Ursolic acid-induced elevation of serum irisin augments muscle strength during resistance training in men

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Pharmacology of oleanolic acid and ursolic acid

Liu, J. (1995) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(95)90032-2 · Cited by 1,431 · see citing works

Role of Myokines in Exercise and Metabolism

Pedersen, B. K., Åkerström, T. C. A., Nielsen, A. R., & Fischer, C. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00080.2007 · Cited by 841 · see citing works

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

Schiaffino, S., & Mammucari, C. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-4 · Cited by 816 · cited 1× · see citing works

The effects of acute and chronic exercise on <scp>PGC</scp> ‐1α, irisin and browning of subcutaneous adipose tissue in humans

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014) · The FEBS Journal · doi:10.1111/febs.12619 · Cited by 563 · see citing works

Circulating irisin in relation to insulin resistance and the metabolic syndrome.

Park, K., Zaichenko, L., Brinkoetter, M. T., Thakkar, B., Sahin-Efe, A., Joung, K., Tsoukas, M. A., Geladari, E., Huh, J., Dinçer, F., et al. (2013) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-2373 · Cited by 527 · see citing works

Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?

Febbraio, M. A., & Pedersen, B. K. (2005) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200507000-00003 · Cited by 402 · see citing works

mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass

Kunkel, S. D., Suneja, M., Ebert, S. M., Bongers, K. S., Fox, D. K., Malmberg, S. E., Alipour, F., Shields, R. K., & Adams, C. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.020 · Cited by 345 · cited 3× · see citing works

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

Huh, J. Y., Dincer, F., Mesfum, E., & Mantzoros, C. S. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.42 · Cited by 309 · see citing works

Are skeletal muscle <i>FNDC5</i> gene expression and irisin release regulated by exercise and related to health?

Pekkala, S., Wiklund, P. K., Hulmi, J. J., Ahtiainen, J. P., Horttanainen, M., Pöllänen, E., Mäkelä, K. A., Kainulainen, H., Häkkinen, K., Nyman, K., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.263707 · Cited by 292 · see citing works

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

Keipert, S., Ost, M., Johann, K., Imber, F., Jastroch, M., van Schothorst, E. M., Keijer, J., & Klaus, S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2013 · Cited by 221 · cited 1× · see citing works

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Kunkel, S. D., Elmore, C., Bongers, K. S., Ebert, S. M., Fox, D. K., Dyle, M. C., Bullard, S. A., & Adams, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039332 · Cited by 220 · see citing works

Irisin and FNDC5 in retrospect

Erickson, H. (2013) · Adipocyte · doi:10.4161/adip.26082 · Cited by 211 · see citing works

Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy.

Philippou, Α., Halapas, A., Maridaki, M. D., & Koutsilieris, M. (2007) · PubMed · Cited by 189 · see citing works

Combined resistance and endurance exercise training improves arterial stiffness, blood pressure, and muscle strength in postmenopausal women

Figueroa, A., Park, S., Seo, D. Y., Sanchez‐Gonzalez, M. A., & Baek, Y. H. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182135442 · Cited by 164 · see citing works

Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative FunctionPreprint

Jang, Y. C., Sinha, M., Cerletti, M., Dall’Osso, C., & Wagers, A. J. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010652 · Cited by 127 · see citing works

Irisin, Two Years Later

Novelle, M. G., Contreras, C., Romero, A., López, M., & Diéguez, C. (2013) · International Journal of Endocrinology · doi:10.1155/2013/746281 · Cited by 117 · see citing works

Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle

Apró, W., Wang, L., Pontén, M., Blomstrand, E., & Sahlin, K. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00091.2013 · Cited by 109 · see citing works

Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma

Kim, S., Hong, J.-H., & Lee, Y. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.033 · Cited by 106 · see citing works

Irisin, Turning Up the Heat

Villarroya, F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.010 · Cited by 104 · see citing works

Is There a Minimum Intensity Threshold for Resistance Training-Induced Hypertrophic Adaptations?

Schoenfeld, B. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0088-z · Cited by 97 · see citing works

Humanized animal exercise model for clinical implication

Seo, D. Y., Lee, S. R., Kim, N., Ko, K. S., Rhee, B. D., & Han, J. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1496-0 · Cited by 92 · see citing works

Yoga Training Improves Metabolic Parameters in Obese Boys

Seo, D. Y., Lee, S.-R., Figueroa, A., Kim, H. K., Baek, Y. H., Kwak, Y., Kim, N., Choi, T. H., Rhee, B. D., Ko, K. S., et al. (2012) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2012.16.3.175 · Cited by 90 · see citing works

Rev-erbβ Regulates the Expression of Genes Involved in Lipid Absorption in Skeletal Muscle Cells

Ramakrishnan, S. N., Lau, P., Burke, L. J., & Muscat, G. E. O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413949200 · Cited by 89 · see citing works

Ursolic Acid, a Pentacyclic Triterpene from Sambucus australis , Prevents Abdominal Adiposity in Mice Fed a High-Fat Diet

Rao, V. S. N., de Melo, C. L., de Queiroz, M. G. R., Lemos, T. L. G., de Menezes, D. B., de Melo, T. S., & Santos, F. A. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0267 · Cited by 86 · see citing works

Resistance Exercise Training does not Affect Plasma Irisin Levels of Hemodialysis Patients

Moraes, C., Leal, V. D. O., Marinho, S. M., Barroso, S. G., Rocha, G. D. S., Boaventura, G. T., & Mafra, D. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1354402 · Cited by 77 · see citing works

Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle

Ogasawara, R., Sato, K., Higashida, K., Nakazato, K., & Fujita, S. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00302.2013 · Cited by 70 · see citing works

Exercise-Induced Insulin-Like Growth Factor I System Concentrations after Training in Women

Gregory, S. M., Spiering, B. A., Alemany, J. A., Tuckow, A. P., Rarick, K. R., Staab, J. S., Hatfield, D. L., Kraemer, W. J., Maresh, C. M., & Nindl, B. C. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182750bd4 · Cited by 68 · see citing works

Dietary Supplement Intake in National-Level Sri Lankan Athletes

de Silva, A., Samarasinghe, Y., SENANAYAKE, D. W., & Lanerolle, P. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.1.15 · Cited by 64 · see citing works

Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle

Li, M., Li, C., & Parkhouse, W. S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00124-6 · Cited by 62 · see citing works

Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism

Verano, J., González‐Trujano, M. E., Déciga‐Campos, M., Ventura‐Martínez, R., & Pellicer, F. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.020 · Cited by 56 · see citing works

PGC-1α Induces Mitochondrial and Myokine Transcriptional Programs and Lipid Droplet and Glycogen Accumulation in Cultured Human Skeletal Muscle Cells

Mormeneo, E., Jimenez-Mallebrera, C., Palomer, X., Nigris, V. D., Vázquez‐Carrera, M., Orozco, A., Nascimento, A., Colomer, J., Lerín, C., & Gómez-Foix, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029985 · Cited by 54 · see citing works

Effects of aged garlic extract and endurance exercise on skeletal muscle FNDC-5 and circulating irisin in high-fat-diet rat models

Seo, D. Y., Kwak, H. B., Lee, S. R., Cho, Y. S., Song, I.-S., Kim, N., Bang, H. S., Rhee, B. D., Ko, K. S., Park, B. J., et al. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.2.177 · Cited by 53 · see citing works

Effect of Exercise Intensity on Unfolded Protein Response in Skeletal Muscle of Rat

Kim, K., Kim, Y.-H., Lee, S.-H., Jeon, M.-J., Park, S., & Doh, K. (2014) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2014.18.3.211 · Cited by 50 · see citing works

Effects of oral adenosine-5′-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men

Wilson, J. M., Joy, J. M., Lowery, R. P., Roberts, M. D., Lockwood, C. M., Manninen, A. H., Fuller, J. C., Souza, E. O. D., Baier, S. M., Wilson, S. M., et al. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-57 · Cited by 46 · see citing works

Resistance Training Improves Insulin Signaling and Action in Skeletal Muscle

Yaspelkis, B. B. (2006) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200601000-00009 · Cited by 42 · see citing works

Supplement consumption in body builder athletes.

Karimian, J., & Shekarchizadeh, P. (2011) · PubMed Central · Cited by 40 · see citing works

Antiobesity potential of ursolic acid stearoyl glucoside by inhibiting pancreatic lipase

Kazmi, I. A., Afzal, M., Rahman, S., Iqbal, M., Imam, F., & Anwar, F. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.02.032 · Cited by 39 · see citing works

Irisin, the metabolic syndrome and follistatin in humans

Boström, P., & Fernández‐Real, J. M. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.230 · Cited by 37 · see citing works

Ursolic acid induces apoptosis via Akt/NF-κB signaling suppression in T24 human bladder cancer cells

Gai, L., CAI, N., Wang, L., Xu, X., & KONG, X. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1364 · Cited by 35 · see citing works

Aged garlic extract enhances exercise-mediated improvement of metabolic parameters in high fat diet-induced obese rats

Seo, D. Y., Lee, S., Figueroa, A., Kwak, Y., Kim, N., Rhee, B. D., Ko, K. S., Bang, H. S., Baek, Y. H., & Han, J. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.6.513 · Cited by 32 · see citing works

Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women

Seo, D. Y., Lee, S. R., Kim, H. K., Baek, Y. H., Kwak, Y., Ko, T. H., Kim, N., Rhee, B. D., Ko, K. S., Park, B., et al. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.3.226 · Cited by 31 · see citing works

Ursolic-Acid-Enriched Herba Cynomorii Extract Protects against Oxidant Injury in H9c2 Cells and Rat Myocardium by Increasing Mitochondrial ATP Generation Capacity and Enhancing Cellular Glutathione Redox Cycling, Possibly through Mitochondrial Uncoupling

Chen, J., & Ko, K. M. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/924128 · Cited by 23 · see citing works

Modulation effects of cordycepin on the skeletal muscle contraction of toad gastrocnemius muscle

Yao, L., Meng, W., Song, R., Xiong, Q.-P., Sun, W., Luo, Z., Yan, W., Li, Y., Liu, X., Li, H., et al. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.016 · Cited by 12 · see citing works

Amlodipine reduces blood pressure during dynamic resistance exercise in hypertensive patients

Souza, D., Gomides, R. S., Costa, L. A. R., Queiroz, A. C. C., de Barros, S., Ortega, K. C., Mion, D., Tinucci, T., & Forjaz, C. L. M. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12152 · Cited by 11 · see citing works

The effects of two weeks of recombinant growth hormone administration on the response of IGF-I and N-terminal pro-peptide of collagen type III (P-III-NP) during a single bout of high resistance exercise in resistance trained young men

Velloso, C. P., Aperghis, M., Godfrey, R., Blazevich, A. J., Bartlett, C., Cowan, D., Holt, R. I. G., Bouloux, P. M., Harridge, S. D. R., & Goldspink, G. (2013) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2013.01.002 · Cited by 7 · see citing works

Accentuation of ursolic acid on muscarinic receptor-induced ANP secretion in beating rabbit atria

Kim, H. Y., Choi, H. R., Lee, Y. J., Cui, H. Z., Jin, S. N., Cho, K. W., Kang, D. G., & Lee, H. S. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.12.001 · Cited by 7 · see citing works

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

Woźniak, Ł., Skąpska, S., & Marszałek, K. (2015) · Molecules · doi:10.3390/molecules201119721 · Cited by 389 · see citing works

Progress and Challenges in the Biology of FNDC5 and Irisin

Maak, S., Norheim, F., Drevon, C. A., & Erickson, H. P. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab003 · Cited by 247 · see citing works

The role of exercise-induced myokines in regulating metabolism

Huh, J. Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0994-y · Cited by 242 · see citing works

Ursolic acid in health and disease

Seo, D. Y., Lee, S. R., Heo, J., No, M., Rhee, B. D., Ko, K. S., Kwak, H., & Han, J. (2018) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2018.22.3.235 · Cited by 228 · see citing works

New strategies in sport nutrition to increase exercise performance

Close, G. L., Hamilton, D. L., Philp, A., Burke, L. M., & Morton, J. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.016 · Cited by 221 · see citing works

Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans

Kim, H.-J., So, B., Choi, M., Kang, D., & Song, W. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.07.006 · Cited by 181 · see citing works

Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance

Bond, P. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-016-0118-y · Cited by 121 · see citing works

Amino acid sensing in skeletal muscle

Moro, T., Ebert, S. M., Adams, C. M., & Rasmussen, B. B. (2016) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2016.06.010 · Cited by 104 · see citing works

Is irisin the new player in exercise-induced adaptations or not? A 2017 update

Fatouros, I. G. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0674 · Cited by 91 · see citing works

Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases

Alam, M., Ali, S., Ahmed, S., Elasbali, A. M., Adnan, M., Islam, A., Hassan, M. I., & Yadav, D. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212162 · Cited by 91 · see citing works

Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults

Zhao, J., Su, Z., Qu, C., & Dong, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00171 · Cited by 82 · see citing works

Supplements with purported effects on muscle mass and strength

Valenzuela, P. L., Morales, J. S., Emanuele, E., Pareja-Galeano, H., & Lucia, A. (2019) · European Journal of Nutrition · doi:10.1007/s00394-018-1882-z · Cited by 78 · see citing works

Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances

Najm, A., Niculescu, A.-G., Grumezescu, A. M., & Beuran, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084300 · Cited by 78 · see citing works

The “irisin system”: From biological roles to pharmacological and nutraceutical perspectives

Flori, L., Testai, L., & Calderone, V. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118954 · Cited by 79 · see citing works

“Nutraceuticals” in relation to human skeletal muscle and exercise

Deane, C. S., Wilkinson, D. J., Phillips, B. E., Smith, K., Etheridge, T., & Atherton, P. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2016 · Cited by 73 · see citing works

Handgrip strength is inversely associated with metabolic syndrome and its separate components in middle aged and older adults: a large-scale population-based study

Wu, H., Liu, M., Quynh, V. T., Wang, J., Zhang, Q., Liu, L., Meng, G., Yao, Z., Bao, X., Gu, Y., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2019.01.011 · Cited by 69 · see citing works

Therapeutic Potential of Ursolic Acid to Manage Neurodegenerative and Psychiatric Diseases

Ramos-Hryb, A. B., Pazini, F. L., Kaster, M. P., & Rodrigues, A. L. S. (2017) · CNS Drugs · doi:10.1007/s40263-017-0474-4 · Cited by 66 · see citing works

Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review

Katashima, C. K., Silva, V. R. R., Gomes, T. L. N., Pichard, C., & Pimentel, G. D. (2017) · Obesity Reviews · doi:10.1111/obr.12523 · Cited by 65 · see citing works

Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis

Jandova, T., Buendía‐Romero, Á., Polanská, H., Hola, V., Říhova, M., Větrovský, T., Courel‐Ibáñez, J., & Šteffl, M. (2021) · Healthcare · doi:10.3390/healthcare9111438 · Cited by 61 · see citing works

Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cosio, P. L., Crespo-Posadas, M., Velarde-Sotres, Á., & Pelaez, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18052476 · Cited by 56 · see citing works

Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver

Kim, H. K., Jeong, Y. J., Song, I.-S., Noh, Y. H., Seo, K. W., Kim, M., & Han, J. (2017) · Scientific Reports · doi:10.1038/srep43296 · Cited by 49 · see citing works

Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia

Aquila, G., Cecconi, A. D. R., Brault, J., Corli, O., & Piccirillo, R. (2020) · Cells · doi:10.3390/cells9122536 · Cited by 41 · see citing works

A comparative study on the effects of high-fat diet and endurance training on the PGC-1α-FNDC5/irisin pathway in obese and nonobese male C57BL/6 mice

Kazeminasab, F., Marandi, S. M., Ghaedi, K., Safaeinejad, Z., Esfarjani, F., & Nasr‐Esfahani, M. H. (2018) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2017-0614 · Cited by 40 · see citing works

Concurrent Treatment with Ursolic Acid and Low-Intensity Treadmill Exercise Improves Muscle Atrophy and Related Outcomes in Rats

Kim, J. C., Kang, Y. S., Noh, E. B., Seo, B. W., Seo, D. Y., Park, G. D., & Kim, S. H. (2018) · The Korean Journal of Physiology &amp; Pharmacology · doi:10.4196/kjpp.2018.22.4.427 · Cited by 36 · see citing works

Increased FNDC5 is associated with insulin resistance in high fat‐fed mice

Guilford, B. L., Parson, J. C., Grote, C., Vick, S. N., Ryals, J. M., & Wright, D. (2017) · Physiological Reports · doi:10.14814/phy2.13319 · Cited by 35 · see citing works

Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia

Sakuma, K., Hamada, K., Yamaguchi, A., & Aoi, W. (2023) · Cells · doi:10.3390/cells12192422 · Cited by 33 · see citing works

Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury

Bigford, G. E., Darr, A. J., Bracchi-Ricard, V. C., Gao, H., Nash, M. S., & Bethea, J. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203042 · Cited by 27 · see citing works

Recent studies on ursolic acid and its biological and pharmacological activity

Lee, S., Kim, Y., Chung, S., & Park, S. U. (2016) · EXCLI journal · doi:10.17179/excli2016-159 · Cited by 24 · see citing works

Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice

Nieoczym, D., Socała, K., & Właź, P. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2505-z · Cited by 24 · see citing works

Effects of functional training with blood occlusion on the irisin, follistatin, and myostatin myokines in elderly men

Pazokian, F., Amani-Shalamzari, S., & Rajabi, H. (2022) · European Review of Aging and Physical Activity · doi:10.1186/s11556-022-00303-2 · Cited by 22 · see citing works

The effects of different types of exercise on circulating irisin levels in healthy individuals and in people with overweight, metabolic syndrome and type 2 diabetes

Parada-Sánchez, S., Macías-Cervantes, M. H., Pérez‐Vázquez, V., & Vargas‐Ortiz, K. (2022) · Physiological Research · doi:10.33549/physiolres.934896 · Cited by 22 · see citing works

Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1

Tao, W., Ouyang, Z., Liao, Z., Li, L., Zhang, Y., Gao, J., Ma, L., & Yu, S. (2023) · Cancers · doi:10.3390/cancers15082378 · Cited by 23 · see citing works

Triterpene-enriched fractions from Eucalyptus tereticornis ameliorate metabolic alterations in a mouse model of diet-induced obesity

Acı́n, S., Muñoz, D. L., Guillén, A., Soscue, D., Castaño, A., Echeverri, F., & Balcázar, N. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113298 · Cited by 22 · see citing works

Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study

Bang, H. S., Seo, D. Y., Chung, Y. M., Kim, D. H., Lee, S., Lee, S. R., Kwak, H., Kim, T. N., Kim, M., Oh, K.-M., et al. (2017) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2017.21.6.651 · Cited by 21 · see citing works

Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy

Adams, C. M., Ebert, S. M., & Dyle, M. C. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000159 · Cited by 20 · see citing works

Cytotoxic Autophagy: A Novel Treatment Paradigm against Breast Cancer Using Oleanolic Acid and Ursolic Acid

Gupta, K. B., Gao, J., Li, X., Thangaraju, M., Panda, S. S., & Lokeshwar, B. L. (2024) · Cancers · doi:10.3390/cancers16193367 · Cited by 19 · see citing works

Dual role of select plant based nutraceuticals as antimicrobial agents to mitigate food borne pathogens and as food preservatives

Subramaniam, S., Rajendran, N., Muralidharan, S., Subramaniam, G., Raju, R., & Sivasubramanian, A. (2015) · RSC Advances · doi:10.1039/c5ra15039f · Cited by 16 · see citing works

Ursolic acid has no additional effect on muscle strength and mass in active men undergoing a high-protein diet and resistance training: A double-blind and placebo-controlled trial

Lobo, P. C. B., Vieira, I. P., Pichard, C., Marques, B. S., Gentil, P., da Silva, E. L., & Pimentel, G. D. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.06.004 · Cited by 16 · see citing works

Molecular targets of exercise mimetics and their natural activators

Jang, Y. J., & Byun, S. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.12.151 · Cited by 16 · see citing works

Effects of ursolic acid on muscle mass and bone microstructure in rats with casting-induced muscle atrophy

Kang, Y. S., Noh, E. B., & Kim, S. H. (2019) · Physical Activity and Nutrition · doi:10.20463/jenb.2019.0022 · Cited by 14 · see citing works

15-Day subchronic developmental toxicity studies of ursolic acid in rats

Geerlofs, L., He, Z., Xiao, S., & Xiao, Z. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111537 · Cited by 12 · see citing works

Nutritional approaches targeting mitochondria for the prevention of sarcopenia

Hahm, J., Nirmala, F. S., Ha, T. Y., & Ahn, J. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad084 · Cited by 12 · see citing works

Ursolic acid improves the indoxyl sulfate-induced impairment of mitochondrial biogenesis in C2C12 cells

Sasaki, Y., Kojima‐Yuasa, A., Tadano, H., Mizuno, A., Kon, A., & Norikura, T. (2022) · Nutrition Research and Practice · doi:10.4162/nrp.2022.16.2.147 · Cited by 12 · see citing works

Voluntary stand-up physical activity enhances endurance exercise capacity in rats

Seo, D. Y., Lee, S. R., Kwak, H., Seo, K. W., McGregor, R. A., Yeo, J. Y., Ko, T. H., Bolorerdene, S., Kim, N., Ko, K. S., et al. (2016) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2016.20.3.287 · Cited by 12 · see citing works

Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy

Ebert, S. M., Nicolas, C. S., Schreiber, P., Lopez, J. G., Taylor, A. T., Judge, A. R., Judge, S. M., Rasmussen, B. B., Talley, J. J., Rème, C. A., et al. (2024) · Animals · doi:10.3390/ani14020186 · Cited by 12 · see citing works

Mitochondria-targeted nutraceuticals in sports medicine: a new perspective

Ostojić, S. M. (2016) · Research in Sports Medicine · doi:10.1080/15438627.2016.1258646 · Cited by 10 · see citing works

The Impact of Different Modes of Exercise Training on Irisin: A Systematic Review and Meta-Analysis Research

Rad, M. M., Bijeh, N., Hosseini, S. R. A., & Saeb, A. R. (2021) · Journal of Advances in Medical and Biomedical Research · doi:10.30699/jambs.29.134.125 · Cited by 10 · see citing works

No additional effects of ursolic acid supplementation associated with combined exercise program on metabolic syndrome of postmenopausal women: A double-blind, randomized, placebo-controlled trial

Cione, J. G. C., Verlengia, R., Barbosa, C. G. R., Ribeiro, A. G. S. V., de Oliveira, J. J., Oliveira, M. A. D., & Crisp, A. H. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.05.031 · Cited by 9 · see citing works

Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men

Asghari, E., Rashidlamir, A., Hosseini, S. R. A., Moazzami, M., Samarghandian, S., & Farkhondeh, T. (2019) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x19666190918144727 · Cited by 9 · see citing works

Dietary Aronia melanocarpa extract enhances mTORC1 signaling, but has no effect on protein synthesis and protein breakdown-related signaling, in response to resistance exercise in rat skeletal muscle

Makanae, Y., Ato, S., Kido, K., & Fujita, S. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0328-1 · Cited by 9 · see citing works

Inclusion complexes of Ursolic acid with Cyclodextrin-based metal-organic Framework-1 enhance its solubility

Inoue, Y., Motoda, A., Tanikawa, T., Takao, K., Arce, F. J., See, G. L., Ishida, Y., Nakata, D., & Terao, K. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104986 · Cited by 8 · see citing works

Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial

Lobo, P. C. B., & Pimentel, G. D. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112289 · Cited by 4 · see citing works

Effects of Apple Pomace on Cookie Quality

오철환, & 강창수 (2016) · Culinary Science & Hospitality Research · doi:10.20878/cshr.2016.22.8.008008008 · Cited by 4 · see citing works

Effect of Eriobotrya japonica Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Nagae, M., Nagata, M., Matsumoto, M., Takemoto, N., Amen, Y. M., Wang, D., Yoshimitsu, Y., & Shimizu, K. (2023) · Allergies · doi:10.3390/allergies3040013 · Cited by 3 · see citing works

Ursolic Acid Improved Sarcopenia in D-Galactose-Induced Aging Mice

Liu, M., Liu, X., & Yuan, L. (2024) · International Journal of Pharmacology · doi:10.3923/ijp.2024.1181.1190 · Cited by 3 · see citing works

A 13-week repeated oral dose toxicity evaluation and a 4-week recovery evaluation of rosemary concentrate containing 50% ursolic acid in male and female rats

Jung, Y. P., Lim, S., An, S., Kim, H. J., & Shin, J.-H. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115308 · Cited by 3 · see citing works

Ursolic Acid: Sources, Synthesis, Properties, Modifications, Application

Kiseleva, D. A., An’kov, S. V., & Толстикова, Т. Г. (2025) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162024605974 · Cited by 3 · see citing works

Ursolic Acid and Maslinic Acid

Bashir, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813922-6.00061-8 · Cited by 3 · see citing works

Investigation of snails transmitting parasitic diseases in Yunnan Province.

Yuan-xiao, C., Zhang, W., Ming, T., Chen, Y., WenLin, W., & Naiguang, Z. (2009) · Journal of Pathogen Biology · Cited by 3 · see citing works

The effects of ursolic acid on cardiometabolic risk factors: a systematic review and meta-analysis

Rafiee, P., Rasaei, N., Amini, M. R., Rabiee, R., Kalantar, Z., Sheikhhossein, F., Gholizadeh, M., & Hekmatdoost, A. (2024) · Future Cardiology · doi:10.1080/14796678.2024.2349476 · Cited by 2 · see citing works

Effect of the Composition of Leuzea and Cranberry Meal Extracts on Metabolic Processes in Norm and Pathology

Халикова, Д. А., An’kov, S. V., Zhukova, N., Tolstikova, T. G., Popov, S. A., & Saiko, A. (2023) · Pharmaceuticals · doi:10.3390/ph16050768 · Cited by 2 · see citing works

Sarcopenia: Molecular mechanism and current nutritional approach

Sakuma, K., Yamaguchi, A., & Shimizu, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821848-8.00103-7 · Cited by 2 · see citing works

Changes in Physicochemical Characteristics of Apple Pre-Treated with Sugar and Salt for Manufacturing Apple Jangachi

오철환 (2017) · Culinary Science & Hospitality Research · doi:10.20878/cshr.2017.23.8.010 · Cited by 1 · see citing works

Effects of Apple Pomace on Cookie Quality

오철환, & 강창수 (2016) · Culinary Science & Hospitality Research · doi:10.20878/cshr.2016.22.8.008 · Cited by 1 · see citing works

An alternative green separation process for the pure isolation of commercially important bioactive molecules from plants

Subramaniam, S., & Sivasubramanian, A. (2016) · Green Processing and Synthesis · doi:10.1515/gps-2016-0072

Spatial memory-enhancing effects and antioxidant activities of leaf and stem bark methanol extracts of Prunus africana in scopolamine-treated mice

Ngai, D. N., Kibiti, C. M., & Ngugi, M. P. (2023) · Journal of Herbmed Pharmacology · doi:10.34172/jhp.2023.33

Effect of 12 Weeks TRX on Irisin and Chemerin Levels, Fat Percentage, and Body Weight in Older Men: A Clinical Trial

Rahmatollahi, M., Valizadehorang, A., Bahram, M. E., & Jafarnezhadgero, A. (2023) · Scientific Journal of Rehabilitation Medicine · doi:10.32598/sjrm.12.3.7

Physical exercise and irisin: managing obesity and related comorbidities

Negroiu, C. E., Tudorașcu, I., Dănoiu, S., Pădureanu, V., Godeanu, S., Dănoiu, R., Ungureanu, A., Beznă, M. C., & Moise, C. G. (2025) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.66.2.05 · Cited by 1 · see citing works

The Effect of Resistance Training and Ursolic Acid on the PI3K ‐ AKT ‐ mTOR Pathway in Aged Diabetic Rats: A Comparative Study

Sadeghi, A., Alizade, S., Faramarzi, M., Rahimi, M., & Thapa, R. K. (2026) · Aging Medicine · doi:10.1002/agm2.70071

Ursolic acid has no additional effect on muscle strength and mass in active men undergoing a high-protein diet and resistance training: A double-blind and placebo-controlled trial

Lobo, P. C. B., Vieira, I. P., Pichard, C., Marques, B. S., Gentil, P., da Silva, E. L., & Pimentel, G. D. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.06.004 · Cited by 16 · see citing works

Effects of Ursolic Acid Supplementation on Early Strength Gains and Body Composition

Roman, A., & Emhoff, C. W. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000519543.21327.2b

Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men

Asghari, E., Rashidlamir, A., Hosseini, S. R. A., Moazzami, M., Samarghandian, S., & Farkhondeh, T. (2019) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x19666190918144727 · Cited by 9 · see citing works

Effects of ursolic acid consumption on strength and body composition

Mattingly, A. J. (2013) · California State University ScholarWorks (system-wide DSpace)

Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study

Bang, H. S., Seo, D. Y., Chung, Y. M., Kim, D. H., Lee, S., Lee, S. R., Kwak, H., Kim, T. N., Kim, M., Oh, K.-M., et al. (2017) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2017.21.6.651 · Cited by 21 · see citing works