Loss of appetite in acutely ill medical inpatients: physiological response or therapeutic target?
Open accessAbstract
Loss of appetite and ensuing weight loss is a key feature of severe illnesses. Protein-energy malnutrition (PEM) contributes significantly to the adverse outcome of these conditions. Pharmacological interventions to target appetite stimulation have little efficacy but considerable side effects. Therefore nutritional therapy appears to be the logical step to combat inadequate nutrition. However, clinical trial data demonstrating benefits are sparse and there is no current established standard algorithm for use of nutritional support in malnourished, acutely ill medical inpatients. Recent high-quality evidence from critical care demonstrating harmful effects when parenteral nutritional support is used indiscriminately has led to speculation that loss of appetite in the acute phase of illness is indeed an adaptive, protective response that improves cell recycling (autophagy) and detoxification. Outside critical care, there is an important gap in high quality clinical trial data shedding further light on these important issues. The selection, timing, and doses of nutrition should be evaluated as carefully as with any other therapeutic intervention, with the aim of maximising efficacy and minimising adverse effects and costs. In light of the current controversy, a reappraisal of how nutritional support should be used in acutely ill medical inpatients outside critical care is urgently required. The aim of this review is to discuss current pathophysiological concepts of PEM and to review the current evidence for the efficacy of nutritional support regarding patient outcomes when used in an acutely ill medical patient population outside critical care.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Diminished food intake plays an additional role as NTIS is associated with diminished appetite and nutritional intake.
“Diminished food intake plays an additional role as NTIS is associated with diminished appetite and nutritional intake [71–74].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [71]
The Pathophysiology of PEM due to acute and chronic illness section describes reduced food intake associated with inflammatory responses, supporting the general point about diminished intake during illness. It does not identify NTIS or establish an association between NTIS and diminished appetite or nutritional intake; searches for NTIS and thyroid-related terms found no such passage. Page numbers were not available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The cochrane database of systematic reviews
Geddes, J. R. (1996) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(96)90063-x · Cited by 5,988 · see citing works
KONDRUP, J. (2003) · Clinical Nutrition · doi:10.1016/s0261-5614(02)00214-5 · Cited by 3,063 · see citing works
Early versus late parenteral nutrition in critically ill adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Van Cromphaut, S., Ingels, C., Meersseman, P., Muller, J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102662 · Cited by 1,696 · see citing works
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
Mitch, W. E., & Goldberg, A. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612193352507 · Cited by 1,163 · see citing works
Alberda, C., Gramlich, L., Jones, N., Jeejeebhoy, K., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1567-4 · Cited by 975 · see citing works
ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology
Arends, J., Bodoky, G., Bozzetti, F., Fearon, K. C. H., Muscaritoli, M., Selga, G., de van der Schueren, M. A. E., MEYENFELDT, M. F. V., Zürcher, G., Fietkau, R., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.020 · Cited by 930 · see citing works
The Interaction between Nutrition and Infection
Katona, P., & Katona‐Apte, J. (2008) · Clinical Infectious Diseases · doi:10.1086/587658 · Cited by 925 · see citing works
NF-κB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia
D, D. C. G., Mayo, M. W., Madrid, L. V., Wang, C., & Baldwin, A. S. (2000) · Science · doi:10.1126/science.289.5488.2363 · Cited by 922 · see citing works
Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922 · see citing works
Dietary supplementation in elderly patients with fractured neck of the femur
Delmi, M., Rapin, C. H., Bengoa, J., Bonjour, J.-P., Vasey, H., & Delmas, P. D. (1990) · The Lancet · doi:10.1016/0140-6736(90)91073-j · Cited by 825 · see citing works
Cachexia: pathophysiology and clinical relevance1,2
Morley, J. E., Thomas, D. R., & Wilson, M.-M. G. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.735 · Cited by 786 · see citing works
Heidegger, C. P., Berger, M. M., Graf, S., Zingg, W., Darmon, P., Costanza, M. C., Thibault, R., & Pichard, C. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61351-8 · Cited by 776 · see citing works
ESPEN Guidelines on Enteral Nutrition: Liver disease
Plauth, M., Cabré, E., Riggio, O., Assis-Camilo, M., Pirlich, M., Kondrup, J., Ferenci, P., Holm, E., Dahl, S. V., Müller, M. J., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.018 · Cited by 679 · see citing works
A.S.P.E.N. clinical guidelines: Nutrition screening, assessment, and intervention in adults.
Mueller, C., Compher, C., & Ellen, D. M. (2013) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607110389335 · Cited by 678 · see citing works
Cancer cachexia is regulated by selective targeting of skeletal muscle gene products
Acharyya, S., Ladner, K. J., Nelsen, L., Damrauer, J. S., Reiser, P. J., Swoap, S. J., & D, D. C. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20174 · Cited by 541 · see citing works
August, D. A., Huhmann, M. B., & the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors (2009) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607109341804 · Cited by 517 · see citing works
ESPEN Guidelines on Enteral Nutrition: Geriatrics
Volkert, D., Berner, Y., Berry, E., Cederholm, T., Bertrand, P. C., Milne, A. C., Palmblad, J. E. W., Schneider, S. M., Sobotka, L., Stanga, Z. G., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.012 · Cited by 479 · see citing works
Self-citationESPEN Guidelines on Parenteral Nutrition: Geriatrics
Sobotka, L., Schneider, S. M., Berner, Y., Cederholm, T., Krznarić, Ž., Shenkin, A., Stanga, Z. G., Toigo, G., Vandewoude, M. F. J., & Volkert, D. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.004 · Cited by 464 · see citing works
Self-citationHiesmayr, M., Schindler, K., Pernicka, E., Schuh, C., Schoeniger-Hekele, A., Bauer, P., Laviano, A., Lovell, A. D., Mouhieddine, M., Schuetz, T., et al. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.05.013 · Cited by 453 · see citing works
ESPEN Guidelines on Parenteral Nutrition: Adult Renal Failure
Cano, N., Aparicio, M., Brunori, G., Carrero, J. J., Cianciaruso, B., Fiaccadori, E., Lindholm, B., Teplan, V., Fouque, D. P., & Guarnieri, G. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.05.016 · Cited by 429 · see citing works
Malnutrition is an independent factor associated with nosocomial infections
Schneider, S. M., Veyres, P., Pivot, X. B., Soummer, A.-M., Jambou, P., Filippi, J., OBBERGHEN, E. V., & Hébuterne, X. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041152 · Cited by 352 · see citing works
Larsson, D. G. J., Unosson, M., Ek, A. ‐., Nilsson, L., Thorslund, S., & Bjurulf, P. (1990) · Clinical Nutrition · doi:10.1016/0261-5614(90)90017-m · Cited by 308 · see citing works
Vanek, V. W., Borum, P. R., Buchman, A. L., Fessler, T. A., Howard, L. J., Jeejeebhoy, K. N., Kochevar, M., Shenkin, A., Valentine, C. J., Novel Nutrient Task Force, P. M. A. M. E. W. G., et al. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612446706 · Cited by 294 · see citing works
Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients
Vanhorebeek, I., Gunst, J., Derde, S., Derese, I., Boussemaere, M., Güiza, F., Martinet, W., Timmermans, J.-P., D'Hoore, A., Wouters, P. J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2563 · Cited by 241 · see citing works
Early Versus Late Parenteral Nutrition in Critically Ill Adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Cromphaut, S. J. V., Ingels, C., Meersseman, P., Muller, J., et al. (2012) · Survey of Anesthesiology · doi:10.1097/01.sa.0000412381.92989.8e · Cited by 235 · see citing works
Does Enteral Nutrition Affect Clinical Outcome? A Systematic Review of the Randomized Trials
Koretz, R. L., Avenell, A., Lipman, T. O., Braunschweig, C. L., & Milne, A. C. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.01024.x · Cited by 213 · see citing works
Malnutrition in acute care patients: a narrative review.
Kubrak, C., & Jensen, L. (2007) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2006.07.015 · Cited by 209 · see citing works
Effect of nutritional support on clinical outcome in patients at nutritional risk
Johansen, N., Kondrup, J., Plum, L. M., Bak, L., Nørregaard, P., Bunch, E., Bærnthsen, H., Andersen, J. R., Larsen, I. H., & Martinsen, A. W. (2003) · Clinical Nutrition · doi:10.1016/j.clnu.2003.10.008 · Cited by 207 · see citing works
A.S.P.E.N. Clinical Guidelines
Choban, P. S., Dickerson, R. N., Malone, A. M., Worthington, P. H., Compher, C. W., & and the American Society for Parenteral and Enteral Nutrition (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113499374 · Cited by 165 · see citing works
Derde, S., Vanhorebeek, I., Güiza, F., Derese, I., Gunst, J., Fahrenkrog, B., Martinet, W., Vervenne, H. B. V. K., Ververs, E.-J., Larsson, L., et al. (2012) · Endocrinology · doi:10.1210/en.2011-2068 · Cited by 164 · see citing works
A.S.P.E.N. Clinical Guidelines
McMahon, M. M., Nystrom, E. M., Braunschweig, C. A., Miles, J., Compher, C. W., & the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607112452001 · Cited by 163 · see citing works
Gunst, J., Derese, I., Aertgeerts, A., Ververs, E.-J., Wauters, A., den Berghe, G. V., & Vanhorebeek, I. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182676657 · Cited by 160 · see citing works
Starke, J., Schneider, H., Alteheld, B., Stehle, P., & Meier, R. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2010.07.021 · Cited by 156 · see citing works
Gariballa, S., Forster, S., Walters, S., & Powers, H. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.12.006 · Cited by 144 · see citing works
Nutrition in the hospitalized patient.
Kirkland, L., Kashiwagi, D., Brantley, S., Scheurer, D., & Varkey, P. (2013) · Journal of Hospital Medicine · doi:10.1002/jhm.1969 · Cited by 120 · see citing works
Protein and energy supplementation in elderly people at risk from malnutrition
Milne, A. C., Potter, J., & Avenell, A. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003288.pub2 · Cited by 120 · see citing works
A.S.P.E.N. Clinical Guidelines
Brown, R. O., Compher, C. W., & American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors (2010) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607110374577 · Cited by 115 · see citing works
Hickson, M., Bulpitt, C. J., Nunes, M., Peters, R. K., Cooke, J., Nicholl, C. G., & Frost, G. S. (2003) · Clinical Nutrition · doi:10.1016/s0261-5614(03)00090-6 · Cited by 106 · see citing works
Rüfenacht, U., Rühlin, M., Wegmann, M., Imoberdorf, R., & Ballmer, P. E. (2010) · Nutrition · doi:10.1016/j.nut.2009.04.018 · Cited by 103 · see citing works
A method for implementation of nutritional therapy in hospitals
Rasmussen, H. H., Kondrup, J., Staun, M., Ladefoged, K., Lindorff, K., Jørgensen, L. M., Jakobsen, J., Kristensen, H., & Wengler, A. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.003 · Cited by 94 · see citing works
The hypothalamic-pituitary-adrenal axis in critical illness.
Schuetz, P., & Müller, B. (2006) · Endocrinology and metabolism clinics of North America (Print) · doi:10.1016/j.ecl.2006.09.013 · Cited by 92 · see citing works
Does artificial nutrition improve outcome of critical illness?
Schetz, M., Casaer, M., & den Berghe, G. V. (2013) · Critical Care · doi:10.1186/cc11828 · Cited by 89 · see citing works
Schüetz, P., Hausfater, P., Amin, D., Haubitz, S., Fässler, L., Grolimund, E., Kutz, A., Schild, U., Caldara, Z., Regez, K., et al. (2013) · BMC Emergency Medicine · doi:10.1186/1471-227x-13-12 · Cited by 66 · see citing works
A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
Heyland, D. K., Muscedere, J., Wischmeyer, P. E., Cook, D., Jones, G., Albert, M., Elke, G., Berger, M. M., & Day, A. G. (2014) · Survey of Anesthesiology · doi:10.1097/01.sa.0000441043.83064.4c · Cited by 63 · see citing works
Tangvik, R., Guttormsen, A., Tell, G., & Ranhoff, A. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.149 · Cited by 49 · see citing works
Appetite-regulating Hormones in Chronic Kidney Disease Patients
Öner-İyidoğan, Y., Gürdöl, F., Koçak, H., Öner, P., Çetinalp, P., Çalışkan, Y., Koçak, T., & Türkmen, A. (2010) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2010.07.005 · Cited by 42 · see citing works
Potential interplay between nutrition and inflammation in dialysis patients.
Kuhlmann, M., & Levin, N. (2008) · Contributions to Nephrology · doi:10.1159/000129759 · Cited by 34 · see citing works
The hypothalamic–pituitary–adrenal axis in critical illness
Venkataraman, S., Munoz, R., Cândido, C., & Witchel, S. (2007) · Reviews in Endocrine & Metabolic Disorders · doi:10.1007/s11154-007-9058-9 · Cited by 23 · see citing works
Early versus Late Parenteral Nutrition in Critically Ill Adults
Jones, Q. C., & Walden, A. (2011) · Journal of the Intensive Care Society · doi:10.1177/175114371101200422 · Cited by 23 · see citing works
Effect of nutritional support on clinical outcome in patients at nutritional risk
Johansen, N., Kondrup, J., Plum, L. M., Bak, L., Nørregaard, P., Lauesen, N., Bunch, E., B˦rnthsen, H., Andersen, J. R., Larsen, I. H., et al. (2003) · Clinical Nutrition · doi:10.1016/s0261-5614(03)80319-9 · Cited by 23 · see citing works
Neuroendocrine effects of interferon alpha 2-a in healthy human subjects.
Pende, A., Musso, N. R., Vergassola, C., Puppo, F., Ioverno, A., Criscuolo, D., Indiveri, F., & Lotti, G. (1990) · PubMed · Cited by 18 · see citing works
Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients
Vanhorebeek, I., Gunst, J., Derde, S., Derese, I., Boussemaere, M., Güiza, F., Martinet, W., Timmermans, J., D’Hoore, A., Wouters, P. J., et al. (2011) · Endocrinology · doi:10.1210/endo.152.3.zee1194a · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr. 2006;83(4):735-43.
- Anthony PS. Nutrition screening tools for hospitalized patients. Nutri- tion in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition. 2008;23(4):373-82.
- Vanek VW, Matarese LE, Robinson M, Sacks GS, Young LS, Kochevar M. A.S.P.E.N. position paper: parenteral nutrition glutamine supple- mentation. Nutrition in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition. 2011;26(4):479-94.
- Guest JF, Panca M, Baeyens JP, de Man F, Ljungqvist O, Pichard C, et al. Health economic impact of managing patients following a community-based diagnosis of malnutrition in the UK. Clin Nutr. 2011;30(4):422-9.
- Starke J, Schneider H, Alteheld B, Stehle P, Meier R. Short-term indi- vidual nutritional care as part of routine clinical setting improves out- come and quality of life in malnourished medical patients. Clin Nutr. 2011;30(2):194-201.
- Gariballa S, Forster S, Walters S, Powers H. A randomized, double- blind, placebo-controlled trial of nutritional supplementation during acute illness. Am J Med. 2006;119(8):693-9.
- Review article: Current opinion Swiss Med Wkly. 2014;144:w13957 Swiss Medical Weekly • PDF of the online version • www.smw.ch
Cited by
Sorted by citations
Schuetz, P., Fehr, R., Baechli, V., Geiser, M., Deiss, M., Gomes, F., Kutz, A., Tribolet, P., Bregenzer, T., Braun, N., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32776-4 · Cited by 910 · see citing works
Self-citationThyroid function in critically ill patients
Fliers, E., Bianco, A. C., Langouche, L., & Boelen, A. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00225-9 · Cited by 441 · see citing works
Management of disease-related malnutrition for patients being treated in hospital
Schuetz, P., Seres, D., Lobo, D. N., Gomes, F., Kaegi-Braun, N., & Stanga, Z. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01451-3 · Cited by 355 · see citing works
Self-citationFelder, S., Lechtenboehmer, C., Bally, M., Fehr, R., Deiss, M., Faessler, L., Kutz, A., Steiner, D., Rast, A. C., Laukemann, S., et al. (2015) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2015.06.007 · Cited by 241 · see citing works
Self-citationMerker, M., Felder, M., Gueissaz, L., Bolliger, R., Tribolet, P., Kägi-Braun, N., Gomes, F., Hoess, C., Pavlicek, V., Bilz, S., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.0663 · Cited by 262 · see citing works
Self-citationRevisiting the refeeding syndrome: Results of a systematic review
Friedli, N., Stanga, Z., Sobotka, L., Culkin, A., Kondrup, J., Laviano, A., Mueller, B., & Schuetz, P. (2017) · Nutrition · doi:10.1016/j.nut.2016.05.016 · Cited by 274 · see citing works
Self-citationHersberger, L., Bargetzi, L., Bargetzi, A., Tribolet, P., Fehr, R., Baechli, V., Geiser, M., Deiss, M., Gomes, F., Kutz, A., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.11.041 · Cited by 226 · see citing works
Self-citationInflammation and nutrition: friend or foe?
Stumpf, F., Keller, B., Gressies, C., & Schuetz, P. (2023) · Nutrients · doi:10.3390/nu15051159 · Cited by 213 · see citing works
Are iron oxide nanoparticles safe? Current knowledge and future perspectives
Valdiglesias, V., Fernández‐Bertólez, N., Kılıç, G., Costa, C., Costa, S., Fraga, S., Bessa, M. J., Pásaro, E., Teixeira, J. P., & Laffón, B. (2016) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2016.03.017 · Cited by 204 · see citing works
An update on non-thyroidal illness syndrome
Fliers, E., & Boelen, A. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01482-4 · Cited by 199 · see citing works
Friedli, N., Stanga, Z., Culkin, A., Crook, M., Laviano, A., Sobotka, L., Kressig, R. W., Kondrup, J., Mueller, B., & Schuetz, P. (2018) · Nutrition · doi:10.1016/j.nut.2017.09.007 · Cited by 169 · see citing works
Self-citationIndividualized Nutritional Support for Hospitalized Patients With Chronic Heart Failure
Hersberger, L., Dietz, A., Bürgler, H., Bargetzi, A., Bargetzi, L., Kägi-Braun, N., Tribolet, P., Gomes, F., Hoess, C., Pavlicek, V., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.03.232 · Cited by 168 · see citing works
Self-citationBally, M. R., Blaser Yildirim, P. Z., Bounoure, L., Gloy, V. L., Mueller, B., Briel, M., & Schuetz, P. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.6587 · Cited by 159 · see citing works
Self-citationBounoure, L., Gomes, F., Stanga, Z., Keller, U., Meier, R., Ballmer, P., Fehr, R., Mueller, B., Genton, L., Bertrand, P. C., et al. (2016) · Nutrition · doi:10.1016/j.nut.2016.01.019 · Cited by 103 · see citing works
Self-citationFelder, S., Braun, N., Stanga, Z., Kulkarni, P., Faessler, L., Kutz, A., Steiner, D., Laukemann, S., Haubitz, S., Huber, A., et al. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000444096 · Cited by 86 · see citing works
Self-citationSchuetz, P., Sulo, S., Walzer, S., Vollmer, L., Stanga, Z., Gomes, F., Rueda, R., Mueller, B., & Partridge, J. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.02.023 · Cited by 90 · see citing works
Self-citationStarving the Enemy? Feeding Behavior Shapes Host-Parasite Interactions
Hite, J. L., Pfenning‐Butterworth, A. C., & Cressler, C. E. (2019) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2019.08.004 · Cited by 87 · see citing works
Glucose homeostasis, nutrition and infections during critical illness
Ingels, C., Vanhorebeek, I., & den Berghe, G. V. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.12.033 · Cited by 71 · see citing works
Refeeding syndrome in the frail elderly population: prevention, diagnosis and management
Aubry, E., Friedli, N., Schuetz, P., & Stanga, Z. (2018) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s136429 · Cited by 60 · see citing works
Self-citationKaegi-Braun, N., Tribolet, P., Baumgartner, A., Fehr, R., Baechli, V., Geiser, M., Deiss, M., Gomes, F., Kutz, A., Hoess, C., et al. (2021) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab042 · Cited by 67 · see citing works
Self-citationBaumgartner, A., Zueger, N., Bargetzi, A., Medinger, M., Passweg, J. R., Stanga, Z. G., Müeller, B., Bargetzi, M. J., & Schüetz, P. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000449451 · Cited by 63 · see citing works
Self-citationBaumgartner, A., Bargetzi, M. J., Bargetzi, A., Zueger, N., Medinger, M., Passweg, J. R., Schanz, U., Samaras, P., Chalandon, Y., Pichard, C., et al. (2016) · Nutrition · doi:10.1016/j.nut.2016.10.007 · Cited by 57 · see citing works
Self-citationSchüetz, P., Fehr, R., Baechli, V., Geiser, M., Gomes, F., Kutz, A., Tribolet, P., Bregenzer, T., Hoess, C., Pavlicek, V., et al. (2018) · International Journal of Clinical Trials · doi:10.18203/2349-3259.ijct20182085 · Cited by 57 · see citing works
Self-citation“The obesity paradox” in disease – is the protective effect of obesity true?
Kaegi-Braun, N., Gomes, F., & Schüetz, P. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14265 · Cited by 51 · see citing works
Nutritional Management of Medical Inpatients
Reber, E., Gomes, F., Bally, L., Schuetz, P., & Stanga, Z. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081130 · Cited by 36 · see citing works
Self-citationSchuetz, P. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14132 · Cited by 42 · see citing works
A novel in-hospital meal service improves protein and energy intake
Dijxhoorn, D. N., van den Berg, M. G. A., Kievit, W., Korzilius, J. W., Drenth, J. P. H., & Wanten, G. J. A. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.10.025 · Cited by 39 · see citing works
Baumgartner, A., Hasenboehler, F., Cantone, J., Hersberger, L., Bargetzi, A., Bargetzi, L., Kaegi-Braun, N., Tribolet, P., Gomes, F., Hoess, C., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.10.009 · Cited by 34 · see citing works
Self-citationWunderle, C., Martin, E., Wittig, A., Tribolet, P., Lutz, T. A., Köster-Hegmann, C., Stanga, Z. G., Müeller, B., & Schüetz, P. (2025) · Journal of Inflammation · doi:10.1186/s12950-025-00442-0 · Cited by 33 · see citing works
Self-citationRefeeding Syndrome: A Critical Reality in Patients with Chronic Disease
Krutkyte, G., Wenk, L., Odermatt, J., Schuetz, P., Stanga, Z., & Friedli, N. (2022) · Nutrients · doi:10.3390/nu14142859 · Cited by 29 · see citing works
Self-citationEvidence-based nutrition for the malnourished, hospitalised patient: one bite at a time
Merker, M., Gomes, F., Stanga, Z. G., & Schüetz, P. (2019) · Swiss Medical Weekly · doi:10.4414/smw.2019.20112 · Cited by 28 · see citing works
Self-citationSchüetz, P. (2017) · BMC Medicine · doi:10.1186/s12916-017-0812-x · Cited by 27 · see citing works
Baumgartner, A., Olpe, T., Griot, S., Mentil, N., Staub, N., Burn, F., Schindera, S. T., Kaegi-Braun, N., Tribolet, P., Hoess, C., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.12.006 · Cited by 26 · see citing works
Self-citationRefeeding-Syndrom: Ein konsensusbasierter Algorithmus für stationäre Patienten
Aubry, É., Aeberhard, C., Leuenberger, M., Stirnimann, J., Friedli, N., Schütz, P., & Stanga, Z. (2019) · Aktuelle Ernãhrungsmedizin · doi:10.1055/a-0604-7900 · Cited by 16 · see citing works
Self-citationYuxiu, Y., Ma, X., Gao, F., Liu, T., Deng, J., & Wang, Z. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-03951-7 · Cited by 20 · see citing works
Efficacy and Safety of Appetite-Stimulating Medications in the Inpatient Setting
Howard, M. L., Hossaini, R., Tolar, C., & Gaviola, M. L. (2018) · Annals of Pharmacotherapy · doi:10.1177/1060028018802816 · Cited by 20 · see citing works
Refeeding Syndrome in Older Hospitalized Patients: Incidence, Management, and Outcomes
Terlisten, K., Wirth, R., Daubert, D., & Pourhassan, M. (2023) · Nutrients · doi:10.3390/nu15184084 · Cited by 19 · see citing works
Transient disease dynamics across ecological scales
Tao, Y., Hite, J. L., Lafferty, K. D., Earn, D. J. D., & Bharti, N. (2021) · Theoretical Ecology · doi:10.1007/s12080-021-00514-w · Cited by 19 · see citing works
Tribolet, P., Kaegi-Braun, N., Gressies, C., Baumgartner, A., Wagner, K., Stanga, Z., & Schuetz, P. (2022) · Nutrients · doi:10.3390/nu14102173 · Cited by 12 · see citing works
Self-citationDijxhoorn, D. N., IJmker-Hemink, V. E., Wanten, G. J. A., & van den Berg, M. G. A. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0288-6 · Cited by 13 · see citing works
Individualised nutritional support in medical inpatients – a practical guideline
Baumgartner, A., Kaegi-Braun, N., Tribolet, P., Gomes, F., Stanga, Z. G., & Schüetz, P. (2020) · Swiss Medical Weekly · doi:10.4414/smw.2020.20204 · Cited by 13 · see citing works
Self-citationWunderle, C., Urbach, K.-H., Buchmueller, L., Randegger, S., Kaegi-Braun, N., Laviano, A., van Zanten, A. R. H., Seres, D. S., & Schüetz, P. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.07.009 · Cited by 10 · see citing works
Malnutrition in hospitalized adults in the United States, 2016–2019
Bhasin, A., Huang, L., Shieh, M., Pekow, P. S., Lindenauer, P. K., & Lagu, T. C. (2024) · Journal of Hospital Medicine · doi:10.1002/jhm.13456 · Cited by 9 · see citing works
The role of immune and metabolic biomarkers for improved management of sepsis patients
Schüetz, P., & Müeller, B. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.932250 · Cited by 9 · see citing works
Advances in personalized food and nutrition
Selvi, M. K., Sowmya, B., Kannan, T., Latha, M., Jena, I., Kumar, V. A., & Vijayaraj, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824369-5.00004-x · Cited by 8 · see citing works
Natural variation in host feeding behaviors impacts host disease and pathogen transmission potential
Pfenning‐Butterworth, A. C., Vetter, R. E., & Hite, J. L. (2023) · Ecology and Evolution · doi:10.1002/ece3.9865 · Cited by 8 · see citing works
Clinical implications of four different nutritional indexes in patients with IgA nephropathy
Qian, C., Li, H., Hou, Y., Wang, W., & Sun, M. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1431910 · Cited by 7 · see citing works
Circulating thyroid hormones and clinical parameters of heart failure in men
Turić, I., Velat, I., Bušić, Ž., & Čulić, V. (2023) · Scientific Reports · doi:10.1038/s41598-023-47391-3 · Cited by 7 · see citing works
Stumpf, F., Wunderle, C., Ritz, J., Bernasconi, L., Neyer, P. J., Tribolet, P., Stanga, Z. G., Müeller, B., Bischoff, S. C., & Schüetz, P. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.01.012 · Cited by 7 · see citing works
Self-citationPaulus, M. C., van Beek, S. W., van Zanten, A. R. H., & Kouw, I. W. K. (2026) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2026.102952 · Cited by 6 · see citing works
Wunderle, C., Suter, S., Endner, N., Haenggi, E., Kaegi-Braun, N., Tribolet, P., Stanga, Z. G., Müeller, B., & Schüetz, P. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.09.020 · Cited by 6 · see citing works
Self-citationDurmisi, M., Kaegi-Braun, N., Müller, N. A., Wunderle, C., Tribolet, P., Stanga, Z. G., Müeller, B., & Schüetz, P. (2023) · Nutrition Journal · doi:10.1186/s12937-023-00881-6 · Cited by 6 · see citing works
Self-citationTribolet, P., Wunderle, C., Kaegi-Braun, N., Buchmueller, L., Laager, R., Stanga, Z. G., Müeller, B., Wagner, K., & Schüetz, P. (2025) · European Journal of Clinical Nutrition · doi:10.1038/s41430-025-01618-w · Cited by 5 · see citing works
Self-citationThe Protective Role of Vitamin K in Aging and Age-Related Diseases
Kaźmierczak-Barańska, J., & Karwowski, B. T. (2024) · Nutrients · doi:10.3390/nu16244341 · Cited by 5 · see citing works
Owczarek, A. J., Ochmann, A., Chudek, A., Mossakowska, M., Puzianowska‐Kuźnicka, M., Kujawska‐Danecka, H., Zdrojewski, T. R., Więcek, A., Chudek, J. T., & Olszanecka‐Glinianowicz, M. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00509-9 · Cited by 4 · see citing works
Urbach, K.-H., Wunderle, C., Tribolet, P., Lutz, T. A., Köster-Hegmann, C., Stanga, Z., Mueller, B., & Schuetz, P. (2025) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2025.112910 · Cited by 4 · see citing works
Self-citationSchüetz, P., Meier, M. A., Bally, M. R., Gomes, F., & Müeller, B. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.12.017 · Cited by 3 · see citing works
Self-citationPain in Austrian hospitals: evaluation of 1089 in-patients
Neuwersch-Sommeregger, S., Köstenberger, M., Pipam, W., Demschar, S., Trummer, B., Breschan, C., & Likar, R. (2022) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-022-00984-5 · Cited by 2 · see citing works
Braasch, T., Hoffmann, I., Wesemann, U., Schreiner, M., Thien, H., Ludwig, M., & Pirlich, M. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.05.003 · Cited by 1 · see citing works
Wunderle, C., Tribolet, P., Kaegi-Braun, N., Haller, V., Escher, R., Aujesky, D., Heinen, G. T. D. C., Brändle, M., Bregenzer, T., Henzen, C., et al. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-115456 · Cited by 1 · see citing works
Self-citationTribolet, P., Fehr, R., Baechli, V., Geiser, M., Toplak, H., Stanga, Z. G., & Schüetz, P. (2017) · Aktuelle Ernährungsmedizin · doi:10.1055/s-0043-109233 · Cited by 1 · see citing works
Self-citationNutritional Risk of Candidates for Simultaneous Pancreatic–Kidney Transplantation—A Narrative Review
Mizerska, A., Durlik, M., & Kędzierska-Kapuza, K. (2023) · Nutrients · doi:10.3390/nu15194179 · Cited by 1 · see citing works
Willi, S., Bacher, U., Krönig, M. N., Daskalakis, M., Bally, L., & Pabst, T. (2024) · OBM Transplantation · doi:10.21926/obm.transplant.2401206 · Cited by 1 · see citing works
Jeong, D., Ha, N.-Y., Jeong, H.-I., Ko, S., Park, J.-W., & Kim, J. (2025) · Medicine · doi:10.1097/md.0000000000043454 · Cited by 1 · see citing works
Thyroidal Changes During Critical Illness
Langouche, L., & den Berghe, G. V. (2016) · Springer eBooks · doi:10.1007/978-3-319-27687-8_11 · Cited by 1 · see citing works
Schüetz, P., Sager, R., Wirz, Y., & Müeller, B. (2018) · Springer eBooks · doi:10.1007/978-3-319-33900-9_7 · Cited by 1 · see citing works
IMPACT OF DIETARY HABITS ON HEALTH STATUS OF COLLEGE GOING STUDENTS IN PUNJAB
Ashraf, A. S., Amir, R. M., Syed, F. Z., Rasheed, M. H., & Ansar, S. (2021) · Humanities & Social Sciences Reviews · doi:10.18510/hssr.2021.9362 · Cited by 1 · see citing works
Prevention and reversal of chronic diseases: A Protocol
Kostoff, R. N. (2021) · Public Health Toxicology · doi:10.18332/pht/144538 · Cited by 1 · see citing works
La malnutrition chez les patients hospitalisés
Wirz, Y., Fehr, R., Baechli, V., Geiser, M., & Schüetz, P. (2017) · Primary and hospital care médecine interne générale · doi:10.4414/phc-f.2017.01552
Enfermedad tiroidea autoinmunitaria y SARS-CoV-2/COVID-19
Sánchez, A. M., Rojas, L. J., Mejia, M. G., Builes, C. A., Arenas-Quintero, H. M., & Duque, J. J. (2020) · Revista Colombiana de Endocrinología Diabetes & Metabolismo · doi:10.53853/encr.7.2s.594
Yuxiu, Y., Ma, X., Gao, F., Liu, T., Deng, J., Li, Q., Liu, Z., Wang, Y., Zheng, Y., Yang, J., et al. (2023) · medRxiv · doi:10.1101/2023.12.11.23299837
Knowledge, Attitude, and Support and Motivation Influenced An Initial Nutrition Screening
Hadiyani, A., Jus’at, I., & Wahidi, K. R. (2023) · International Journal of Nursing and Health Services (IJNHS) · doi:10.35654/ijnhs.v6i4.718
Zhang, Y., Fei, P., & Liu, X. (2025) · Journal of Medical Biochemistry · doi:10.5937/jomb0-56202
A key step toward gaining a deeper understanding of individual responses to protein supplementation.
Schuetz, P. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.05.030
Individualized nutritional care for the critically ill: focus on obesity
Schüetz, P. (2026) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.101177
Stern, A., Wunderle, C., Tribolet, P., Neyer, P. J., Bernasconi, L., Stanga, Z. G., Müeller, B., & Schüetz, P. (2026) · European Journal of Clinical Nutrition · doi:10.1038/s41430-026-01750-1
Self-citationObesity Paradox in Critical Illness Patients
Velarde-Pineda, A. A., Sat-Muñoz, D., Balderas-Peña, L.-M.-A., Gómez-Sánchez, E., Márquez-López, L.-M., Cortés-Fregoso, D., Martínez-Herrera, B.-E., & Mireles-Ramírez, J. A. G.-A. A. M.-A. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1016212
- Authors
- Schütz, P., Bally, M., Stanga, Z., & Keller, U.
- Affiliations
- Kantonsspital Aarau (CH)
- University Hospital of Bern (CH)
- University of Basel (CH)
- Venue
- Swiss Medical Weekly
- Publisher
- SMW Supporting Association
- Published
- 2014-04-20
- Volume
- 144
- Issue
- 1718
- Pages
- w13957
- ISSN
- 0036-7672 (ISSN-L)
- 1424-3997
- OpenAlex
- W2011166837
- Cited by
- 78
- References
- 52
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Swiss Medical Weekly (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Open Access CRIS of the University of Bern
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- appetite loss, protein-energy malnutrition, nutritional support, acute medical inpatients, parenteral nutrition, autophagy, weight loss, patient outcomes
- MeSH terms
- Anorexia, Humans, Protein-Energy Malnutrition, Nutrition Assessment, Randomized Controlled Trials as Topic, Critical Illness, Practice Guidelines as Topic, Nutritional Support, Illness Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
