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Aging of Skeletal Muscle Fibers
Open accessAbstract
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional capacity and independence. Sarcopenia is partly responsible for this decline. Many changes underlying the loss of muscle mass and force-generating capacity of skeletal muscle can be understood at the cellular and molecular levels. Muscle size and architecture are both altered with advanced adult age. Further, changes in myofibers include impairments in several physiological domains including muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, and repair and regeneration. A thorough understanding of these alterations can lead to the design of improved preventative and rehabilitative interventions, such as personalized exercise training programs.
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“These changes are also accompanied by a diminished regenerative capacity of the muscle due to a loss in the number and activity of satellite cells in type II “fast” fibers [14,16,17].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [17]
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Cites
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Joseph, A.-M., Adhihetty, P. J., Wawrzyniak, N. R., Wohlgemuth, S. E., Picca, A., Kujoth, G. C., Prolla, T. A., & Leeuwenburgh, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069327 · Cited by 161 · cited 1×
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Broskey, N. T., Greggio, C., Boss, A., Boutant, M., Dwyer, A., Schlueter, L., Hans, D., Gremion, G., Kreis, R., Boesch, C., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3983 · Cited by 157
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“The mechanism underlying this reduction includes agerelated alterations in cellular and molecular processes such as changes in the satellite cell population, excitation-contraction coupling, myofilament interaction, mitochondrial function, and adipocyte infiltration [37,38] (see below).”
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“Functional changes in elderly Aging is associated with changes in body composition (increase in body fat and decreases in muscle and bone mass) which together with a decline in cognitive, visual, and hearing function, sleeping disorders, depression, and increased fatigue lead to a decline in physical function and sign…”
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“Several studies [4,5] have shown that older men and women transition more frequently from intermittent to continuous mobility limitation, than from no mobility limitation to intermittent mobility limitation.”
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“It is interesting that longitudinal studies suggest that clusters of fibers that are not lost during aging try to compensate for these agerelated differences in fiber size and quality [18,46,47] and although whole muscle performance is reduced, single muscle fiber properties may be relatively well preserved.”
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Cited by
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Nishikawa, H., Shiraki, M., Hiramatsu, A., Moriya, K., Hino, K., & Nishiguchi, S. (2016) · Hepatology Research · doi:10.1111/hepr.12774 · Cited by 656
The bystander effect contributes to the accumulation of senescent cells in vivo
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Kara, M., Kaymak, B., Frontera, W. R., Ata, A. M., Ricci, V., Ekiz, T., Chang, K. C., Han, D., Michail, X., Quittan, M., et al. (2021) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-2851 · Cited by 190
“Although it is assumed that type I fibres are protected from atrophy by the peroxisome proliferator-activated receptor-gamma coactivator 1-α (52), it has been reported that the number of type I fibres in pectoralis minor muscle decreased after 60 years of age.”
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Metadata
- Authors
- Miljkovic, N., Lim, J.-Y., Miljkovic, I., & Frontera, W. R.
- Affiliations
- Vanderbilt University (US)
- Seoul National University (KR)
- University of Pittsburgh (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Corresponding author
- Frontera, Walter R.
- Venue
- Annals of Rehabilitation Medicine
- Published
- 2015
- Volume
- 39
- Issue
- 2
- Pages
- 155
- ISSN
- 2234-0645 (ISSN-L)
- 2234-0653
- PMC
- PMC4414960
- OpenAlex
- W2049942632
- Cited by
- 309
- References
- 58
- Citations by year
- 2026: 21 · 2025: 20 · 2024: 32 · 2023: 30 · 2022: 24 · 2021: 42 · 2020: 44 · 2019: 28 · 2018: 30 · 2017: 14 · 2016: 23 · 2015: 1
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Annals of Rehabilitation Medicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, sarcopenia, muscle fiber atrophy, muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridges, muscle energy metabolism, muscle regeneration, muscle architecture, functional capacity decline, exercise training intervention
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