Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics

Kubota, Takeo; Miyake, Kunio; Hirasawa, Takae

doi:10.1186/1868-7083-4-1

Cited by 157Epigenetics and DNA MethylationGenetic Associations and EpidemiologyGenetic Syndromes and Imprinting

Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics

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Kubota, Takeo, Miyake, Kunio, Hirasawa, Takae·2012·Clinical Epigenetics

DOI 10.1186/1868-7083-4-1PMC PMC3305338

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Abstract

Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins. Although environmental and genetic factors were thought to be independently associated with disorders, several recent lines of evidence suggest that epigenetics bridges these two factors. Epigenetic gene regulation is essential for normal development, thus defects in epigenetics cause various rare congenital diseases. Because epigenetics is a reversible system that can be affected by various environmental factors, such as drugs, nutrition, and mental stress, the epigenetic disorders also include common diseases induced by environmental factors. In this review, we discuss the nature of epigenetic disorders, particularly psychiatric disorders, on the basis of recent findings: 1) susceptibility of the conditions to environmental factors, 2) treatment by taking advantage of their reversible nature, and 3) transgenerational inheritance of epigenetic changes, that is, acquired adaptive epigenetic changes that are passed on to offspring. These recently discovered aspects of epigenetics provide a new concept of clinical genetics.

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DNA methylation regulates gene expression without altering DNA sequence.
“DNA methylation (DNAm) is an epigenetic mechanism that regulates gene expression without altering DNA sequence”
From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [18]
DNA methylation is susceptible to environmental factors that modify disease risk.
“and it is susceptible to environmental factors that modify the risk of diseases [18].”
From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [18]

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Grape Seed Proanthocyanidins (GSPs) Inhibit the Growth of Cervical Cancer by Inducing Apoptosis Mediated by the Mitochondrial Pathway
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A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia
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Epigenetics and Nutritional Environmental Signals
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Activation vs. Experiential Avoidance as a Transdiagnostic Condition of Emotional Distress: An Empirical Study
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Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration
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Epigenetic Treatment of Neuropsychiatric Disorders: Autism and Schizophrenia
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ADHD-originating in the gut? The emergence of a new explanatory model
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The role of DNA methylation in the association between childhood adversity and cardiometabolic disease
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Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions
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Microbial dysbiosis and epigenetics modulation in cancer development – A chemopreventive approach
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Distinct sex-specific DNA methylation differences in Alzheimer’s disease
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“DNA methylation (DNAm) is an epigenetic mechanism that regulates gene expression without altering DNA sequence, and it is susceptible to environmental factors that modify the risk of diseases [18].”
Background
The Role of Epigenetics in Type 1 Diabetes.
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Epigenetic perspectives associated with COVID-19 infection and related cytokine storm: an updated review
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Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women
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In vitro modeling of the neurobiological effects of glucocorticoids: A review
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Epigenetic silencing of TMEM176A promotes esophageal squamous cell cancer development
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Yacón (Smallanthus sonchifolius) prevented inflammation, oxidative stress, and intestinal alterations in an animal model of colorectal carcinogenesis
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The Matrix of Needs: Reframing Maslow’s Hierarchy
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Implication of gut microbes and its metabolites in colorectal cancer
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Defining epigenetic literacy: How to integrate epigenetics into the biology curriculum
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The role of nutraceuticals in the management of autism
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Histone deacetylase activity is altered in brain areas from aged rats
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Epigenetic Mechanisms Might Help Explain Environmental Contributions to the Pathogenesis of Keratoconus
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Mild daily stress, in interaction with NR3C1 DNA methylation levels, is linked to alterations in the HPA axis and ANS response to acute stress in early adolescents
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Attachment-related dimensions in the epigenetic era: A systematic review of the human research
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Epigenetic regulation in the pathophysiology of Lewy body dementia
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Near-infrared Raman spectroscopy for assessing biochemical changes of cervical tissue associated with precarcinogenic transformation
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Low Concentration of Sodium Butyrate from Ultrabraid+NaBu suture, Promotes Angiogenesis and Tissue Remodelling in Tendon-bones Injury
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Active Cigarette Smoking Is Associated With an Exacerbation of Genetic Susceptibility to Diabetes
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Clinical prediction of the need for interventions for the control of myopia
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Methionine concentration in the diet has a tissue-specific effect on chromosomal stability in female mice
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Calcium butyrate: Anti-inflammatory effect on experimental colitis in rats and antitumor properties
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A critical appraisal of clinical epigenetics
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How environments get to the skin: biosensory ethnography as a method for investigating the relation between psychosis and the city
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Aberrant DNA methylation of DLX 4 and SIM 1 is a predictive marker for disease progression of uterine cervical low‐grade squamous intraepithelial lesion
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The missing heritability in type 1 diabetes
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The histone deacetylase inhibitor, entinostat (MS-275), induces the odontogenic differentiation of an odontoblast-like cell line in the absence of an osteoblast mineralization medium
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Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice
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Zinc as a plausible epigenetic modulator of glioblastoma multiforme
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Epigenome-wide DNA methylation in externalizing behaviours: a review and combined analysis
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Epigenetic Alterations in Prescription Opioid Misuse: New Strategies for Precision Pain Management
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Synthesis, characterization, and evaluation of Cd[L-proline]2, a novel histone deacetylase inhibitor that induces epigenetic modification of histone deacetylase isoforms in A549 cells
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Gene-Environment Interactions in Attention-Deficit/Hyperactivity Disorder Symptom Dimensions: The Role of Unhealthy Food Habits
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The early life exposome and autism risk: a role for the maternal microbiome?
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A higher dysregulation burden of brain DNA methylation in female patients implicated in the sex bias of Schizophrenia
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Fructooligosaccharide intake promotes epigenetic changes in the intestinal mucosa in growing and ageing rats
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Early exposure to a methyl donor supplemented diet and the development of repetitive motor behavior in a mouse model
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Role of Epigenetics in Type 2 Diabetes and Obesity
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Color, light, and birth space design: An integrative review
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CRISPR/Cas9-directed epigenetic editing in colorectal cancer
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Dietary Sodium Butyrate Supplementation Promotes Oxidative Fiber Formation in Mice
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Regulatory Functions of Fatty Acids with Different Chain Lengths on the Intestinal Health in Pigs and Relative Signaling Pathways
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Neuroprotective Epigenetic Changes Induced by Maternal Treatment with an Inhibitor of Soluble Epoxide Hydrolase Prevents Early Alzheimer′s Disease Neurodegeneration
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Authors: Kubota, T., Miyake, K., & Hirasawa, T.
Affiliations: University of Yamanashi (JP)
Corresponding author: Kubota, Takeo
ORCID: Miyake, Kunio
Venue: Clinical Epigenetics
Publisher: Springer Science and Business Media LLC
Published: 2012-01-20
Volume: 4
Issue: 1
Pages: 1-1
ISSN: 1868-7075 (ISSN-L)
1868-7083
DOI: 10.1186/1868-7083-4-1
PMC: PMC3305338
OpenAlex: W2156106199
Cited by: 157
References: 77
Citations by year: 2026: 2 · 2025: 11 · 2024: 7 · 2023: 15 · 2022: 12 · 2021: 16 · 2020: 14 · 2019: 12 · 2018: 11 · 2017: 14 · 2016: 7 · 2015: 8 · 2014: 14 · 2013: 11 · 2012: 3
FWCI: 4.63
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/2.0 (tdm)
Locations: Clinical Epigenetics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science (23791156, 24659437, 23390272, 23591491, 23659519)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: epigenetics, gene-environment interaction, mental illness, epigenetic disorders, DNA methylation, histone modifications, environmental factors, transgenerational epigenetic inheritance, medical genetics, epigenetic therapy

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Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics

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