Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects
Open accessAbstract
High intakes of whole grain foods are inversely related to the incidence of coronary heart diseases and type 2 diabetes, but the mechanisms remain unclear. Our study aimed to evaluate the effects of a diet rich in whole grains compared with a diet containing the same amount of refined grains on insulin sensitivity and markers of lipid peroxidation and inflammation. In a randomized crossover study, 22 women and 8 men (BMI 28 +/- 2) were given either whole-grain or refined-grain products (3 bread slices, 2 crisp bread slices, 1 portion muesli, and 1 portion pasta) to include in their habitual daily diet for two 6-wk periods. Peripheral insulin sensitivity was determined by euglycemic hyperinsulinemic clamp tests. 8-Iso-prostaglandin F(2alpha) (8-iso PGF(2alpha)), an F(2)-isoprostane, was measured in the urine as a marker of lipid peroxidation, and highly sensitive C-reactive protein and IL-6 were analyzed in plasma as markers of inflammation. Peripheral insulin sensitivity [mg glucose . kg body wt(-1) . min(-1) per unit plasma insulin (mU/L) x 100] did not improve when subjects consumed whole-grain products (6.8 +/- 3.0 at baseline and 6.5 +/- 2.7 after 6 wk) or refined products (6.4 +/- 2.9 and 6.9 +/- 3.2, respectively) and there were no differences between the 2 periods. Whole-grain consumption also did not affect 8-iso-PGF(2alpha) in urine, IL-6 and C-reactive protein in plasma, blood pressure, or serum lipid concentrations. In conclusion, substitution of whole grains (mainly based on milled wheat) for refined-grain products in the habitual daily diet of healthy moderately overweight adults for 6-wk did not affect insulin sensitivity or markers of lipid peroxidation and inflammation.
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Vitamin D down-regulates TLR2 and TLR4 expression in human monocytes.
“down-regulates the expression of TLR2 and TLR4 in human monocytes (735 -737) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [737]
Vitamin D has several anti-inflammatory actions.
“Vitamin D has several anti-inflammatory actions.”
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- Authors
- Andersson, A., Tengblad, S., Karlström, B., Kamal-Eldin, A., Landberg, R., Basu, S., Åman, P., & Vessby, B.
- Affiliations
- Uppsala University (SE)
- Swedish University of Agricultural Sciences (SE)
- Corresponding author
- Andersson, Agneta
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 137
- Issue
- 6
- Pages
- 1401-1407
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2145135339
- Cited by
- 221
- References
- 51
- Citations by year
- 2025: 2 · 2024: 9 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 13 · 2018: 19 · 2017: 12 · 2016: 17 · 2015: 16 · 2014: 30 · 2013: 19 · 2012: 21
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- VINNOVA
- Svenska Forskningsrådet Formas
- Vetenskapsrådet
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- whole grains, refined grains, insulin sensitivity, lipid peroxidation, inflammation, 8-isoprostane, C-reactive protein, interleukin-6, overweight adults, dietary intervention, blood pressure, serum lipids
- MeSH terms
- Adult, Aged, Blood Pressure, Edible Grain, Diet, Female, Humans, Inflammation, Insulin, Lipids, Male, Middle Aged, Dinoprost, Interleukin-6, Body Mass Index, Cross-Over Studies, Overweight
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