M. A., McCarthy, J. F., Dalack, G. W., & Blow, F. C. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.07.008 · Cited by 181 · see citing works
The burden of obesity among adults with bipolar disorder in the United States
Goldstein, B. I., Liu, S.-M., Zivkovic, N., Schaffer, A., Chien, L.-C., & Blanco, C. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00932.x · Cited by 173 · see citing works
Manic/Hypomanic Symptom Burden and Cardiovascular Mortality in Bipolar Disorder
Fiedorowicz, J. G., Solomon, D. A., Endicott, J., Leon, A. C., Li, C., Rice, J. P., & Coryell, W. H. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181acee26 · Cited by 167 · see citing works
Correll, C. U., Frederickson, A. M., Kane, J. M., & Manu, P. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00625.x · Cited by 158 · see citing works
Hope, S., Melle, I. S., Aukrust, P., Steen, N. E., Birkenaes, A. B., Lorentzen, S., Agartz, I., Ueland, T., & Andreassen, O. A. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00757.x · Cited by 152 · see citing works
Self-citationDrexhage, R. C., van der Heul-Nieuwenhuijsen, L., Padmos, R. C., van Beveren, N. J. M., Cohen, D., Versnel, M. A., Nolen, W. A., & Drexhage, H. A. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000799 · Cited by 152 · see citing works
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SayuriYamagata, A., Brietzke, E. M., Rosenblat, J. D., Kakar, R., & McIntyre, R. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.059 · Cited by 153 · see citing works
Hope, S., Ueland, T., Steen, N. E., Dieset, I., Lorentzen, S., Berg, A. O., Agartz, I., Aukrust, P., & Andreassen, O. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.12.023 · Cited by 131 · see citing works
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Andreassen, O. A., Thompson, W. K., & Dale, A. M. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt168 · Cited by 112 · see citing works
Self-citationDyslipidemia Independent of Body Mass in Antipsychotic-Treated Patients Under Real-Life Conditions
Birkenaes, A. B., Birkeland, K. I., Engh, J. A., Færden, A., Jónsdóttir, H., Ringen, P. A., Friis, S., Opjordsmoen, S., & Andreassen, O. A. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318166c4f7 · Cited by 114 · see citing works
Self-citationShared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
Morris, G., Puri, B. K., Walker, A. J., Maes, M. H. J., Carvalho, A. F., Bortolasci, C. C., Walder, K. R., & Berk, M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.025 · Cited by 112 · see citing works
Pompili, M., Venturini, P., Campi, S., Seretti, M. E., Montebovi, F., Lamis, D. A., Serafini, G., Amore, M., & Girardi, P. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00364.x · Cited by 111 · see citing works
Medication Adherence in Patients with Bipolar Disorder: A Comprehensive Review
Levin, J. B., Krivenko, A., Howland, M., Schlachet, R., & Sajatovic, M. (2016) · CNS Drugs · doi:10.1007/s40263-016-0368-x · Cited by 114 · see citing works
Immunity, Inflammation, and Bipolar Disorder: Diagnostic and Therapeutic Implications
Hamdani, N., Doukhan, R., Kurtlucan, O., Tamouza, R., & Leboyer, M. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0387-y · Cited by 103 · see citing works
Fiedorowicz, J. G., He, J., & Merikangas, K. R. (2011) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.07.010 · Cited by 98 · see citing works
Andreassen, O. A., McEvoy, L. K., Thompson, W. K., Wang, Y., Reppe, S., Schork, A. J., Zuber, V., Barrett-Connor, E. L., Gautvik, K. M., Aukrust, P., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02077 · Cited by 88 · see citing works
Self-citationSuicide in Stroke Survivors: Epidemiology and Prevention
Pompili, M., Venturini, P., Lamis, D. A., Giordano, G., Serafini, G., Murri, M. B., Amore, M., & Girardi, P. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0233-x · Cited by 87 · see citing works
The impact of mental illness on cardiac outcomes: A review for the cardiologist
Sowden, G. L., & Huffman, J. C. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.10.002 · Cited by 86 · see citing works
Balancing Efficacy and Safety in Treatment with Antipsychotics
Correll, C. U. (2007) · CNS Spectrums · doi:10.1017/s1092852900026298 · Cited by 85 · see citing works
Bipolar Disorder and Metabolic Syndrome: A Systematic Review
Czepielewski, L. S., Filho, L. D., Brietzke, E. M., & Grassi‐Oliveira, R. (2013) · Brazilian Journal of Psychiatry · doi:10.1016/j.rbp.2012.07.004 · Cited by 81 · see citing works
Health Care for Patients with Serious Mental Illness: Family Medicine's Role
Morden, N. E., Mistler, L. A., Weeks, W. B., & Bartels, S. J. (2009) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2009.02.080059 · Cited by 77 · see citing works
Cardiovascular risk in patients with bipolar disorder
García‐Portilla, M. P., Sáiz, P. A., Bobes-Bascarán, T., Martíneza, S., Benabarre, A., Sierra, P., Torres, P., Montes, J. M. G., Bousoño, M., & Bobes, J. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.09.008 · Cited by 76 · see citing works
Reduced heart rate variability in schizophrenia and bipolar disorder compared to healthy controls
Quintana, D. S., Westlye, L. T., Kaufmann, T., Rustan, Ø. G., Brandt, C. L., Haatveit, B., Steen, N. E., & Andreassen, O. A. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12498 · Cited by 73 · see citing works
Self-citationHartberg, C. B., Sundet, K. S., Rimol, L. M., Haukvik, U. K., Lange, E. H., Nesvåg, R., Melle, I. S., Andreassen, O. A., & Agartz, I. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.03.014 · Cited by 78 · see citing works
Self-citationWirgenes, K. V., Sønderby, I. E., Haukvik, U. K., Mattingsdal, M., Tesli, M., Athanasiu, L., Sundet, K. S., Røssberg, J. I., Dale, A. M., Brown, A. A., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.39 · Cited by 71 · see citing works
Self-citationAppeal of electronic cigarettes in smokers with serious mental illness
Pratt, S. I., Sargent, J. D., Daniels, L., Santos, M. M., & Brunette, M. F. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.03.009 · Cited by 71 · see citing works
Onyeka, I. N., Høegh, M. C., Eien, E. M. N., Nwaru, B. I., & Melle, I. S. (2019) · Journal of Dual Diagnosis · doi:10.1080/15504263.2019.1619007 · Cited by 69 · see citing works
Cardiovascular aspects of antipsychotics
Raedler, T. J. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32833f46c9 · Cited by 89 · see citing works
Vik‐Mo, A. O., Birkenaes, A. B., Fernø, J., Jónsdóttir, H., Andreassen, O. A., & Steen, V. M. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008468 · Cited by 68 · see citing works
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Goldstein, B. I. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.10.006 · Cited by 64 · see citing works
Metabolic syndrome in Italian patients with bipolar disorder
Salvi, V., Albert, U., Chiarle, A., Soreca, I., Bogetto, F., & Maina, G. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2008.04.009 · Cited by 63 · see citing works
Managing the side effects associated with commonly used treatments for bipolar depression.
Kemp, D. E. (2014) · Journal of Affective Disorders · doi:10.1016/s0165-0327(14)70007-2 · Cited by 66 · see citing works
A prospective study of the impact of smoking on outcomes in bipolar and schizoaffective disorder
Dodd, S., Brnabic, A. J. M., Berk, L., Fitzgerald, P. B., de Castella, A. R., Filia, S., Filia, K., Kelin, K., Smith, M., Montgomery, W. S., et al. (2010) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2009.12.001 · Cited by 55 · see citing works
Moreno, C., Merchán‐Naranjo, J., Álvarez, M., Baeza, I., Alda, J. A., Martínez‐Cantarero, C., Parellada, M., Sánchez, B., de la Serna, E., Giráldez, M., et al. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00797.x · Cited by 54 · see citing works
Bakken, T. E., Roddey, J. C., Djurovic, S., Akshoomoff, N. A., Amaral, D. G., Bloss, C. S., Casey, B. J., Chang, L., Ernst, T. M., Gruen, J. R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105829109 · Cited by 52 · see citing works
Self-citationBobo, W. V., & Shelton, R. C. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.143 · Cited by 50 · see citing works
LeBlanc, M., Kulle, B., Sundet, K. S., Agartz, I., Melle, I. S., Djurovic, S., Frigessi, A., & Andreassen, O. A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.11.001 · Cited by 48 · see citing works
Self-citationRettenbacher, M. A., Hofer, A., Ebenbichler, C. F., Baumgartner, S., Edlinger, M., Engl, J., Kaser, S., Kemmler, G., Malík, P., Tschoner, A., et al. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181faf0e3 · Cited by 47 · see citing works
Solberg, D. K., Bentsen, H., Refsum, H., & Andreassen, O. A. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12388 · Cited by 47 · see citing works
Self-citationRødevand, L. N., Steen, N. E., Elvsåshagen, T., Quintana, D. S., Reponen, E. J., Mørch, R. H., Lunding, S. H., Vedal, T. S. J., Dieset, I., Melle, I. S., et al. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13008 · Cited by 45 · see citing works
Self-citationCallaghan, R. C., & Khizar, A. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.029 · Cited by 46 · see citing works
Choong, E., Bondolfi, G., Etter, M., Jermann, F., Aubry, J., Bartolomei, J., Gholam‐Rezaee, M., & Eap, C. B. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.014 · Cited by 46 · see citing works
Impaired glucose metabolism in bipolar patients and response to mood stabilizer treatments
Steardo, L., Fabrazzo, M., Sampogna, G., Monteleone, A. M., D’Agostino, G., Monteleone, P., & Maj, M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.360 · Cited by 50 · see citing works
Ziprasidone and the Corrected QT Interval
Camm, A. J., Karayal, O. N., Meltzer, H. Y., Kolluri, S., O’Gorman, C., Miceli, J. J., Tensfeldt, T. G., & Kane, J. M. (2012) · CNS Drugs · doi:10.2165/11599010-000000000-00000 · Cited by 46 · see citing works
Dieset, I., Hope, S., Ueland, T., Bjella, T. D., Agartz, I., Melle, I. S., Aukrust, P., Røssberg, J. I., & Andreassen, O. A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.040 · Cited by 43 · see citing works
Self-citationIncreased risk of hyperlipidemia in patients with bipolar disorder: a population-based study
Hsu, J., Chien, I., & Lin, C. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.04.003 · Cited by 42 · see citing works
Increased cardiometabolic dysfunction in first-degree relatives of patients with psychotic disorders
Mothi, S. S., Tandon, N., Padmanabhan, J. L., Mathew, I. T., Clementz, B. A., Tamminga, C. A., Pearlson, G. D., Sweeney, J. A., & Keshavan, M. S. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.03.034 · Cited by 41 · see citing works
Why are somatic diseases in bipolar disorder insufficiently treated?
Nielsen, R. E., Kugathasan, P., Straszek, S. P. V., Jensen, S. E., & Licht, R. W. (2019) · International Journal of Bipolar Disorders · doi:10.1186/s40345-019-0147-y · Cited by 42 · see citing works
Kasteng, F., Eriksson, J. W., Sennfält, K., & Lindgren, P. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01716.x · Cited by 40 · see citing works
Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39 · see citing works
Self-citationVuksan‐Ćusa, B., Jakovljević, M., Šagud, M., Peleš, A. M., Marčinko, D., Topić, R., Mihaljević, S., & Sertić, J. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.11.021 · Cited by 39 · see citing works
Engh, J. A., Andersen, E., Holmen, T. L., Martinsen, E. W., Mordal, J., Morken, G., & Egeland, J. (2015) · Trials · doi:10.1186/s13063-015-1094-2 · Cited by 38 · see citing works
Self-citationCircadian rhythms and sleep in bipolar disorder
Soreca, I. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000108 · Cited by 38 · see citing works
Lv, Q., Hu, Q., Zhang, W., Huang, X., Zhu, M., Geng, R., Cheng, X., Bao, C., Wang, Y., Zhang, C., et al. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa003 · Cited by 37 · see citing works
Earley, W. R., Durgam, S., Lu, K., Debelle, M., Laszlovszky, I., Vieta, E., & Yatham, L. N. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.032 · Cited by 36 · see citing works
Chen, Y., Bobo, W. V., Watts, K., Jayathilake, K., Tang, T., & Meltzer, H. Y. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111430748 · Cited by 36 · see citing works
Bipolar Disorder, Schizophrenia, and Metabolic Syndrome
Bartoli, F., Carrà, G., Crocamo, C., Carretta, D., & Clerici, M. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13040447 · Cited by 35 · see citing works
Gomes, F. A., de Almeida, K. M., Magalhães, P. V. D. S., Caetano, S. C., Kauer‐Sant’Anna, M., Lafer, B., & Kapczinski, F. P. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2011-0768 · Cited by 35 · see citing works
Consenso Español de Salud Física del Paciente con Trastorno Bipolar
Bobes, J., Ruiz, J. S., Montes, J. M. G., Mostaza, J. M., Rico‐Villademoros, F., & Vieta, E. (2008) · Revista de Psiquiatría y Salud Mental · doi:10.1016/s1888-9891(08)72513-8 · Cited by 35 · see citing works
Graham, C. R., Griffiths, B., Tillotson, S. M., & Rollings, C. (2013) · Psychiatric Rehabilitation Journal · doi:10.1037/prj0000009 · Cited by 34 · see citing works
Fjukstad, K. K., Engum, A., Lydersen, S., Dieset, I., Steen, N. E., Andreassen, O. A., & Spigset, O. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000582 · Cited by 34 · see citing works
Self-citationMohamed, M., Rashid, M. O., Farooq, S., Siddiqui, N., Parwani, P. J., Shiers, D., Thamman, R., Gulati, M., Shoaib, A., Chew-Graham, C. A., et al. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.04.021 · Cited by 33 · see citing works
Metabolic syndrome in Italian patients with bipolar disorder: A 2-year follow-up study
Salvi, V., D’Ambrosio, V., Bogetto, F., & Maina, G. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.10.025 · Cited by 34 · see citing works
Keane, B. P., Silverstein, S. M., Wang, Y., Roché, M. W., & Papathomas, T. V. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.06.015 · Cited by 34 · see citing works
Fornaro, M., Solmi, M., Veronese, N., Berardis, D. D., Buonaguro, E. F., Tomasetti, C., Perna, G., Preti, A., & Carta, M. G. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1299695 · Cited by 34 · see citing works
Lee, N. Y., Kim, S. H., Cho, B., Lee, Y. J., Chang, J. S., Kang, U. G., Kim, Y. S., & Ahn, Y. M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.029 · Cited by 33 · see citing works
Clerici, M., Bartoli, F., Carretta, D., Crocamo, C., Bebbington, P., & Carrà, G. (2014) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2014.08.005 · Cited by 32 · see citing works
Psychiatric admissions and hospitalization costs in bipolar disorder in Sweden
Ösby, U., Tiainen, A., Backlund, L., Edman, G., Adler, M., Hällgren, J., Sennfält, K., van Baardewijk, M., & Sparén, P. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.09.011 · Cited by 32 · see citing works
Callaghan, R. C., Boire, M. D., Lazo, R. G., McKenzie, K. J., & Cohn, T. A. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.07.018 · Cited by 31 · see citing works
Steen, N. E., Lorentzen, S., Barrett, E. A., Lagerberg, T. V., Hope, S., Larsson, S., Berg, A. O., Agartz, I., Melle, I. S., Berg, J. P., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.03.008 · Cited by 31 · see citing works
Self-citationInhibition of mouse brown adipocyte differentiation by second-generation antipsychotics
Oh, J.-E., Cho, Y. M., Kwak, S.-N., Kim, J. H., Lee, K., Jung, H., Jeong, S., & Kwon, O.-J. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.9.062 · Cited by 30 · see citing works
Lin, H.-C., Chen, Y., Lee, H.-C., & Lin, H. (2010) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048670903487209 · Cited by 30 · see citing works
Sud, D., Laughton, E., McAskill, R., Bradley, E., & Maidment, I. D. (2021) · Systematic Reviews · doi:10.1186/s13643-021-01586-9 · Cited by 30 · see citing works
Treatment of bipolar disorder: New perspectives
Alda, M., Hájek, T., Calkin, C. V., & O’Donovan, C. (2008) · Annals of Medicine · doi:10.1080/07853890802409489 · Cited by 29 · see citing works
Birkenaes, A. B., Birkeland, K., Friis, S., Opjordsmoen, S., & Andreassen, O. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31819b95fc · Cited by 32 · see citing works
Self-citationGuan, N., Liu, H., Diao, F., Zhang, J., Zhang, M., & Wu, T. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02150.x · Cited by 28 · see citing works
Selfish brain and neuroprogression in bipolar disorder.
Mansur, R., Cha, D., Asevedo, E., McIntyre, R., & Brietzke, E. (2013) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.004 · Cited by 27 · see citing works
Łojko, D., Owecki, M., & Suwalska, A. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16071132 · Cited by 27 · see citing works
Plasma oxysterols: Altered level of plasma 24-hydroxycholesterol in patients with bipolar disorder
Guidara, W., Messedi, M., Maalej, M., Naifar, M., Khrouf, W., Grayaa, S., Maalej, M. A., Bonnefont‐Rousselot, D., Lamari, F., & Ayadi, F. M. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105902 · Cited by 25 · see citing works
Nilsson, N., Bendix, M., Öhlund, L., Widerström, M., Werneke, U., & Maripuu, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194411 · Cited by 25 · see citing works
Osteoprotegerin levels in patients with severe mental disorders
Hope, S., Melle, I. S., Aukrust, P., Agartz, I., Lorentzen, S., Steen, N. E., Djurovic, S., Ueland, T., & Andreassen, O. A. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090088 · Cited by 24 · see citing works
Self-citationGoffi, F., Maggioni, E., Bianchi, A. M., Brambilla, P., & Delvecchio, G. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03430-3 · Cited by 26 · see citing works
Graham, C. R., Rollings, C., de Leeuw, S., Anderson, L., Griffiths, B., & Long, N. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/870497 · Cited by 23 · see citing works
SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders
Steen, N. E., Tesli, M., Kähler, A. K., Methlie, P., Hope, S., Barrett, E. A., Larsson, S., Mork, E., Løvås, K., Røssberg, J. I., et al. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.08.013 · Cited by 21 · see citing works
Self-citation
- Authors
- Birkenaes, A. B., Opjordsmoen, S., Brunborg, C., Engh, J. A., Jonsdottir, H., Ringen, P. A., Simonsen, C., Vaskinn, A., Birkeland, K. I., Friis, S., Sundet, K., & Andreassen, O. A.
- Affiliations
- Oslo University Hospital (NO)
- ORCID
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2007-06-15
- Volume
- 68
- Issue
- 06
- Pages
- 917-923
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2055786778
- Cited by
- 185
- References
- 35
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 9 · 2021: 9 · 2020: 4 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 11 · 2015: 11 · 2014: 13 · 2013: 15 · 2012: 17
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- bipolar disorder, schizophrenia, cardiovascular risk factors, smoking, metabolic syndrome, obesity, diabetes mellitus, HDL cholesterol, systolic blood pressure
- MeSH terms
- Adult, Bipolar Disorder, Cardiovascular Diseases, Female, Humans, Longitudinal Studies, Male, Middle Aged, Norway, Risk Factors, Schizophrenia, Smoking, Prevalence, Metabolic Syndrome
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