Impact of early adverse experience on complexity of adult-generated neurons

Leslie, A T; Akers, K G; Krakowski, A D; Stone, S S D; Sakaguchi, M; Arruda-Carvalho, M; Frankland, P W

doi:10.1038/tp.2011.38

Cited by 30Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsStress Responses and Cortisol

Impact of early adverse experience on complexity of adult-generated neurons

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Leslie, A T, Akers, K G, Krakowski, A D, Stone, S S D, Sakaguchi, M, Arruda-Carvalho, M, Frankland, P W·2011·Translational Psychiatry

DOI 10.1038/tp.2011.38PMC PMC3309502

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Abstract

New neurons continue to be generated in the dentate gyrus (DG) region of the hippocampus throughout adulthood, and abnormal regulation of this process has emerged as an endophenotype common to several psychiatric disorders. Previous research shows that genetic risk factors associated with schizophrenia alter the maturation of adult-generated neurons. Here, we investigate whether early adversity, a potential environmental risk factor, similarly influences adult neurogenesis. During the first 2 weeks of postnatal life, mice were subject to repeated and unpredictable periods of separation from their mothers. When the mice reached adulthood, pharmacological and retroviral labelling techniques were used to assess the generation and maturation of new neurons. We found that adult mice that were repeatedly separated from their mothers early in life had similar rates of proliferation in the DG, but had fewer numbers of cells that survived and differentiated into neurons. Furthermore, neurons generated in adulthood had less complex dendritic arborization and fewer dendritic spines. These findings indicate that early adverse experience has a long-lasting impact on both the number and the complexity of adult-generated neurons in the hippocampus, suggesting that the abnormal regulation of adult neurogenesis associated with psychiatric disorders could arise from environmental influence alone, or from complex interactions of environmental factors with genetic predisposition.

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Maternal separation stress reduced adult neurogenesis in the rat hippocampus in previous work.
“Previous work showed maternal separation stress reduced adult neurogenesis in the rat hippocampus (37; 62–64), although other studies failed to show this (65).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [63]

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Authors: Leslie, A. T., Akers, K. G., Krakowski, A. D., Stone, S. S. D., Sakaguchi, M., Arruda-Carvalho, M., & Frankland, P. W.
Affiliations: Hospital for Sick Children (CA)
University of Toronto (CA)
Corresponding author: Frankland, P W
ORCID: Leslie, A T
Akers, K G
Krakowski, A D
Stone, S S D
Sakaguchi, M
Arruda-Carvalho, M
Frankland, P W
Venue: Translational Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2011-08-30
Volume: 1
Issue: 8
Pages: e35-e35
ISSN: 2158-3188 (ISSN-L)
DOI: 10.1038/tp.2011.38
PMC: PMC3309502
OpenAlex: W2039133312
Cited by: 30
References: 43
Citations by year: 2026: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 2
FWCI: 0.74
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.springer.com/tdm (unspecified)
Locations: Translational Psychiatry (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Hospital for Sick Children
Canadian Institutes of Health Research (MOP- 86762)
Natural Sciences and Engineering Research Council of Canada
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: childhood adversity, adult neurogenesis, dentate gyrus, hippocampus, maternal separation, dendritic spines, neuronal maturation, environmental risk factors, schizophrenia endophenotype, mental illness, gene-environment interaction
MeSH terms: Aging, Animals, Animals, Newborn, Female, Hippocampus, Mice, Inbred C57BL, Mothers, Neurons, Risk Factors, Stress, Physiological, Stress, Psychological, Dentate Gyrus, Dendritic Spines, Mice, Neurogenesis

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Impact of early adverse experience on complexity of adult-generated neurons

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