The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Basics and Recent Advances in Peptide and Protein Drug Delivery
Open accessAbstract
While the peptide and protein therapeutic market has developed significantly in the past decades, delivery has limited their use. Although oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract. Therefore, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to facilitate oral peptide delivery. Additionally, transdermal peptide delivery avoids the issues of the gastrointestinal tract, but also faces absorption limitations. Due to proteases, opsonization and agglutination, free peptides are not systemically stable without modifications. This review discusses oral and transdermal peptide drug delivery, focusing on barriers and solutions to absorption and stability issues. Methods to increase systemic stability and site-specific delivery are also discussed.
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BackgroundInsight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
Foroozandeh, P., & Aziz, A. A. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2728-6 · Cited by 1,377
The evolution of commercial drug delivery technologies
Vargason, A. M., Anselmo, A. C., & Mitragotri, S. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00698-w · Cited by 1,361
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073
Molecular representations in AI-driven drug discovery: a review and practical guide
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Metadata
- Authors
- Bruno, B. J., Miller, G. D., & Lim, C. S.
- Venue
- Therapeutic Delivery
- Publisher
- Informa UK Limited
- Published
- 2013-11
- Volume
- 4
- Issue
- 11
- Pages
- 1443-1467
- ISSN
- 2041-5990 (ISSN-L)
- 2041-6008
- OpenAlex
- W2109598625
- Cited by
- 754
- References
- 12
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
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