Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes
Open accessAbstract
Higher nut consumption has been associated with lower risk of coronary heart disease (CHD) events in several epidemiologic studies. The study examined the association between intake of nuts and incident cardiovascular disease (CVD) in a cohort of women with type 2 diabetes. For the primary analysis, there were 6309 women with type 2 diabetes who completed a validated FFQ every 2-4 y between 1980 and 2002 and were without CVD or cancer at study entry. Major CVD events included incident myocardial infarction (MI), revascularization, and stroke. During 54,656 person-years of follow-up, there were 452 CHD events (including MI and revascularization) and 182 incident stroke cases. Frequent nut and peanut butter consumption was inversely associated with total CVD risk in age-adjusted analyses. After adjustment for conventional CVD risk factors, consumption of at least 5 servings/wk of nuts or peanut butter [serving size, 28 g (1 ounce) for nuts and 16 g (1 tablespoon) for peanut butter] was significantly associated with a lower risk of CVD (relative risk = 0.56; 95% CI: 0.36-0.89). Furthermore, when we evaluated plasma lipid and inflammatory biomarkers, we observed that increasing nut consumption was significantly associated with a more favorable plasma lipid profile, including lower LDL cholesterol, non-HDL cholesterol, total cholesterol, and apolipoprotein-B-100 concentrations. However, we did not observe significant associations for HDL cholesterol or inflammatory markers. These data suggest that frequent nut and peanut butter consumption is associated with a significantly lower CVD risk in women with type 2 diabetes.
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Two of the 4 cohort studies in the previous meta-analysis have updated their data with a longer duration of follow-up and more incident cases.
“However, 2 of the included 4 cohort studies have updated the data with a longer duration of follow-up and more incident cases for each study (6,7).”
From Nut consumption in relation to cardiovascular disease risk and type 2 diabetes: a systematic review and meta-analysis of prospective studies (2014) · cites this paper as [7]
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- Authors
- Li, T. Y., Brennan, A. M., Wedick, N. M., Mantzoros, C., Rifai, N., & Hu, F. B.
- Affiliations
- Harvard University (US)
- Beth Israel Deaconess Medical Center (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Hu, Frank B.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 139
- Issue
- 7
- Pages
- 1333-1338
- ISSN
- 0022-3166 (ISSN-L)
- PMC
- PMC2696988
- OpenAlex
- W2154943809
- Cited by
- 143
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 16 · 2015: 12 · 2014: 22 · 2013: 14 · 2012: 9
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK58845, DK58785)
- National Heart, Lung, and Blood Institute (HL34594, R01HL034594)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK079929, R01DK058785, R56DK058785, R01DK058845, DK 79929, DK 58785, DK58845)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- nut consumption, peanut butter, type 2 diabetes, cardiovascular risk, coronary artery disease, myocardial infarction, stroke, plasma lipids, LDL cholesterol, apolipoprotein B, women
- MeSH terms
- Aged, Apolipoproteins B, Cardiovascular Diseases, Cholesterol, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Diet, Feeding Behavior, Female, Humans, Hypertension, Life Style, Lipids, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Nuts, Arachis, Surveys and Questionnaires, Risk Reduction Behavior
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