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FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases

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Mitochondria as Cellular and Organismal Signaling Hubs

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Skeletal muscle autophagy and its role in sarcopenia and organismal aging

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FGF21: A Novel Regulator of Glucose and Lipid Metabolism and Whole-Body Energy Balance

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Fibroblast growth factor 21 and browning of white adipose tissue

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New developments in the biology of fibroblast growth factors

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Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors

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Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

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The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy

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Regulation of myokine expression: Role of exercise and cellular stress

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Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation

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Stress-induced FGF21 and GDF15 in obesity and obesity resistance

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Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

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Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

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Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

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Regulation of longevity by FGF21: interaction between energy metabolism and stress responses

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The Role of GDF15 as a Myomitokine

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Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine

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FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

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Mitochondrial stress and mitokines in aging

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FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism

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Brite/beige fat and UCP1 — is it thermogenesis?

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Muscle-to-Brain Signaling Via Myokines and Myometabolites

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Protein-dependent regulation of feeding and metabolism

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Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

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Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals

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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

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Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21

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The Interplay between Mitochondrial Morphology and Myomitokines in Aging Sarcopenia

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Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

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Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle

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Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

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Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway

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Polyunsaturated Fatty Acids Attenuate Diet Induced Obesity and Insulin Resistance, Modulating Mitochondrial Respiratory Uncoupling in Rat Skeletal Muscle

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Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges

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Systemic effects of mitochondrial stress

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Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

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Mitochondrial uncoupling and longevity – A role for mitokines?

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Mild cold induced thermogenesis: are BAT and skeletal muscle synergistic partners?

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Physical Exercise-Induced Myokines in Neurodegenerative Diseases

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Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

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Exploring the Role of Skeletal Muscle in Insulin Resistance: Lessons from Cultured Cells to Animal Models

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The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model

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Ursolic acid-induced elevation of serum irisin augments muscle strength during resistance training in men

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Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux

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Homeostatic sensing of dietary protein restriction: a case for FGF21

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Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21

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BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species

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Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

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Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues

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Association between serum FGF21 level and sarcopenia in older adults

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Retinoic Acid Increases Fatty Acid Oxidation and Irisin Expression in Skeletal Muscle Cells and Impacts Irisin In Vivo

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Myokines: Metabolic regulation in obesity and type 2 diabetes

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Skeletal Muscle and Bone – Emerging Targets of Fibroblast Growth Factor-21

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FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway

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Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1.

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Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease

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Mitochondrial stress: a key role of neuroinflammation in stroke

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The Interplay Between Mitochondrial Reactive Oxygen Species, Endoplasmic Reticulum Stress, and Nrf2 Signaling in Cardiometabolic Health

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Mitochondrial retrograde signaling in the nervous system

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FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival

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Plasma FGF‐21 and GDF‐15 are elevated in different inherited metabolic diseases and are not diagnostic for mitochondrial disorders

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Implications of mitochondrial fusion and fission in skeletal muscle mass and health

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Experimental Conditions That Influence the Utility of 2′7′-Dichlorodihydrofluorescein Diacetate (DCFH2-DA) as a Fluorogenic Biosensor for Mitochondrial Redox Status

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Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice

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Targeted mitochondrial uncoupling beyond UCP1 – The fine line between death and metabolic health

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Stress Signaling Between Organs in Metazoa

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Paternal exercise protects mouse offspring from high-fat-diet-induced type 2 diabetes risk by increasing skeletal muscle insulin signaling.

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Mitochondrial stress and GDF15 in the pathophysiology of sepsis

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Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics

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Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions

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Novel Mediators of Adipose Tissue and Muscle Crosstalk

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Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress–Fibroblast Growth Factor 21 Axis in Skeletal Muscle

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Skeletal muscle mitochondrial uncoupling induces a metabolic rescue cycle involving FGF21 as a myokine

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Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

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Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

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Activation of AMPKa2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity

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