The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.
Aging of Skeletal Muscle Fibers
Open accessAbstract
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional capacity and independence. Sarcopenia is partly responsible for this decline. Many changes underlying the loss of muscle mass and force-generating capacity of skeletal muscle can be understood at the cellular and molecular levels. Muscle size and architecture are both altered with advanced adult age. Further, changes in myofibers include impairments in several physiological domains including muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, and repair and regeneration. A thorough understanding of these alterations can lead to the design of improved preventative and rehabilitative interventions, such as personalized exercise training programs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These changes are also accompanied by a diminished regenerative capacity of the muscle due to a loss in the number and activity of satellite cells in type II “fast” fibers [14,16,17].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · cited 1×
“More recently, the European Working Group on Sarcopenia in Older People has expanded the definition and suggested criteria for diagnosis [12] including the presence of muscle weakness (for example handgrip strength), a lower muscle mass (determined by bioelec1960 40”
BackgroundSkeletal muscle mass and distribution in 468 men and women aged 18–88 yr
Janssen, I., Heymsfield, S. B., Wang, Z., & Ross, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.81 · Cited by 3,087 · cited 1×
“In contrast, type I muscle fiber size is largely unaffected [22,28,29].”
BackgroundStudenski, S. A., Peters, K. W., Alley, D. E., Cawthon, P. M., McLean, R. R., Harris, T. B., Ferrucci, L., Guralnik, J. M., Fragala, M. S., Kenny, A. M., et al. (2014) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu010 · Cited by 2,545 · cited 2×
“The FNIH Sarcopenia Project Group [13] recently recommended normative values for muscle strength and lean body mass as follows: 1) grip strength in men <26 kg and in women <16 kg, or alternate grip strength adjusted for BMI <1.0 for men and <0.56 for women; and 2) appendicular lean body mass in men <19.75 kg and <15.0…”
MethodInfluentialSarcopenia: origins and clinical relevance
Rosenberg, I. H. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.5.990s · Cited by 2,399 · cited 1×
“The term sarcopenia was used for the first time by Rosenberg [10,11] to refer to the loss of lean body mass with aging.”
MethodSatellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166 · cited 1×
“Pax7-expressing adult stem cells are normally quiescent, but when stimulated by damage or stress, they become activated and enter the cell cycle to either form new muscle fibers or self-renew and replenish the satellite cell pool, that will be used in the future [19-21].”
BackgroundLongitudinal study of muscle strength, quality, and adipose tissue infiltration
Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B., Velasquez-Mieyer, P., Boudreau, R., Manini, T. M., Nevitt, M., Newman, A. B., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28047 · Cited by 1,446 · cited 1×
“However, a direct relationship between increased intermuscular fat and age-related muscle weakness has not been established [51].”
BackgroundAging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443 · cited 3×
“The loss of muscle mass and strength in older people is of greater magnitude in longitudinal compared to cross-sectional studies [15].”
BackgroundResultHuman aging, muscle mass, and fiber type composition.
Evans, W. J., & Lexell, J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.11 · Cited by 1,308 · cited 1×
“The decline in muscle mass, most prominent in the lower limbs, is accompanied by a 30% to 40% decrease in muscle fiber number between the second and eight decade [25].”
BackgroundRosenberg, I. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1231 · Cited by 1,234
Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226
Flagged first, then by citations
1 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Lexell, 1995, J Gerontol A Biol Sci Med Sci, 50 Spec No, 11
- Delbono, 2000, J Nutr Health Aging, 4, 162
Cited by
Sorted by citations
Nishikawa, H., Shiraki, M., Hiramatsu, A., Moriya, K., Hino, K., & Nishiguchi, S. (2016) · Hepatology Research · doi:10.1111/hepr.12774 · Cited by 656
The bystander effect contributes to the accumulation of senescent cells in vivo
da Silva, P. F. L., Ogrodnik, M., Kucheryavenko, O., Glibert, J., Miwa, S., Cameron, K., Ishaq, A., Saretzki, G., Nagaraja‐Grellscheid, S., Nelson, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12848 · Cited by 247
Roman, M. A., Rossiter, H. B., & Casaburi, R. H. (2016) · European Respiratory Journal · doi:10.1183/13993003.00347-2016 · Cited by 208
“Muscle size, architecture and metabolism are altered with advancing adult age.[23] Limb muscles, particularly large locomotor muscles, are 25335% smaller in older age and have more fat and connective tissue than those of younger individuals.”
BackgroundDiagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM
Kara, M., Kaymak, B., Frontera, W. R., Ata, A. M., Ricci, V., Ekiz, T., Chang, K. C., Han, D., Michail, X., Quittan, M., et al. (2021) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-2851 · Cited by 190
“Although it is assumed that type I fibres are protected from atrophy by the peroxisome proliferator-activated receptor-gamma coactivator 1-α (52), it has been reported that the number of type I fibres in pectoralis minor muscle decreased after 60 years of age.”
BackgroundAngulo, J., Assar, M. E., & Rodríguez‐Mañas, L. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.06.001 · Cited by 195
Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis
Li, G., Zhang, L., Wang, D., AIQudsy, L., Jiang, J. X., Xu, H., & Shang, P. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28946 · Cited by 166
Calf circumference: clinical validation for evaluation of muscle mass in the elderly
Pagotto, V., dos Santos, K. F., Malaquias, S. G., Bachion, M. M., & Silveira, É. A. (2018) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167-2017-0121 · Cited by 174
“Human aging is accompanied by changes in body composition that include progressive decrease in muscle mass(1), termed sarcopenia in 1989 by Rosenberg(2).”
BackgroundSarcopenia and Its Implications for Metabolic Health
Hunter, G. R., Singh, H., Carter, S. J., Bryan, D. R., & Fisher, G. (2019) · Journal of Obesity · doi:10.1155/2019/8031705 · Cited by 156
“Interestingly, a preferential denervation of fast motor units could lead to a greater loss in number and area of Type II versus Type I motor units with aging [36].”
BackgroundMuscle and Bone Mass Loss in the Elderly Population: Advances in diagnosis and treatment
Colón, C. J. P., Molina-Vicenty, I. L., Frontera-Rodríguez, M., García-Ferré, A., Rivera, B. P., Cintrón-Vélez, G., & Frontera-Rodríguez, S. (2018) · Journal of Biomedicine · doi:10.7150/jbm.23390 · Cited by 166
“Of those, approximately 400 million will be 80 years or older [5, 6].”
BackgroundIntrinsic muscle clock is necessary for musculoskeletal health
Schroder, E. A., Harfmann, B. D., Zhang, X., Srikuea, R., England, J. H., Hodge, B. A., Wen, Y., Riley, L. A., Yu, Q., Christie, A., et al. (2015) · The Journal of Physiology · doi:10.1113/jp271436 · Cited by 145
“A well-known feature of ageing in skeletal muscle is a shift in fibre type characterized by a decrease in the type IIB fibres with increases in the more oxidative type IIA fibres (Ciciliot et al. 2013; Miller et al. 2014; Purves-Smith et al. 2014; Miljkovic et al. 2015).”
BackgroundOsteosarcopenic Obesity: Current Knowledge, Revised Identification Criteria and Treatment Principles
Kelly, O. J., Gilman, J. C., Boschiero, D., & Ilich, J. Z. (2019) · Nutrients · doi:10.3390/nu11040747 · Cited by 131
Van Ancum, J. M., Scheerman, K., Jonkman, N. H., Smeenk, H. E., Kruizinga, R. C., Meskers, C. G. M., & Maier, A. B. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.03.006 · Cited by 118
The Role of Ultrasound as a Diagnostic Tool for Sarcopenia
Stringer, H. J., & Wilson, D. V. (2018) · The Journal of Frailty & Aging · doi:10.14283/jfa.2018.24 · Cited by 113
“Whilst a direct relationship between adipose infiltration and muscle weakness is not yet fully understood, there are several potential mechanisms explaining the phenomenon (38–41).”
Effects of Jumping Exercise on Muscular Power in Older Adults: A Meta-Analysis
Moran, J., Ramírez‐Campillo, R., & Granacher, U. (2018) · Sports Medicine · doi:10.1007/s40279-018-1002-5 · Cited by 123
Handgrip Strength: An Irreplaceable Indicator of Muscle Function
Lee, S. Y. (2021) · Annals of Rehabilitation Medicine · doi:10.5535/arm.21106 · Cited by 127
“It is an important tool for diagnosing sarcopenia and is widely used as a single indicator to represent overall muscle strength [1-4].”
MethodPotential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration
Tachtsis, B., Camera, D., & Lacham-Kaplan, O. (2018) · Nutrients · doi:10.3390/nu10030309 · Cited by 104
“These changes are also accompanied by a diminished regenerative capacity of the muscle due to a loss in the number and activity of satellite cells in type II “fast” fibers [14,16,17].”
BackgroundPérez, K., Ciotlos, S., McGirr, J., Limbad, C., Doi, R., Nederveen, J. P., Nilsson, M. I., Winer, D. A., Evans, W. J., Tarnopolsky, M. A., et al. (2022) · Aging · doi:10.18632/aging.204435 · Cited by 114
Impact of Melatonin on Skeletal Muscle and Exercise
Stacchiotti, A., Favero, G., & Rodella, L. F. (2020) · Cells · doi:10.3390/cells9020288 · Cited by 116
“Satellite cells Present Reduced/Absent [6,42,47]”
The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature
González‐Freire, M., Semba, R. D., Ubaida‐Mohien, C., Fabbri, E., Scalzo, P., Højlund, K., Dufresne, C. P., Lyashkov, A. E., & Ferrucci, L. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12121 · Cited by 98
Ali, A. M., & Kunugi, H. (2020) · Foods · doi:10.3390/foods9101362 · Cited by 103
“Loss of lean body mass is a direct effect of the inflammatory and oxidative conditions that develop with aging [1,2]—described as inflammaging.”
BackgroundDowling, P., Gargan, S., Swandulla, D., & Ohlendieck, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032415 · Cited by 103
“Skeletal muscle aging can be considered a fundamental biological process that occurs in all humans of advanced age [334].”
BackgroundMitochondrial Dysfunction in Skeletal Muscle Pathologies
Abrigo, J., Simon, F., Cabrera, D., Vilos, C., & Cabello-Verrugio, C. (2019) · Current Protein & Peptide Science · doi:10.2174/1389203720666190402100902 · Cited by 88
Zampieri, S., Mammucari, C., Romanello, V., Barberi, L., Pietrangelo, L., Fusella, A., Mosole, S., Gherardi, G., Höfer, C., Löfler, S., et al. (2016) · Physiological Reports · doi:10.14814/phy2.13005 · Cited by 92
“Age-related sarcopenia is a syndrome characterized by a progressive loss of muscle mass and strength that greatly impacts on mobility and mortality in elderly persons (Hughes et al. 2001; Aagaard et al. 2010; Cruz-Jentoft et al. 2010; Mitchell et al. 2012; Bijlsma et al. 2013; Miljkovic et al. 2015).”
BackgroundKim, H.-K., & Kim, C.-H. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.1348 · Cited by 89
“A major factor that affects muscle strength is myosteatosis because increased myosteatosis leads to changes in muscle fiber orientation and significantly impairs the force generation of muscle fibers [61].”
BackgroundMoro, T., Brightwell, C. R., Phalen, D. E., McKenna, C. F., Lane, S. J., Porter, C., Volpi, E., Rasmussen, B. B., & Fry, C. S. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110723 · Cited by 85
Improved efficacy of a next-generation ERT in murine Pompe disease
Xu, S., Lun, Y., Frascella, M., Garcia, A., Soska, R., Nair, A., Ponery, A. S., Schilling, A. E., Feng, J., Tuske, S. J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.125358 · Cited by 92
“Muscle atrophy is a prominent feature in Pompe disease (45, 55, 56) as well as in other myopathies and muscular dystrophies (57), and in aging (58).”
BackgroundAli, A. M., & Kunugi, H. (2020) · Antioxidants · doi:10.3390/antiox9100937 · Cited by 88
Potential roles of vitamin E in age-related changes in skeletal muscle health
Chung, E., Mo, H., Wang, S. F., Zu, Y., Elfakhani, M., Rios, S. R., Chyu, M.-C., Yang, R., & Shen, C. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.09.005 · Cited by 74
Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte
Armani, A., Berry, A., Cirulli, F., & Caprio, M. (2017) · The FASEB Journal · doi:10.1096/fj.201601125rrr · Cited by 76
“Myosteatosis can contribute to type 2 diabetes (T2D) development and is associatedwith cardiovascularmortality (29, 30).”
BackgroundPhua, W. W. T., Wong, M. X. Y., Liao, Z., & Tan, N. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051425 · Cited by 72
“In aged muscles, type II glycolytic fibers, particularly type IIx, are susceptible to both atrophy and fiber type switching [180].”
BackgroundIncreased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy
Miller, S. G., Hafen, P. S., & Brault, J. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010088 · Cited by 67
“These decreases are mainly attributed to reductions in the average size of type II (fast) fibers, while type I (slow) fibers change to a lesser extent [127,128].”
BackgroundZullo, A., Fleckenstein, J., Schleip, R., Hoppe, K., Wearing, S. C., & Klingler, W. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00592 · Cited by 73
Advanced Glycation End-Products in Skeletal Muscle Aging
Olson, L. C., Redden, J. T., Schwartz, Z., Cohen, D. J., & McClure, M. J. (2021) · Bioengineering · doi:10.3390/bioengineering8110168 · Cited by 66
Evaluation of effects of aging on skeletal muscle elasticity using shear wave elastography
Şendur, H. N., Cindil, E., Cerit, M. N., Kılıç, P., Gültekin, I. İ., & Oktar, S. Ö. (2020) · European Journal of Radiology · doi:10.1016/j.ejrad.2020.109038 · Cited by 60
Apigenin Enhances Skeletal Muscle Hypertrophy and Myoblast Differentiation by Regulating Prmt7
Jang, Y. J., Son, H. J., Choi, Y. M., Ahn, J., Jung, C. H., & Ha, T. Y. (2017) · Oncotarget · doi:10.18632/oncotarget.20962 · Cited by 59
“Type 1 is an oxidative muscle fiber that contains MHC1, and type 2 is a fast oxidative/glycolytic fiber that contains MHC2A and the fast-glycolytic fiber MHC2B [39].”
BackgroundImpacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition
Luk, H., Appell, C. R., Chyu, M., Chen, C., Wang, C., Yang, R., & Shen, C. (2020) · Antioxidants · doi:10.3390/antiox9111050 · Cited by 60
“According to the World Health Organization, by 2050, about two billion people worldwide will be 60 years or older and approximately 400 million will be 80 years or older [9], making SC a potentially serious health issue.”
D’Souza, R. F., Woodhead, J. S. T., Hedges, C. P., Zeng, N., Wan, J., Kumagai, H., Lee, C., Cohen, P., Cameron-Smith, D., Mitchell, C. J., et al. (2020) · Aging · doi:10.18632/aging.102944 · Cited by 55
“In addition to loss of muscle mass, aging is associated with a fast-to-slow fiber type shift [31].”
BackgroundLee, J. H., Jeon, J. H., & Lee, M. J. (2020) · Nutrients · doi:10.3390/nu12092597 · Cited by 62
“During the aging process, while slow-twitch muscle fibers (type I, which relies on aerobic respiration for muscle endurance) remain largely unchanged, the mass of fast-twitch fibers (type II, which determines muscle power) is significantly reduced via the progressive denervation and reinnervation processes [1].”
BackgroundScreening for Sarcopenia (Physical Frailty) in the COVID-19 Era
Ali, A. M., & Kunugi, H. (2021) · International Journal of Endocrinology · doi:10.1155/2021/5563960 · Cited by 54
“Beyond these measures, current guidelines recommend interventional studies addressing sarcopenia to assess a number of outcome indicators that take into account the progressive nature of sarcopenia [16, 76].”
BackgroundInfluentialThe biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function
Clemens, Z. J., Sivakumar, S., Pius, A., Sahu, A., Shinde, S. S., Mamiya, H., Luketich, N., Cui, J., Dixit, P. D., Hoeck, J. D., et al. (2021) · eLife · doi:10.7554/elife.61138 · Cited by 54
“Tissue-level features of sarcopenia have been described extensively, and include a decreased myofiber size, increased intramuscular fat accumulation, a preferential atrophy of type II (fast-twitch) muscle fibers, and compromised function (Doherty, 2003; Morley et al., 2014; Miljkovic et al., 2015).”
BackgroundMitochondrial function in skeletal myofibers is controlled by a TRF2‐SIRT3 axis over lifetime
Robin, J. D., Burbano, M. S. J., Peng, H., Croce, O., Thomas, J. L., Laberthonnìère, C., Renault, V. M., Lototska, L., Pousse, M., Tessier, F., et al. (2020) · Aging Cell · doi:10.1111/acel.13097 · Cited by 58
“…NADH-TR staining in downregulated TERF2 myotubes (Figure S5b), suggesting a switch from glycolytic (fast, type II) toward oxidative (slow, type I) fibers, the latter being associated with development, aging, and stronger resistance to oxidative stress (Lexell, 1995; Miljkovic et al., 2015).”
BackgroundMethodInfluentialSukari, A. W., Muqbil, I., Mohammad, R. M., Philip, P. A., & Azmi, A. S. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.01.002 · Cited by 52
“The number of fibers in a muscle and the size of fibers remain relatively stable from puberty until the fifth decade of life, at which point a noticeable decline in muscle fiber number and size begins [15].”
BackgroundMelatonin as a Potential Agent in the Treatment of Sarcopenia
Coto‐Montes, A. M., Boga, J. A., Tan, D., & Reiter, R. J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101771 · Cited by 52
“Eventually, sarcopenia is related to adipocyte infiltration with increases in both intra- and inter-muscular adipose tissue which significantly contributes to the decline in muscle quality [21].”
BackgroundAChRs Degeneration at NMJ in Aging-Associated Sarcopenia–A Systematic Review
Bao, Z., Cui, C., Chow, S. K., Qin, L., Wong, R. M. Y., & Cheung, W. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.597811 · Cited by 48
“Notably, sarcopenia is also accompanied with obviously smaller type II fibers and commonly unaffected type I fibers (Miljkovic et al., 2015).”
BackgroundNeuromuscular junction transmission failure is a late phenotype in aging mice
Chugh, D., Iyer, C. C., Wang, X., Bobbili, P. J., Rich, M. M., & Arnold, W. D. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.022 · Cited by 47
Morphological and Functional Aspects of Human Skeletal Muscle
Trovato, F. M., Imbesi, R., Conway, N., & Castrogiovanni, P. (2016) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk1030289 · Cited by 51
“In age-related sarcopenia, a reduced number of satellite cells have been highlighted [66,67].”
BackgroundHart, C. R., Layec, G., Trinity, J. D., Kwon, O. S., Zhao, J., Reese, V. R., Gifford, J. R., & Richardson, R. S. (2018) · Experimental Physiology · doi:10.1113/ep086905 · Cited by 44
Lee, M. J., Kim, H., Kim, E. H., Bae, S. J., Kim, K. W., Kim, M.-J., & Choe, J. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315054 · Cited by 46
Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
Zhang, F., Wu, H.-F., Wang, K., Yu, D., Zhang, X.-Z., Ren, Q., Chen, W., Lin, F., Yu, Z., & Zhuang, C.-L. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06851-y · Cited by 42
Sinclair, A. J., Pennells, D., & Abdelhafiz, A. H. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02142-8 · Cited by 45
“With increasing age, there is increased atrophy of type II muscle fibres that accounts for the majority of body muscle loss [49, 50].”
BackgroundAge-Associated Differences in Recovery from Exercise-Induced Muscle Damage
Li, D. C. W., Rudloff, S., Langer, H. T., Norman, K., & Herpich, C. (2024) · Cells · doi:10.3390/cells13030255 · Cited by 45
“…trained middle-age, then young trained males [17] Here, the results hint that training status may benefit older athletes in recovery, but the impacts of external Similarly, in another subset of trained young and old men, the therapeutic applications (i.e., nutrition and exercise) are out of the”
Dankel, S. J., Kang, M., Abe, T., & Loenneke, J. P. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-4022-9 · Cited by 41
Lee, C., Woods, P. C., Paluch, A. E., & Miller, M. S. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00347.2024 · Cited by 45
YALVAÇ, M. E., Amornvit, J., Chen, L., Shontz, K. M., Lewis, S., & Sahenk, Z. (2018) · Gene Therapy · doi:10.1038/s41434-018-0009-8 · Cited by 41
Vitamin D 3 supplementation does not enhance the effects of resistance training in older adults
Mølmen, K. S., Hammarström, D., Pedersen, K. K., Lie, A. C. L., Steile, R. B., Nygaard, H., Khan, Y., Hamarsland, H., Koll, L., Hanestadhaugen, M., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12688 · Cited by 40
“older adults, for whom larger spatial heterogeneity are present in muscle fibre characteristics compared with young adults,(110) possibly relating to the age-related remodeling of motor units.(111) Despite these issues, the data provided sufficient resolution to disclose marked increases in muscle fibre CSA and change…”
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging
Lim, J., & Frontera, W. R. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04924-4 · Cited by 44
“Chemical alterations of the myofilaments include posttranslational modifications such as protein methylation, glycosylation, phosphorylation, carbonylation, and oxidation (Miljkovic et al. 2015).”
BackgroundInfluentialNeural and musculotendinous mechanisms underpinning age-related force reductions
Orssatto, L. B. R., Wiest, M. J., & Diefenthaeler, F. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.06.005 · Cited by 55
Metabolic Impact of Frailty Changes Diabetes Trajectory
Sinclair, A. J., & Abdelhafiz, A. H. (2023) · Metabolites · doi:10.3390/metabo13020295 · Cited by 46
“Increasing age is also associated with significant type II muscle fibres atrophy, which accounts for most of the muscle loss in old age [61,62].”
BackgroundThe Prospect of the Fourth Industrial Revolution and Home Healthcare in Super-Aged Society
Lee, J.-Y., & Lim, J. (2017) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.2017.21.3.95 · Cited by 37
Relationship Between Low Handgrip Strength and Chronic Kidney Disease: KNHANES 2014-2017
Lee, Y. L., Jin, H., Lim, J., & Lee, S. Y. (2020) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2020.03.002 · Cited by 39
Serrano, N., Hyatt, J. K., Houmard, J. A., Murgia, M., & Katsanos, C. S. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2023 · Cited by 36
Relationship between serum vitamin D level and sarcopenia in chronic liver disease
Okubo, T., Atsukawa, M., Tsubota, A., Yoshida, Y., Arai, T., Iwashita, A., Itokawa, N., Kondo, C., & Iwakiri, K. (2020) · Hepatology Research · doi:10.1111/hepr.13485 · Cited by 36
Prdx6 Plays a Main Role in the Crosstalk between Aging and Metabolic Sarcopenia
Pacifici, F., Della‐Morte, D., Piermarini, F., Arriga, R., Scioli, M. G., Capuani, B., Pastore, D., Coppola, A., Rea, S., Donadel, G., et al. (2020) · Antioxidants · doi:10.3390/antiox9040329 · Cited by 37
“In particular, Prdx4 may protect from diabetes and its chronic complications, by reducing oxidative stress levels [45].”
Assessing the Effects of Aging on Muscle Stiffness Using Shear Wave Elastography and Myotonometer
Do, Y., Lall, P. S., & Lee, H. (2021) · Healthcare · doi:10.3390/healthcare9121733 · Cited by 36
“In the present study, the relationship was stronger in young adults than in older adults in the MG and TA at rest and under contraction, which is evident from the contractility of muscle fibers, the muscle mass, and the total amount that force generation decreases with aging due to structural changes in the skeletal m…”
BackgroundMüller, D. C., Izquierdo, M., Boeno, F. P., Aagaard, P., Teodoro, J. L., Grazioli, R., Radaelli, R., Bayer, H., Neske, R., Pinto, R. S., et al. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04355-z · Cited by 35
Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats
Das, M. M., Avalos, P., Suezaki, P., Godoy, M. I., Garcia, L., Chang, C. D., Vit, J., Shelley, B., Gowing, G., & Svendsen, C. N. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.023 · Cited by 33
Toyoda, H., Hoshino, M., Ohyama, S., Terai, H., Suzuki, A., Yamada, K., Takahashi, S., Hayashi, K., Tamai, K., Hori, Y., et al. (2018) · European Spine Journal · doi:10.1007/s00586-018-5858-8 · Cited by 33
Handgrip Strength in the Korean Population: Normative Data and Cutoff Values
Lee, Y. L., Lee, B. H., & Lee, S. Y. (2019) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.19.0042 · Cited by 33
“Ann Geriatr Med Res 2019;23(4):183-189 185 Handgrip Strength in Korean”
BackgroundInfluentialHerbst, A. J., Prior, S. J., Lee, C. C., Aiken, J. M., McKenzie, D. I., Hoang, A. N., Liu, N., Chen, X., Xun, P., Allison, D. B., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00351-z · Cited by 38
Diet and exercise in frailty and sarcopenia. Molecular aspects
Millan-Domingo, F., Garcia-Dominguez, E., Gambini, J., Olaso-Gonzalez, G., Viña, J., & Gomez-Cabrera, M. C. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101322 · Cited by 31
Bioengineered Skeletal Muscle as a Model of Muscle Aging and Regeneration
Rajabian, N., Shahini, A., Asmani, M., Vydiam, K., Choudhury, D., Nguyen, T. M., Ikhapoh, I. A., Zhao, R., Lei, P., & Andreadis, S. T. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0005 · Cited by 36
“With aging, these cells lose their proliferation and differentiation potential, and SkM tissues exhibit decreased fiber number, volume, and contractile protein content, and dysregulated calcium flux, leading to significantly impaired contractile force generation.(7) Consequently, senescent SkM develops sarcopenia and…”
BackgroundWhy Fast Velocity Resistance Training Should Be Prioritized for Elderly People
Orssatto, L. B. R., Cadore, E. L., Andersen, L. L., & Diefenthaeler, F. (2018) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000407 · Cited by 31
“(36,37) including muscle atrophy and loss of maxima l strength, muscle power output, and explosive force (33,35,52).”
Exercise capacity, physical activity, and morbidity
Brunjes, D. L., Kennel, P. J., & Schulze, P. C. (2017) · Heart Failure Reviews · doi:10.1007/s10741-016-9592-1 · Cited by 31
Gargallo, P., Tamayo-Torres, E., Jiménez‐Martínez, P., Juesas, Á., Casaña, J., Benítez-Martínez, J. C., Gené‐Morales, J., Garrido, J. F., Sáez, G. T., & Colado, J. C. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112340 · Cited by 30
“Considering its significance in diagnosing sarcopenia and predicting mortality (Miljkovic et al., 2015), the improvement in manual dynamometry is crucial for older adults.”
Yamada, S., Tsuruya, K., Yoshida, H., Tokumoto, M., Ueki, K., Ooboshi, H., & Kitazono, T. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0118-6 · Cited by 30
Chen, Z.-T., Jin, F.-S., Guo, L.-H., Li, X.-L., Wang, Q., Zhao, H., Sun, L.-P., & Xu, H.-X. (2023) · European Radiology · doi:10.1007/s00330-022-09382-2 · Cited by 29
“It is considered one of the main causes of depression, social isolation, frailty, and invalidity, which places an increasing burden on public health and social services [2, 3].”
BackgroundLean, fast and strong: Determinants of functional performance in the elderly
Orssatto, L. B. R., Bezerra, E. S., Schoenfeld, B. J., & Diefenthaeler, F. (2020) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2020.105073 · Cited by 28
Microstructural analysis of skeletal muscle force generation during aging
Zhang, Y., Chen, J., He, Q., He, X., Basava, R. R., Hodgson, J. A., Sinha, U. S., & Sinha, S. (2019) · International Journal for Numerical Methods in Biomedical Engineering · doi:10.1002/cnm.3295 · Cited by 28
“Apart from the microstructural changes in the passive components, the loss of muscle's force generation capacity can result from other age-associated factors, such as the decreased force generation capacity of muscle fibers.(62) It was reported that the specific force generated by muscle fiber decreases by around 30%…”
BackgroundAli, A. M., & Kunugi, H. (2021) · BioMed · doi:10.3390/biomed1010002 · Cited by 28
“Evidence denotes that biological aging of human skeletal muscle is not necessarily related to chronological aging—loss of muscle mass can start as early as the second decade of life, and it is exacerbated by muscle inactivity associated with a sedentary lifestyle [2,3,15].”
BackgroundLim, J., & Frontera, W. R. (2023) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2023.111559 · Cited by 32
Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent
Malhan, D., Yalçın, M., Schoenrock, B., Blottner, D., & Relógio, A. (2023) · npj Microgravity · doi:10.1038/s41526-023-00273-4 · Cited by 28
From molecular to physical function: The aging trajectory
Janssen, T., Lowisz, C. V., & Phillips, S. M. (2024) · Current Research in Physiology · doi:10.1016/j.crphys.2024.100138 · Cited by 31
“A reduction in myosin protein content and post-translational modifications may disrupt the mechanism of contraction at the cross-bridge level (Miljkovic et al., 2015).”
Responsiveness to muscle mass gain following 12 and 24 weeks of resistance training in older women
Nunes, J. P., Pina, F. L. C., Ribeiro, A. S., Cunha, P. M., Kassiano, W., Costa, B. D. V., Kunevaliki, G., do Nascimento, M. A., Carneiro, N. H., Venturini, D., et al. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01587-z · Cited by 26
“This seems to be plausible in older women since the aging process leads to a reduction in the innervation of high-threshold fibers and decrease in the proportion of type II fibers [24], which might explain the small improvements or absence of gains in SMM in N-RP individuals.”
BackgroundCamerino, G. M., Bellis, M. D., Conte, E., Liantonio, A., Musaraj, K., Cannone, M., Fonzino, A., Giustino, A., Luca, A. D., Romano, R., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.06.032 · Cited by 27
Current Status of Sarcopenia in Korea: A Focus on Korean Geripausal Women
Park, H. M. (2018) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.2018.22.2.52 · Cited by 25
Association between echo intensity of the tongue and its thickness and function in elderly subjects
Ariya, C., Tohara, H., Nakagawa, K., Hara, K., Nakane, A., Yamaguchi, K., Yoshimi, K., Furuya, J., & Minakuchi, S. (2019) · Journal of Oral Rehabilitation · doi:10.1111/joor.12788 · Cited by 25
Fritzen, A. M., Thøgersen, F. B., Qadri, K. A. N., Krag, T. O. B., Sveen, M., Vissing, J., & Jeppesen, T. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072188 · Cited by 26
Long, D. E., Peck, B. D., Tuggle, S. C., Villasante Tezanos, A. G., Windham, S. T., Bamman, M. M., Kern, P. A., Peterson, C. A., & Walton, R. G. (2021) · GeroScience · doi:10.1007/s11357-020-00315-9 · Cited by 25
Mobley, C. B., Mumford, P. W., Kephart, W. C., Haun, C. T., Holland, A. M., Beck, D. T., Martin, J. S., Young, K. C., Anderson, R. G., Patel, R. K., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00518 · Cited by 24
“Hence, these data collectively suggest a potential fiber type shift in the plantaris muscle whereby older rats may lose type IIa fibers thereby increasing the proportion of type I fibers, and this phenomena has been reported in past human (Miljkovic et al., 2015) and rodent literature (Putman et al.”
BackgroundKrumpolec, P., Klepochová, R., Just, I., Jelenc, M. T., Frollo, I., Ukropec, J., Ukropcová, B., Trattnig, S., Krššák, M., & Valkovič, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00644 · Cited by 24
“With the average age of the earth’s population increasing steadily, incidence of chronic diseases, and prevalence of impairments and disabilities increases as well (Miljkovic et al., 2015).”
BackgroundAbdelhafiz, A. H., Emmerton, D., & Sinclair, A. J. (2021) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14214 · Cited by 25
Markotegi, M., Irazusta, J., Sanz, B., & Rodriguez‐Larrad, A. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111580 · Cited by 24
Sawaya, Y., Ishizaka, M., Akira, K. U. B. O., Sadakiyo, K., Yakabi, A., Sato, T., Shiba, T., Onoda, K., & Maruyama, H. (2018) · Journal of Physical Therapy Science · doi:10.1589/jpts.30.1424 · Cited by 23
Castillo-Mariqueo, L., Pérez‐García, M. J., & Giménez‐Llort, L. (2021) · Biomedicines · doi:10.3390/biomedicines9101365 · Cited by 23
Abdelhafiz, A. H., & SINCLAIR, A. J. (2022) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2022.108144 · Cited by 22
Essex, A. L., Huot, J. R., Deosthale, P. J., Wagner, A., Figueras, J. H., Davis, A., Damrath, J. G., Pin, F., Wallace, J. M., Bonetto, A., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4572 · Cited by 20
“Aging skeletal muscle is known to undergo fiber-type–specific changes, primarily affecting glycolytic, Type II fibers which are the predominant fiber type found in the EDL.((74,75)) These Type II fibers that make up the majority of the EDL have been shown to express more Activin receptor type-2B (ACVRIIB) receptors fo…”
BackgroundOh, H., Jin, H., & Lee, B.-Y. (2023) · Cells · doi:10.3390/cells12152015 · Cited by 23
Wen, D., Zheng, L., Ni, L., Wang, H., Feng, Y., & Zhang, M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.006 · Cited by 23
“…decline in locomotor ability including the ability to walk because aging profoundly affects skeletal muscle, including loss ofmusclemass and strength and increasing the levels of fat and connective tissue (Miljkovic et al., 2015; Flachsbart et al., 2009; Suh et al., 2008; Willcox et al., 2008).”
Nishiguchi, S., Hino, K., Moriya, K., Shiraki, M., Hiramatsu, A., & Nishikawa, H. (2016) · Kanzo · doi:10.2957/kanzo.57.353 · Cited by 22
Olson, L. C., Nguyen, T., Heise, R. L., Boyan, B. D., Schwartz, Z., & McClure, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168832 · Cited by 21
“Slow‐twitch mus‐ cle fibers are known to increase relative to fast‐twitch muscle fibers with age, especially in sarcopenia [85,86].”
Background
Metadata
- Authors
- Miljkovic, N., Lim, J.-Y., Miljkovic, I., & Frontera, W. R.
- Affiliations
- Vanderbilt University (US)
- Seoul National University (KR)
- University of Pittsburgh (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Corresponding author
- Frontera, Walter R.
- Venue
- Annals of Rehabilitation Medicine
- Published
- 2015
- Volume
- 39
- Issue
- 2
- Pages
- 155
- ISSN
- 2234-0645 (ISSN-L)
- 2234-0653
- PMC
- PMC4414960
- OpenAlex
- W2049942632
- Cited by
- 309
- References
- 58
- Citations by year
- 2026: 21 · 2025: 20 · 2024: 32 · 2023: 30 · 2022: 24 · 2021: 42 · 2020: 44 · 2019: 28 · 2018: 30 · 2017: 14 · 2016: 23 · 2015: 1
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Annals of Rehabilitation Medicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, sarcopenia, muscle fiber atrophy, muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridges, muscle energy metabolism, muscle regeneration, muscle architecture, functional capacity decline, exercise training intervention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
