Association of Baseline Inflammation With Effectiveness of Nutritional Support Among Patients With Disease-Related Malnutrition: A Secondary Analysis of a Randomized Clinical Trial
Open accessAbstract
Importance: Inflammation is a key driver of malnutrition during illness and is often accompanied by metabolic effects, including insulin resistance and reduction of appetite. However, it still remains unclear if inflammation influences the response to nutritional support among patients with disease-related malnutrition. Objective: To examine whether patients' baseline inflammatory status is associated with the effect of nutritional support on 30-day mortality. Design, Setting, and Participants: This is a secondary analysis of the Effect of Early Nutritional Support on Frailty, Functional Outcomes, and Recovery of Malnourished Medical Inpatients Trial (EFFORT), a randomized clinical trial conducted in 8 Swiss hospitals from April 2014 to February 2018. A total of 1950 participants who had C-reactive protein measurements at the time of admission were included in this secondary analysis. Data analysis was conducted between June and July 2019. Interventions: Hospitalized patients at risk for malnutrition were randomly assigned to receive protocol-guided individualized nutritional support to reach protein and energy goals (intervention group) or standard hospital food (control group). Main Outcomes and Measures: The primary end point was 30-day mortality. Based on C-reactive protein levels at admission, patients were stratified into groups with low, moderate, or high inflammation (<10 mg/L, 10-100 mg/L, and >100 mg/L, respectively). Results: A total of 1950 patients (median [interquartile range] age, 75 [65-83] years; 1025 [52.6%] men) were included; 533 (27.3%) had low levels of inflammation, 894 (45.9%) had moderate levels of inflammation, and 523 (26.8%) had high levels of inflammation. Compared with the control group, patients receiving nutritional support showed a significant reduction in 30-day mortality, regardless of C-reactive protein level (adjusted odds ratio, 0.61; 95% CI, 0.43-0.86; P = .005). In the subgroup of patients with high inflammation, there was no beneficial effect of nutritional support (adjusted odds ratio, 1.32; 95% CI, 0.70-2.50; P = .39), providing evidence that inflammation has a significant modifying association (P for interaction = .005). Conclusions and Relevance: Based on this secondary analysis of a multicenter randomized trial, a patient's admission inflammatory status was associated with their response to nutritional support. If validated in future clinical trials, nutritional support may need to be individualized based on a patient's initial presentation and markers of inflammation. These results may also help to explain some of the heterogeneity in treatment effects of nutrition seen in previous critical care trials. Trial Registration: ClinicalTrials.gov Identifier: NCT02517476.
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An RCT in non-ICU patients suggests that nutritional intervention including both macro- and micronutrients may improve outcomes.
“An RCT in non-ICU patients suggests that nutritional intervention, including both macro- and micronutrients, may improve outcomes [85].”
From Gastrointestinal function and nutritional interventions in septic shock (2025) · cites this paper as [85]
The Introduction reports that the EFFORT randomized trial found fewer complications and deaths with early individualized nutritional support, and Methods > Patient Population and Management says patients initially admitted to an ICU were excluded. This paper is a secondary analysis of that trial, and our copy does not specify that the intervention included both macro- and micronutrients. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn a secondary analysis of the EFFORT trial, patients with CRP levels ≥100 mg/l no longer responded to nutritional therapy, while patients with lower levels had a significant mortality benefit from nutritional support.
“A secondary analysis of the multicentre randomized-controlled EFFORT trial suggested that patients with CRP levels of !100 mg/l no longer responded to nutritional therapy, while patients with lower levels had a significant mortality benefit from nutritional support [147] (Level of evidence: 1þþ).”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [147]
The Results section (Effect of Nutritional Support on 30-Day Mortality According to Inflammation Groups; page unavailable) reports a significant 30-day mortality benefit in the low- and moderate-CRP groups, but no significant benefit in the high-CRP group. The claim broadens that outcome-specific finding to patients ‘no longer responding’ to nutritional therapy; the paper also defines the high group as CRP >100 mg/L, not ≥100 mg/L. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMarkers of inflammation (i.e., C-reactive protein) have been shown to correlate with disease-related anorexia, reduced food intake, and muscle catabolism, and to predict lack of response to nutritional treatment.
“Markers of inflammation (i.e.C-reactive protein [CRP]) have been shown to correlate with disease-related anorexia, reduced food intake and muscle catabolism, and at the same predict lack of response to nutritional treatment [147,190,191].”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [147]
The Introduction describes inflammation as a proposed driver of disease-related anorexia, reduced food intake, and muscle catabolism. The Discussion says patients with initially very high CRP may not respond to nutritional support. The paper does not establish that CRP itself correlates with all three conditions or that it reliably predicts lack of response; its Strengths and Limitations section calls the secondary-analysis findings hypothesis-generating. (LLM, conf=0.85)
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“…levels, or decreased albumin levels, may identify patients who are less likely to experience favorable clinical outcomes, but they were not independently affected by the initiation of nutrition interventions, nor did they modify effects on outcomes in post hoc analyses of large RCTs (19, 36, 53).”
Validation of GLIM criteria on malnutrition in older Chinese inpatients
Ji, T., Li, Y., Liu, P., Zhang, Y.-X., Song, Y., & Ma, L.-N. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.969666 · Cited by 23 · see citing works
Ma, X., Shao, Q., Li, Q.-X., Yang, Z., Han, K., Liang, J., Shen, H., Liu, X.-L., Zhou, Y.-J., & Wang, Z. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.773200 · Cited by 30 · see citing works
Enge, M., Peelen, F. O., Nielsen, R. L., Beck, A. M., Olin, A. Ö., Cederholm, T., Boström, A., & Paur, I. (2024) · European Journal of Nutrition · doi:10.1007/s00394-023-03323-5 · Cited by 30 · see citing works
“Presence of inflammation was defined as Plasma C-reactive protein (CRP) > 10 mg/L [19].”
BackgroundLópez-Gómez, J. J., García-Beneitez, D., Jiménez-Sahagún, R., Izaola-Jáuregui, O., Primo-Martín, D., Ramos-Bachiller, B., Gómez-Hoyos, E., Delgado-García, E., Pérez-López, P., & de Luis-Román, D. D. (2023) · Nutrients · doi:10.3390/nu15183923 · Cited by 22 · see citing works
“The main societies in nutrition worldwide, like the European Society of Clinical Nutrition and Metabolism (ESPEN) and the American Society of Parenteral and Enteral Nutrition (ASPEN), recommend starting medical nutrition treatment in medical and surgical patients at risk of malnutrition [2].”
BackgroundGarcía-Herreros, S., Gómez, J. J. L., Cebriá, Á., Izaola, O., Salvador-Coloma, P., Nozal, S., Cano, J., Primo, D., Godoy, E. J., & de Luis, D. A. (2024) · Nutrients · doi:10.3390/nu16121806 · Cited by 22 · see citing works
“Disease-related malnutrition (DRM) [1] is a prevalent health issue that poses a significant challenge in our healthcare system, affecting 20% to 50% of hospitalized patients [2,3].”
BackgroundYuxiu, Y., Ma, X., Gao, F., Liu, T., Deng, J., & Wang, Z. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-03951-7 · Cited by 20 · see citing works
“…therapy and that nutritional support alone is inadequate to prevent muscle loss during severe, sustained, or repeated bouts of inflammation [34, 35], which emphasizes the importance of considering the double burden of inflammation and malnutrition in disease assessment, intervention, and…”
BackgroundWhen can we start early enteral nutrition safely in patients with shock on vasopressors?
Wang, L., Zhong, X., Yang, H., Yang, J., Zhang, Y., Zou, X., Wang, L., Zhang, Z., Jin, X., Kang, Y., et al. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.03.007 · Cited by 19 · see citing works
The association between albumin and C-reactive protein in older adults
Jiang, Y.-Q., Yang, Z.-L., Wu, Q.-H., Cao, J., & Qiu, T. (2023) · Medicine · doi:10.1097/md.0000000000034726 · Cited by 19 · see citing works
“[26] Hospitalized patients with severe inflammatory responses (defined as CRP > 100 mg/L) did not demonstrate a strong, measurable response to nutrition support in a large randomized controlled trial.[27] Among our representative United States population, a lower albumin was associated with a greater CRP in old adults.”
BackgroundKang, S.-H., Song, H., Moon, J., Kim, S.-H., Sung, J.-H., Kim, I., Lim, S.-W., Cha, D., & Kim, W.-J. (2022) · Medicine · doi:10.1097/md.0000000000030100 · Cited by 18 · see citing works
“[15,16] In addition, a high degree of malnutrition is associated with a high level of inflammation, reflecting a high atherosclerotic burden.”
Wei, W., Zhang, L.-Y., Li, G.-D., Huang, Z., Liu, J., Wu, Z., Wu, Y.-H., Lin, J.-C., Zhang, Y.-H., Yu, Y., et al. (2021) · Nutrition and Metabolism · doi:10.1186/s12986-021-00626-4 · Cited by 18
Ji, T., Zhang, L., Han, R., Peng, L., Shen, S., Liu, X., Shi, Y., Chen, X., Chen, Q., Li, Y., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.851590 · Cited by 19 · see citing works
Weng, C.-S., Huang, W.-C., Chang, C.-L., Jan, Y.-T., Chen, T.-C., & Lee, J. (2023) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.13289 · Cited by 16 · see citing works
“of nutrition and exercise, suggesting the potential role of anti-inflammation in multimodal interventions.(41) In a randomized phase III trial of treatment for cachexia in patients”
BackgroundShang, S.-J., Huang, Y., Zhan, X.-J., Peng, F.-F., Wang, X.-Y., Wen, Y.-Q., Feng, X.-R., Zhou, Q., Tang, L., Long, H., et al. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03233-1 · Cited by 16 · see citing works
Plauth, M., Sulz, I., Viertel, M., Höfer, V., Witt, M., Raddatz, F., Reich, M., Hiesmayr, M., & Bauer, P. (2022) · Nutrients · doi:10.3390/nu14091780 · Cited by 16 · see citing works
“CRP was extracted from the electronic patient chart for assessing inflammatory status [43] in 4 categories: < 10, 10–100, > 100 mg/L, and missing.”
BackgroundMethodResultInfluentialEffect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients
Scarcella, M., Scarpellini, E., Ascani, A., Commissari, R., Scorcella, C., Zanetti, M., Parisi, A., Monti, R., Milić, N., Donati, A., et al. (2022) · Nutrients · doi:10.3390/nu14030437 · Cited by 16 · see citing works
“Moreover, the higher is the Nutritional Risk Score (NRS), the higher is the incidence of acquired healthcare associated infections and the mortality risk index [3,5].”
BackgroundChen, X.-F., Hao, L., Zhou, Y., Zhang, H., Wang, H.-Y., & Yu, W.-J. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s521440 · Cited by 15
Wunderle, C., Haller, L., Laager, R., Bernasconi, L., Neyer, P. J., Stumpf, F., Tribolet, P., Stanga, Z. G., Müeller, B., & Schüetz, P. (2024) · Nutrients · doi:10.3390/nu16162608 · Cited by 16 · see citing works
“However, while the EFFORT focused on an individualized nutritional strategy to reach individual nutritional targets, certain groups of malnourished patients may benefit from more specific, personalized nutritional interventions [11].”
BackgroundResultSelf-citationZhu, X.-Y., Yang, D., Zhang, K., Zhu, H., Su, F.-F., & Tian, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-47793-3 · Cited by 15
Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis
Xiang, X., Zhu, X., & Zhang, L. (2023) · International journal of clinical practice · doi:10.1155/2023/9910718 · Cited by 15 · see citing works
Relationship of Inflammatory Parameters and Nutritional Status in Cancer Patients
Sambataro, D., Politi, M., Messina, A., Scarpello, L., Messina, S., Guggino, R., Carnaghi, C., Caccialanza, R., & Gebbia, V. (2023) · Anticancer Research · doi:10.21873/anticanres.16451 · Cited by 15
Malnutrition and sarcopenia worsen short- and long-term outcomes in internal medicine inpatients
Carretero‐Gómez, J., Fernández, T. F. G., Ríos, A. S. V., Palacios, M. R. P., García, G. M. G., Carrasco, C. G., Requena, J. M. R., Recio, J. M. F., López-Alegría, L. N., Pijierro-Amador, A., et al. (2023) · Postgraduate Medical Journal · doi:10.1093/postmj/qgad006 · Cited by 18 · see citing works
Chen, L.-L., Huang, Z., Li, W.-G., He, Y.-B., Liang, J., Lu, J., Yang, Y., Huang, H., Lin, Y.-H., Lin, R., et al. (2021) · International Urology and Nephrology · doi:10.1007/s11255-021-02915-6 · Cited by 15
“Inflammation is associated with decreasing albumin synthesis and increasing catabolism [20].”
Tanaka, K., Kimura, H., Ejiri, H., Saito, H., Watanabe, K., Kazama, S., Shimabukuro, M., Asahi, K., Watanabe, T., & Kazama, J. J. (2024) · Hypertension Research · doi:10.1038/s41440-024-01716-5 · Cited by 14 · see citing works
Gastrointestinal function and nutritional interventions in septic shock
Bachmann, K. F., Cotoia, A., & Reintam Blaser, A. (2025) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001302 · Cited by 13 · see citing works
Peng, L., Tang, J.-F., Zhang, N., Zhang, Z., Wang, D.-Q., & He, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1518822 · Cited by 13 · see citing works
Madini, N., Vincenti, A., Beretta, A., Santero, S., Viroli, G., & Cena, H. (2024) · Nutrients · doi:10.3390/nu16234141 · Cited by 12 · see citing works
“The EFFORT Study, in fact, revealed that dietary supplementation is less effective in those with severe inflammation (CRP > 100 mg/dl) compared to individuals with CRP concentrations ≤ 100 mg/L, independently of infection and illness severity [142].”
Thompson, J., McGovern, J., Roxburgh, C., Edwards, J., Dolan, R., & McMillan, D. C. (2024) · Critical reviews in oncology/hematology · doi:10.1016/j.critrevonc.2024.104378 · Cited by 13 · see citing works
Qian, Y.-Z., Qian, X., Shen, M., Vu, A., & Seres, D. (2022) · Nutrition in clinical practice · doi:10.1002/ncp.10815 · Cited by 13 · see citing works
Zengin, A., Karataş, M., Çanga, Y., Durmuş, G., Güzelburç, Ö., Durak, F., & Emre, A. (2021) · Anatolian journal of cardiology · doi:10.5152/anatoljcardiol.2021.190 · Cited by 13
“Inflammation induces metabolic turnover, muscle catabolism, and decreased serum albumin levels (16).”
BackgroundMeulemans, A., Matthys, C., Vangoitsenhoven, R., Sabino, J., der Schueren, B. V., Maertens, P., Pans, C., Stijnen, P., & Bruyneel, L. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab135 · Cited by 13
Ventura, J. C., Oliveira, L. D. D. A., Silveira, T. T., Hauschild, D. B., Mehta, N., & Moreno, Y. M. (2021) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2116 · Cited by 13 · see citing works
Association of GNRI, NLR, and FT3 with the Clinical Prognosis of Older Patients with Heart Failure.
Liu, L., Chen, Y., & Xie, J. (2022) · International Heart Journal · doi:10.1536/ihj.22-306 · Cited by 12 · see citing works
Tribolet, P., Kaegi-Braun, N., Gressies, C., Baumgartner, A., Wagner, K., Stanga, Z., & Schuetz, P. (2022) · Nutrients · doi:10.3390/nu14102173 · Cited by 12 · see citing works
Self-citationThe role of prehabilitation in HNSCC patients treated with chemoradiotherapy
Gili, R., Gianluca, S., Paolo, A., Federica, S., Paola, L. C., Simone, C., Matteo, S., Almalina, B., Filippo, M., Lucia, D., et al. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-024-08834-3 · Cited by 11 · see citing works
Tey, S. L., Huynh, D. T. T., Kong, S. T., Oliver, J. W., Baggs, G. E., Low, Y. L., How, C. H., Cheong, M., Chow, W. L., Tan, N. C., et al. (2024) · Nutrients · doi:10.3390/nu16152495 · Cited by 10 · see citing works
Martins, P., Gomes, T. L., Franco, E. P., Vieira, L. L., & Pimentel, G. (2021) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2318 · Cited by 11 · see citing works
Struja, T., Wolski, W., Schapbach, R., Mueller, B., Laczko, E., & Schuetz, P. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.07.029 · Cited by 11 · see citing works
Self-citationBuchmueller, L., Wunderle, C., Laager, R., Bernasconi, L., Neyer, P. J., Tribolet, P., Stanga, Z. G., Müeller, B., & Schüetz, P. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1451081 · Cited by 12 · see citing works
Self-citationRitz, J., Wunderle, C., Stumpf, F., Laager, R., Tribolet, P., Neyer, P. J., Bernasconi, L., Stanga, Z. G., Müeller, B., & Schüetz, P. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1335242 · Cited by 10 · see citing works
Self-citationWunderle, C., von Arx, D., Mueller, S. C., Bernasconi, L., Neyer, P. J., Tribolet, P., Stanga, Z. G., Müeller, B., & Schüetz, P. (2024) · Nutrients · doi:10.3390/nu16020222 · Cited by 11 · see citing works
Self-citationLee, J., Weng, C.-S., Chang, C.-L., Hsu, W.-H., Jan, Y.-T., & Wu, K.-P. (2023) · Supportive Care in Cancer · doi:10.1007/s00520-023-07719-1 · Cited by 10 · see citing works
Lauwers, C., Langouche, L., Wouters, P. J., Wilmer, A. P., den Berghe, G. V., Casaer, M. P., & Gunst, J. (2025) · Critical Care · doi:10.1186/s13054-025-05273-2 · Cited by 14 · see citing works
“In non-critically ill patients, a large RCT showed benefit by enhanced nutritional support, although this benefit was not observed in patients with severe inflammation [33, 34].”
Fu, J.-X., Zou, Y., Luo, L., Zhang, J., Wang, X.-J., & Zhang, D.-L. (2024) · Scientific Reports · doi:10.1038/s41598-024-80983-1 · Cited by 9 · see citing works
“In addition, inflammation induces insulin resistance, decreases appetite, and hinders the absorption of nutrients, ultimately leading to weight loss 27–29 .”
Early Feeding in Critical Care - Where Are We Now?
Berger, M. M., Blaser, A. R., Raphaeli, O., & Singer, P. (2024) · Critical Care Clinics · doi:10.1016/j.ccc.2024.09.002 · Cited by 9 · see citing works
Malnutrition: muscle wasting, inflammation, RDW, and their relation with adverse outcomes.
Galindo-Martín, C. A., Chong-Aviña, P. A., Godínez-Breacher, V., Aportela-Vázquez, V. A., Bueno-Hernández, G., Gante-García, M. F. D., Pimentel-Luna, K. Y., & Sánchez-Abrego, M. (2024) · Cirugía y Cirujanos · doi:10.24875/cirue.m23000658 · Cited by 9
“Furthermore, nutritional support did not influence C reactive protein levels during the intervention 17 .”
Wunderle, C., Siegenthaler, J., Seres, D. S., Owen‐Michaane, M., Tribolet, P., Stanga, Z. G., Müeller, B., & Schüetz, P. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.01.013 · Cited by 16 · see citing works
Self-citationXu, Y.-F., Yan, Z., & Liu, L.-J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1421696 · Cited by 8
Zou, Y., Cong, J., Fu, J.-X., & Yang, X. (2025) · Medicine · doi:10.1097/md.0000000000042386 · Cited by 7 · see citing works
“14–16] Thus, both inflammatory and nutritional statuses play pivotal roles in assessing ASCVD development and prognosis.”
Pan, L., Peng, Y.-J., & Jiang, L.-H. (2024) · Journal of Stroke & Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.108165 · Cited by 7 · see citing works
Román, D. A. D. L., & Gómez, J. J. L. (2023) · Nutrients · doi:10.3390/nu15194300 · Cited by 7
“This disease has a prevalence between 20 and 50% in hospitalized patients [1,2].”
BackgroundMatsui, R., Inaki, N., Tsuji, T., & Fukunaga, T. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041579 · Cited by 7
“A randomized controlled trial has shown that conventional nutritional support in the presence of inflammation does not improve prognosis [9].”
BackgroundNutritional Support Among Medical Inpatients—Feed the Cold (and Malnourished) and Starve the Febrile
Marik, P. E. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.15707 · Cited by 9 · see citing works
The Global Leadership Initiative on Malnutrition (GLIM)
Jensen, G. L., & Compher, C. W. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.06.028 · Cited by 4 · see citing works
Lin, W.-C., Weng, C.-S., Ko, A.-T., Jan, Y.-T., Lin, J.-B., Wu, K.-P., & Lee, J. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-024-08757-z · Cited by 6 · see citing works
“These findings potentially suggest that systemic inflammation may be a target for modulation to preserve muscles, based on the machine learning model [37].”
Walsh, M., & Martindale, R. (2024) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2634 · Cited by 6 · see citing works
Durmisi, M., Kaegi-Braun, N., Müller, N. A., Wunderle, C., Tribolet, P., Stanga, Z. G., Müeller, B., & Schüetz, P. (2023) · Nutrition Journal · doi:10.1186/s12937-023-00881-6 · Cited by 6 · see citing works
“Based on results from a former analysis [17], low CRP was defined as 100 mg/l and high CRP as ≥ 100 mg/l. Based on admission NRS 2002 score, we categorized patients as “moderately mal-nourished” (NRS 2002 score 3 and 4 points), or “severely malnourished” (NRS 2002 score ≥ 5 points).”
BackgroundMethodResultSelf-citationMcGovern, J., Dolan, R., Simmons, C., Daly, L., Ryan, A., Power, D., Fallon, M., Laird, B., & McMillan, D. (2023) · Cancers · doi:10.3390/cancers15133497 · Cited by 6 · see citing works
“The present observations, together with those in clinical trials [6,23,29], favor a framework where the systemic inflammatory response is the dominant factor to be used in patients with good performance status to predict the likely outcome.”
ResultYe, S., Xiang, G., Liu, Z., Li, W.-D., Tang, T., Qian, A.-M., Li, X.-Q., & Sun, L.-L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1129255 · Cited by 6
“Additionally, nutritional status partly reflects the development of inflammation (31–33), which promotes cytokine production and muscle catabolism, suppresses appetite, and lowers the albumin concentration (34).”
BackgroundGressies, C., & Schüetz, P. (2022) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000894 · Cited by 8 · see citing works
Self-citation
- Authors
- Merker, M., Felder, M., Gueissaz, L., Bolliger, R., Tribolet, P., Kägi-Braun, N., Gomes, F., Hoess, C., Pavlicek, V., Bilz, S., Sigrist, S., Brändle, M., Henzen, C., Thomann, R., Rutishauser, J., Aujesky, D., Rodondi, N., Donzé, J., Stanga, Z., Mueller, B., & Schuetz, P.
- Affiliations
- University of Basel (CH)
- Bern University of Applied Sciences (CH)
- Internal Medicine, Kantonsspital Muensterlingen, Muensterlingen, Switzerland
- New York Academy of Sciences (US)
- Kantonsspital Münsterlingen (CH)
- Kantonsspital St. Gallen (CH)
- Luzerner Kantonsspital (CH)
- Internal Medicine, Kantonsspital Solothurn, Solothurn, Switzerland
- Kantonsspital Baselland (CH)
- University of Bern (CH)
- Medical University Department, University of Basel, Kantonsspital Aarau, Aarau, Switzerland
- ORCID
- Venue
- JAMA Network Open
- Publisher
- American Medical Association (AMA)
- Published
- 2020-03-10
- Volume
- 3
- Issue
- 3
- Pages
- e200663
- ISSN
- 2574-3805 (ISSN-L)
- PMC
- PMC7064875
- OpenAlex
- W3011737478
- Cited by
- 262
- References
- 31
- Citations by year
- 2026: 26 · 2025: 71 · 2024: 56 · 2023: 46 · 2022: 35 · 2021: 21 · 2020: 5 · 2019: 1
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- JAMA Network Open (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ARBOR - Bern University of Applied Sciences Repository (submittedVersion, other-oa)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- BFH: ARBOR
- Open Access CRIS of the University of Bern
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (150531)
- Forschungsrat des Kantonsspitals Aarau (1410.000.044, 1410.000.058)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- disease-related malnutrition, inflammation, C-reactive protein, nutritional support, 30-day mortality, frailty, insulin resistance, appetite, older adults, hospital food service, functional outcome, length of hospital stay, hospital readmission
- MeSH terms
- Aged, Aged, 80 and over, C-Reactive Protein, Female, Hospitalization, Humans, Inflammation, Male, Middle Aged, Cohort Studies, Survival Rate, Treatment Outcome, Nutritional Support, Malnutrition
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