Alzheim(i)R: MicroRNAs in Alzheimer’s Disease
Open accessAbstract
Alzheimer's Disease (AD) is a progressive degenerative disease affecting the central nervous system, characterized by early memory impairments followed by cognitive deficit as aphasia, agnosia and apraxia.AD affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 [1].Cellular and molecular neurodegeneration detected in AD is characterized by synapse and neuronal loss, extracellular amyloid β (Aβ) peptide accumulation and intracellular neurofibrillary tangles (hyperphosphorylated tau) [2,3].Less than 1% of AD cases are familial, (onset before 60 to 65 years of age) due to mutations in three genes, APP, presenilin 1 (PSEN1), and presenilin 2 (PSEN2), all involved in Abeta overproduction [4].To date, high Ab levels were suggested to trigger neuronal dysfunctions as major contributors to disease development in the familial form of AD, but for the majority of AD cases, also called sporadic AD, with no obvious genetic bases, other mechanisms are expected to be responsible.Recently, expression profiles of microRNA (miRNA) in Alzheimer's disease brain revealed alterations in many individual miRNAs, and several in vitro and in vivo studies have suggested that a deregulated microRNA expression could contribute to AD [5,6].
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More miRNAs can be detected in postmortem CSF because CSF can be contaminated by miRNAs released from degenerated brain tissues.
“It has been reported that more miRNAs can be detected in postmortem CSF, because CSF can be contaminated by miRNAs released from degenerated brain tissues19,37.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [37]
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Yoon, H., Belmonte, K. C., Kasten, T., Bateman, R., & Kim, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13031-w · Cited by 26 · see citing works
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- Authors
- Barbato, C.
- Affiliations
- National Research Council (IT)
- Corresponding author
- Barbato, Christian
- ORCID
- Barbato, Christian
- Venue
- Journal of Cytology & Histology
- Publisher
- OMICS Publishing Group
- Published
- 2014
- Volume
- 05
- Issue
- 05
- ISSN
- 2157-7099 (ISSN-L)
- OpenAlex
- W2318723538
- Cited by
- 3
- References
- 40
- Citations by year
- 2018: 1 · 2017: 1 · 2014: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cytology & Histology (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Regione Lazio
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, microRNA, amyloid-beta, tau hyperphosphorylation, neurofibrillary tangles, synaptic loss, neuronal loss, familial Alzheimer's disease, sporadic Alzheimer's disease, APP, presenilin 1, presenilin 2, cognitive impairment
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